WDR75

Summary

WDR75 (WD repeat domain 75, HGNC:25725) is a protein-coding gene on chromosome 2q32.2, encoding WD repeat-containing protein 75 (Q8IWA0). Ribosome biogenesis factor. It is a common-essential gene (DepMap: required in 99.6% of cancer cell lines).

Enables RNA binding activity. Involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and ribosomal small subunit biogenesis. Located in nucleolus. Part of small-subunit processome.

Source: NCBI Gene 84128 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 106 total
• Cancer dependency (DepMap): dependent in 99.6% of screened cell lines (common-essential)
• MANE Select transcript: NM_032168

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25725
Approved symbol	WDR75
Name	WD repeat domain 75
Location	2q32.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ12519, NET16, UTP17
Ensembl gene	ENSG00000115368
Ensembl biotype	protein_coding
OMIM	620341
Entrez	84128

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 8 protein_coding, 3 retained_intron, 2 nonsense_mediated_decay

ENST00000314761, ENST00000427960, ENST00000436347, ENST00000472286, ENST00000475596, ENST00000498365, ENST00000631047, ENST00000873640, ENST00000922924, ENST00000922925, ENST00000922926, ENST00000922927, ENST00000922928

RefSeq mRNA: 2 — MANE Select: NM_032168 NM_001303096, NM_032168

CCDS: CCDS2298

Canonical transcript exons

ENST00000314761 — 21 exons

Exon	Start	End
ENSE00001070666	189441474	189441578
ENSE00001233905	189475213	189475552
ENSE00003462757	189463694	189463753
ENSE00003494394	189466425	189466582
ENSE00003494695	189469344	189469439
ENSE00003495544	189458753	189458872
ENSE00003504762	189470819	189470878
ENSE00003507228	189474717	189474808
ENSE00003507351	189468475	189468569
ENSE00003513124	189463846	189463961
ENSE00003536714	189467468	189467648
ENSE00003537595	189474186	189474332
ENSE00003539395	189462484	189462642
ENSE00003577705	189450903	189450968
ENSE00003589568	189457311	189457381
ENSE00003605154	189448379	189448508
ENSE00003606347	189465079	189465254
ENSE00003639176	189459336	189459424
ENSE00003655735	189451805	189451895
ENSE00003662349	189455320	189455444
ENSE00003677252	189470076	189470245

Expression profiles

Bgee: expression breadth ubiquitous, 260 present calls, max score 93.58.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 29.9946 / max 429.4280, expressed in 1803 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
24251	26.7468	1797
24250	3.2478	1379

Top tissues by expression

262 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
upper arm skin	UBERON:0004263	93.58	gold quality
cardiac muscle of right atrium	UBERON:0003379	93.47	gold quality
left ventricle myocardium	UBERON:0006566	93.30	gold quality
kidney epithelium	UBERON:0004819	93.02	gold quality
myocardium	UBERON:0002349	92.51	gold quality
cartilage tissue	UBERON:0002418	92.45	gold quality
smooth muscle tissue	UBERON:0001135	92.31	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	92.27	gold quality
calcaneal tendon	UBERON:0003701	92.18	gold quality
body of uterus	UBERON:0009853	92.07	gold quality
left ovary	UBERON:0002119	92.04	gold quality
right ovary	UBERON:0002118	91.98	gold quality
oocyte	CL:0000023	91.72	gold quality
endometrium	UBERON:0001295	91.43	gold quality
ovary	UBERON:0000992	91.32	gold quality
mucosa of stomach	UBERON:0001199	91.28	gold quality
endocervix	UBERON:0000458	91.22	gold quality
uterus	UBERON:0000995	91.12	gold quality
lymph node	UBERON:0000029	91.00	gold quality
superficial temporal artery	UBERON:0001614	91.00	gold quality
rectum	UBERON:0001052	90.99	gold quality
left uterine tube	UBERON:0001303	90.94	gold quality
corpus callosum	UBERON:0002336	90.77	gold quality
mucosa of paranasal sinus	UBERON:0005030	90.73	gold quality
ectocervix	UBERON:0012249	90.64	gold quality
uterine cervix	UBERON:0000002	90.62	gold quality
left adrenal gland cortex	UBERON:0035825	90.53	gold quality
right uterine tube	UBERON:0001302	90.51	gold quality
body of pancreas	UBERON:0001150	90.47	gold quality
adrenal tissue	UBERON:0018303	90.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.97

