WWTR1-AS1

Summary

WWTR1-AS1 (WWTR1 antisense RNA 1, HGNC:41035) is a long non-coding RNA gene on chromosome 3q25.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41035
Approved symbol	WWTR1-AS1
Name	WWTR1 antisense RNA 1
Location	3q25.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000241313
Ensembl biotype	lncRNA
Entrez	100128025
RNAcentral	URS00002DAAC2 — lncRNA, 1700 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000466836, ENST00000479752, ENST00000495094, ENST00000663001

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000466836 — 2 exons

Exon	Start	End
ENSE00001886615	149657052	149657322
ENSE00001941563	149657610	149657806

Expression profiles

Bgee: expression breadth ubiquitous, 147 present calls, max score 86.10.

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	86.10	gold quality
bone marrow cell	CL:0002092	76.71	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.01	gold quality
colonic epithelium	UBERON:0000397	74.13	gold quality
tendon of biceps brachii	UBERON:0008188	71.84	gold quality
buccal mucosa cell	CL:0002336	69.33	gold quality
metanephros cortex	UBERON:0010533	67.52	gold quality
stromal cell of endometrium	CL:0002255	65.19	gold quality
left lobe of thyroid gland	UBERON:0001120	64.91	gold quality
ganglionic eminence	UBERON:0004023	64.08	gold quality
right lobe of thyroid gland	UBERON:0001119	64.04	gold quality
thyroid gland	UBERON:0002046	63.67	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.22	gold quality
tendon	UBERON:0000043	62.82	gold quality
adult mammalian kidney	UBERON:0000082	62.74	gold quality
left ovary	UBERON:0002119	62.41	gold quality
popliteal artery	UBERON:0002250	62.18	gold quality
tibial artery	UBERON:0007610	62.18	gold quality
right ovary	UBERON:0002118	61.84	gold quality
left adrenal gland	UBERON:0001234	61.75	gold quality
left adrenal gland cortex	UBERON:0035825	61.51	gold quality
right atrium auricular region	UBERON:0006631	61.16	gold quality
cortical plate	UBERON:0005343	60.99	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	60.87	gold quality
ventricular zone	UBERON:0003053	60.86	gold quality
cardiac atrium	UBERON:0002081	60.62	gold quality
aorta	UBERON:0000947	60.60	gold quality
cortex of kidney	UBERON:0001225	60.47	gold quality
descending thoracic aorta	UBERON:0002345	60.35	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.28	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	1230.11
E-ANND-3	no	1.89

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Overexpression of lncRNA WWTR1-AS1 associates with tumor aggressiveness and unfavorable survival in head-neck squamous cell carcinoma. (PMID:31172583)
• LncRNA WWTR1-AS1 upregulates Notch3 through miR-136 to increase cancer cell stemness in cervical squamous cell carcinoma. (PMID:38331752)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.