WDR24

Summary

WDR24 (WD repeat domain 24, HGNC:20852) is a protein-coding gene on chromosome 16p13.3, encoding GATOR2 complex protein WDR24 (Q96S15). Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. It is a selective cancer dependency (DepMap: 60.0% of cell lines).

Enables ubiquitin protein ligase activity. Involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and protein K6-linked ubiquitination. Located in cytosol and lysosomal membrane. Part of GATOR2 complex.

Source: NCBI Gene 84219 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 120 total
• Cancer dependency (DepMap): dependent in 60.0% of screened cell lines
• MANE Select transcript: NM_032259

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20852
Approved symbol	WDR24
Name	WD repeat domain 24
Location	16p13.3
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp434F054, JFP7
Ensembl gene	ENSG00000127580
Ensembl biotype	protein_coding
OMIM	620307
Entrez	84219

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 retained_intron

ENST00000248142, ENST00000293883, ENST00000567014, ENST00000647644, ENST00000886263, ENST00000886264, ENST00000933313

RefSeq mRNA: 1 — MANE Select: NM_032259 NM_032259

CCDS: CCDS10420

Canonical transcript exons

ENST00000293883 — 9 exons

Exon	Start	End
ENSE00000873928	684992	685176
ENSE00000873929	685257	685597
ENSE00000873931	685869	685990
ENSE00000873932	686068	686186
ENSE00000873933	686744	687416
ENSE00000873934	687562	687739
ENSE00001352797	689160	690398
ENSE00001529438	684622	684902
ENSE00003496887	685679	685783

Expression profiles

Bgee: expression breadth ubiquitous, 170 present calls, max score 85.20.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.8991 / max 73.0948, expressed in 1784 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155750	9.6508	1777
155751	1.2482	815

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	85.20	gold quality
apex of heart	UBERON:0002098	84.01	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.13	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.88	gold quality
gastrocnemius	UBERON:0001388	82.11	gold quality
cerebellar hemisphere	UBERON:0002245	81.83	gold quality
stromal cell of endometrium	CL:0002255	81.70	gold quality
hindlimb stylopod muscle	UBERON:0004252	81.61	gold quality
cerebellar cortex	UBERON:0002129	81.60	gold quality
right adrenal gland	UBERON:0001233	81.29	gold quality
left testis	UBERON:0004533	81.26	gold quality
right testis	UBERON:0004534	81.18	gold quality
right frontal lobe	UBERON:0002810	81.12	gold quality
granulocyte	CL:0000094	81.05	gold quality
muscle of leg	UBERON:0001383	80.95	gold quality
right lobe of thyroid gland	UBERON:0001119	80.90	gold quality
right adrenal gland cortex	UBERON:0035827	80.82	gold quality
left adrenal gland	UBERON:0001234	80.57	gold quality
right lobe of liver	UBERON:0001114	80.46	gold quality
left adrenal gland cortex	UBERON:0035825	80.44	gold quality
right ovary	UBERON:0002118	80.03	gold quality
left ovary	UBERON:0002119	79.73	gold quality
left lobe of thyroid gland	UBERON:0001120	79.64	gold quality
skin of leg	UBERON:0001511	79.63	gold quality
adenohypophysis	UBERON:0002196	79.58	gold quality
mucosa of transverse colon	UBERON:0004991	79.56	gold quality
lower esophagus muscularis layer	UBERON:0035833	79.54	gold quality
lower esophagus	UBERON:0013473	79.51	gold quality
body of stomach	UBERON:0001161	79.43	gold quality
cerebellum	UBERON:0002037	79.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.73

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

1 targeting WDR24, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-138-1-3P	98.25	67.89	867

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 60.0% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 3)

• Consistent with our findings in Drosophila, through the characterization of a wdr24-/- knockout HeLa cell line we determined that Wdr24 promotes lysosome acidification and autophagic flux in mammalian cells (PMID:27166823)
• The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation. (PMID:31915252)
• CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth. (PMID:36995937)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	wdr24	ENSDARG00000025507
mus_musculus	Wdr24	ENSMUSG00000025737
rattus_norvegicus	Wdr24	ENSRNOG00000019713
drosophila_melanogaster	Wdr24	FBGN0027518

