WDR41

Summary

WDR41 (WD repeat domain 41, HGNC:25601) is a protein-coding gene on chromosome 5q13.3-q14.1, encoding WD repeat-containing protein 41 (Q9HAD4). Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy.

Enables GTPase activator activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in regulation of autophagy. Located in cytoplasm. Part of guanyl-nucleotide exchange factor complex.

Source: NCBI Gene 55255 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 85 total
• MANE Select transcript: NM_018268

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25601
Approved symbol	WDR41
Name	WD repeat domain 41
Location	5q13.3-q14.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10904
Ensembl gene	ENSG00000164253
Ensembl biotype	protein_coding
OMIM	617502
Entrez	55255

Gene structure

Transcript identifiers

Ensembl transcripts: 37 — 19 protein_coding, 9 protein_coding_CDS_not_defined, 7 nonsense_mediated_decay, 2 retained_intron

ENST00000296679, ENST00000502528, ENST00000503035, ENST00000504895, ENST00000505129, ENST00000506307, ENST00000506474, ENST00000507029, ENST00000507239, ENST00000507452, ENST00000507654, ENST00000508154, ENST00000509701, ENST00000509858, ENST00000509892, ENST00000509971, ENST00000511036, ENST00000511630, ENST00000511791, ENST00000512033, ENST00000512168, ENST00000513417, ENST00000513917, ENST00000514451, ENST00000514559, ENST00000514878, ENST00000515253, ENST00000515321, ENST00000862580, ENST00000862581, ENST00000862582, ENST00000862583, ENST00000912488, ENST00000912489, ENST00000955388, ENST00000955389, ENST00000955390

RefSeq mRNA: 1 — MANE Select: NM_018268 NM_018268

CCDS: CCDS4038

Canonical transcript exons

ENST00000296679 — 13 exons

Exon	Start	End
ENSE00001595103	77430933	77433287
ENSE00002020309	77492170	77492316
ENSE00003464277	77463095	77463226
ENSE00003467542	77459062	77459124
ENSE00003493326	77437336	77437424
ENSE00003507110	77464761	77464809
ENSE00003518823	77436261	77436394
ENSE00003557223	77489457	77489572
ENSE00003571430	77440813	77440997
ENSE00003625626	77438240	77438361
ENSE00003643483	77453817	77453928
ENSE00003646662	77449760	77449870
ENSE00003786986	77451291	77451353

Expression profiles

Bgee: expression breadth ubiquitous, 290 present calls, max score 96.98.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 23.9994 / max 354.5567, expressed in 1820 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
62181	14.6227	1789
62185	4.4410	1361
62182	2.2641	1176
62184	1.6061	849
62183	1.0438	628
62187	0.0217	6

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	96.98	gold quality
ventricular zone	UBERON:0003053	95.90	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	95.68	gold quality
calcaneal tendon	UBERON:0003701	95.31	gold quality
endothelial cell	CL:0000115	95.02	gold quality
ganglionic eminence	UBERON:0004023	94.07	gold quality
descending thoracic aorta	UBERON:0002345	93.92	gold quality
tendon	UBERON:0000043	93.87	gold quality
right testis	UBERON:0004534	93.72	gold quality
cortical plate	UBERON:0005343	93.49	gold quality
oocyte	CL:0000023	93.34	gold quality
colonic epithelium	UBERON:0000397	93.32	gold quality
left testis	UBERON:0004533	93.31	gold quality
thoracic aorta	UBERON:0001515	93.28	gold quality
stromal cell of endometrium	CL:0002255	93.23	gold quality
ascending aorta	UBERON:0001496	93.22	gold quality
monocyte	CL:0000576	93.19	gold quality
testis	UBERON:0000473	93.13	gold quality
mononuclear cell	CL:0000842	93.01	gold quality
corpus callosum	UBERON:0002336	92.86	gold quality
adrenal tissue	UBERON:0018303	92.80	gold quality
leukocyte	CL:0000738	92.69	gold quality
islet of Langerhans	UBERON:0000006	92.65	gold quality
tendon of biceps brachii	UBERON:0008188	92.65	gold quality
prefrontal cortex	UBERON:0000451	92.34	gold quality
aorta	UBERON:0000947	91.84	gold quality
sperm	CL:0000019	91.77	gold quality
embryo	UBERON:0000922	91.77	gold quality
right lobe of thyroid gland	UBERON:0001119	91.74	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.66	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.42
E-GEOD-111727	no	484.62

