WDR6

Summary

WDR6 (WD repeat domain 6, HGNC:12758) is a protein-coding gene on chromosome 3p21.31, encoding tRNA (34-2’-O)-methyltransferase regulator WDR6 (Q9NNW5). Together with methyltransferase FTSJ1, methylates the 2’-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs.

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms.

Source: NCBI Gene 11180 — RefSeq curated summary.

At a glance

• GWAS associations: 16
• Clinical variants (ClinVar): 192 total
• Druggable target: yes
• MANE Select transcript: NM_018031

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12758
Approved symbol	WDR6
Name	WD repeat domain 6
Location	3p21.31
Locus type	gene with protein product
Status	Approved
Aliases	Trm734
Ensembl gene	ENSG00000178252
Ensembl biotype	protein_coding
OMIM	606031
Entrez	11180

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 18 protein_coding, 6 protein_coding_CDS_not_defined, 3 retained_intron, 2 nonsense_mediated_decay

ENST00000395474, ENST00000415265, ENST00000419837, ENST00000420783, ENST00000429900, ENST00000438660, ENST00000448293, ENST00000452875, ENST00000461687, ENST00000462064, ENST00000471162, ENST00000472878, ENST00000473238, ENST00000488572, ENST00000489427, ENST00000489684, ENST00000491365, ENST00000492780, ENST00000498023, ENST00000608424, ENST00000610967, ENST00000627177, ENST00000873507, ENST00000873508, ENST00000873509, ENST00000873510, ENST00000916085, ENST00000916086, ENST00000969620

RefSeq mRNA: 3 — MANE Select: NM_018031 NM_001320546, NM_001320547, NM_018031

CCDS: CCDS2782, CCDS82772

Canonical transcript exons

ENST00000608424 — 6 exons

Exon	Start	End
ENSE00003479586	49014600	49014718
ENSE00003552784	49014383	49014499
ENSE00003617303	49011635	49014116
ENSE00003659376	49014210	49014293
ENSE00003845350	49014825	49015951
ENSE00003849526	49007391	49007531

Expression profiles

Bgee: expression breadth ubiquitous, 281 present calls, max score 99.33.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 52.5738 / max 348.0970, expressed in 1819 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
36599	39.3558	1816
36600	12.0009	1781
36598	1.2171	861

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	99.33	gold quality
pituitary gland	UBERON:0000007	99.19	gold quality
adenohypophysis	UBERON:0002196	99.19	gold quality
right lobe of thyroid gland	UBERON:0001119	99.18	gold quality
left lobe of thyroid gland	UBERON:0001120	99.11	gold quality
left ovary	UBERON:0002119	99.05	gold quality
right ovary	UBERON:0002118	98.97	gold quality
thyroid gland	UBERON:0002046	98.90	gold quality
tendon of biceps brachii	UBERON:0008188	98.88	gold quality
endocervix	UBERON:0000458	98.76	gold quality
body of uterus	UBERON:0009853	98.67	gold quality
right adrenal gland	UBERON:0001233	98.62	gold quality
right adrenal gland cortex	UBERON:0035827	98.62	gold quality
body of pancreas	UBERON:0001150	98.56	gold quality
left adrenal gland cortex	UBERON:0035825	98.53	gold quality
muscle layer of sigmoid colon	UBERON:0035805	98.46	gold quality
metanephros cortex	UBERON:0010533	98.41	gold quality
left adrenal gland	UBERON:0001234	98.38	gold quality
left uterine tube	UBERON:0001303	98.37	gold quality
adrenal cortex	UBERON:0001235	98.36	gold quality
small intestine Peyer’s patch	UBERON:0003454	98.22	gold quality
ovary	UBERON:0000992	98.20	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	98.19	gold quality
lower esophagus muscularis layer	UBERON:0035833	98.18	gold quality
lower esophagus	UBERON:0013473	98.17	gold quality
ventricular zone	UBERON:0003053	98.11	gold quality
ganglionic eminence	UBERON:0004023	98.09	gold quality
stromal cell of endometrium	CL:0002255	98.05	gold quality
gall bladder	UBERON:0002110	98.00	gold quality
right hemisphere of cerebellum	UBERON:0014890	98.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.84

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NR1I2

miRNA regulators (miRDB)

