WDR20

Summary

WDR20 (WD repeat domain 20, HGNC:19667) is a protein-coding gene on chromosome 14q32.31, encoding WD repeat-containing protein 20 (Q8TBZ3). Regulator of deubiquitinating complexes.

This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene.

Source: NCBI Gene 91833 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 65 total
• Druggable target: yes
• MANE Select transcript: NM_144574

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19667
Approved symbol	WDR20
Name	WD repeat domain 20
Location	14q32.31
Locus type	gene with protein product
Status	Approved
Aliases	DMR, MGC33177, FLJ33659, Bun107
Ensembl gene	ENSG00000140153
Ensembl biotype	protein_coding
OMIM	617741
Entrez	91833

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 14 protein_coding, 7 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000299135, ENST00000322340, ENST00000335263, ENST00000342702, ENST00000424963, ENST00000454394, ENST00000555879, ENST00000555973, ENST00000556094, ENST00000556511, ENST00000556807, ENST00000557186, ENST00000557485, ENST00000558135, ENST00000558448, ENST00000558567, ENST00000558854, ENST00000559478, ENST00000559708, ENST00000561154, ENST00000879557, ENST00000879558, ENST00000944828

RefSeq mRNA: 33 — MANE Select: NM_144574 NM_001242414, NM_001242415, NM_001242416, NM_001242417, NM_001242418, NM_001320130, NM_001330228, NM_001353656, NM_001353657, NM_001353658, NM_001353659, NM_001353660, NM_001353661, NM_001353662, NM_001353663, NM_001353664, NM_001353665, NM_001353666, NM_001353667, NM_001353669, NM_001353671, NM_001353672, NM_001353673, NM_001353674, NM_001353675, NM_001353676, NM_001353677, NM_001353678, NM_001353680, NM_001353681, NM_144574, NM_181291, NM_181308

CCDS: CCDS55942, CCDS55943, CCDS55944, CCDS55945, CCDS81853, CCDS9968, CCDS9969, CCDS9970

Canonical transcript exons

ENST00000342702 — 3 exons

Exon	Start	End
ENSE00002531835	102208603	102210527
ENSE00002546532	102139897	102140172
ENSE00003633323	102194938	102195120

Expression profiles

Bgee: expression breadth ubiquitous, 244 present calls, max score 99.26.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 18.3474 / max 107.1139, expressed in 1805 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
141647	17.6070	1804
141646	0.4322	246
141648	0.3082	147

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	99.26	gold quality
sperm	CL:0000019	95.91	gold quality
oocyte	CL:0000023	95.79	gold quality
buccal mucosa cell	CL:0002336	92.23	gold quality
left testis	UBERON:0004533	91.48	gold quality
right testis	UBERON:0004534	91.36	gold quality
cortical plate	UBERON:0005343	90.92	gold quality
calcaneal tendon	UBERON:0003701	90.52	gold quality
testis	UBERON:0000473	90.20	gold quality
corpus callosum	UBERON:0002336	90.13	gold quality
ganglionic eminence	UBERON:0004023	89.83	gold quality
bone marrow cell	CL:0002092	89.60	gold quality
oviduct epithelium	UBERON:0004804	89.50	gold quality
epithelial cell of pancreas	CL:0000083	88.47	gold quality
right adrenal gland	UBERON:0001233	88.11	gold quality
right adrenal gland cortex	UBERON:0035827	87.98	gold quality
lower esophagus mucosa	UBERON:0035834	87.65	gold quality
left adrenal gland	UBERON:0001234	87.62	gold quality
adrenal tissue	UBERON:0018303	87.53	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	87.41	gold quality
islet of Langerhans	UBERON:0000006	87.26	gold quality
left adrenal gland cortex	UBERON:0035825	87.26	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.24	gold quality
adrenal gland	UBERON:0002369	87.03	gold quality
sural nerve	UBERON:0015488	86.77	gold quality
right uterine tube	UBERON:0001302	86.71	gold quality
adrenal cortex	UBERON:0001235	86.65	gold quality
monocyte	CL:0000576	86.57	gold quality
jejunal mucosa	UBERON:0000399	86.56	gold quality
leukocyte	CL:0000738	86.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

