XCL2

Summary

XCL2 (X-C motif chemokine ligand 2, HGNC:10646) is a protein-coding gene on chromosome 1q24.2, encoding Cytokine SCM-1 beta (Q9UBD3). Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cell chemotaxis; and chemokine-mediated signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space.

Source: NCBI Gene 6846 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 21 total
• MANE Select transcript: NM_003175

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10646
Approved symbol	XCL2
Name	X-C motif chemokine ligand 2
Location	1q24.2
Locus type	gene with protein product
Status	Approved
Aliases	SCM-1b
Ensembl gene	ENSG00000143185
Ensembl biotype	protein_coding
OMIM	604828
Entrez	6846

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000367819

RefSeq mRNA: 1 — MANE Select: NM_003175 NM_003175

CCDS: CCDS1273

Canonical transcript exons

ENST00000367819 — 3 exons

Exon	Start	End
ENSE00001445685	168540768	168541120
ENSE00001445686	168543904	168543997
ENSE00002347798	168541993	168542107

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 91.02.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.2395 / max 146.6482, expressed in 124 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
15822	1.2395	124

Top tissues by expression

148 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	91.02	gold quality
spleen	UBERON:0002106	80.83	gold quality
blood	UBERON:0000178	78.06	gold quality
vastus lateralis	UBERON:0001379	75.92	gold quality
lymph node	UBERON:0000029	75.38	gold quality
thymus	UBERON:0002370	75.04	gold quality
quadriceps femoris	UBERON:0001377	71.94	gold quality
bone marrow	UBERON:0002371	71.85	gold quality
cerebellar vermis	UBERON:0004720	71.14	gold quality
duodenum	UBERON:0002114	71.05	gold quality
vermiform appendix	UBERON:0001154	70.91	gold quality
colonic epithelium	UBERON:0000397	68.83	gold quality
placenta	UBERON:0001987	67.77	gold quality
right lobe of liver	UBERON:0001114	67.26	gold quality
smooth muscle tissue	UBERON:0001135	66.05	gold quality
gall bladder	UBERON:0002110	64.98	gold quality
mucosa of transverse colon	UBERON:0004991	64.92	gold quality
liver	UBERON:0002107	64.68	gold quality
right uterine tube	UBERON:0001302	64.03	gold quality
rectum	UBERON:0001052	63.70	gold quality
bone marrow cell	CL:0002092	62.73	silver quality
upper lobe of left lung	UBERON:0008952	62.55	gold quality
lung	UBERON:0002048	61.70	gold quality
endometrium	UBERON:0001295	61.25	gold quality
fallopian tube	UBERON:0003889	61.23	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.22	gold quality
small intestine	UBERON:0002108	60.44	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	59.91	gold quality
trachea	UBERON:0003126	59.07	gold quality
dorsal plus ventral thalamus	UBERON:0001897	59.03	gold quality

Single-cell (SCXA)

Detected in 24 experiment(s), a significant marker in 23.

Experiment	Marker?	Max mean expression
E-HCAD-36	yes	4998.77
E-MTAB-6701	yes	4607.50
E-HCAD-24	yes	3313.67
E-MTAB-8142	yes	2735.83
E-MTAB-10042	yes	2310.92
E-CURD-79	yes	976.86
E-CURD-84	yes	802.81
E-HCAD-32	yes	794.77
E-GEOD-70580	yes	645.83
E-HCAD-1	yes	110.56
E-HCAD-4	yes	109.31
E-CURD-122	yes	62.49
E-MTAB-10287	yes	34.65
E-MTAB-9467	yes	29.43
E-MTAB-6678	yes	27.78

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ESR1

miRNA regulators (miRDB)

44 targeting XCL2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-6772-5P	99.94	67.01	577
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489
HSA-MIR-548O-5P	99.94	71.24	3488
HSA-MIR-548W	99.94	71.24	3488
HSA-MIR-548Y	99.94	71.28	3514
HSA-MIR-3617-5P	99.75	69.41	1968
HSA-MIR-641	99.75	69.35	1975

Literature-anchored findings (GeneRIF, showing 9)