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

101 targeting WDR41, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-98-5P	99.98	72.33	1787
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7B-5P	99.98	72.31	1790
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-3658	99.96	73.87	4379
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-5682	99.89	72.56	1005
HSA-MIR-3140-3P	99.88	68.47	2069

Literature-anchored findings (GeneRIF, showing 7)

• The peak of association was found in and around two genes, WDR41 and PDE8B, involved in dopamine signaling and development. (PMID:21502949)
• Study describes the identification of two binding partners for C9orf72: SMCR8 and WDR41 and demonstrated that C9orf72/SMCR8/WDR41 interacts with the FIP200/Ulk1/ATG13/ATG101 complex. (PMID:27193190)
• Study reveals an essential role for WDR41 in supporting the regulated binding of C9orf72 to lysosomes and solidifies the requirement for a larger C9orf72 containing protein complex in coordinating lysosomal responses to changes in amino acid availability. (PMID:29995611)
• Our study not only illustrates the basis of C9ORF72-SMCR8-WDR41 complex assembly but also reveals the GAP activity of the C9ORF72-SMCR8 complex (PMID:32303654)
• Aberrant methylation of WD-repeat protein 41 contributes to tumour progression in triple-negative breast cancer. (PMID:32394588)
• Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD. (PMID:32848248)
• Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids. (PMID:33597295)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	wdr41	ENSDARG00000009851
mus_musculus	Wdr41	ENSMUSG00000042015
rattus_norvegicus	Wdr41	ENSRNOG00000025462

Protein

Protein identifiers

WD repeat-containing protein 41 — Q9HAD4 (reviewed: Q9HAD4)

All UniProt accessions (18): A0A0S2Z5D8, Q9HAD4, A0A0S2Z5E0, B4DHS8, B4DK73, D6R9E7, D6R9M1, D6RA22, D6RB94, D6RBY6, D6RE66, D6RGW4, D6RH33, D6RIX6, D6RJA5, H0Y9Z3, H0YAA3, H0YAI6

UniProt curated annotations — full annotation on UniProt →

Function. Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.

Subunit / interactions. Component of the C9orf72-SMCR8 complex, at least composed of C9orf72, SMCR8 and WDR41. The complex is formed of two protomers, each individually consisting of one molecule each of C9orf72, SMCR8 and WDR41. The protomers homodimerize via an interaction between C9orf72 (via C-terminus) and SMCR8 (via N-terminus). Within each protomer SMCR8 (via DENN domain) acts as a bridging protein between WDR41 (via C-terminus and N-terminus) and C9orf72 (via C-terminus). The C9orf72-SMCR8 complex associates with the ULK1/ATG1 kinase complex.

Subcellular location. Cytoplasm.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9HAD4-1	1	yes
Q9HAD4-2	2

RefSeq proteins (1): NP_060738* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR020472	WD40_PAC1	Repeat
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR040102	WDR41	Family

Pfam: PF25178

UniProt features (54 total): strand 31, repeat 6, mutagenesis site 6, turn 4, sequence variant 3, chain 1, sequence conflict 1, helix 1, splice variant 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
8W3V	X-RAY DIFFRACTION	2.2
6LT0	ELECTRON MICROSCOPY	3.2
6V4U	ELECTRON MICROSCOPY	3.8
7MGE	ELECTRON MICROSCOPY	3.94

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9HAD4-F1	82.43	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (6):

Position	Phenotype
438	no effect on interaction with smcr8.
441	no effect on interaction with smcr8.
442	no effect on interaction with smcr8.
445	reduces interaction with the c9orf72-smcr8 complex; when associated with r-449. no effect on interaction with smcr8.
446	no effect on interaction with smcr8.
449	reduces interaction with the c9orf72-smcr8 complex; when associated with r-445. no effect on interaction with smcr8.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 130 (showing top): GOBP_REGULATION_OF_AUTOPHAGY, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOCC_VACUOLAR_MEMBRANE, GOBP_REGULATION_OF_EXOCYTOSIS, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_NEGATIVE_REGULATION_OF_EXOCYTOSIS, GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT, GOBP_EXOCYTOSIS, GOBP_REGULATION_OF_IMMUNE_RESPONSE, GOBP_NEGATIVE_REGULATION_OF_TRANSPORT, WANG_LMO4_TARGETS_DN, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_NEGATIVE_REGULATION_OF_SECRETION, GOBP_SECRETION, GOBP_REGULATION_OF_TRANSPORT