51 targeting WDR6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-202-3P	99.84	71.41	1290
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-10393-3P	99.72	66.56	961
HSA-MIR-6801-5P	99.72	66.50	981
HSA-MIR-26A-1-3P	99.64	66.81	788
HSA-MIR-26A-2-3P	99.64	66.82	786
HSA-MIR-875-3P	99.63	69.47	2548
HSA-MIR-4663	99.62	65.33	957
HSA-MIR-6752-5P	99.59	67.32	1243
HSA-MIR-4310	99.59	68.84	2527
HSA-MIR-6716-5P	99.56	68.62	1244
HSA-MIR-4777-5P	99.33	67.53	1148
HSA-MIR-3678-3P	99.31	67.10	1432
HSA-MIR-4667-3P	99.26	65.45	1608
HSA-MIR-3922-3P	99.25	64.96	1136
HSA-MIR-593-3P	99.22	67.28	1327
HSA-MIR-449B-3P	99.20	67.24	1047
HSA-MIR-6852-5P	99.17	66.69	2073

Literature-anchored findings (GeneRIF, showing 3)

• Results suggest that WDR6 is implicated in the cell growth inhibitory pathway of LKB1 via regulation of p27(Kip1). (PMID:17216128)
• Transgenic rat gene WDR6 is expressed in the hypothalamus and interacts with insulin receptor substrate 4 (IRS-4) in the brain. (PMID:17720279)
• Replication of the K1L(-)C7L(-) mutant vaccinia virus virus was enabled by multiple siRNAs to SAMD9 or WDR6. (PMID:26242627)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	wdr6	ENSDARG00000078571
mus_musculus	Wdr6	ENSMUSG00000066357
rattus_norvegicus	Wdr6	ENSRNOG00000020185
drosophila_melanogaster	CG33172	FBGN0053172

Protein

Protein identifiers

tRNA (34-2’-O)-methyltransferase regulator WDR6 — Q9NNW5 (reviewed: Q9NNW5)

Alternative names: WD repeat-containing protein 6

All UniProt accessions (11): Q9NNW5, A0A087X295, C9JFP6, C9K020, E5RFX3, E9PBK6, E9PDU5, F8WE36, V9GYU1, V9GZ48, V9GZ65

UniProt curated annotations — full annotation on UniProt →

Function. Together with methyltransferase FTSJ1, methylates the 2’-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs. Required for the correct positioning of the substrate tRNA for methylation. Required to suppress amino acid starvation-induced autophagy. Enhances the STK11/LKB1-induced cell growth suppression activity.

Subunit / interactions. Interacts with FTSJ1; the interaction is direct, and required for 2’-O-methylation of position 34 in substrate tRNAs. Interacts with IRS4. Interacts with STK11/LKB1.

Subcellular location. Cytoplasm.

Tissue specificity. Ubiquitous.

Similarity. Belongs to the WD repeat WDR6 family.

RefSeq proteins (3): NP_001307475, NP_001307476, NP_060501* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR011043	Gal_Oxase/kelch_b-propeller	Homologous_superfamily
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR051973	tRNA_Anticodon_Mtase-Reg	Family

Pfam: PF00400

UniProt features (24 total): repeat 19, sequence conflict 3, chain 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NNW5-F1	85.72	0.59

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 1

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-9013420	RHOU GTPase cycle
R-HSA-9013424	RHOV GTPase cycle
R-HSA-9696264	RND3 GTPase cycle
R-HSA-9696270	RND2 GTPase cycle
R-HSA-9696273	RND1 GTPase cycle

MSigDB gene sets: 175 (showing top): GOBP_REGULATION_OF_AUTOPHAGY, GCM_GSPT1, AREB6_03, GOBP_TRNA_METABOLIC_PROCESS, GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP, GOBP_RNA_METHYLATION, GOBP_NEGATIVE_REGULATION_OF_AUTOPHAGY, GOBP_RNA_MODIFICATION, WANG_LMO4_TARGETS_DN, GOBP_REGULATION_OF_CATABOLIC_PROCESS, BLALOCK_ALZHEIMERS_DISEASE_UP, ACATTCC_MIR1_MIR206, GOBP_TRNA_METHYLATION, GCM_NUMA1, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN

GO Biological Process (6): wobble position ribose methylation (GO:0002130), negative regulation of cell population proliferation (GO:0008285), negative regulation of autophagy (GO:0010507), tRNA methylation (GO:0030488), G1 to G0 transition (GO:0070314), tRNA processing (GO:0008033)

GO Molecular Function (5): tRNA binding (GO:0000049), RNA binding (GO:0003723), enzyme regulator activity (GO:0030234), enzyme-substrate adaptor activity (GO:0140767), protein binding (GO:0005515)

