WSPAR

Summary

WSPAR (Wnt signaling pathway activating non-coding RNA, HGNC:51639) is a long non-coding RNA gene on chromosome 5q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51639
Approved symbol	WSPAR
Name	Wnt signaling pathway activating non-coding RNA
Location	5q31.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_00009511-XLOC_004555, lncTCF7
Ensembl gene	ENSG00000249073
Ensembl biotype	lncRNA
OMIM	616333
Entrez	105664404
RNAcentral	URS000006CB8E — lncRNA, 683 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000513561

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000513561 — 3 exons

Exon	Start	End
ENSE00002021986	133913677	133913996
ENSE00002022841	133914775	133914922
ENSE00002073638	133917055	133917269

Expression profiles

Bgee: expression breadth broad, 43 present calls, max score 65.49.

Top tissues by expression

43 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	65.49	gold quality
prefrontal cortex	UBERON:0000451	57.06	gold quality
blood	UBERON:0000178	53.54	silver quality
monocyte	CL:0000576	52.15	gold quality
duodenum	UBERON:0002114	52.00	gold quality
bone marrow	UBERON:0002371	50.15	silver quality
cortex of kidney	UBERON:0001225	49.16	gold quality
islet of Langerhans	UBERON:0000006	49.14	gold quality
pancreas	UBERON:0001264	48.33	gold quality
kidney	UBERON:0002113	48.10	gold quality
lymph node	UBERON:0000029	47.97	gold quality
adult mammalian kidney	UBERON:0000082	47.04	gold quality
Brodmann (1909) area 9	UBERON:0013540	46.11	gold quality
tonsil	UBERON:0002372	46.06	gold quality
tibial artery	UBERON:0007610	45.75	silver quality
putamen	UBERON:0001874	44.70	gold quality
small intestine	UBERON:0002108	44.05	gold quality
prostate gland	UBERON:0002367	43.65	gold quality
transverse colon	UBERON:0001157	43.53	silver quality
gastrocnemius	UBERON:0001388	42.73	silver quality
body of pancreas	UBERON:0001150	42.29	silver quality
small intestine Peyer’s patch	UBERON:0003454	42.09	silver quality
heart left ventricle	UBERON:0002084	42.03	silver quality
spleen	UBERON:0002106	41.04	silver quality
ascending aorta	UBERON:0001496	40.86	silver quality
thoracic aorta	UBERON:0001515	40.71	silver quality
esophagus mucosa	UBERON:0002469	40.63	silver quality
amygdala	UBERON:0001876	40.58	silver quality
testis	UBERON:0000473	40.11	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	39.87	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• lncTCF7 expression was increased in glioma tissues compared with that in normal brain tissues and significantly associated with WHO grade and tumour size. Knockdown of lncTCF7 significantly inhibited glioma cell migration, proliferation and tumorigenicity in vitro and in vivo. Hypoxia induced lncTCF7 expression in an autocrine manner through IL-6 in glioma. (PMID:29234033)
• Long non-coding RNA T-cell factor 7 in multiple myeloma: A potential biomarker for deteriorated clinical features and poor prognosis. (PMID:32578294)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.