WDTC1

Summary

WDTC1 (WD and tetratricopeptide repeats 1, HGNC:29175) is a protein-coding gene on chromosome 1p36.11, encoding WD and tetratricopeptide repeats protein 1 (Q8N5D0). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Predicted to enable enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to act upstream of or within several processes, including cellular response to insulin stimulus; glucose metabolic process; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm.

Source: NCBI Gene 23038 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 87 total — 1 likely-pathogenic
• MANE Select transcript: NM_001276252

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29175
Approved symbol	WDTC1
Name	WD and tetratricopeptide repeats 1
Location	1p36.11
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1037, ADP, DCAF9
Ensembl gene	ENSG00000142784
Ensembl biotype	protein_coding
OMIM	619763
Entrez	23038

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 16 protein_coding, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000319394, ENST00000361771, ENST00000447062, ENST00000472249, ENST00000491239, ENST00000868293, ENST00000868294, ENST00000868295, ENST00000868296, ENST00000868297, ENST00000868298, ENST00000868299, ENST00000868300, ENST00000868301, ENST00000868302, ENST00000913940, ENST00000913941, ENST00000913942, ENST00000913943

RefSeq mRNA: 3 — MANE Select: NM_001276252 NM_001276252, NM_001410767, NM_015023

CCDS: CCDS296, CCDS60044, CCDS90895

Canonical transcript exons

ENST00000319394 — 16 exons

Exon	Start	End
ENSE00001685646	27234632	27234951
ENSE00003465039	27296326	27296401
ENSE00003510931	27294022	27294116
ENSE00003539618	27294514	27294629
ENSE00003573835	27297938	27298111
ENSE00003576585	27306186	27308636
ENSE00003584615	27292215	27292397
ENSE00003660983	27301226	27301461
ENSE00003671236	27297048	27297156
ENSE00003889256	27305001	27305193
ENSE00003889785	27260956	27261102
ENSE00003892921	27283338	27283449
ENSE00003893053	27282239	27282285
ENSE00003893182	27287674	27287861
ENSE00003894262	27263152	27263235
ENSE00003894889	27303621	27303795

Expression profiles

Bgee: expression breadth ubiquitous, 281 present calls, max score 94.76.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 19.4334 / max 279.1184, expressed in 1812 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
1692	7.3890	1761
1693	5.4619	1616
1694	5.2730	1618
1695	1.0919	705
1691	0.2176	67

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	94.76	gold quality
gastrocnemius	UBERON:0001388	94.65	gold quality
muscle of leg	UBERON:0001383	94.14	gold quality
pancreatic ductal cell	CL:0002079	93.26	gold quality
cardia of stomach	UBERON:0001162	93.12	gold quality
apex of heart	UBERON:0002098	92.79	gold quality
muscle organ	UBERON:0001630	92.69	gold quality
granulocyte	CL:0000094	92.42	gold quality
heart left ventricle	UBERON:0002084	92.17	gold quality
right atrium auricular region	UBERON:0006631	92.16	gold quality
cardiac ventricle	UBERON:0002082	92.02	gold quality
left testis	UBERON:0004533	91.95	gold quality
right testis	UBERON:0004534	91.80	gold quality
nipple	UBERON:0002030	91.78	gold quality
cardiac atrium	UBERON:0002081	91.75	gold quality
blood	UBERON:0000178	91.62	gold quality
vena cava	UBERON:0004087	91.47	gold quality
prefrontal cortex	UBERON:0000451	91.15	gold quality
body of tongue	UBERON:0011876	91.13	gold quality
heart	UBERON:0000948	91.00	gold quality
lower esophagus muscularis layer	UBERON:0035833	90.98	gold quality
lower esophagus	UBERON:0013473	90.96	gold quality
tongue	UBERON:0001723	90.90	gold quality
pylorus	UBERON:0001166	90.89	gold quality
Brodmann (1909) area 10	UBERON:0013541	90.76	silver quality
stromal cell of endometrium	CL:0002255	90.75	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	90.70	gold quality
superior surface of tongue	UBERON:0007371	90.70	gold quality
mucosa of stomach	UBERON:0001199	90.68	gold quality
left adrenal gland cortex	UBERON:0035825	90.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.29

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CEBPG, NFKB, SSRP1, TFAP2A

miRNA regulators (miRDB)

179 targeting WDTC1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-4731-5P	99.89	67.23	2537

Literature-anchored findings (GeneRIF, showing 4)

