WDFY3-AS2

Summary

WDFY3-AS2 (WDFY3 antisense RNA 2, HGNC:21603) is a long non-coding RNA gene on chromosome 4q21.23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21603
Approved symbol	WDFY3-AS2
Name	WDFY3 antisense RNA 2
Location	4q21.23
Locus type	RNA, long non-coding
Status	Approved
Aliases	FBI4
Ensembl gene	ENSG00000180769
Ensembl biotype	lncRNA
Entrez	404201
RNAcentral	URS0000CCE129 — lncRNA, 3383 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 35 lncRNA

ENST00000318186, ENST00000451762, ENST00000624443, ENST00000650984, ENST00000650985, ENST00000651069, ENST00000651209, ENST00000651404, ENST00000651772, ENST00000651773, ENST00000651845, ENST00000651964, ENST00000651995, ENST00000652101, ENST00000652114, ENST00000652163, ENST00000652207, ENST00000652312, ENST00000652392, ENST00000652452, ENST00000652474, ENST00000652481, ENST00000652490, ENST00000652498, ENST00000652610, ENST00000652652, ENST00000652697, ENST00000849098, ENST00000849099, ENST00000849100, ENST00000849101, ENST00000849102, ENST00000849103, ENST00000849104, ENST00000849105

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000318186 — 5 exons

Exon	Start	End
ENSE00001537770	85004230	85004327
ENSE00001537774	84969725	84969876
ENSE00001678374	85000691	85000765
ENSE00001707906	84966935	84967127
ENSE00003842725	85006007	85008729

Expression profiles

Bgee: expression breadth ubiquitous, 223 present calls, max score 91.59.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.4549 / max 325.6449, expressed in 1458 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
48631	6.9281	1427
48630	0.3957	194
48632	0.1311	73

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	91.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.31	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	83.27	gold quality
amygdala	UBERON:0001876	82.94	gold quality
spinal cord	UBERON:0002240	82.81	gold quality
caudate nucleus	UBERON:0001873	81.98	gold quality
substantia nigra	UBERON:0002038	81.52	gold quality
medial globus pallidus	UBERON:0002477	81.42	gold quality
putamen	UBERON:0001874	81.40	gold quality
nucleus accumbens	UBERON:0001882	81.25	gold quality
anterior cingulate cortex	UBERON:0009835	80.44	gold quality
midbrain	UBERON:0001891	80.32	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.23	gold quality
calcaneal tendon	UBERON:0003701	80.14	gold quality
kidney	UBERON:0002113	79.97	gold quality
globus pallidus	UBERON:0001875	79.87	gold quality
ventricular zone	UBERON:0003053	79.76	gold quality
adult mammalian kidney	UBERON:0000082	79.40	gold quality
hypothalamus	UBERON:0001898	79.15	gold quality
temporal lobe	UBERON:0001871	79.06	gold quality
corpus callosum	UBERON:0002336	79.00	gold quality
ganglionic eminence	UBERON:0004023	78.55	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	78.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	78.42	gold quality
right frontal lobe	UBERON:0002810	78.30	gold quality
Ammon’s horn	UBERON:0001954	78.14	gold quality
renal medulla	UBERON:0000362	77.82	gold quality
forebrain	UBERON:0001890	77.67	gold quality
brain	UBERON:0000955	77.50	gold quality
cerebral cortex	UBERON:0000956	77.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.36

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• USF1-induced overexpression of long noncoding RNA WDFY3-AS2 promotes lung adenocarcinoma progression via targeting miR-491-5p/ZNF703 axis. (PMID:32275336)
• WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors (PMID:32401758)
• LncRNA WDFY3-AS2 suppresses proliferation and invasion in oesophageal squamous cell carcinoma by regulating miR-2355-5p/SOCS2 axis. (PMID:32536038)
• Immunity-related long noncoding RNA WDFY3-AS2 inhibited cell proliferation and metastasis through Wnt/beta-catenin signaling in oral squamous cell carcinoma. (PMID:36657277)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.