Paralogs (9): ERCC8 (ENSG00000049167), GEMIN5 (ENSG00000082516), RBBP7 (ENSG00000102054), WDR59 (ENSG00000103091), GRWD1 (ENSG00000105447), PEX7 (ENSG00000112357), WDR77 (ENSG00000116455), RBBP4 (ENSG00000162521), WDR73 (ENSG00000177082)

Protein

Protein identifiers

GATOR2 complex protein WDR24 — Q96S15 (reviewed: Q96S15)

Alternative names: WD repeat-containing protein 24

All UniProt accessions (3): Q96S15, A0A3B3ISA1, A0A499FJD3

UniProt curated annotations — full annotation on UniProt →

Function. Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. In addition to its role in regulation of the mTORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux. Within the GATOR2 complex, WDR24 constitutes the catalytic subunit that mediates ‘Lys-6’-linked ubiquitination of NPRL2.

Subunit / interactions. Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine. The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids. SESN1, SESN2 and SESN3 convey leucine availability via direct interaction with SEH1L and WDR24.

Subcellular location. Lysosome membrane.

Post-translational modifications. Phosphorylation at Ser-155 by AMPK in response to glucose deprivation inactivates WDR24 by promoting interaction with 14-3-3 proteins, such as YWHAG, preventing assembly of the GATOR2 complex. Autoubiquitinated; MIOS is required to prevent autoubiquitination.

Activity regulation. The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids. In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated.

Pathway. Protein modification; protein ubiquitination.

Similarity. Belongs to the WD repeat WDR24 family.

RefSeq proteins (1): NP_115635* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR037590	WDR24	Family

Pfam: PF00400

UniProt features (35 total): binding site 15, repeat 6, modified residue 6, mutagenesis site 5, zinc finger region 2, chain 1

Structure

Experimental structures (PDB)

5 structures.

PDB	Method	Resolution (Å)
9LWF	ELECTRON MICROSCOPY	3.41
9OTI	ELECTRON MICROSCOPY	3.5
9LVK	ELECTRON MICROSCOPY	3.59
7UHY	ELECTRON MICROSCOPY	3.66
9LVJ	ELECTRON MICROSCOPY	3.82

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96S15-F1	74.26	0.47

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (15): 722; 733; 736; 743; 746; 757; 760; 762; 765; 768; 779; 783 …

Post-translational modifications (6): 155, 470, 496, 581, 594, 598

Mutagenesis-validated functional residues (5):

Position	Phenotype
155	abolished phosphorylation by ampk.
155	mimics phosphorylation, leading to inhibit mtorc1 activation.
451	abolished interaction with wdr59 and assembly of the gator2 complex; when associated with e-632-633-e.
632–633	abolished interaction with wdr59 and assembly of the gator2 complex; when associated with e-451.
743–746	impaired amino-acid-mediated mtorc1 activation.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9639288	Amino acids regulate mTORC1

MSigDB gene sets: 119 (showing top): GOBP_REGULATION_OF_AUTOPHAGY, GOCC_VACUOLAR_MEMBRANE, GOBP_POSITIVE_REGULATION_OF_TOR_SIGNALING, GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY, GOBP_MACROAUTOPHAGY, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS, GOBP_NEGATIVE_REGULATION_OF_TOR_SIGNALING, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBP_PROTEIN_POLYUBIQUITINATION, GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_CELLULAR_RESPONSE_TO_STARVATION, GOBP_TOR_SIGNALING, GOBP_LOCALIZATION_WITHIN_MEMBRANE

