WDR86

Summary

WDR86 (WD repeat domain 86, HGNC:28020) is a protein-coding gene on chromosome 7q36.1, encoding WD repeat-containing protein 86 (Q86TI4).

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 86 total — 2 pathogenic
• MANE Select transcript: NM_198285

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28020
Approved symbol	WDR86
Name	WD repeat domain 86
Location	7q36.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000187260
Ensembl biotype	protein_coding
Entrez	349136

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 5 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000334493, ENST00000463000, ENST00000469830, ENST00000477459, ENST00000484630, ENST00000496971, ENST00000621812, ENST00000628331

RefSeq mRNA: 4 — MANE Select: NM_198285 NM_001284260, NM_001284261, NM_001284262, NM_198285

CCDS: CCDS5925, CCDS64805, CCDS64806, CCDS75680

Canonical transcript exons

ENST00000334493 — 6 exons

Exon	Start	End
ENSE00000000105	151381124	151381746
ENSE00001821441	151409427	151410038
ENSE00003418765	151385088	151385223
ENSE00003525654	151400100	151400241
ENSE00003590477	151395776	151396196
ENSE00003694393	151381878	151381981

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 96.24.

FANTOM5 (CAGE): breadth broad, TPM avg 2.5797 / max 69.5741, expressed in 469 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
86899	1.0031	320
86897	0.7058	287
86901	0.6231	283
86898	0.2071	111
86900	0.0406	17

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	96.24	gold quality
left lobe of thyroid gland	UBERON:0001120	94.95	gold quality
right lobe of thyroid gland	UBERON:0001119	94.84	gold quality
thyroid gland	UBERON:0002046	94.01	gold quality
tibial nerve	UBERON:0001323	92.28	gold quality
endocervix	UBERON:0000458	91.26	gold quality
spleen	UBERON:0002106	88.35	gold quality
sural nerve	UBERON:0015488	87.00	gold quality
ganglionic eminence	UBERON:0004023	86.20	gold quality
left uterine tube	UBERON:0001303	85.65	gold quality
omental fat pad	UBERON:0010414	84.64	gold quality
peritoneum	UBERON:0002358	84.56	gold quality
muscle layer of sigmoid colon	UBERON:0035805	84.38	gold quality
mucosa of paranasal sinus	UBERON:0005030	84.15	gold quality
body of uterus	UBERON:0009853	83.93	gold quality
cortical plate	UBERON:0005343	83.92	gold quality
adipose tissue of abdominal region	UBERON:0007808	83.69	gold quality
ectocervix	UBERON:0012249	83.27	gold quality
oviduct epithelium	UBERON:0004804	83.15	gold quality
fallopian tube	UBERON:0003889	82.62	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	81.79	gold quality
uterine cervix	UBERON:0000002	81.52	gold quality
adenohypophysis	UBERON:0002196	81.13	gold quality
right ovary	UBERON:0002118	80.48	gold quality
left ovary	UBERON:0002119	80.06	gold quality
pigmented layer of retina	UBERON:0001782	79.87	gold quality
body of stomach	UBERON:0001161	79.66	gold quality
amygdala	UBERON:0001876	79.46	gold quality
metanephros cortex	UBERON:0010533	78.48	gold quality
tibia	UBERON:0000979	78.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.85

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

9 targeting WDR86, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-5693	99.24	66.67	1106
HSA-MIR-6815-3P	99.13	68.98	1530
HSA-MIR-3619-5P	99.00	68.87	2308
HSA-MIR-214-3P	98.71	68.12	2128
HSA-MIR-761	98.71	68.07	2051

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Wdr86	ENSMUSG00000055235
rattus_norvegicus	Wdr86	ENSRNOG00000025735
caenorhabditis_elegans		WBGENE00004767

Paralogs (14): WDR54 (ENSG00000005448), FBXW11 (ENSG00000072803), FBXW7 (ENSG00000109670), TRAF7 (ENSG00000131653), FBXW9 (ENSG00000132004), FBXO36 (ENSG00000153832), WDR64 (ENSG00000162843), FBXW12 (ENSG00000164049), BTRC (ENSG00000166167), WDR49 (ENSG00000174776), FBXW8 (ENSG00000174989), PAAF1 (ENSG00000175575), FBXO16 (ENSG00000214050), EFCAB8 (ENSG00000215529)

Protein

Protein identifiers

WD repeat-containing protein 86 — Q86TI4 (reviewed: Q86TI4)

All UniProt accessions (3): A0A090N7X3, Q86TI4, A0A0C4DGX6

UniProt curated annotations — full annotation on UniProt →

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoforms (4)