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

9 targeting WDR75, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-2053	99.57	69.15	1635
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-374A-3P	98.87	67.82	1531
HSA-MIR-4773	98.35	67.30	1710
HSA-MIR-217-3P	95.67	68.42	1000

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.6% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 1)

• RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis. (PMID:34611297)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	wdr75	ENSDARG00000040730
mus_musculus	Wdr75	ENSMUSG00000025995
rattus_norvegicus	Wdr75	ENSRNOG00000003825

Paralogs (26): PAFAH1B1 (ENSG00000007168), SNRNP40 (ENSG00000060688), WDR62 (ENSG00000075702), WDR7 (ENSG00000091157), TBL2 (ENSG00000106638), PAK1IP1 (ENSG00000111845), DCAF4 (ENSG00000119599), DAW1 (ENSG00000123977), TEP1 (ENSG00000129566), AHI1 (ENSG00000135541), WDR38 (ENSG00000136918), MAPKBP1 (ENSG00000137802), POC1B (ENSG00000139323), NEDD1 (ENSG00000139350), COP1 (ENSG00000143207), WDR17 (ENSG00000150627), WDR43 (ENSG00000163811), POC1A (ENSG00000164087), WDR88 (ENSG00000166359), WDR81 (ENSG00000167716), DCAF4L2 (ENSG00000176566), DCAF4L1 (ENSG00000182308), WDR27 (ENSG00000184465), NWD1 (ENSG00000188039), WDR5 (ENSG00000196363), WDR5B (ENSG00000196981)

Protein

Protein identifiers

WD repeat-containing protein 75 — Q8IWA0 (reviewed: Q8IWA0)

Alternative names: U3 small nucleolar RNA-associated protein 17 homolog

All UniProt accessions (3): Q8IWA0, F8WC81, F8WE20

UniProt curated annotations — full annotation on UniProt →

Function. Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.

Subunit / interactions. Component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome. SSU processome is composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.

Subcellular location. Nucleus. Nucleolus.

RefSeq proteins (2): NP_001290025, NP_115544* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR011047	Quinoprotein_ADH-like_sf	Homologous_superfamily
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR053826	WDR75	Family
IPR057644	Beta-prop_WDR75_2nd	Domain

Pfam: PF23769, PF23869

UniProt features (33 total): repeat 13, modified residue 7, sequence conflict 7, cross-link 3, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
7MQA	ELECTRON MICROSCOPY	2.7
7MQ8	ELECTRON MICROSCOPY	3.6
7MQ9	ELECTRON MICROSCOPY	3.87

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IWA0-F1	80.43	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (10): 466, 664, 672, 779, 782, 796, 811, 123, 427, 676

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-6790901	rRNA modification in the nucleus and cytosol
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol

MSigDB gene sets: 155 (showing top): GSE45365_NK_CELL_VS_BCELL_UP, MODULE_97, GOBP_RIBOSOME_BIOGENESIS, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_MATURATION_OF_SSU_RRNA, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, MODULE_182, WEI_MYCN_TARGETS_WITH_E_BOX, MARTINEZ_RB1_TARGETS_DN, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS, DODD_NASOPHARYNGEAL_CARCINOMA_UP

GO Biological Process (5): rRNA processing (GO:0006364), ribosomal small subunit biogenesis (GO:0042274), positive regulation of transcription by RNA polymerase I (GO:0045943), positive regulation of rRNA processing (GO:2000234), ribosome biogenesis (GO:0042254)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (4): nucleoplasm (GO:0005654), nucleolus (GO:0005730), small-subunit processome (GO:0032040), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
rRNA processing in the nucleus and cytosol	2