GO Biological Process (16): autophagy (GO:0006914), regulation of autophagy (GO:0010506), positive regulation of macroautophagy (GO:0016239), cellular response to nutrient levels (GO:0031669), positive regulation of TOR signaling (GO:0032008), cellular response to amino acid starvation (GO:0034198), protein localization to plasma membrane (GO:0072659), protein K6-linked ubiquitination (GO:0085020), negative regulation of TORC1 signaling (GO:1904262), positive regulation of TORC1 signaling (GO:1904263), cytoplasmic translation (GO:0002181), protein ubiquitination (GO:0016567), TORC1 signaling (GO:0038202), negative regulation of translational initiation (GO:0045947), positive regulation of translational initiation (GO:0045948), protein localization to lysosome (GO:0061462)

GO Molecular Function (5): zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (6): lysosomal membrane (GO:0005765), vacuolar membrane (GO:0005774), cytosol (GO:0005829), GATOR2 complex (GO:0061700), lysosome (GO:0005764), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Cellular response to starvation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
TOR signaling	2
TORC1 signaling	2
regulation of TORC1 signaling	2
translational initiation	2
regulation of translational initiation	2
cellular anatomical structure	2
catabolic process	1
transmembrane transport	1
process utilizing autophagic mechanism	1
autophagy	1
regulation of catabolic process	1
positive regulation of autophagy	1
macroautophagy	1
regulation of macroautophagy	1
response to nutrient levels	1
cellular response to stimulus	1
regulation of TOR signaling	1
positive regulation of intracellular signal transduction	1
cellular response to starvation	1
response to amino acid starvation	1
protein localization to membrane	1
protein localization to cell periphery	1
protein polyubiquitination	1
negative regulation of TOR signaling	1
positive regulation of TOR signaling	1
translation	1
protein modification by small protein conjugation	1
negative regulation of translation	1
positive regulation of translation	1
protein localization to vacuole	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
catalytic activity	1
cation binding	1
lysosome	1
lytic vacuole membrane	1
vacuole	1
bounding membrane of organelle	1

Protein interactions and networks

STRING

1086 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
WDR24	MIOS	Q9NXC5	998
WDR24	SEC13	P55735	997
WDR24	SEH1L	Q96EE3	997
WDR24	WDR59	Q6PJI9	993
WDR24	NPRL2	Q8WTW4	848
WDR24	NPRL3	Q12980	847
WDR24	DEPDC5	O75140	817
WDR24	SESN2	P58004	767
WDR24	RRAGB	Q5VZM2	759
WDR24	RRAGC	Q9HB90	732
WDR24	CASTOR2	A6NHX0	728
WDR24	RRAGA	Q7L523	725
WDR24	SESN1	Q9Y6P5	724
WDR24	RRAGD	Q9NQL2	715
WDR24	ITFG2	Q969R8	684

IntAct

83 interactions, top by confidence:

A	B	Type	Score
WDR24	MIOS	psi-mi:“MI:0915”(physical association)	0.940
MIOS	WDR24	psi-mi:“MI:0915”(physical association)	0.940
WDR24	SESN2	psi-mi:“MI:0915”(physical association)	0.890
WDR24	SESN2	psi-mi:“MI:0914”(association)	0.890
SESN2	WDR24	psi-mi:“MI:0914”(association)	0.890
SESN2	WDR24	psi-mi:“MI:0915”(physical association)	0.890
NPRL2	NPRL3	psi-mi:“MI:0914”(association)	0.850
NPRL2	NPRL3	psi-mi:“MI:0403”(colocalization)	0.850
RBBP5	KMT2D	psi-mi:“MI:0914”(association)	0.840
MIOS	SEC13	psi-mi:“MI:0914”(association)	0.790
CASTOR1	CASTOR1	psi-mi:“MI:0914”(association)	0.770
WDR24	SEC13	psi-mi:“MI:0914”(association)	0.730
CASTOR1	CASTOR2	psi-mi:“MI:0914”(association)	0.710

