WAC-AS1

Summary

WAC-AS1 (WAC antisense RNA 1, HGNC:27347) is a long non-coding RNA gene on chromosome 10p12.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27347
Approved symbol	WAC-AS1
Name	WAC antisense RNA 1
Location	10p12.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000254635
Ensembl biotype	lncRNA
Entrez	220906
RNAcentral	URS0000759FCD — lncRNA, 5376 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000527986, ENST00000528337, ENST00000664327

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000527986 — 3 exons

Exon	Start	End
ENSE00002179783	28519917	28524611
ENSE00002179850	28525948	28526008
ENSE00002198525	28532442	28532743

Expression profiles

Bgee: expression breadth ubiquitous, 253 present calls, max score 94.56.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.4459 / max 431.3695, expressed in 1801 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
108828	5.6505	1629
108830	4.9077	1669
108829	2.8878	1356

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
superior surface of tongue	UBERON:0007371	94.56	gold quality
renal medulla	UBERON:0000362	94.39	gold quality
buccal mucosa cell	CL:0002336	94.06	gold quality
kidney epithelium	UBERON:0004819	93.42	silver quality
cerebellar cortex	UBERON:0002129	92.25	gold quality
cerebellar hemisphere	UBERON:0002245	92.21	gold quality
cardiac muscle of right atrium	UBERON:0003379	92.18	silver quality
mammary duct	UBERON:0001765	92.15	silver quality
cerebellum	UBERON:0002037	92.14	gold quality
cerebellar vermis	UBERON:0004720	92.06	gold quality
monocyte	CL:0000576	91.98	gold quality
epithelium of mammary gland	UBERON:0003244	91.97	silver quality
right hemisphere of cerebellum	UBERON:0014890	91.84	gold quality
left ventricle myocardium	UBERON:0006566	91.70	silver quality
leukocyte	CL:0000738	91.59	gold quality
nipple	UBERON:0002030	91.57	gold quality
saphenous vein	UBERON:0007318	91.44	gold quality
inferior vagus X ganglion	UBERON:0005363	91.39	gold quality
pylorus	UBERON:0001166	91.25	gold quality
medulla oblongata	UBERON:0001896	91.14	gold quality
cortical plate	UBERON:0005343	91.11	gold quality
superior vestibular nucleus	UBERON:0007227	90.89	gold quality
dorsal plus ventral thalamus	UBERON:0001897	90.84	gold quality
trigeminal ganglion	UBERON:0001675	90.75	gold quality
ventral tegmental area	UBERON:0002691	90.74	gold quality
calcaneal tendon	UBERON:0003701	90.71	gold quality
lateral globus pallidus	UBERON:0002476	90.69	gold quality
trachea	UBERON:0003126	90.40	gold quality
Brodmann (1909) area 46	UBERON:0006483	90.38	gold quality
subthalamic nucleus	UBERON:0001906	90.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Long non-coding RNA WAC antisense RNA 1 mediates hepatitis B virus replication in vitro by reinforcing miR-192-5p/ATG7-induced autophagy. (PMID:36053263)
• LncRNA WAC-AS1 expression in human tumors correlates with immune infiltration and affects prognosis. (PMID:37248547)
• LncRNA WAC-AS1 promotes osteosarcoma Metastasis and stemness by sponging miR-5047 to upregulate SOX2. (PMID:37957698)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.