WRN-AS1

Summary

WRN-AS1 (WRN antisense RNA 1, HGNC:58431) is a long non-coding RNA gene on chromosome 8p12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58431
Approved symbol	WRN-AS1
Name	WRN antisense RNA 1
Location	8p12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000253961
Ensembl biotype	lncRNA
Entrez	141731996

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000521252, ENST00000523365

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000521252 — 2 exons

Exon	Start	End
ENSE00002123895	31176692	31176872
ENSE00002134028	31167078	31167192

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 84.14.

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.14	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.10	silver quality
bone marrow cell	CL:0002092	72.98	gold quality
hindlimb stylopod muscle	UBERON:0004252	67.10	gold quality
testis	UBERON:0000473	66.13	gold quality
left testis	UBERON:0004533	65.74	gold quality
sural nerve	UBERON:0015488	64.64	gold quality
right testis	UBERON:0004534	64.62	gold quality
skeletal muscle tissue	UBERON:0001134	61.66	gold quality
ganglionic eminence	UBERON:0004023	61.61	gold quality
bone marrow	UBERON:0002371	60.39	gold quality
vermiform appendix	UBERON:0001154	57.73	gold quality
leukocyte	CL:0000738	57.14	gold quality
tonsil	UBERON:0002372	56.79	gold quality
lymph node	UBERON:0000029	56.78	gold quality
calcaneal tendon	UBERON:0003701	56.48	gold quality
liver	UBERON:0002107	55.60	gold quality
monocyte	CL:0000576	55.07	gold quality
blood	UBERON:0000178	54.83	gold quality
stromal cell of endometrium	CL:0002255	53.63	silver quality
muscle of leg	UBERON:0001383	53.48	gold quality
gastrocnemius	UBERON:0001388	52.78	gold quality
prefrontal cortex	UBERON:0000451	51.70	gold quality
endometrium	UBERON:0001295	51.16	gold quality
right lobe of liver	UBERON:0001114	49.88	gold quality
uterine cervix	UBERON:0000002	49.77	gold quality
myometrium	UBERON:0001296	49.32	gold quality
pancreas	UBERON:0001264	48.80	gold quality
superior frontal gyrus	UBERON:0002661	48.38	gold quality
urinary bladder	UBERON:0001255	48.23	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.59

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.