UniProt ID	Names	Canonical?
Q86TI4-3	3	yes
Q86TI4-1	1
Q86TI4-2	2
Q86TI4-4	4

RefSeq proteins (4): NP_001271189, NP_001271190, NP_001271191, NP_938026* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR011047	Quinoprotein_ADH-like_sf	Homologous_superfamily
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR020472	WD40_PAC1	Repeat
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR044715	WDR86-like	Family

Pfam: PF00400

UniProt features (16 total): repeat 8, splice variant 4, sequence conflict 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86TI4-F1	91.04	0.85

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 45 (showing top): ROZANOV_MMP14_TARGETS_UP, TGCTGAY_UNKNOWN, MYB_Q6, MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED, MEISSNER_BRAIN_HCP_WITH_H3K27ME3, MIKKELSEN_MCV6_HCP_WITH_H3K27ME3, BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, ZNF423_TARGET_GENES, MIR3686, GSE13229_MATURE_VS_INTMATURE_NKCELL_DN, GSE17721_CTRL_VS_POLYIC_4H_BMDC_DN, HAY_BONE_MARROW_STROMAL, GSE17721_PAM3CSK4_VS_GADIQUIMOD_6H_BMDC_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_16H_BMDC_DN

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1

Protein interactions and networks

STRING

579 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
WDR86	CRYGN	Q8WXF5	503
WDR86	C7orf33	Q8WU49	477
WDR86	DRC11L	A6NCM1	469
WDR86	ETV3L	Q6ZN32	444
WDR86	KRABD3	A5PL33	439
WDR86	AGAP3	Q96P47	438
WDR86	TMUB1	Q9BVT8	431
WDR86	A0A087WTJ2	A0A087WTJ2	431
WDR86	ZNF425	Q6IV72	420
WDR86	ZBED10P	Q96FA7	417
WDR86	CPEB1	Q9BZB8	413
WDR86	TBCCD1	Q9NVR7	410
WDR86	ZNF786	Q8N393	403
WDR86	GIMAP1	Q8WWP7	400
WDR86	C16orf89	Q6UX73	399
WDR86	ZNF212	Q9UDV6	399

IntAct

4 interactions, top by confidence:

A	B	Type	Score
P		psi-mi:“MI:0914”(association)	0.350
WDR86	TXNDC9	psi-mi:“MI:0914”(association)	0.350

BioGRID (36): IPCEF1 (Affinity Capture-MS), TXNDC9 (Affinity Capture-MS), CCT2 (Affinity Capture-MS), CCT4 (Affinity Capture-MS), CCT3 (Affinity Capture-MS), CCT6B (Affinity Capture-MS), CCT6A (Affinity Capture-MS), TCP1 (Affinity Capture-MS), CCT7 (Affinity Capture-MS), PDCL (Affinity Capture-MS), CCT5 (Affinity Capture-MS), PPP2CA (Affinity Capture-MS), PFDN4 (Affinity Capture-MS), WDR86 (Proximity Label-MS), CCT6A (Affinity Capture-MS)

ESM2 similar proteins: A1A5C7, A5D7B1, A6H7A0, A6NCF5, A6QLN9, A8MUP2, D3YYU8, D3ZZ80, O43688, O75147, O88843, P08887, Q14CX5, Q3SZQ2, Q3UHH2, Q58CT4, Q5EA19, Q5R4Q7, Q5R7S9, Q5RCI5, Q5RFN0, Q5SP67, Q5SUV1, Q642A6, Q6IA17, Q6PCB0, Q7TPB4, Q86TI4, Q8BGR6, Q8BZI6, Q8K5A4, Q8N5I2, Q8N653, Q8R2Z5, Q8TBF2, Q8VE98, Q92737, Q969P0, Q96NJ5, Q96NT3

Diamond homologs: A0JPH4, A1CUD6, A1D7I5, A1DP19, A2QEV8, A6H603, B0XM00, B0XYC8, C4R6H3, F4JY12, G4MQX3, O54929, O94527, P07834, P0DPA1, P20484, P25635, P29829, P40042, P43254, P53699, P83774, P93471, Q01369, Q08E38, Q0V8J1, Q10281, Q2UQ34, Q4WLM7, Q4WX90, Q54DS8, Q54QU5, Q54ZP5, Q58D20, Q5ZMA2, Q6P1V3, Q7T2F6, Q86TI4, Q99KP6, Q9JMJ4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

86 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	0
Uncertain significance	72
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
1340055	GRCh37/hg19 7q36.1-36.3(chr7:148695373-159119707)x1	Pathogenic
625550	GRCh37/hg19 7q32.1-36.3(chr7:128312450-159119220)	Pathogenic

SpliceAI

1906 predictions. Top by Δscore:

Variant	Effect	Δscore
7:151375939:ACCGA:A	donor_gain	1.0000
7:151375940:CCGA:C	donor_gain	1.0000
7:151375941:CGA:C	donor_gain	1.0000
7:151375942:GA:G	donor_gain	1.0000
7:151375942:GAG:G	donor_gain	1.0000
7:151375943:AGTG:A	donor_loss	1.0000
7:151375944:G:GG	donor_gain	1.0000
7:151375945:T:A	donor_loss	1.0000
7:151375946:G:GT	donor_loss	1.0000
7:151376629:CCTA:C	acceptor_loss	1.0000
7:151376630:CTA:C	acceptor_loss	1.0000
7:151376631:TAGT:T	acceptor_loss	1.0000
7:151376632:A:AG	acceptor_gain	1.0000
7:151376632:A:C	acceptor_loss	1.0000
7:151376632:AGTT:A	acceptor_gain	1.0000
7:151376632:AGTTG:A	acceptor_gain	1.0000
7:151376633:G:GA	acceptor_gain	1.0000
7:151376633:G:T	acceptor_loss	1.0000
7:151376633:GT:G	acceptor_gain	1.0000
7:151376633:GTT:G	acceptor_gain	1.0000
7:151376633:GTTG:G	acceptor_gain	1.0000
7:151376633:GTTGG:G	acceptor_gain	1.0000
7:151376809:CAGG:C	donor_loss	1.0000
7:151376810:AGG:A	donor_loss	1.0000
7:151376813:T:A	donor_loss	1.0000
7:151377127:G:GT	donor_gain	1.0000
7:151377151:G:GT	donor_gain	1.0000
7:151377201:G:GT	donor_gain	1.0000
7:151381873:CCTA:C	donor_loss	1.0000
7:151381874:CTA:C	donor_loss	1.0000

AlphaMissense

2426 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:151396166:G:C	S112R	1.000
7:151396166:G:T	S112R	1.000
7:151396168:T:G	S112R	1.000
7:151396163:G:C	S113R	0.998
7:151396163:G:T	S113R	0.998
7:151396165:T:G	S113R	0.998
7:151400159:C:A	W82C	0.998
7:151400159:C:G	W82C	0.998
7:151400161:A:G	W82R	0.998
7:151400161:A:T	W82R	0.998
7:151400183:G:C	S74R	0.998
7:151400183:G:T	S74R	0.998
7:151400184:C:A	S74I	0.998
7:151400185:T:G	S74R	0.998
7:151400190:G:T	T72K	0.998
7:151396143:C:G	R120P	0.997
7:151396146:G:T	A119D	0.997
7:151396161:G:A	S114F	0.997
7:151409474:G:T	A39D	0.997
7:151396161:G:T	S114Y	0.996
7:151409484:C:G	D36H	0.996
7:151409488:G:C	S34R	0.996
7:151409488:G:T	S34R	0.996
7:151409489:C:A	S34I	0.996
7:151409490:T:G	S34R	0.996
7:151395968:C:A	W178C	0.995
7:151395968:C:G	W178C	0.995
7:151395970:A:G	W178R	0.995
7:151395970:A:T	W178R	0.995
7:151395992:G:C	S170R	0.995

dbSNP variants (sampled 300 via entrez): RS1000022998 (7:151402864 C>T), RS1000045468 (7:151388192 T>C), RS1000077011 (7:151407731 T>A,C), RS1000171408 (7:151392204 C>A), RS1000225913 (7:151400474 C>T), RS1000282152 (7:151395369 C>A,T), RS1000288127 (7:151368680 ATTAAGCT>A), RS1000297419 (7:151377656 C>T), RS1000342289 (7:151369012 CTTTTT>C,CTTT,CTTTT,CTTTTTT,CTTTTTTT,CTTTTTTTT,CTTTTTTTTTT,CTTTTTTTTTTTTTTTTTT), RS1000352701 (7:151405162 A>G), RS1000534518 (7:151407632 A>T), RS1000592070 (7:151374963 C>T), RS1000726776 (7:151391291 T>C), RS1000778251 (7:151391532 G>A,C), RS1000807232 (7:151405379 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003476_9	Eyebrow thickness	7.000000e-06
GCST010002_266	Refractive error	1.000000e-20

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression, increases methylation	6
Benzo(a)pyrene	decreases methylation, increases methylation, affects methylation	2
Tobacco Smoke Pollution	decreases expression	2
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
lead acetate	decreases expression	1
sodium arsenite	decreases expression	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
theaflavin-3,3’-digallate	affects expression	1
Resveratrol	decreases expression, affects cotreatment	1
Calcitriol	decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Thiram	increases expression	1
Tretinoin	increases expression	1
Triclosan	decreases expression	1
Aflatoxin B1	increases methylation	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.