GO Biological Process (4): autophagy (GO:0006914), regulation of autophagy (GO:0010506), negative regulation of exocytosis (GO:0045920), negative regulation of immune response (GO:0050777)

GO Molecular Function (3): GTPase activator activity (GO:0005096), guanyl-nucleotide exchange factor activity (GO:0005085), protein binding (GO:0005515)

GO Cellular Component (3): cytoplasm (GO:0005737), lysosomal membrane (GO:0005765), guanyl-nucleotide exchange factor complex (GO:0032045)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
GTPase regulator activity	2
catabolic process	1
transmembrane transport	1
process utilizing autophagic mechanism	1
autophagy	1
regulation of catabolic process	1
exocytosis	1
regulation of exocytosis	1
negative regulation of secretion by cell	1
negative regulation of immune system process	1
immune response	1
negative regulation of response to stimulus	1
regulation of immune response	1
GTPase activity	1
enzyme activator activity	1
GTP binding	1
GDP binding	1
binding	1
intracellular anatomical structure	1
cellular anatomical structure	1
lysosome	1
lytic vacuole membrane	1
intracellular protein-containing complex	1

Protein interactions and networks

STRING

2324 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
WDR41	SMCR8	Q8TEV9	998
WDR41	C9orf72	Q96LT7	995
WDR41	RAB1A	P11476	724
WDR41	RAB39B	Q96DA2	723
WDR41	MADD	Q8WXG6	715
WDR41	ATG101	Q9BSB4	712
WDR41	RAI1	Q7Z5J4	699
WDR41	RAB8A	P24407	639
WDR41	RAB29	O14966	637
WDR41	OPTN	Q96CV9	593
WDR41	RB1CC1	Q8TDY2	589
WDR41	RAB33A	Q14088	580
WDR41	RAB5A	P20339	577
WDR41	FLCN	Q8NFG4	556
WDR41	SLC66A1	Q6ZP29	546

IntAct

55 interactions, top by confidence:

A	B	Type	Score
C9orf72	SMCR8	psi-mi:“MI:2252”(guanine nucleotide exchange factor reaction)	0.850
C9orf72	SMCR8	psi-mi:“MI:0217”(phosphorylation reaction)	0.850
C9orf72	SMCR8	psi-mi:“MI:0914”(association)	0.850
RB1CC1	ATG13	psi-mi:“MI:0914”(association)	0.820
C9orf72	ATG13	psi-mi:“MI:0914”(association)	0.690
DNAJC7	PLD2	psi-mi:“MI:0914”(association)	0.640
SLC27A6	TTC4	psi-mi:“MI:0914”(association)	0.640
C9orf72	SMCR8	psi-mi:“MI:0914”(association)	0.620
IGF1R	PIK3R2	psi-mi:“MI:2364”(proximity)	0.590
C9orf72	ULK1	psi-mi:“MI:0217”(phosphorylation reaction)	0.570
TKT	POTEF	psi-mi:“MI:0914”(association)	0.530
PICK1	ILVBL	psi-mi:“MI:0914”(association)	0.530
MRAP2	GOLIM4	psi-mi:“MI:0914”(association)	0.530
TSPAN5	SC5D	psi-mi:“MI:0914”(association)	0.530
C9orf72	RAB8A	psi-mi:“MI:2252”(guanine nucleotide exchange factor reaction)	0.440
SQSTM1	WDR41	psi-mi:“MI:0915”(physical association)	0.400
OPTN	WDR41	psi-mi:“MI:0915”(physical association)	0.400
TSPAN5	KLHL2	psi-mi:“MI:0914”(association)	0.350
MRAP2	GOSR1	psi-mi:“MI:0914”(association)	0.350
APBB2	APBB1	psi-mi:“MI:0914”(association)	0.350
KRTCAP3	SLC22A23	psi-mi:“MI:0914”(association)	0.350
ATP13A3	GPR89A	psi-mi:“MI:0914”(association)	0.350
MCM5	WDR62	psi-mi:“MI:0914”(association)	0.350
SLC27A6	NBAS	psi-mi:“MI:0914”(association)	0.350

