WWOX-AS1

Summary

WWOX-AS1 (WWOX antisense RNA 1, HGNC:53169) is a long non-coding RNA gene on chromosome 16q23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53169
Approved symbol	WWOX-AS1
Name	WWOX antisense RNA 1
Location	16q23.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-190D6.2
Ensembl gene	ENSG00000260969
Ensembl biotype	lncRNA
Entrez	102724047
RNAcentral	URS00026A1B06 — lncRNA, 1046 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000567099, ENST00000664344, ENST00000666211

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000567099 — 3 exons

Exon	Start	End
ENSE00002578174	78241198	78241218
ENSE00002615007	78238088	78238188
ENSE00002622421	78237362	78237682

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 84.12.

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	84.12	gold quality
right testis	UBERON:0004534	83.91	gold quality
testis	UBERON:0000473	83.65	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.71	gold quality
bone marrow cell	CL:0002092	68.72	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	68.64	gold quality
sural nerve	UBERON:0015488	66.26	gold quality
tonsil	UBERON:0002372	62.91	silver quality
cortex of kidney	UBERON:0001225	61.39	gold quality
ventricular zone	UBERON:0003053	60.77	gold quality
ganglionic eminence	UBERON:0004023	60.26	gold quality
calcaneal tendon	UBERON:0003701	59.77	gold quality
corpus callosum	UBERON:0002336	59.46	gold quality
kidney	UBERON:0002113	59.15	gold quality
adult mammalian kidney	UBERON:0000082	58.58	gold quality
skeletal muscle tissue	UBERON:0001134	58.32	silver quality
thoracic mammary gland	UBERON:0005200	57.96	gold quality
monocyte	CL:0000576	57.70	gold quality
liver	UBERON:0002107	57.67	gold quality
hindlimb stylopod muscle	UBERON:0004252	55.95	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	55.57	gold quality
urinary bladder	UBERON:0001255	55.35	silver quality
blood	UBERON:0000178	53.14	gold quality
lung	UBERON:0002048	51.48	gold quality
multicellular organism	UBERON:0000468	51.00	gold quality
lymph node	UBERON:0000029	50.92	silver quality
stomach	UBERON:0000945	50.90	gold quality
fallopian tube	UBERON:0003889	50.58	gold quality
right uterine tube	UBERON:0001302	50.51	gold quality
muscle of leg	UBERON:0001383	50.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• the results of the knockdown and overexpression functional experiments suggested that WWOXAS1 overexpression inhibited the proliferation, migration and invasion of MG63 cells, and knockdown of WWOXAS1 enhanced the proliferation, migration and invasion of MG63 cells in SAOS2 cells. (PMID:29845204)
• LncRNA WWOX-AS1 sponges miR-20b-5p in hepatocellular carcinoma and represses its progression by upregulating WWOX. (PMID:32931356)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.