56 targeting WDR20, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-130A-3P	99.90	73.31	1861
HSA-MIR-130B-3P	99.90	73.27	1850
HSA-MIR-301A-3P	99.90	73.15	1839
HSA-MIR-301B-3P	99.90	73.19	1836
HSA-MIR-3666	99.90	73.24	1833
HSA-MIR-4295	99.90	73.11	1838
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-374C-5P	99.80	72.06	2910
HSA-MIR-655-3P	99.80	72.19	2909
HSA-MIR-148A-3P	99.74	73.77	1700
HSA-MIR-148B-3P	99.74	73.75	1700
HSA-MIR-152-3P	99.74	73.75	1703
HSA-MIR-519C-3P	99.67	71.67	1870

Literature-anchored findings (GeneRIF, showing 6)

• WDR20 serves as a stimulatory subunit for preserving and regulating the activity of the subset of the UAF1 x USP12 complexes (PMID:20147737)
• our data suggest that downregulation of WDR20 due to 14q loss may be involved in the malignant transformation of ccRCCs, in part through activation of the ERK and protein kinase B/AKT pathways (PMID:26790128)
• UAF1 and WDR20 interact with USP12 at two distinct sites far from its catalytic center, allosterically activating the enzyme. (PMID:27373336)
• Results identified WDR20 as an important adaptor protein involved in ERAD system by promoting protein ubiquitination. (PMID:29655804)
• WDR20 plays a crucial role in as a “targeting subunit” that modulates CRM1-dependent shuttling of the USP12/UAF1/WDR20 complex between the plasma membrane, cytoplasm and nucleus. (PMID:30466959)
• WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc. (PMID:39432777)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	wdr20b	ENSDARG00000041239
danio_rerio	wdr20a	ENSDARG00000079220
mus_musculus	Wdr20rt	ENSMUSG00000035560
mus_musculus	Wdr20	ENSMUSG00000037957
rattus_norvegicus	Wdr20	ENSRNOG00000007333
drosophila_melanogaster	CG6420	FBGN0039451
caenorhabditis_elegans		WBGENE00007428

Paralogs (1): DMWD (ENSG00000185800)

Protein

Protein identifiers

WD repeat-containing protein 20 — Q8TBZ3 (reviewed: Q8TBZ3)

Alternative names: Protein DMR

All UniProt accessions (7): Q8TBZ3, A0A088AWN2, G3V5V2, H0YK31, H0YKE8, H0YNU0, Q5JPH5

UniProt curated annotations — full annotation on UniProt →

Function. Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme. Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus.

Subunit / interactions. Interacts with USP12; promotes translocation of USP12/WDR20 to the plasma membrane. Component of the USP12/WDR20/WDR48 deubiquitinating complex. Interacts with USP46; contributes to the cytoplasmic localization of the USP46/WDR20 complex. Component of the USP12/DMWD/WDR48 deubiquitinating complex.

Subcellular location. Cytoplasm. Nucleus.

Isoforms (8)

UniProt ID	Names	Canonical?
Q8TBZ3-1	1	yes
Q8TBZ3-2	2
Q8TBZ3-3	3
Q8TBZ3-4	4
Q8TBZ3-5	5
Q8TBZ3-6	6
Q8TBZ3-7	7
Q8TBZ3-8	8

RefSeq proteins (33): NP_001229343, NP_001229344, NP_001229345, NP_001229346, NP_001229347, NP_001307059, NP_001317157, NP_001340585, NP_001340586, NP_001340587, NP_001340588, NP_001340589, NP_001340590, NP_001340591, NP_001340592, NP_001340593, NP_001340594, NP_001340595, NP_001340596, NP_001340598, NP_001340600, NP_001340601, NP_001340602, NP_001340603, NP_001340604, NP_001340605, NP_001340606, NP_001340607, NP_001340609, NP_001340610, NP_653175, NP_851808, NP_851825 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR051362	WD_repeat_creC_regulators	Family