• WDTC1 variation may be an important risk factor contributing to obesity in both Puerto Rican and white populations. (PMID:19238144)
• High adp expression in human adipose tissue is associated with lower adiposity and enhanced glucose utilization. (PMID:23512946)
• Our results identify a biochemical role for WDTC1 and extend the functional range of the CRL4 complex to the suppression of fat accumulation. (PMID:27113764)
• The putative oncogenic role of WDTC1 in colorectal cancer. (PMID:35238908)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	wdtc1	ENSDARG00000059760
mus_musculus	Wdtc1	ENSMUSG00000037622
rattus_norvegicus	Wdtc1	ENSRNOG00000008377
drosophila_melanogaster	adp	FBGN0000057
caenorhabditis_elegans	adpr-1	WBGENE00044440

Paralogs (5): DCAF8 (ENSG00000132716), DCAF5 (ENSG00000139990), DCAF6 (ENSG00000143164), DCAF8L2 (ENSG00000189186), DCAF8L1 (ENSG00000226372)

Protein

Protein identifiers

WD and tetratricopeptide repeats protein 1 — Q8N5D0 (reviewed: Q8N5D0)

All UniProt accessions (2): Q8N5D0, H0YEI6

UniProt curated annotations — full annotation on UniProt →

Function. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Pathway. Protein modification; protein ubiquitination.

Isoforms (6)

UniProt ID	Names	Canonical?
Q8N5D0-1	1	yes
Q8N5D0-2	2
Q8N5D0-3	3
Q8N5D0-4	4
Q8N5D0-5	5
Q8N5D0-6	6

RefSeq proteins (3): NP_001263181, NP_001397696, NP_055838 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019734	TPR_rpt	Repeat
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR045151	DCAF8	Family

Pfam: PF00400

UniProt features (19 total): repeat 9, splice variant 3, region of interest 2, modified residue 2, chain 1, sequence conflict 1, helix 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
3I7N	X-RAY DIFFRACTION	2.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N5D0-F1	82.35	0.64

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 353, 511

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-8951664	Neddylation

MSigDB gene sets: 267 (showing top): GOBP_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, MYOGENIN_Q6, TGCGCANK_UNKNOWN, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GOBP_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS, GOBP_GROWTH, GOBP_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS, AP4_Q6, AP2_Q3, GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_KETONE_METABOLIC_PROCESS, CAGCTG_AP4_Q5, GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS

GO Biological Process (9): negative regulation of transcription by RNA polymerase II (GO:0000122), in utero embryonic development (GO:0001701), glucose metabolic process (GO:0006006), regulation of cell size (GO:0008361), protein ubiquitination (GO:0016567), cellular response to insulin stimulus (GO:0032869), multicellular organism growth (GO:0035264), negative regulation of fatty acid biosynthetic process (GO:0045717), intracellular chemical homeostasis (GO:0055082)

GO Molecular Function (4): enzyme inhibitor activity (GO:0004857), histone binding (GO:0042393), histone deacetylase binding (GO:0042826), protein binding (GO:0005515)

GO Cellular Component (5): nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), Cul4-RING E3 ubiquitin ligase complex (GO:0080008), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Post-translational protein modification	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
chordate embryonic development	1
hexose metabolic process	1
regulation of cellular component size	1
protein modification by small protein conjugation	1
response to insulin	1
cellular response to peptide hormone stimulus	1
multicellular organismal process	1
developmental growth	1
fatty acid biosynthetic process	1
regulation of fatty acid biosynthetic process	1
negative regulation of fatty acid metabolic process	1
negative regulation of lipid biosynthetic process	1
cellular homeostasis	1
chemical homeostasis	1
catalytic activity	1
enzyme regulator activity	1
molecular function inhibitor activity	1
protein binding	1
enzyme binding	1
binding	1
nuclear lumen	1
intracellular anatomical structure	1
cytoplasm	1
cullin-RING ubiquitin ligase complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1002 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
WDTC1	DDB1	Q16531	628
WDTC1	MAPT	P10636	541
WDTC1	ZNF70	Q9UC06	493
WDTC1	SYNPO2L	Q9H987	485
WDTC1	PARK7	Q99497	438
WDTC1	ZC3H14	Q6PJT7	425
WDTC1	KANSL1	Q7Z3B3	424
WDTC1	HOOK2	Q96ED9	411
WDTC1	DNASE2	O00115	410
WDTC1	DEFA4	P12838	409
WDTC1	DCAF4	Q8WV16	409
WDTC1	DDB2	Q92466	404
WDTC1	MRTO4	Q9UKD2	399
WDTC1	PLAGL2	Q9UPG8	398
WDTC1	SUMO2	P55855	390

IntAct

87 interactions, top by confidence:

A	B	Type	Score
SEPTIN3	SEPTIN6	psi-mi:“MI:0914”(association)	0.800
CUL4B	COPS2	psi-mi:“MI:0914”(association)	0.790
COPS6	RHOBTB1	psi-mi:“MI:0914”(association)	0.730
CCT2	TXNDC9	psi-mi:“MI:0914”(association)	0.730
CUL4A	COPS2	psi-mi:“MI:0914”(association)	0.640
BCKDK	CETN3	psi-mi:“MI:0914”(association)	0.640
CCT3	TXNDC9	psi-mi:“MI:0914”(association)	0.640
ARL4C	RGS12	psi-mi:“MI:0914”(association)	0.640
BOD1	WDTC1	psi-mi:“MI:0915”(physical association)	0.620
PNOC	CETN3	psi-mi:“MI:0914”(association)	0.530
TRMT10B	MRPS14	psi-mi:“MI:0914”(association)	0.530
ARHGAP44	VPS26A	psi-mi:“MI:0914”(association)	0.530
WDTC1	TCP1	psi-mi:“MI:0914”(association)	0.530
SLC25A22	DNLZ	psi-mi:“MI:0914”(association)	0.530
BOD1	PLXDC2	psi-mi:“MI:0914”(association)	0.530
CCT7	PEX7	psi-mi:“MI:0914”(association)	0.530
MRPS11	MRPS14	psi-mi:“MI:0914”(association)	0.530
PNOC	NUP155	psi-mi:“MI:0914”(association)	0.530
GALNS	FBXO21	psi-mi:“MI:0914”(association)	0.530
APBA3	CLSTN1	psi-mi:“MI:0914”(association)	0.530
GALNS	CLGN	psi-mi:“MI:0914”(association)	0.530

BioGRID (409): DDB1 (Affinity Capture-Western), CUL4A (Affinity Capture-Western), WDTC1 (Affinity Capture-MS), WDTC1 (Affinity Capture-MS), WDTC1 (Affinity Capture-MS), WDTC1 (Affinity Capture-MS), WDTC1 (Affinity Capture-MS), WDTC1 (Affinity Capture-Western), WDTC1 (Affinity Capture-Western), DDB1 (Affinity Capture-Western), CUL4A (Affinity Capture-Western), CUL4B (Affinity Capture-Western), RBX1 (Affinity Capture-Western), STXBP4 (Affinity Capture-MS), CUL4A (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8QP51, E9PYK3, E9Q4Z2, G1SPE9, O00763, O15228, O23617, P13676, P13798, P19205, P25154, P35574, P80227, P83006, P98192, Q10MJ1, Q2PQH8, Q338C0, Q496Z0, Q5EBA1, Q5IH13, Q5IH14, Q5R5S1, Q5U5V2, Q5ZIB9, Q641Y5, Q6V1X1, Q6YXW6, Q80YA7, Q80YD1, Q80ZK9, Q86TI2, Q8BVG4, Q8C0P5, Q8C5P5, Q8IYB8, Q8K4M9, Q8N5D0, Q8R146, Q8VZF3

Diamond homologs: A4K2V0, A6HD62, A6ZRW3, D7REX8, F1RBN2, F4IRM4, F4JTI1, F4K487, F4KCL7, O13754, O14217, O16259, O35814, O48802, O54981, O94826, O95801, P07213, P23231, P25638, P31948, P33313, P38825, P53041, P53042, Q07617, Q12118, Q13451, Q15785, Q32PZ3, Q3KRD5, Q3ZBR5, Q43207, Q4R8N7, Q5EA11, Q5PPS5, Q5R8D8, Q5RAP0, Q5U2X2, Q5VJS5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 108 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Association of TriC/CCT with target proteins during biosynthesis	5	19.3×	6e-04
DNA Damage Recognition in GG-NER	5	18.8×	6e-04
Formation of TC-NER Pre-Incision Complex	5	13.9×	1e-03
Neddylation	9	5.6×	1e-03

GO biological processes:

GO term	Partners	Fold	FDR
binding of sperm to zona pellucida	6	25.3×	5e-05
protein folding	8	8.3×	9e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

87 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	68
Likely benign	0
Benign	5

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
4813977	NM_001276252.2(WDTC1):c.1099C>T (p.Gln367Ter)	Likely pathogenic

SpliceAI

3200 predictions. Top by Δscore:

Variant	Effect	Δscore
1:27263148:CTAG:C	acceptor_loss	1.0000
1:27263149:TAG:T	acceptor_loss	1.0000
1:27263150:A:AC	acceptor_loss	1.0000
1:27263151:GGA:G	acceptor_gain	1.0000
1:27263151:GGAGC:G	acceptor_gain	1.0000
1:27263235:GGT:G	donor_loss	1.0000
1:27263236:G:C	donor_loss	1.0000
1:27263237:T:G	donor_loss	1.0000
1:27282281:GGAGA:G	donor_gain	1.0000
1:27282282:GAGA:G	donor_gain	1.0000
1:27282282:GAGAG:G	donor_gain	1.0000
1:27282283:A:T	donor_gain	1.0000
1:27282284:GA:G	donor_gain	1.0000
1:27282286:G:GG	donor_gain	1.0000
1:27283334:TCAG:T	acceptor_loss	1.0000
1:27283335:CA:C	acceptor_loss	1.0000
1:27283336:A:AG	acceptor_gain	1.0000
1:27283336:A:C	acceptor_loss	1.0000
1:27283336:AGCTT:A	acceptor_gain	1.0000
1:27283337:G:GG	acceptor_gain	1.0000
1:27283337:GC:G	acceptor_gain	1.0000
1:27283337:GCT:G	acceptor_gain	1.0000
1:27283337:GCTT:G	acceptor_gain	1.0000
1:27283337:GCTTG:G	acceptor_gain	1.0000
1:27287671:T:G	acceptor_gain	1.0000
1:27287672:A:AG	acceptor_gain	1.0000
1:27287673:G:GG	acceptor_gain	1.0000
1:27287673:GTTC:G	acceptor_gain	1.0000
1:27292213:A:AG	acceptor_gain	1.0000
1:27292214:G:GA	acceptor_gain	1.0000

AlphaMissense

4486 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:27263231:T:C	L43P	1.000
1:27282244:C:A	H46Q	1.000
1:27282244:C:G	H46Q	1.000
1:27282249:G:A	G48E	1.000
1:27282251:T:A	C49S	1.000
1:27282251:T:C	C49R	1.000
1:27282252:G:A	C49Y	1.000
1:27282252:G:C	C49S	1.000
1:27282254:G:T	V50F	1.000
1:27282255:T:A	V50D	1.000
1:27282257:A:G	N51D	1.000
1:27282259:C:A	N51K	1.000
1:27282259:C:G	N51K	1.000
1:27282264:T:C	L53P	1.000
1:27282269:T:A	W55R	1.000
1:27282269:T:C	W55R	1.000
1:27282270:G:C	W55S	1.000
1:27282271:G:C	W55C	1.000
1:27282271:G:T	W55C	1.000
1:27283343:T:C	L62P	1.000
1:27283346:C:A	A63D	1.000
1:27283348:T:C	S64P	1.000
1:27283349:C:A	S64Y	1.000
1:27283349:C:T	S64F	1.000
1:27283352:G:A	G65D	1.000
1:27283354:T:C	S66P	1.000
1:27283355:C:T	S66F	1.000
1:27283357:G:C	D67H	1.000
1:27283357:G:T	D67Y	1.000
1:27283358:A:C	D67A	1.000

dbSNP variants (sampled 300 via entrez): RS1000009528 (1:27235437 T>TCC), RS1000013999 (1:27276075 A>G), RS1000023631 (1:27304254 C>T), RS1000082223 (1:27261504 T>C), RS1000087532 (1:27283849 A>C), RS1000174509 (1:27297284 A>T), RS1000204775 (1:27305723 G>A), RS1000267951 (1:27261068 A>G), RS1000285456 (1:27255602 T>C), RS1000388349 (1:27248199 C>G), RS1000429174 (1:27241274 T>C), RS1000441129 (1:27299192 T>C), RS1000504379 (1:27304585 C>T), RS1000535320 (1:27304265 T>C), RS1000567870 (1:27254275 C>T)

Disease associations

OMIM: gene MIM:619763 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression, affects cotreatment, decreases expression, increases abundance	3
Arsenic	affects cotreatment, decreases expression, increases abundance, increases expression	2
Rotenone	decreases expression	2
FR900359	increases phosphorylation	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
azoxystrobin	decreases expression	1
CGP 52608	affects binding, increases reaction	1
deguelin	decreases expression	1
pyrimidifen	decreases expression	1
thifluzamide	decreases expression	1
pyrachlostrobin	decreases expression	1
picoxystrobin	decreases expression	1
Zoledronic Acid	increases expression	1
Fulvestrant	increases methylation	1
Acetaminophen	increases expression	1
Antimycin A	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Diazinon	increases methylation	1
Methapyrilene	increases methylation	1
Tetrachlorodibenzodioxin	affects expression	1
Urethane	increases expression	1
Valproic Acid	affects expression	1
Aflatoxin B1	increases methylation	1
Cadmium Chloride	decreases expression	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.