GO Cellular Component (4): cytoplasm (GO:0005737), cytosol (GO:0005829), plasma membrane (GO:0005886), COP9 signalosome (GO:0008180)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RHO GTPase cycle	5

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
tRNA nucleoside ribose methylation	1
cell population proliferation	1
regulation of cell population proliferation	1
negative regulation of cellular process	1
autophagy	1
negative regulation of catabolic process	1
regulation of autophagy	1
RNA methylation	1
tRNA modification	1
cell cycle process	1
RNA processing	1
tRNA metabolic process	1
RNA binding	1
nucleic acid binding	1
catalytic activity	1
molecular function regulator activity	1
protein-macromolecule adaptor activity	1
binding	1
intracellular anatomical structure	1
cytoplasm	1
membrane	1
cell periphery	1
nuclear protein-containing complex	1

Protein interactions and networks

STRING

1918 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
WDR6	DALRD3	Q5D0E6	795
WDR6	SAMD9	Q5K651	688
WDR6	FTSJ1	Q9UET6	681
WDR6	STK11	Q15831	678
WDR6	GPALPP1	Q8IXQ4	542
WDR6	THADA	Q6YHU6	536
WDR6	TRMT44	Q8IYL2	521
WDR6	WDR4	P57081	507
WDR6	ARMC6	Q6NXE6	507
WDR6	DPH7	Q9BTV6	479
WDR6	PTGR3	Q8N4Q0	470
WDR6	TBL2	Q9Y4P3	457
WDR6	DDB1	Q16531	445
WDR6	CUL4B	Q13620	436
WDR6	CUL4A	Q13619	430

IntAct

263 interactions, top by confidence:

A	B	Type	Score
PIK3R1	PIK3CD	psi-mi:“MI:0914”(association)	0.890
CDC37	IKBKB	psi-mi:“MI:0914”(association)	0.850
NS	PIK3R2	psi-mi:“MI:0914”(association)	0.750
WDR6	PTPN3	psi-mi:“MI:0915”(physical association)	0.720
PTPN3	WDR6	psi-mi:“MI:0915”(physical association)	0.720
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
PKN3	ARHGAP10	psi-mi:“MI:0914”(association)	0.680
PIK3R2	IRS4	psi-mi:“MI:0914”(association)	0.640
DNAJC7	PLD2	psi-mi:“MI:0914”(association)	0.640
INSR	PIK3R2	psi-mi:“MI:2364”(proximity)	0.570
NS1	PIK3R2	psi-mi:“MI:0914”(association)	0.560
WDR6	GRIP1	psi-mi:“MI:0915”(physical association)	0.560
WDR6	STK11	psi-mi:“MI:0915”(physical association)	0.540
STK11	WDR6	psi-mi:“MI:0915”(physical association)	0.540
STK11	WDR6	psi-mi:“MI:0403”(colocalization)	0.540
KSR2	POLR3A	psi-mi:“MI:0914”(association)	0.530
DMWD	GAK	psi-mi:“MI:0914”(association)	0.530
MINK1	CNOT1	psi-mi:“MI:0914”(association)	0.530
GRB2	SH3PXD2B	psi-mi:“MI:0914”(association)	0.530
FTSJ1	WDR6	psi-mi:“MI:0914”(association)	0.530
STK35	HSP90AA1	psi-mi:“MI:0914”(association)	0.530

BioGRID (390): WDR6 (Two-hybrid), WDR6 (Affinity Capture-MS), WDR6 (Affinity Capture-Western), CDC42EP4 (Two-hybrid), G2E3 (Two-hybrid), WDR6 (Co-fractionation), WDR6 (Affinity Capture-MS), WDR6 (Proximity Label-MS), WDR6 (Proximity Label-MS), WDR6 (Affinity Capture-MS), WDR6 (Affinity Capture-MS), WDR6 (Affinity Capture-MS), WDR6 (Affinity Capture-MS), WDR6 (Affinity Capture-MS), WDR6 (Affinity Capture-MS)

ESM2 similar proteins: A0A1L8HX76, A0JP70, A4IG72, A7E3S5, A7Z052, D3ZW91, E9PY46, P57081, Q05B17, Q0P5H9, Q15061, Q32P44, Q3SZD4, Q3U821, Q499N3, Q4VBE8, Q5BK48, Q5F3K4, Q5RB07, Q5RBH8, Q5RD06, Q5XFW6, Q68EI0, Q6DFC6, Q6KAU8, Q6PFM9, Q6PGF3, Q6ZQL4, Q7ZVF0, Q7ZVR1, Q7ZY78, Q8BH57, Q8C5V5, Q8IWA0, Q8N0Z6, Q8NA23, Q8NAA4, Q8VC03, Q969R8, Q96KV7