BioGRID (168): WDR41 (Affinity Capture-MS), WDR41 (Affinity Capture-MS), WDR41 (Proximity Label-MS), WDR41 (Proximity Label-MS), WDR41 (Proximity Label-MS), WDR41 (Proximity Label-MS), WDR41 (Affinity Capture-MS), WDR41 (Affinity Capture-MS), WDR41 (Affinity Capture-MS), WDR41 (Affinity Capture-MS), WDR41 (Affinity Capture-MS), WDR41 (Affinity Capture-MS), WDR41 (Affinity Capture-Western), WDR41 (Reconstituted Complex), WDR41 (Proximity Label-MS)

ESM2 similar proteins: A0JM23, A0JP70, B2RZ17, E1BVR9, O14727, O54927, O88879, O94952, P0CI65, Q08BB3, Q08DV6, Q13309, Q32KQ2, Q3U3W5, Q3U821, Q3UDP0, Q3UMR0, Q3UR70, Q58D00, Q5R5S1, Q5REW9, Q5XJS5, Q60584, Q68EI0, Q6AX81, Q6AZT7, Q6DFC6, Q6P1V3, Q6P2P2, Q6P2S7, Q6ZMY6, Q7T2F6, Q7TNH6, Q7Z494, Q8BHD1, Q8C5V5, Q8IWA0, Q8NA23, Q8VDH1, Q96NW4

Diamond homologs: A1CF18, A1CUD6, A4IIX9, A8XZJ9, B6HP56, B6QC06, B6QC56, C0NRC6, C6HTE8, D1ZEB4, D5GBI7, O14011, O22785, O94289, P07834, P20053, P32523, P43254, P49846, P74598, Q08E38, Q09715, Q0U1B1, Q10051, Q12220, Q28D01, Q2GT28, Q2HBX6, Q2KJJ5, Q4ICM0, Q54ZP5, Q5R650, Q5ZMA2, Q6CG48, Q6DDF0, Q6GM65, Q7K0L4, Q7KWK5, Q7RY30, Q8C4J7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 64 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
regulation of autophagy	5	21.1×	9e-04
positive regulation of autophagy	5	18.2×	1e-03
protein autophosphorylation	6	15.3×	9e-04
autophagy	6	11.6×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

85 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	63
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2485 predictions. Top by Δscore:

Variant	Effect	Δscore
5:77426443:A:AG	acceptor_gain	1.0000
5:77426444:G:GG	acceptor_gain	1.0000
5:77426444:GC:G	acceptor_gain	1.0000
5:77426444:GCC:G	acceptor_gain	1.0000
5:77426444:GCCT:G	acceptor_gain	1.0000
5:77426444:GCCTT:G	acceptor_gain	1.0000
5:77433285:CAT:C	acceptor_gain	1.0000
5:77436262:T:TA	donor_gain	1.0000
5:77449753:AGCTT:A	donor_loss	1.0000
5:77449754:GCTT:G	donor_loss	1.0000
5:77449755:CTTAC:C	donor_loss	1.0000
5:77449756:TTAC:T	donor_loss	1.0000
5:77449757:T:TG	donor_loss	1.0000
5:77449758:ACCAT:A	donor_loss	1.0000
5:77449759:C:CG	donor_loss	1.0000
5:77449866:AATTA:A	acceptor_gain	1.0000
5:77449867:ATTA:A	acceptor_gain	1.0000
5:77449868:TTA:T	acceptor_gain	1.0000
5:77449869:TA:T	acceptor_gain	1.0000
5:77449871:C:CC	acceptor_gain	1.0000
5:77451357:C:CT	acceptor_gain	1.0000
5:77451358:A:T	acceptor_gain	1.0000
5:77451364:A:C	acceptor_gain	1.0000
5:77463099:A:C	donor_gain	1.0000
5:77489579:T:C	acceptor_gain	1.0000
5:77489579:T:TC	acceptor_gain	1.0000
5:77490642:T:TA	donor_gain	1.0000
5:77426442:CAG:C	acceptor_loss	0.9900
5:77426443:A:C	acceptor_loss	0.9900
5:77426444:G:GT	acceptor_loss	0.9900