Pfam: PF00400

UniProt features (80 total): strand 35, splice variant 7, repeat 7, modified residue 6, sequence conflict 5, turn 5, mutagenesis site 4, helix 3, region of interest 2, compositionally biased region 2, sequence variant 2, initiator methionine 1, chain 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
5K19	X-RAY DIFFRACTION	2.6
5K1C	X-RAY DIFFRACTION	3
6JLQ	X-RAY DIFFRACTION	3.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TBZ3-F1	78.40	0.63

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 2, 357, 360, 432, 434, 465

Mutagenesis-validated functional residues (4):

Position	Phenotype
262	impaired binding to usp12. does not induce plasma localization of usp12; when associated with a-306.
306	impaired binding to usp12. does not induce plasma localization of usp12; when associated with a-262.
464	induces partial relocation of wdr20 from the cytoplasm to the nucleus; when associated with a-466.
466	induces partial relocation of wdr20 from the cytoplasm to the nucleus; when associated with a-464.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-5689880	Ub-specific processing proteases

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (2): deubiquitinase activator activity (GO:0035800), protein binding (GO:0005515)

GO Cellular Component (3): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Deubiquitination	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
peptidase activator activity	1
deubiquitinase activity	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

2556 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
WDR20	WDR48	Q8TAF3	959
WDR20	USP12	O75317	934
WDR20	USP46	P62068	863
WDR20	USP1	O94782	585
WDR20	USP14	P54578	531
WDR20	DLK1	P15803	518
WDR20	ZUP1	Q96AP4	515
WDR20	ZNF839	A8K0R7	485
WDR20	MCTS2	A0A3B3IRV3	480
WDR20	FAM50B	Q9Y247	478
WDR20	DIO3	P55073	476
WDR20	PHLPP1	O60346	464
WDR20	PHLPP2	Q6ZVD8	453
WDR20	HTT	P42858	448
WDR20	FRRS1L	Q9P0K9	447

IntAct

73 interactions, top by confidence:

A	B	Type	Score
USP46	WDR20	psi-mi:“MI:0915”(physical association)	0.800
USP12	WDR20	psi-mi:“MI:0915”(physical association)	0.800
WDR20	USP12	psi-mi:“MI:0914”(association)	0.800
PHLPP2	NHERF1	psi-mi:“MI:0914”(association)	0.760
USP46	PHLPP1	psi-mi:“MI:0914”(association)	0.740
VSX1	USP12	psi-mi:“MI:0914”(association)	0.730
TMEM266	KDM1A	psi-mi:“MI:0914”(association)	0.670
WDR20	PHLPP1	psi-mi:“MI:0914”(association)	0.670
WDR20	YWHAH	psi-mi:“MI:0914”(association)	0.640
TSPYL6	USP12	psi-mi:“MI:0914”(association)	0.640
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
WDR20	DAPP1	psi-mi:“MI:0915”(physical association)	0.570
DAPP1	WDR20	psi-mi:“MI:0915”(physical association)	0.570
USP12	PHLPP1	psi-mi:“MI:0914”(association)	0.570
PHLPP1	USP12	psi-mi:“MI:0914”(association)	0.570
WDR48	USP12	psi-mi:“MI:0914”(association)	0.530
YWHAZ	BLTP3B	psi-mi:“MI:0914”(association)	0.530
HSPB8	VWA8	psi-mi:“MI:0914”(association)	0.530
RNF19B	PIK3R2	psi-mi:“MI:0914”(association)	0.530
RAD51AP1	USP12	psi-mi:“MI:0914”(association)	0.530
VSX2	USP12	psi-mi:“MI:0914”(association)	0.530
TRIM35	MTA2	psi-mi:“MI:0914”(association)	0.530
SGO1	USP12	psi-mi:“MI:0914”(association)	0.530
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
WDR20	H1-2	psi-mi:“MI:0915”(physical association)	0.400
TYK2	BAG2	psi-mi:“MI:0914”(association)	0.350