Diamond homologs: A7Z052, Q5RB07, Q5U4D9, Q5XFW6, Q99ME2, Q9NNW5, Q25306

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 234 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Signaling by ERBB2 ECD mutants	9	40.6×	2e-10
Constitutive Signaling by EGFRvIII	8	38.3×	3e-09
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	9	34.5×	6e-10
Insulin receptor signalling cascade	6	27.1×	4e-06
Signaling by ERBB2 KD Mutants	9	25.6×	8e-09
Signaling by ERBB2 TMD/JMD mutants	8	25.6×	7e-08
GRB2 events in ERBB2 signaling	6	25.6×	5e-06
GRB2 events in EGFR signaling	5	25.6×	3e-05

GO biological processes:

GO term	Partners	Fold	FDR
Schwann cell development	5	26.7×	3e-04
peptidyl-tyrosine phosphorylation	7	15.0×	1e-04
insulin-like growth factor receptor signaling pathway	5	12.6×	5e-03
ephrin receptor signaling pathway	7	12.2×	3e-04
insulin receptor signaling pathway	10	11.3×	1e-05
protein autophosphorylation	14	10.3×	6e-08
protein phosphorylation	22	7.6×	2e-10
phosphatidylinositol 3-kinase/protein kinase B signal transduction	7	7.5×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

192 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	172
Likely benign	8
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1806 predictions. Top by Δscore:

Variant	Effect	Δscore
3:49014204:CTGCA:C	acceptor_loss	1.0000
3:49014205:TGCAG:T	acceptor_loss	1.0000
3:49014206:GCAGG:G	acceptor_loss	1.0000
3:49014207:CAG:C	acceptor_loss	1.0000
3:49014209:GGT:G	acceptor_gain	1.0000
3:49014209:GGTAC:G	acceptor_gain	1.0000
3:49014290:TAAG:T	donor_loss	1.0000
3:49014294:G:A	donor_loss	1.0000
3:49014295:T:A	donor_loss	1.0000
3:49014497:GCG:G	donor_gain	1.0000
3:49014498:CGGT:C	donor_loss	1.0000
3:49014500:G:GG	donor_gain	1.0000
3:49014500:G:T	donor_loss	1.0000
3:49014501:T:A	donor_loss	1.0000
3:49014590:T:A	acceptor_gain	1.0000
3:49014591:G:A	acceptor_gain	1.0000
3:49014598:A:AG	acceptor_gain	1.0000
3:49014598:AG:A	acceptor_gain	1.0000
3:49014598:AGGAG:A	acceptor_gain	1.0000
3:49014599:G:GG	acceptor_gain	1.0000
3:49014599:GG:G	acceptor_gain	1.0000
3:49014599:GGA:G	acceptor_gain	1.0000
3:49014599:GGAGG:G	acceptor_gain	1.0000
3:49014714:CTACC:C	donor_gain	1.0000
3:49014715:TACC:T	donor_gain	1.0000
3:49014716:ACC:A	donor_gain	1.0000
3:49014717:CC:C	donor_gain	1.0000
3:49014717:CCG:C	donor_loss	1.0000
3:49014719:G:GG	donor_gain	1.0000
3:49014719:GT:G	donor_loss	1.0000

AlphaMissense

7231 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:49012351:A:C	S273R	0.999
3:49012353:T:A	S273R	0.999
3:49012353:T:G	S273R	0.999
3:49013428:T:C	F632L	0.999
3:49013430:C:A	F632L	0.999
3:49013430:C:G	F632L	0.999
3:49015122:G:C	R1067P	0.999
3:49012222:G:C	D230H	0.998
3:49012226:G:C	R231P	0.998
3:49012240:T:A	W236R	0.998
3:49012240:T:C	W236R	0.998
3:49012363:G:C	D277H	0.998
3:49012381:T:A	W283R	0.998
3:49012381:T:C	W283R	0.998
3:49012861:T:A	W443R	0.998
3:49012861:T:C	W443R	0.998
3:49013429:T:C	F632S	0.998
3:49013773:A:C	S747R	0.998
3:49013775:T:A	S747R	0.998
3:49013775:T:G	S747R	0.998
3:49014616:A:C	S934R	0.998
3:49014618:C:A	S934R	0.998
3:49014618:C:G	S934R	0.998
3:49014920:A:C	S1000R	0.998
3:49014922:T:A	S1000R	0.998
3:49014922:T:G	S1000R	0.998
3:49015110:C:A	S1063Y	0.998
3:49015110:C:T	S1063F	0.998
3:49012208:C:A	A225D	0.997
3:49012223:A:C	D230A	0.997