AlphaMissense

2988 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:77433224:A:G	W431R	0.998
5:77433224:A:T	W431R	0.998
5:77437389:C:G	R347P	0.998
5:77433253:G:T	T421K	0.997
5:77437384:A:G	W349R	0.997
5:77437384:A:T	W349R	0.997
5:77464772:A:G	W69R	0.997
5:77464772:A:T	W69R	0.997
5:77433253:G:C	T421R	0.996
5:77437402:C:G	D343H	0.996
5:77433222:C:A	W431C	0.995
5:77433222:C:G	W431C	0.995
5:77433223:C:G	W431S	0.995
5:77433235:A:G	L427P	0.995
5:77433241:T:A	D425V	0.995
5:77433242:C:G	D425H	0.995
5:77433247:G:A	S423F	0.995
5:77437408:A:G	S341P	0.995
5:77433249:G:C	C422W	0.994
5:77453898:A:G	W148R	0.994
5:77453898:A:T	W148R	0.994
5:77463178:C:G	A89P	0.994
5:77464798:G:T	A60D	0.994
5:77433247:G:T	S423Y	0.993
5:77433251:A:G	C422R	0.993
5:77436276:G:C	H404Q	0.993
5:77436276:G:T	H404Q	0.993
5:77436280:C:T	G403E	0.993
5:77464801:G:T	S59Y	0.993
5:77464802:A:G	S59P	0.993

dbSNP variants (sampled 300 via entrez): RS1000003397 (5:77575635 G>A,C), RS1000019289 (5:77605680 C>T), RS1000031760 (5:77481463 G>A), RS1000104874 (5:77481166 C>T), RS1000105631 (5:77470892 C>A), RS1000111716 (5:77569394 G>C,T), RS1000140776 (5:77536183 C>T), RS1000153420 (5:77515153 T>C), RS1000174814 (5:77471791 T>A,C), RS1000195811 (5:77550002 G>T), RS1000196407 (5:77593235 G>T), RS1000233677 (5:77567107 C>T), RS1000293873 (5:77529066 T>A,C,G), RS1000311230 (5:77485516 C>G), RS1000335745 (5:77463211 A>C,G)

Disease associations

OMIM: gene MIM:617502 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST001045_2	Caudate nucleus volume	2.000000e-07
GCST004210_3	Body fat percentage	3.000000e-09
GCST008058_185	Estimated glomerular filtration rate	4.000000e-06
GCST010295_1	Response to valproic acid in genetic generalized epilepsy	5.000000e-06
GCST010396_288	Gut microbiota (bacterial taxa, hurdle binary method)	4.000000e-08
GCST010396_76	Gut microbiota (bacterial taxa, hurdle binary method)	8.000000e-07
GCST012431_5	Parkinson’s disease	2.000000e-08
GCST012489_24	Heel bone mineral density x serum urate levels interaction	1.000000e-10
GCST90011899_68	Aspartate aminotransferase levels	3.000000e-08

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0007800	body fat percentage
EFO:0007874	gut microbiome measurement
EFO:0004531	urate measurement
EFO:0009270	heel bone mineral density
EFO:0004736	aspartate aminotransferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, increases abundance, affects expression, decreases expression	4
Cyclosporine	increases expression	3
Benzo(a)pyrene	increases expression, increases methylation	2
Valproic Acid	decreases expression, increases expression	2
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
terbufos	increases methylation	1
beta-lapachone	decreases expression, increases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
potassium chromate(VI)	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
erastin	decreases expression	1
ICG 001	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Arsenic Trioxide	decreases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Cisplatin	increases expression	1
Doxorubicin	increases expression	1
Fonofos	increases methylation	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Parathion	increases methylation	1
Quercetin	decreases expression	1
Testosterone	decreases expression	1
Vanadates	increases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2LC	Abcam HeLa WDR41 KO	Cancer cell line	Female
CVCL_E2NZ	HAP1 WDR41 (-) 1	Cancer cell line	Male
CVCL_E2P0	HAP1 WDR41 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.