WDR11-DT

Summary

WDR11-DT (WDR11 divergent transcript, HGNC:27437) is a long non-coding RNA gene on chromosome 10q26.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27437
Approved symbol	WDR11-DT
Name	WDR11 divergent transcript
Location	10q26.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227165
Ensembl biotype	lncRNA
Entrez	283089
RNAcentral	URS000075EAC8 — lncRNA, 2500 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000451706, ENST00000456120, ENST00000598981, ENST00000608667, ENST00000610133, ENST00000628194, ENST00000630905, ENST00000648536, ENST00000661416, ENST00000661709, ENST00000805417, ENST00000805418, ENST00000805419, ENST00000805420, ENST00000805421

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000451706 — 5 exons

Exon	Start	End
ENSE00001687536	120791728	120791926
ENSE00001688980	120791314	120791597
ENSE00001738055	120776735	120776884
ENSE00004197647	120793326	120793530
ENSE00004197655	120762773	120763675

Expression profiles

Bgee: expression breadth ubiquitous, 155 present calls, max score 88.91.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1111 / max 186.5970, expressed in 350 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111715	0.7921	262
111716	0.1837	70
111714	0.1353	17

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	88.91	gold quality
leukocyte	CL:0000738	87.81	gold quality
sural nerve	UBERON:0015488	84.19	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.88	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.01	gold quality
hindlimb stylopod muscle	UBERON:0004252	75.50	gold quality
buccal mucosa cell	CL:0002336	75.08	gold quality
granulocyte	CL:0000094	71.96	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.66	gold quality
cerebellar hemisphere	UBERON:0002245	70.38	gold quality
cerebellar cortex	UBERON:0002129	70.24	gold quality
bone marrow cell	CL:0002092	69.64	silver quality
cerebellum	UBERON:0002037	68.16	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.31	gold quality
spinal cord	UBERON:0002240	65.20	gold quality
superficial temporal artery	UBERON:0001614	64.96	gold quality
right uterine tube	UBERON:0001302	64.58	gold quality
hypothalamus	UBERON:0001898	64.33	gold quality
corpus callosum	UBERON:0002336	64.19	gold quality
amygdala	UBERON:0001876	63.80	gold quality
right frontal lobe	UBERON:0002810	63.05	gold quality
anterior cingulate cortex	UBERON:0009835	62.93	gold quality
putamen	UBERON:0001874	62.70	gold quality
ventricular zone	UBERON:0003053	62.59	gold quality
Brodmann (1909) area 9	UBERON:0013540	62.57	gold quality
prefrontal cortex	UBERON:0000451	62.32	gold quality
vermiform appendix	UBERON:0001154	62.19	gold quality
nucleus accumbens	UBERON:0001882	62.17	gold quality
cortical plate	UBERON:0005343	62.03	gold quality
caudate nucleus	UBERON:0001873	61.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.84

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.