WAKMAR2

Summary

WAKMAR2 (wound and keratinocyte migration associated lncRNA 2, HGNC:53754) is a long non-coding RNA gene on chromosome 6q23.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53754
Approved symbol	WAKMAR2
Name	wound and keratinocyte migration associated lncRNA 2
Location	6q23.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-TNFAIP3
Ensembl gene	ENSG00000237499
Ensembl biotype	lncRNA
OMIM	618508
Entrez	100130476
RNAcentral	URS000075B835 — lncRNA, 1965 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 39 — 39 lncRNA

ENST00000431144, ENST00000440578, ENST00000448942, ENST00000606327, ENST00000606998, ENST00000607671, ENST00000662141, ENST00000763029, ENST00000763030, ENST00000763031, ENST00000763032, ENST00000763033, ENST00000763034, ENST00000763035, ENST00000763036, ENST00000763037, ENST00000763038, ENST00000763039, ENST00000763040, ENST00000763041, ENST00000763042, ENST00000763043, ENST00000763044, ENST00000763045, ENST00000763046, ENST00000763047, ENST00000763048, ENST00000763049, ENST00000763050, ENST00000763051, ENST00000763052, ENST00000763053, ENST00000763054, ENST00000763055, ENST00000763056, ENST00000763057, ENST00000763058, ENST00000763059, ENST00000763060

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000431144 — 2 exons

Exon	Start	End
ENSE00001676466	137860982	137861491
ENSE00001800473	137857700	137857966

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 88.57.

FANTOM5 (CAGE): breadth broad, TPM avg 1.9664 / max 198.4577, expressed in 396 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
75873	0.8577	158
75876	0.6675	216
75874	0.3387	111
75875	0.1024	47

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	88.57	gold quality
upper arm skin	UBERON:0004263	88.34	gold quality
skin of leg	UBERON:0001511	87.04	gold quality
skin of abdomen	UBERON:0001416	86.29	gold quality
zone of skin	UBERON:0000014	85.47	gold quality
upper leg skin	UBERON:0004262	85.27	gold quality
thymus	UBERON:0002370	83.62	gold quality
gingival epithelium	UBERON:0001949	79.81	gold quality
vermiform appendix	UBERON:0001154	78.98	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.49	gold quality
right ovary	UBERON:0002118	78.23	gold quality
lower esophagus mucosa	UBERON:0035834	77.71	gold quality
small intestine Peyer’s patch	UBERON:0003454	77.65	gold quality
monocyte	CL:0000576	77.62	gold quality
leukocyte	CL:0000738	77.39	gold quality
left ovary	UBERON:0002119	77.34	gold quality
spleen	UBERON:0002106	76.73	gold quality
right lung	UBERON:0002167	76.42	gold quality
lymph node	UBERON:0000029	76.25	gold quality
esophagus mucosa	UBERON:0002469	75.56	gold quality
granulocyte	CL:0000094	74.98	gold quality
gingiva	UBERON:0001828	74.70	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.45	gold quality
vagina	UBERON:0000996	74.17	gold quality
small intestine	UBERON:0002108	73.84	gold quality
minor salivary gland	UBERON:0001830	73.80	gold quality
skin of hip	UBERON:0001554	73.79	gold quality
esophagus	UBERON:0001043	73.55	gold quality
mouth mucosa	UBERON:0003729	73.35	gold quality
upper lobe of left lung	UBERON:0008952	73.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• aberrant methylation of LOC100130476 in peripheral white blood cells andgastric cardia adenocarcinoma ( GCA) tissues may be used as a potential valuable biomarker in GCA diagnosis and prognosis (PMID:27189370)
• Study data suggest that WAKMAR2 is an important regulator of skin wound healing through production of inflammatory chemokines by keratinocytes, and cell migration enhancing and its deficiency may contribute to the pathogenesis of chronic wounds. (PMID:30594489)
• LncRNA-WAKMAR2 regulates expression of CLDN1 to affect skin barrier through recruiting c-Fos. (PMID:36461623)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.