WT1-AS

Summary

WT1-AS (WT1 antisense RNA, HGNC:18135) is a long non-coding RNA gene on chromosome 11p13.

This gene is located upstream of the Wilms tumor 1 (WT1) gene; these two genes are bi-directionally transcribed from the same promoter region. This gene is imprinted in kidney, with preferential expression from the paternal allele. Imprinting defects at chromosome 11p13 may contribute to tumorigenesis.

Source: NCBI Gene 51352 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18135
Approved symbol	WT1-AS
Name	WT1 antisense RNA
Location	11p13
Locus type	RNA, long non-coding
Status	Approved
Aliases	WIT-1, WT1AS, WT1-AS1
Ensembl gene	ENSG00000183242
Ensembl biotype	lncRNA
OMIM	607899
Entrez	51352
RNAcentral	URS000075E21A — lncRNA, 1075 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 61 — 61 lncRNA

ENST00000395900, ENST00000442957, ENST00000459866, ENST00000478367, ENST00000494911, ENST00000525436, ENST00000686872, ENST00000687495, ENST00000687964, ENST00000690579, ENST00000691801, ENST00000702558, ENST00000813621, ENST00000813622, ENST00000813623, ENST00000813624, ENST00000813625, ENST00000813626, ENST00000813627, ENST00000813628, ENST00000813629, ENST00000813630, ENST00000813631, ENST00000813632, ENST00000813633, ENST00000813634, ENST00000813635, ENST00000813636, ENST00000813637, ENST00000813638, ENST00000813639, ENST00000813640, ENST00000813641, ENST00000813642, ENST00000813643, ENST00000813644, ENST00000813645, ENST00000813646, ENST00000813647, ENST00000813648, ENST00000813649, ENST00000813650, ENST00000813651, ENST00000813652, ENST00000813653, ENST00000813654, ENST00000813655, ENST00000813656, ENST00000813657, ENST00000813658, ENST00000813659, ENST00000813660, ENST00000813661, ENST00000813662, ENST00000813663, ENST00000813664, ENST00000813665, ENST00000813666, ENST00000813667, ENST00000813668, ENST00000813669

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000395900 — 2 exons

Exon	Start	End
ENSE00001523210	32437845	32441404
ENSE00001523211	32435579	32435846

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 95.44.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3645 / max 23.7672, expressed in 151 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
113622	0.1888	106
206242	0.0655	37
113625	0.0401	24
113624	0.0373	14
113621	0.0238	9
113626	0.0090	2

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	95.44	gold quality
left ovary	UBERON:0002119	93.55	gold quality
ovary	UBERON:0000992	92.43	gold quality
right ovary	UBERON:0002118	92.09	gold quality
body of uterus	UBERON:0009853	90.95	gold quality
fallopian tube	UBERON:0003889	90.27	gold quality
left uterine tube	UBERON:0001303	88.72	gold quality
myometrium	UBERON:0001296	88.33	gold quality
endometrium	UBERON:0001295	83.77	gold quality
endocervix	UBERON:0000458	81.31	gold quality
ectocervix	UBERON:0012249	79.10	gold quality
uterine cervix	UBERON:0000002	78.81	gold quality
omental fat pad	UBERON:0010414	78.57	gold quality
spleen	UBERON:0002106	78.12	gold quality
vagina	UBERON:0000996	76.44	gold quality
apex of heart	UBERON:0002098	75.62	gold quality
adipose tissue	UBERON:0001013	74.96	gold quality
right atrium auricular region	UBERON:0006631	74.36	gold quality
heart left ventricle	UBERON:0002084	73.59	gold quality
right testis	UBERON:0004534	72.44	gold quality
heart	UBERON:0000948	72.41	gold quality
testis	UBERON:0000473	71.59	gold quality
left testis	UBERON:0004533	71.54	gold quality
smooth muscle tissue	UBERON:0001135	71.50	gold quality
adult mammalian kidney	UBERON:0000082	70.90	gold quality
kidney	UBERON:0002113	70.67	gold quality
muscle tissue	UBERON:0002385	69.61	gold quality
colonic epithelium	UBERON:0000397	69.28	gold quality
stromal cell of endometrium	CL:0002255	67.12	gold quality
metanephros cortex	UBERON:0010533	66.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• WT1 and WT1AS (WT1 antisense RNA) genes are imprinted in human kidney, with preferential expression from the paternal allele, and imprinting defects at chromosome 11p13 may contribute to Wilms’ tumourigenesis. (PMID:17210670)
• Data suggest that WT1-as, MEG3 and ANRIL could potentially be used as new primary myelofibrosis (PMF) diagnostic biomarkers with prognostic implications. (PMID:24707949)
• WT1-AS expression was significantly down-regulated in tumor tissues compared to matched adjacent non-tumor tissues. The WT1-AS expression level was also associated with tumor size and the clinicopathological stage. Cell proliferation, migration, and invasion were inhibited, and the proportion of G0/G1 cells increased when WT1-AS was ectopically-expressed in gastric cancer cells. (PMID:26449525)
• WT1-AS downregulates WT1 expression in hepatocellular carcinoma tumors and promotes apoptosis by binding to the promoter region of WT1. WT1-AS may function as a tumor suppressor in hepatocellular carcinoma by reversing the oncogenic effects of WT1. (PMID:26462627)
• Long non-coding RNA WT1-AS inhibits cell aggressiveness via miR-203a-5p/FOXN2 axis and is associated with prognosis in cervical cancer. (PMID:30720155)
• WT1-AS overexpression caused inhibited migration and invasion of TNBC cells. TGF-beta1 overexpression showed opposite functions and reduced the effects of WT1-AS overexpression. WT1-AS may downregulate TGF-beta to inhibit the migration and invasion of TNBC cells. (PMID:31621381)
• Tumor protein p53 (P53) was down-regulated in cervical squamous cell carcinoma (CSCC) tissues and positively correlated with LncRNA WT1-AS. WT1-AS. (PMID:31694597)
• LncRNA WT1-AS over-expression inhibits non-small cell lung cancer cell stemness by down-regulating TGF-beta1. (PMID:32349718)
• Long Noncoding RNA WT1-AS Inhibit Cell Malignancy via miR-494-3p in Glioma. (PMID:32419643)
• LncRNA WT1-AS downregulates lncRNA UCA1 to suppress non-small cell lung cancer and predicts poor survival. (PMID:33514344)
• Unravelling the Role of LncRNA WT1-AS/miR-206/NAMPT Axis as Prognostic Biomarkers in Lung Adenocarcinoma. (PMID:33540574)
• Overexpression of long non-coding RNA WT1-AS or silencing of PIK3AP1 are inhibitory to cervical cancer progression. (PMID:34839795)
• WT1-AS/IGF2BP2 Axis Is a Potential Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma According to ceRNA Network Comprehensive Analysis Combined with Experiments. (PMID:35011587)
• Up-regulation of lncRNA WT1-AS ameliorates Abeta-stimulated neuronal injury through modulation of miR-186-5p/CCND2 axis in Alzheimer’s disease. (PMID:38372094)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.