dbSNP variants (sampled 300 via entrez): RS1000378201 (3:49009463 G>A,C), RS1000433245 (3:49009949 A>G), RS1000550060 (3:49015348 G>C), RS1000995727 (3:49007979 G>C), RS1001139342 (3:49009484 G>A,T), RS1001380832 (3:49009181 C>T), RS1001770694 (3:49015972 C>A), RS1002143488 (3:49007909 G>A), RS1002462876 (3:49015701 G>A,C), RS1002508316 (3:49012534 G>A,T), RS1003144378 (3:49006626 G>A), RS1003385408 (3:49006257 C>T), RS1003709813 (3:49012809 A>G), RS1004384542 (3:49008203 A>C,G), RS1004413895 (3:49008573 A>G)

Disease associations

OMIM: gene MIM:606031 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

16 associations (top):

Study	Trait	p-value
GCST002541_47	Menarche (age at onset)	1.000000e-16
GCST002541_48	Menarche (age at onset)	8.000000e-12
GCST004131_23	Inflammatory bowel disease	1.000000e-33
GCST004132_17	Crohn’s disease	3.000000e-23
GCST004133_11	Ulcerative colitis	8.000000e-20
GCST007294_107	Body fat distribution (trunk fat ratio)	9.000000e-06
GCST007294_72	Body fat distribution (trunk fat ratio)	1.000000e-18
GCST007294_98	Body fat distribution (trunk fat ratio)	3.000000e-15
GCST007295_21	Body fat distribution (leg fat ratio)	8.000000e-06
GCST007295_45	Body fat distribution (leg fat ratio)	1.000000e-10
GCST007295_80	Body fat distribution (leg fat ratio)	1.000000e-14
GCST010698_80	Subcortical volume (min-P)	3.000000e-24
GCST010699_110	Brain morphology (min-P)	4.000000e-08
GCST010701_52	Cortical surface area (MOSTest)	1.000000e-16
GCST010702_36	Subcortical volume (MOSTest)	1.000000e-10
GCST010703_262	Brain morphology (MOSTest)	2.000000e-13

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004703	age at menarche
EFO:0004341	body fat distribution
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5725054 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects binding, increases reaction, decreases expression, affects cotreatment, increases abundance	3
Valproic Acid	decreases expression, affects expression	3
Cadmium Chloride	decreases expression, increases abundance, increases expression, increases methylation	3
Air Pollutants	increases expression, affects cotreatment, increases abundance, increases oxidation	2
Arsenic	affects methylation, affects cotreatment, decreases expression, increases abundance	2
TAK-243	increases sumoylation	1
alpha-pinene	increases abundance, affects cotreatment, increases oxidation	1
cobaltous chloride	decreases expression	1
butyraldehyde	decreases expression	1
manganese chloride	decreases expression, increases abundance, affects cotreatment	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
chloropicrin	affects expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	decreases expression	1
jinfukang	increases expression	1
Leflunomide	decreases expression	1
Acetaminophen	decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Benzo(a)pyrene	decreases expression	1
Cadmium	increases abundance, increases expression	1
Carbamazepine	affects expression	1
Diazinon	increases methylation	1
Endosulfan	decreases expression	1
Estradiol	increases expression	1
Ivermectin	decreases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Ozone	increases oxidation, increases abundance, affects cotreatment	1
Ribonucleotides	affects binding	1

ChEMBL screening assays

6 unique, capped per target: 6 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5697551	Binding	Inhibition of WDR6 (unknown origin) assessed as fold change at 10 uM incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. — Nature

Cellosaurus cell lines

5 cell lines: 5 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2LF	Abcam HeLa WDR6 KO	Cancer cell line	Female
CVCL_TX91	HAP1 WDR6 (-) 1	Cancer cell line	Male
CVCL_XV06	HAP1 WDR6 (-) 2	Cancer cell line	Male
CVCL_XV07	HAP1 WDR6 (-) 3	Cancer cell line	Male
CVCL_XV08	HAP1 WDR6 (-) 4	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.