• The G carrier of the -2510A/G promoter polymorphism was found to be associated with primary knee knee osteoarthritis among Koreans. (PMID:17763208)
• Wag31 was found to specifically stimulate XCL2 expression in macrophages (PMID:18618175)
• S1P induced the macrophage-recruiting factor CCL2 expression in NB cells via S1P2, providing new insights into the complicated functions of S1P2 in cancer. (PMID:25092091)
• identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3, CCL4/CCL4L1/CCL4L2, CD160, IFNG, NR4A3 and XCL1/XCL2) were analyzed in 127 kidney biopsies (PMID:25449536)
• analysis of XCL1 and XCL2, members of the C-chemokine subfamily, in the immune system (PMID:25497737)
• XCL2 and CX3CL1 expression in lung cancers and adjacent non-cancerous tissues was detected by quantitative PCR and ELISA. The expression of XCL2 and CX3CL1 increases with increasing degree of malignancy, indicating that both chemokines might be important targets in gene therapy for lung cancer. (PMID:27156946)
• Upregulated X-C motif chemokine ligand 2 (XCL2) is associated with poor prognosis and increased immune infiltration in clear cell renal cell carcinoma. (PMID:36503163)
• The effect of ITLN1, XCL2 and DOT1L variants on knee osteoarthritis risk in the Han population. (PMID:36773049)
• Comprehensive analysis reveals XCL2 as a cancer prognosis and immune infiltration-related biomarker. (PMID:37905956)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	cxcl32b.1	ENSDARG00000071499
mus_musculus	Xcl1	ENSMUSG00000026573
rattus_norvegicus	Xcl1	ENSRNOG00000002964

Paralogs (26): CX3CL1 (ENSG00000006210), CCL26 (ENSG00000006606), CCL22 (ENSG00000102962), CCL17 (ENSG00000102970), CCL24 (ENSG00000106178), CCL7 (ENSG00000108688), CCL2 (ENSG00000108691), CCL8 (ENSG00000108700), CCL1 (ENSG00000108702), CCL20 (ENSG00000115009), CCL25 (ENSG00000131142), CCL21 (ENSG00000137077), XCL1 (ENSG00000143184), CCL11 (ENSG00000172156), CCL19 (ENSG00000172724), CCL13 (ENSG00000181374), CCL5 (ENSG00000271503), CCL23 (ENSG00000274736), CCL16 (ENSG00000275152), CCL4 (ENSG00000275302), CCL18 (ENSG00000275385), CCL15 (ENSG00000275718), CCL4L2 (ENSG00000276070), CCL3L3 (ENSG00000276085), CCL14 (ENSG00000276409), CCL3 (ENSG00000277632)

Protein

Protein identifiers

Cytokine SCM-1 beta — Q9UBD3 (reviewed: Q9UBD3)

Alternative names: C motif chemokine 2, XC chemokine ligand 2

All UniProt accessions (1): Q9UBD3

UniProt curated annotations — full annotation on UniProt →

Function. Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

Subcellular location. Secreted.

Similarity. Belongs to the intercrine gamma family.

RefSeq proteins (1): NP_003166* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001811	Chemokine_IL8-like_dom	Domain
IPR008105	Chemokine_XCL1/XCL2	Family
IPR036048	Interleukin_8-like_sf	Homologous_superfamily
IPR039809	Chemokine_b/g/d	Family

Pfam: PF00048

UniProt features (6 total): sequence variant 2, signal peptide 1, chain 1, region of interest 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UBD3-F1	81.47	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 32–69

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-380108	Chemokine receptors bind chemokines
R-HSA-416476	G alpha (q) signalling events

MSigDB gene sets: 98 (showing top): BROWNE_HCMV_INFECTION_30MIN_DN, GOBP_ANTIMICROBIAL_HUMORAL_RESPONSE, GOBP_CIRCULATORY_SYSTEM_PROCESS, GOBP_CELL_CHEMOTAXIS, GOBP_INFLAMMATORY_RESPONSE, GOBP_RESPONSE_TO_PEPTIDE, AP4_Q6, CAGCTG_AP4_Q5, GOBP_TAXIS, REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, AML_Q6, GNF2_IL2RB, GOBP_HUMORAL_IMMUNE_RESPONSE, GOMF_CHEMOKINE_ACTIVITY

GO Biological Process (9): inflammatory response (GO:0006954), signal transduction (GO:0007165), blood circulation (GO:0008015), positive regulation of cell migration (GO:0030335), cell chemotaxis (GO:0060326), antimicrobial humoral immune response mediated by antimicrobial peptide (GO:0061844), chemokine-mediated signaling pathway (GO:0070098), chemotaxis (GO:0006935), immune response (GO:0006955)