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ribosome biogenesis	2
ribonucleoprotein complex biogenesis	2
nuclear lumen	2
RNA processing	1
rRNA metabolic process	1
regulation of transcription by RNA polymerase I	1
transcription by RNA polymerase I	1
positive regulation of DNA-templated transcription	1
rRNA processing	1
positive regulation of RNA metabolic process	1
regulation of rRNA processing	1
nucleic acid binding	1
binding	1
cellular anatomical structure	1
intracellular membraneless organelle	1
nucleolus	1
preribosome	1
t-UTP complex	1
nuclear protein-containing complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

2353 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
WDR75	UTP15	Q8TED0	941
WDR75	WDR43	Q15061	935
WDR75	UTP4	Q969X6	919
WDR75	HEATR1	Q9H583	914
WDR75	MPHOSPH10	O00566	703
WDR75	WDR36	Q8NI36	665
WDR75	UTP18	Q9Y5J1	646
WDR75	UTP20	O75691	635
WDR75	WDR46	O15213	625
WDR75	NOP58	Q9Y2X3	589
WDR75	SNU13	P55769	579
WDR75	BMS1	Q14692	579
WDR75	UTP6	Q9NYH9	578
WDR75	PWP2	Q15269	576
WDR75	TBL3	Q12788	560

IntAct

97 interactions, top by confidence:

A	B	Type	Score
C1D	ZFC3H1	psi-mi:“MI:0914”(association)	0.640
CACNB1	CACNB3	psi-mi:“MI:0914”(association)	0.640
NIPAL1	ESYT2	psi-mi:“MI:0914”(association)	0.640
EXOSC5	ZFC3H1	psi-mi:“MI:0914”(association)	0.640
EXOSC3	MTREX	psi-mi:“MI:0914”(association)	0.640
NOL7	WDR43	psi-mi:“MI:0914”(association)	0.640
PWP2	FBL	psi-mi:“MI:0914”(association)	0.610
PLEK	WDR75	psi-mi:“MI:0915”(physical association)	0.590
ASB7	POLR3A	psi-mi:“MI:0914”(association)	0.530
SERPINA12	TSPAN6	psi-mi:“MI:0914”(association)	0.530
NOL11	WDR43	psi-mi:“MI:0914”(association)	0.530
WDR75	WDR43	psi-mi:“MI:0914”(association)	0.530
FBL	ZNF316	psi-mi:“MI:0914”(association)	0.530
UTP4	ANKRD28	psi-mi:“MI:0914”(association)	0.530
RBM4	NVL	psi-mi:“MI:0914”(association)	0.530
WDR43	WDR75	psi-mi:“MI:0914”(association)	0.530
NOL7	IPO5	psi-mi:“MI:0914”(association)	0.530
MPHOSPH6	ZFC3H1	psi-mi:“MI:0914”(association)	0.530
Smad3		psi-mi:“MI:0914”(association)	0.350
CEP170P1	PCYT1A	psi-mi:“MI:0914”(association)	0.350
ATP6AP2	TMUB1	psi-mi:“MI:0914”(association)	0.350
Srp72		psi-mi:“MI:0914”(association)	0.350
KIF21B		psi-mi:“MI:0914”(association)	0.350
Setdb1	INPP5B	psi-mi:“MI:0914”(association)	0.350
EXOSC5	PAPD5	psi-mi:“MI:0914”(association)	0.350

BioGRID (144): WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS), WDR75 (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2JEB6, A0JM56, B0DOB4, B0FXQ5, B1ANS9, B4F7L9, B4GQJ7, B5DHW4, B7FF06, B7FF07, B7FF08, B7FF09, B7FF12, C5IAW9, F1LW30, F1P4W9, O08747, O95185, P0DM40, Q008S8, Q18264, Q32NR9, Q3V0B4, Q402B2, Q4G0P3, Q5R4M2, Q5T0N1, Q5XI14, Q6AXU1, Q6DCF6, Q6NRS1, Q6P2C0, Q6P5D8, Q6UXZ4, Q6ZTR5, Q6ZU64, Q761X5, Q7T2Z5, Q80W93, Q86YR7

