WDR86-AS1

Summary

WDR86-AS1 (WDR86 antisense RNA 1, HGNC:41186) is a long non-coding RNA gene on chromosome 7q36.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41186
Approved symbol	WDR86-AS1
Name	WDR86 antisense RNA 1
Location	7q36.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000243836
Ensembl biotype	lncRNA
Entrez	100131176
RNAcentral	URS000075B24D — lncRNA, 874 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 41 — 39 lncRNA, 2 retained_intron

ENST00000460148, ENST00000466677, ENST00000480632, ENST00000489632, ENST00000690609, ENST00000691372, ENST00000701222, ENST00000741556, ENST00000741557, ENST00000741558, ENST00000741559, ENST00000741560, ENST00000741561, ENST00000741562, ENST00000741563, ENST00000741564, ENST00000741565, ENST00000741566, ENST00000741567, ENST00000741568, ENST00000741569, ENST00000741570, ENST00000741571, ENST00000741572, ENST00000741573, ENST00000741574, ENST00000741575, ENST00000741576, ENST00000741577, ENST00000741578, ENST00000741579, ENST00000741580, ENST00000741581, ENST00000741582, ENST00000741583, ENST00000741584, ENST00000741585, ENST00000741586, ENST00000741587, ENST00000741588, ENST00000741589

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000460148 — 3 exons

Exon	Start	End
ENSE00001954670	151411670	151411792
ENSE00004078893	151410504	151410763
ENSE00004078930	151411967	151413048

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 99.09.

FANTOM5 (CAGE): breadth broad, TPM avg 1.3468 / max 111.7788, expressed in 323 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
82081	1.3468	323

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	99.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	92.30	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.92	gold quality
fallopian tube	UBERON:0003889	89.63	gold quality
spleen	UBERON:0002106	87.31	gold quality
thyroid gland	UBERON:0002046	85.58	gold quality
right lobe of thyroid gland	UBERON:0001119	85.43	gold quality
left lobe of thyroid gland	UBERON:0001120	85.15	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.49	gold quality
endocervix	UBERON:0000458	83.27	gold quality
granulocyte	CL:0000094	83.19	gold quality
endometrium	UBERON:0001295	82.54	gold quality
tibial nerve	UBERON:0001323	81.33	gold quality
placenta	UBERON:0001987	79.96	gold quality
omental fat pad	UBERON:0010414	79.57	gold quality
right lung	UBERON:0002167	79.16	gold quality
left uterine tube	UBERON:0001303	79.01	gold quality
cortical plate	UBERON:0005343	78.10	gold quality
sural nerve	UBERON:0015488	77.91	gold quality
uterine cervix	UBERON:0000002	75.56	gold quality
muscle layer of sigmoid colon	UBERON:0035805	74.36	gold quality
thoracic mammary gland	UBERON:0005200	74.25	gold quality
adipose tissue	UBERON:0001013	72.81	gold quality
lymph node	UBERON:0000029	72.13	gold quality
blood	UBERON:0000178	71.67	gold quality
body of uterus	UBERON:0009853	71.49	gold quality
myometrium	UBERON:0001296	71.43	gold quality
fundus of stomach	UBERON:0001160	71.17	gold quality
ectocervix	UBERON:0012249	71.17	gold quality
lung	UBERON:0002048	71.01	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-10287	yes	26.63
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The authors show that WDR86-AS1, miR-10b-3p, and LITAF are involved in preeclampsia pathogenesis. (PMID:30552989)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.