GO Molecular Function (4): chemokine activity (GO:0008009), CCR chemokine receptor binding (GO:0048020), cytokine activity (GO:0005125), protein binding (GO:0005515)

GO Cellular Component (2): extracellular region (GO:0005576), obsolete extracellular space (GO:0005615)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Peptide ligand-binding receptors	1
GPCR downstream signalling	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell migration	2
chemokine receptor binding	2
defense response	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
circulatory system process	1
regulation of cell migration	1
positive regulation of cell motility	1
chemotaxis	1
cellular response to chemical stimulus	1
antimicrobial humoral response	1
G protein-coupled receptor signaling pathway	1
cytokine-mediated signaling pathway	1
cellular response to chemokine	1
response to chemical	1
taxis	1
immune system process	1
response to stimulus	1
cytokine activity	1
cell chemotaxis	1
receptor ligand activity	1
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1094 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
XCL2	XCR1	P46094	997
XCL2	CCL3	P10147	751
XCL2	CCR7	P32248	594
XCL2	CCL19	Q99731	591
XCL2	CCL21	O00585	582
XCL2	CD8A	P01732	574
XCL2	CCR5	P51681	566
XCL2	CCL25	O15444	563
XCL2	CCR2	P41597	552
XCL2	CD160	O95971	507
XCL2	CXCR3	P49682	480
XCL2	CXCL10	P02778	469
XCL2	CCL4	P13236	468
XCL2	CXCL8	P10145	467
XCL2	PROK2	Q9HC23	456

IntAct

26 interactions, top by confidence:

A	B	Type	Score
XCL2	KRTAP10-9	psi-mi:“MI:0915”(physical association)	0.560
XCL2	NOTCH2NLA	psi-mi:“MI:0915”(physical association)	0.560
XCL2	CCL5	psi-mi:“MI:0407”(direct interaction)	0.560
XCL2	CXCL12	psi-mi:“MI:0407”(direct interaction)	0.560
CCL5	XCL2	psi-mi:“MI:0407”(direct interaction)	0.560
CXCL12	XCL2	psi-mi:“MI:0407”(direct interaction)	0.560
KRTAP1-3	XCL2	psi-mi:“MI:0915”(physical association)	0.560
CCL7	XCL2	psi-mi:“MI:0407”(direct interaction)	0.440
CCL8	XCL2	psi-mi:“MI:0407”(direct interaction)	0.440
CCL20	XCL2	psi-mi:“MI:0407”(direct interaction)	0.440
CCL21	XCL2	psi-mi:“MI:0407”(direct interaction)	0.440
CCL26	XCL2	psi-mi:“MI:0407”(direct interaction)	0.440
CCL28	XCL2	psi-mi:“MI:0407”(direct interaction)	0.440
CXCL2	XCL2	psi-mi:“MI:0407”(direct interaction)	0.440
CXCL3	XCL2	psi-mi:“MI:0407”(direct interaction)	0.440
PF4	XCL2	psi-mi:“MI:0407”(direct interaction)	0.440
PF4V1	XCL2	psi-mi:“MI:0407”(direct interaction)	0.440
CXCL5	XCL2	psi-mi:“MI:0407”(direct interaction)	0.440
CXCL17	XCL2	psi-mi:“MI:0407”(direct interaction)	0.440
XCL2	KRTAP1-3	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (18): KRTAP10-9 (Two-hybrid), NOTCH2NL (Two-hybrid), KRTAP1-3 (Two-hybrid), XCL2 (Reconstituted Complex), XCL2 (Reconstituted Complex), XCL2 (Reconstituted Complex), XCL2 (Reconstituted Complex), XCL2 (Reconstituted Complex), XCL2 (Reconstituted Complex), XCL2 (Reconstituted Complex), XCL2 (Reconstituted Complex), XCL2 (Reconstituted Complex), XCL2 (Reconstituted Complex), XCL2 (Reconstituted Complex), XCL2 (Reconstituted Complex)

ESM2 similar proteins: A0A0R4INB9, A9QWP9, B0R191, K7XWG4, O00175, O35903, O43927, O55038, O62812, O70460, P02775, P02778, P10146, P10720, P17515, P18340, P22362, P26894, P27784, P28292, P41324, P43030, P47992, P47993, P48298, P48973, P49113, P50228, P51672, P79255, P84444, P86792, P86793, P97545, P97885, Q07325, Q08782, Q2KIQ8, Q5KSV9, Q62401