BioGRID (170): WDR20 (Affinity Capture-Western), WDR20 (Affinity Capture-Western), WDR20 (Two-hybrid), WDR20 (Affinity Capture-MS), WDR20 (Affinity Capture-MS), WDR20 (Affinity Capture-MS), WDR20 (Affinity Capture-MS), WDR20 (Affinity Capture-MS), WDR20 (Two-hybrid), DAPP1 (Affinity Capture-Luminescence), WDR20 (Proximity Label-MS), WDR20 (Affinity Capture-MS), WDR20 (Affinity Capture-MS), WDR20 (Affinity Capture-MS), WDR20 (Proximity Label-MS)

ESM2 similar proteins: A1CTE6, A1DMI8, A2QVV2, A5DHI9, A7UWE6, B0Y7H6, B8N4F5, B8PBQ6, G0S8H7, O94979, Q05B30, Q0CKB1, Q0CQ54, Q0J7U6, Q0UNC6, Q0WV90, Q10NY2, Q1DHE1, Q24246, Q24371, Q27GK7, Q2GSJ9, Q2KG01, Q2TAF3, Q2UBU2, Q2UM42, Q3UMY5, Q4IBR4, Q4WN25, Q4WQJ1, Q4WTC4, Q5BDU4, Q5BGR2, Q5E915, Q5NBT9, Q5QA94, Q5ZLG9, Q6C553, Q6DIP5, Q7RZI0

Diamond homologs: A1CTE6, A1DMI8, A2QVV2, B0Y7H6, B8N4F5, D9N129, P16649, P56094, Q08274, Q09019, Q0CKB1, Q10437, Q2HJH6, Q2UM42, Q4WN25, Q5RF51, Q5XIG8, Q6ZMW3, Q8TBZ3, Q96DI7, Q9P4R5, Q9VBC4, Q9Y3F4, Q9Z1Z2, Q9D5R2, F1SS88, O35242, Q09150, Q5F201, Q6C553, Q6PE01, Q6ZPG2, Q8N1V2, Q92636, Q95JL5, Q54PE0, C4R6H3, Q5EBD9, Q5SQM0, Q00664

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 81 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
RHO GTPases activate PKNs	5	28.3×	4e-05
SARS-CoV-2-host interactions	5	10.6×	1e-03
Potential therapeutics for SARS	5	10.2×	1e-03
SARS-CoV Infections	8	7.9×	1e-04
Cell Cycle Checkpoints	5	7.9×	3e-03
RHO GTPase Effectors	6	7.3×	1e-03
SARS-CoV-2 Infection	5	7.2×	4e-03
Transcriptional Regulation by TP53	6	6.7×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

65 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	60
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1269 predictions. Top by Δscore:

Variant	Effect	Δscore
14:102140161:G:GT	donor_gain	1.0000
14:102194932:CTCCA:C	acceptor_loss	1.0000
14:102194933:TCCA:T	acceptor_loss	1.0000
14:102194934:CCA:C	acceptor_loss	1.0000
14:102194935:CA:C	acceptor_loss	1.0000
14:102194936:A:AG	acceptor_gain	1.0000
14:102194936:AG:A	acceptor_gain	1.0000
14:102194937:G:A	acceptor_loss	1.0000
14:102194937:G:GG	acceptor_gain	1.0000
14:102194937:GG:G	acceptor_gain	1.0000
14:102194937:GGCT:G	acceptor_gain	1.0000
14:102195116:AGGAA:A	donor_gain	1.0000
14:102195117:GGAA:G	donor_gain	1.0000
14:102195117:GGAAG:G	donor_gain	1.0000
14:102195118:G:GT	donor_gain	1.0000
14:102195118:GAA:G	donor_gain	1.0000
14:102195121:G:GG	donor_gain	1.0000
14:102140169:CAAG:C	donor_loss	0.9900
14:102140170:AAGG:A	donor_loss	0.9900
14:102140171:AGG:A	donor_loss	0.9900
14:102140172:GG:G	donor_loss	0.9900
14:102140174:T:A	donor_loss	0.9900
14:102140204:GCGGC:G	donor_gain	0.9900
14:102194936:AGGCT:A	acceptor_gain	0.9900
14:102194937:GGC:G	acceptor_gain	0.9900
14:102194937:GGCTG:G	acceptor_gain	0.9900
14:102195118:GAAGT:G	donor_loss	0.9900
14:102195119:AAGTA:A	donor_loss	0.9900
14:102195120:AG:A	donor_loss	0.9900
14:102195121:G:A	donor_loss	0.9900

