WEE2-AS1

Summary

WEE2-AS1 (WEE2 antisense RNA 1, HGNC:48669) is a long non-coding RNA gene on chromosome 7q34.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be part of U1 snRNP.

Source: NCBI Gene 285962 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48669
Approved symbol	WEE2-AS1
Name	WEE2 antisense RNA 1
Location	7q34
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000228775
Ensembl biotype	lncRNA
Entrez	285962
RNAcentral	URS000022CFA6 — lncRNA, 2262 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 14 lncRNA, 2 retained_intron

ENST00000459753, ENST00000462383, ENST00000465110, ENST00000471512, ENST00000473776, ENST00000478332, ENST00000484172, ENST00000486906, ENST00000488785, ENST00000495800, ENST00000653232, ENST00000654845, ENST00000660874, ENST00000664486, ENST00000665340, ENST00000666407

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000459753 — 5 exons

Exon	Start	End
ENSE00001820528	141738198	141738252
ENSE00001902516	141705696	141705757
ENSE00002437619	141727992	141728145
ENSE00002514262	141723916	141724024
ENSE00002518914	141737383	141737567

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 86.58.

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	86.58	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.50	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.04	gold quality
sural nerve	UBERON:0015488	78.73	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.51	gold quality
endometrium	UBERON:0001295	75.53	gold quality
calcaneal tendon	UBERON:0003701	74.95	gold quality
ventricular zone	UBERON:0003053	73.34	gold quality
fallopian tube	UBERON:0003889	73.16	gold quality
body of pancreas	UBERON:0001150	72.89	gold quality
lymph node	UBERON:0000029	71.78	gold quality
cortex of kidney	UBERON:0001225	71.73	gold quality
pancreas	UBERON:0001264	71.01	gold quality
metanephros cortex	UBERON:0010533	70.90	gold quality
right adrenal gland cortex	UBERON:0035827	70.85	gold quality
kidney	UBERON:0002113	70.29	gold quality
ganglionic eminence	UBERON:0004023	70.29	gold quality
primary visual cortex	UBERON:0002436	70.06	gold quality
stromal cell of endometrium	CL:0002255	69.85	gold quality
thoracic mammary gland	UBERON:0005200	69.81	gold quality
skeletal muscle tissue	UBERON:0001134	69.75	gold quality
ovary	UBERON:0000992	69.74	gold quality
adult mammalian kidney	UBERON:0000082	69.51	gold quality
left ovary	UBERON:0002119	69.47	gold quality
cortical plate	UBERON:0005343	69.18	gold quality
right lobe of liver	UBERON:0001114	69.17	gold quality
smooth muscle tissue	UBERON:0001135	69.13	gold quality
placenta	UBERON:0001987	69.10	gold quality
right adrenal gland	UBERON:0001233	69.05	gold quality
skin of leg	UBERON:0001511	68.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.91

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• LncRNA WEE2-AS1 promotes proliferation and inhibits apoptosis in triple negative breast cancer cells via regulating miR-32-5p/TOB1 axis. (PMID:32307083)
• Antisense long noncoding RNA WEE2AS1 regulates human vascular endothelial cell viability via cell cycle G2/M transition in arteriosclerosis obliterans. (PMID:33174040)
• CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway. (PMID:36123327)
• The N(6)-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2. (PMID:36168628)
• LncRNA WEE2-AS1 is a diagnostic biomarker that predicts poor prognoses in patients with glioma. (PMID:36747161)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.