Diamond homologs: A4RDD7, A6ZPA6, A7EF03, A7THX0, B3LJT5, B4HSL3, B4QHG6, B8P4B0, B8PD53, B9WD30, C4YPI7, C5DF48, C5DY07, C5FP68, C5MJE8, C7GWC1, C8ZH19, D3TLL6, D4AM37, D4D8P3, O00628, P39946, P97865, Q54WA3, Q5A7Q3, Q5A7Q6, Q6CJ50, Q6CU55, Q6DFC6, Q6FT96, Q6FWT9, Q759U7, Q7KNS3, Q7RXH4, Q8IWA0, Q8R537, Q8RXA7, Q9H2Y7, A0JMQ0, A2QP30

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
WDR75	“form complex”	“UTP-A complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 129 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Nuclear RNA decay	7	25.4×	1e-06
rRNA modification in the nucleus and cytosol	9	19.8×	1e-07
Major pathway of rRNA processing in the nucleolus and cytosol	17	12.3×	9e-12
mRNA Splicing	9	11.6×	5e-06
Processing of Capped Intron-Containing Pre-mRNA	10	9.7×	5e-06
mRNA Splicing - Major Pathway	12	7.7×	4e-06
Metabolism of RNA	14	6.9×	1e-06

GO biological processes:

GO term	Partners	Fold	FDR
maturation of SSU-rRNA	5	32.5×	6e-05
RNA catabolic process	5	19.3×	6e-04
ribosomal small subunit biogenesis	9	17.4×	7e-07
rRNA processing	11	13.2×	4e-07
RNA processing	7	13.0×	1e-04
regulation of alternative mRNA splicing, via spliceosome	6	12.4×	8e-04
RNA splicing	11	8.2×	2e-05
mRNA splicing, via spliceosome	8	6.2×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

106 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	76
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3245 predictions. Top by Δscore:

Variant	Effect	Δscore
2:189441553:A:T	donor_gain	1.0000
2:189441571:GATTC:G	donor_gain	1.0000
2:189441575:C:CG	donor_gain	1.0000
2:189441579:G:GG	donor_gain	1.0000
2:189448378:GGT:G	acceptor_gain	1.0000
2:189448378:GGTAT:G	acceptor_gain	1.0000
2:189450901:A:AG	acceptor_gain	1.0000
2:189450902:G:GG	acceptor_gain	1.0000
2:189450902:GCT:G	acceptor_gain	1.0000
2:189450902:GCTGT:G	acceptor_gain	1.0000
2:189455318:A:AG	acceptor_gain	1.0000
2:189455319:G:GG	acceptor_gain	1.0000
2:189455319:GA:G	acceptor_gain	1.0000
2:189455319:GAT:G	acceptor_gain	1.0000
2:189455319:GATA:G	acceptor_gain	1.0000
2:189455319:GATAT:G	acceptor_gain	1.0000
2:189455441:CGAGG:C	donor_loss	1.0000
2:189455442:GAG:G	donor_gain	1.0000
2:189455442:GAGG:G	donor_loss	1.0000
2:189455445:GT:G	donor_loss	1.0000
2:189455446:T:A	donor_loss	1.0000
2:189458905:T:G	donor_gain	1.0000
2:189460374:G:GT	donor_gain	1.0000
2:189460374:G:T	donor_gain	1.0000
2:189462347:A:G	donor_gain	1.0000
2:189462445:A:AG	acceptor_gain	1.0000
2:189462446:A:AG	acceptor_gain	1.0000
2:189462447:A:G	acceptor_gain	1.0000
2:189462448:A:G	acceptor_gain	1.0000
2:189462449:C:G	acceptor_gain	1.0000