AlphaMissense

3762 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:102139973:T:C	F17S	1.000
14:102139993:T:G	Y24D	1.000
14:102140066:T:A	V48D	1.000
14:102140127:T:A	N68K	1.000
14:102140127:T:G	N68K	1.000
14:102140141:T:C	L73P	1.000
14:102194965:A:G	K93E	1.000
14:102194966:A:T	K93I	1.000
14:102194967:A:C	K93N	1.000
14:102194967:A:T	K93N	1.000
14:102194970:G:C	R94S	1.000
14:102194970:G:T	R94S	1.000
14:102194974:T:G	Y96D	1.000
14:102194977:A:G	K97E	1.000
14:102194978:A:T	K97I	1.000
14:102194979:A:C	K97N	1.000
14:102194979:A:T	K97N	1.000
14:102194980:G:A	G98R	1.000
14:102194980:G:C	G98R	1.000
14:102194981:G:A	G98E	1.000
14:102194990:C:A	P101H	1.000
14:102194990:C:G	P101R	1.000
14:102195041:T:C	L118P	1.000
14:102195049:G:C	G121R	1.000
14:102195050:G:A	G121D	1.000
14:102195052:T:C	F122L	1.000
14:102195053:T:C	F122S	1.000
14:102195054:T:A	F122L	1.000
14:102195054:T:G	F122L	1.000
14:102195061:G:C	G125R	1.000

dbSNP variants (sampled 300 via entrez): RS1000002600 (14:102182320 A>G), RS1000035258 (14:102181880 G>A), RS1000045271 (14:102180396 T>G), RS1000055689 (14:102139847 G>A), RS1000099013 (14:102174093 G>A,T), RS1000101687 (14:102147535 C>G), RS1000107987 (14:102213490 G>A), RS1000109496 (14:102154040 G>A,C), RS1000144814 (14:102188092 C>G,T), RS1000176671 (14:102224991 G>A,T), RS1000190959 (14:102162140 G>A), RS1000203485 (14:102191481 T>C), RS1000209593 (14:102157315 A>G), RS1000231711 (14:102197626 T>G), RS1000246283 (14:102184157 G>A)

Disease associations

OMIM: gene MIM:617741 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST004621_74	Red cell distribution width	1.000000e-11
GCST006804_160	Red cell distribution width	1.000000e-09
GCST007656_14	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy)	1.000000e-11
GCST90002385_35	High light scatter reticulocyte count	4.000000e-11
GCST90002386_584	High light scatter reticulocyte percentage of red cells	2.000000e-10
GCST90002400_146	Plateletcrit	2.000000e-10
GCST90002405_377	Reticulocyte count	1.000000e-10
GCST90002406_379	Reticulocyte fraction of red cells	2.000000e-09

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0009188	Red cell distribution width
EFO:0007986	reticulocyte count
EFO:0007985	platelet crit

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (2): CHEMBL5291970 (PROTEIN COMPLEX), CHEMBL5291973 (PROTEIN COMPLEX)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, decreases methylation	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
FR900359	decreases phosphorylation	1
bufotalin	increases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
deoxynivalenol	increases expression	1
di-n-butylphosphoric acid	affects expression	1
PCI 5002	affects cotreatment, increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	affects methylation	1
Vehicle Emissions	increases abundance, increases expression	1
Caffeine	affects phosphorylation	1
Copper	affects binding, decreases expression	1
Disulfiram	decreases expression, affects binding	1
Formaldehyde	decreases expression	1
Hydrogen Peroxide	affects cotreatment, increases expression, decreases expression	1
Theophylline	affects cotreatment, increases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	decreases expression	1
Zinc	increases expression, affects cotreatment	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Asbestos, Crocidolite	increases expression	1
Antirheumatic Agents	increases expression	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5251168	Binding	Inhibition of USP46/UAF1/WDR20 (unknown origin) using ubiquitin rhodamine 110 as substrate at 1 to 10 uM by DUBprofiler fluorometric assay	Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.