BioGRID (96): WDR24 (Two-hybrid), WDR24 (Affinity Capture-MS), WDR24 (Affinity Capture-MS), WDR24 (Two-hybrid), WDR24 (Affinity Capture-MS), WDR24 (Biochemical Activity), WDR24 (Affinity Capture-MS), WDR24 (Affinity Capture-MS), WDR24 (Affinity Capture-MS), MIOS (Affinity Capture-Western), WDR59 (Affinity Capture-Western), SEH1L (Affinity Capture-Western), SEC13 (Affinity Capture-Western), DEPDC5 (Affinity Capture-Western), NPRL3 (Affinity Capture-Western)

ESM2 similar proteins: A0A396ISC0, O00423, O13286, O17468, O61585, O94423, P26309, P38328, P43254, P53197, P78972, P93471, Q04199, Q05BC3, Q09373, Q12834, Q16MY0, Q2TAF3, Q32SG6, Q3E906, Q4PSE4, Q4V7Y7, Q4V8C3, Q54MZ3, Q5H7C0, Q5ZIU8, Q62623, Q652L2, Q6DIP5, Q6NVM2, Q6S7B0, Q7K0L4, Q7ZUV2, Q7ZVL2, Q7ZX22, Q86Y33, Q8BG40, Q8CFJ9, Q8L3Z8, Q8LPL5

Diamond homologs: A5E6M3, A6ZN74, A7TR10, B3LIS9, C5DJV1, C5DSV0, C7GV13, C8ZHH9, Q08281, Q5ZMV9, Q6CME1, Q6FVJ1, Q75AV6, Q7ZVL2, Q8CFJ9, Q96S15, Q7ZX22, Q9VKK2, A3GIA4, B9WN49, C4Y5P7, C4YN69, C5MIB1, Q5ACL4, Q6BXX5, A2AKB9, A7RHG8, B2AEZ5, B2B766, B4JPT9, B9WD30, C4YPI7, C5MJE8, O14021, O22466, O22467, O22468, O22469, O93377, O94244

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
WDR24	“form complex”	GATOR2	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 47 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Amino acids regulate mTORC1	11	61.2×	3e-15
Cellular response to starvation	7	32.2×	2e-07
Cellular responses to stress	10	10.2×	2e-06
Cellular responses to stimuli	10	8.7×	8e-06

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of TORC1 signaling	12	90.4×	6e-19
cellular response to amino acid starvation	11	81.3×	6e-17
positive regulation of TORC1 signaling	6	41.2×	5e-07
protein stabilization	5	7.8×	6e-03
intracellular protein transport	5	7.5×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

120 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	107
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1978 predictions. Top by Δscore:

Variant	Effect	Δscore
16:685019:ATGGG:A	donor_gain	1.0000
16:685172:TGCTC:T	acceptor_gain	1.0000
16:685174:CTC:C	acceptor_gain	1.0000
16:685175:TC:T	acceptor_gain	1.0000
16:685176:CC:C	acceptor_gain	1.0000
16:685177:C:CC	acceptor_gain	1.0000
16:685177:CTGG:C	acceptor_loss	1.0000
16:685178:T:G	acceptor_loss	1.0000
16:685253:ACACC:A	donor_loss	1.0000
16:685256:C:T	donor_loss	1.0000
16:685677:A:AC	donor_gain	1.0000
16:685678:C:CC	donor_gain	1.0000
16:685678:CG:C	donor_gain	1.0000
16:685678:CGGTG:C	donor_gain	1.0000
16:685780:TTAT:T	acceptor_gain	1.0000
16:685781:TAT:T	acceptor_gain	1.0000
16:685782:ATC:A	acceptor_loss	1.0000
16:685783:TCT:T	acceptor_loss	1.0000
16:685784:C:CA	acceptor_loss	1.0000
16:685784:C:CC	acceptor_gain	1.0000
16:685785:T:A	acceptor_loss	1.0000
16:685789:C:T	acceptor_gain	1.0000
16:685790:G:T	acceptor_gain	1.0000
16:685867:AC:A	donor_gain	1.0000
16:685868:CC:C	donor_gain	1.0000
16:685868:CCCT:C	donor_gain	1.0000
16:685986:TGAAA:T	acceptor_gain	1.0000
16:685991:C:CC	acceptor_gain	1.0000
16:686739:CCTA:C	donor_gain	1.0000
16:684988:CCA:C	donor_loss	0.9900