AlphaMissense

5496 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:189450939:T:A	W85R	0.999
2:189450939:T:C	W85R	0.999
2:189462498:A:C	S265R	0.999
2:189462500:T:A	S265R	0.999
2:189462500:T:G	S265R	0.999
2:189466552:T:A	W473R	0.999
2:189466552:T:C	W473R	0.999
2:189467482:T:A	W488R	0.999
2:189467482:T:C	W488R	0.999
2:189458857:G:T	G225V	0.998
2:189458871:T:A	W230R	0.998
2:189458871:T:C	W230R	0.998
2:189462528:T:A	W275R	0.998
2:189462528:T:C	W275R	0.998
2:189463897:T:A	V350D	0.998
2:189463921:T:C	L358P	0.998
2:189467590:T:A	W524R	0.998
2:189467590:T:C	W524R	0.998
2:189458839:C:A	A219E	0.997
2:189458857:G:A	G225D	0.997
2:189458866:G:C	R228P	0.997
2:189459382:T:A	W246R	0.997
2:189459382:T:C	W246R	0.997
2:189465170:T:C	L402P	0.997
2:189466520:T:A	V462D	0.997
2:189470204:T:A	W650R	0.997
2:189470204:T:C	W650R	0.997
2:189458845:G:A	G221D	0.996
2:189462520:T:C	L272P	0.996
2:189465229:T:A	W422R	0.996

dbSNP variants (sampled 300 via entrez): RS1000100795 (2:189441546 C>A), RS1000265209 (2:189472693 G>A), RS1000342115 (2:189448036 T>C), RS1000472594 (2:189459359 A>C), RS1000551485 (2:189440011 G>A,C), RS1000714829 (2:189453921 G>A), RS1000991207 (2:189440830 C>G), RS1001024489 (2:189471151 C>G), RS1001193860 (2:189457445 T>C), RS1001269404 (2:189470969 T>C), RS1001308476 (2:189457679 G>A), RS1001339920 (2:189441093 C>A,G,T), RS1001422374 (2:189464193 T>C), RS1001472604 (2:189458079 A>T), RS1001524740 (2:189457904 C>T)

Disease associations

OMIM: gene MIM:620341 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST002677_1	Iron status biomarkers (ferritin levels)	8.000000e-19
GCST002678_1	Iron status biomarkers (transferrin levels)	1.000000e-11
GCST004571_22	Iron status biomarkers (total iron binding capacity)	8.000000e-07
GCST004572_3	Iron status biomarkers (transferrin saturation)	8.000000e-07
GCST010698_39	Subcortical volume (min-P)	9.000000e-26
GCST010699_36	Brain morphology (min-P)	9.000000e-09
GCST010700_26	Cortical thickness (MOSTest)	9.000000e-52
GCST010701_48	Cortical surface area (MOSTest)	2.000000e-18
GCST010702_50	Subcortical volume (MOSTest)	8.000000e-10
GCST010703_340	Brain morphology (MOSTest)	3.000000e-10

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0004459	ferritin measurement
EFO:0004461	iron biomarker measurement
EFO:0006341	transferrin measurement
EFO:0006334	total iron binding capacity
EFO:0004346	neuroimaging measurement
EFO:0004840	cortical thickness

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression, decreases expression, increases abundance	3
Valproic Acid	decreases expression	2
Cadmium Chloride	decreases expression	2
FR900359	affects phosphorylation	1
dicrotophos	decreases expression	1
alpha phellandrene	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
propionaldehyde	increases methylation	1
deoxynivalenol	increases expression	1
nonanal	increases methylation	1
n-hexanal	increases methylation	1
beta-lapachone	increases expression	1
arsenite	decreases reaction, affects binding	1
butyraldehyde	increases methylation	1
caprylic aldehyde	increases methylation	1
nivalenol	increases expression	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
pentanal	increases methylation	1
heptanal	increases methylation	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
jinfukang	decreases expression	1
(+)-JQ1 compound	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Acrolein	affects cotreatment, increases expression, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases expression	1
Arsenic	increases abundance, increases expression	1
Doxorubicin	decreases expression	1
Estradiol	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.