WAKMAR1

Summary

WAKMAR1 (wound and keratinocyte migration associated lncRNA 1, HGNC:53753) is a long non-coding RNA gene on chromosome 20p11.21.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53753
Approved symbol	WAKMAR1
Name	wound and keratinocyte migration associated lncRNA 1
Location	20p11.21
Locus type	RNA, long non-coding
Status	Approved
OMIM	618507
Entrez	105372576

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• study revealed that WAKMAR1 regulated a network of protein-coding genes important for cell migration, most of which were under the control of transcription factor E2F1. Mechanistically, WAKMAR1 enhanced E2F1 expression by interfering with E2F1 promoter methylation through the sequestration of DNA methyltransferases. (PMID:31019085)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000016113 (20:24102444 A>G), RS1000180309 (20:24098919 A>G), RS1000229270 (20:24093787 C>T), RS1000454689 (20:24109960 A>T), RS1000550391 (20:24109238 A>G), RS1000615335 (20:24103689 G>T), RS1000645325 (20:24109385 C>T), RS1000695120 (20:24093788 G>A), RS1000833654 (20:24103010 C>G,T), RS1001041881 (20:24108607 G>A), RS1001191411 (20:24100106 G>A), RS1001554925 (20:24108809 T>G), RS1001796902 (20:24097813 C>A,T), RS1001888058 (20:24101778 G>C), RS1002085576 (20:24096207 C>T)

Disease associations

OMIM: gene MIM:618507 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.