AlphaMissense

5242 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:684880:A:G	C743R	1.000
16:684999:A:G	C733R	1.000
16:685039:G:C	C719W	1.000
16:685041:A:G	C719R	1.000
16:686174:A:G	W449R	1.000
16:686174:A:T	W449R	1.000
16:687119:C:A	K319N	1.000
16:687119:C:G	K319N	1.000
16:687161:C:A	W305C	1.000
16:687161:C:G	W305C	1.000
16:687162:C:G	W305S	1.000
16:687163:A:G	W305R	1.000
16:687163:A:T	W305R	1.000
16:687233:C:A	W281C	1.000
16:687233:C:G	W281C	1.000
16:687235:A:G	W281R	1.000
16:687235:A:T	W281R	1.000
16:687237:A:T	V280D	1.000
16:687270:G:T	T269K	1.000
16:687273:G:T	A268D	1.000
16:687274:C:G	A268P	1.000
16:687299:C:A	W259C	1.000
16:687299:C:G	W259C	1.000
16:687300:C:G	W259S	1.000
16:687301:A:G	W259R	1.000
16:687301:A:T	W259R	1.000
16:687321:G:T	A252D	1.000
16:687371:C:A	W235C	1.000
16:687371:C:G	W235C	1.000
16:687372:C:G	W235S	1.000

dbSNP variants (sampled 300 via entrez): RS1000709095 (16:688058 T>C,G), RS1001145224 (16:691073 T>C,G), RS1001194178 (16:684298 G>A,C), RS1001333493 (16:690549 G>T), RS1001429415 (16:688007 G>A,C,T), RS1001460664 (16:688325 C>A), RS1001783449 (16:691981 A>G), RS1002097573 (16:692159 G>A), RS1002479150 (16:687317 C>T), RS1002796321 (16:691193 C>T), RS1003067741 (16:691572 G>A,T), RS1003098762 (16:691384 G>A), RS1003650523 (16:684783 C>A,G,T), RS1003711995 (16:686517 A>G), RS1004445903 (16:691393 G>A,C,T)

Disease associations

OMIM: gene MIM:620307 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST008810_72	Smoking initiation (ever regular vs never regular)	5.000000e-09
GCST012227_279	Hip circumference adjusted for BMI	3.000000e-12
GCST90000047_259	Age at first sexual intercourse	5.000000e-11

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0005670	smoking initiation
EFO:0008039	BMI-adjusted hip circumference
EFO:0009749	age at first sexual intercourse measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

1 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs11640115	Efficacy	3	aspirin;clopidogrel	Acute coronary syndrome;Major Adverse Cardiac Events (MACE)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs11640115	JMJD8, WDR24	3	3.50	1	aspirin;clopidogrel

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases methylation	1
sodium arsenite	decreases expression	1
benzo(e)pyrene	increases methylation	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
abrine	increases expression	1
Sunitinib	increases expression	1
Fulvestrant	increases methylation	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	decreases expression	1
Caffeine	affects phosphorylation	1
Methapyrilene	increases methylation	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Valproic Acid	increases methylation	1
Vanadium	increases abundance, increases methylation	1
Metals, Heavy	increases abundance, increases methylation	1
Lactic Acid	decreases expression	1
Acrylamide	decreases expression	1
Particulate Matter	decreases expression, increases abundance	1

Cellosaurus cell lines

3 cell lines: 2 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D9VQ	Ubigene HEK293 WDR24 KO	Transformed cell line	Female
CVCL_TX86	HAP1 WDR24 (-) 1	Cancer cell line	Male
CVCL_TX87	HAP1 WDR24 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.