Diamond homologs: K7XWG4, P16619, P42831, P47992, P47993, P49873, P51671, P51672, P52203, P80075, P80343, P82943, P97545, Q03366, Q09141, Q62401, Q68AY9, Q68Y88, Q8MIT7, Q99616, Q9JKC0, Q9QXY8, Q9TTQ4, Q9TTS6, Q9UBD3, F5HET8, O00626, O15467, O55145, O70460, O88430, O89093, O97919, P10147, P10148, P10855, P13236, P13500, P13501, P14097

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 17 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Chemokine receptors bind chemokines	10	133.7×	2e-19
Class A/1 (Rhodopsin-like receptors)	6	31.8×	1e-07
Peptide ligand-binding receptors	6	31.8×	1e-07
GPCR ligand binding	6	27.5×	2e-07
G alpha (i) signalling events	9	25.1×	1e-10
Signaling by GPCR	6	17.2×	3e-06
GPCR downstream signalling	5	15.5×	4e-05

GO biological processes:

GO term	Partners	Fold	FDR
eosinophil chemotaxis	5	244.2×	2e-10
monocyte chemotaxis	5	193.7×	7e-10
chemokine-mediated signaling pathway	7	151.2×	4e-13
neutrophil chemotaxis	6	114.2×	2e-10
antimicrobial humoral immune response mediated by antimicrobial peptide	9	97.2×	4e-15
chemotaxis	9	81.5×	1e-14
cell chemotaxis	5	61.7×	2e-07
cell-cell signaling	7	32.5×	1e-08

Disease & clinical

Clinical variants and AI predictions

ClinVar

21 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	16
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

152 predictions. Top by Δscore:

Variant	Effect	Δscore
1:168541116:TAAAA:T	acceptor_gain	1.0000
1:168541121:C:CC	acceptor_gain	1.0000
1:168541988:CTCA:C	donor_loss	1.0000
1:168541991:A:AC	donor_gain	1.0000
1:168541992:C:A	donor_loss	1.0000
1:168541992:C:CC	donor_gain	1.0000
1:168541992:CATT:C	donor_gain	1.0000
1:168541992:CATTA:C	donor_gain	1.0000
1:168541996:A:AC	donor_gain	1.0000
1:168541997:C:CC	donor_gain	1.0000
1:168541997:CTG:C	donor_gain	1.0000
1:168541997:CTGCT:C	donor_gain	1.0000
1:168542014:T:TA	donor_gain	1.0000
1:168542103:TACAC:T	acceptor_gain	1.0000
1:168542104:ACAC:A	acceptor_gain	1.0000
1:168542105:CAC:C	acceptor_gain	1.0000
1:168542105:CACC:C	acceptor_gain	1.0000
1:168543899:CTTA:C	donor_loss	1.0000
1:168543900:TTAC:T	donor_loss	1.0000
1:168543902:A:AC	donor_gain	1.0000
1:168543902:ACCTT:A	donor_gain	1.0000
1:168543903:C:CA	donor_loss	1.0000
1:168543903:C:CC	donor_gain	1.0000
1:168543903:CCTT:C	donor_gain	1.0000
1:168543903:CCTTC:C	donor_gain	1.0000
1:168541117:AAAA:A	acceptor_gain	0.9900
1:168541118:AAA:A	acceptor_gain	0.9900
1:168541118:AAAC:A	acceptor_loss	0.9900
1:168541119:AA:A	acceptor_gain	0.9900
1:168541121:C:G	acceptor_loss	0.9900

AlphaMissense

729 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:168541069:C:A	W76C	0.998
1:168541069:C:G	W76C	0.998
1:168541118:A:G	F60S	0.996
1:168541071:A:G	W76R	0.995
1:168541071:A:T	W76R	0.995
1:168541091:C:G	C69S	0.982
1:168541092:A:T	C69S	0.982
1:168542027:A:C	Y48D	0.977
1:168541112:G:A	T62I	0.976
1:168542035:A:C	I45S	0.975
1:168541118:A:C	F60C	0.974
1:168542035:A:G	I45T	0.972
1:168541088:G:T	A70D	0.971
1:168541089:C:G	A70P	0.971
1:168541092:A:G	C69R	0.971
1:168541091:C:T	C69Y	0.967
1:168542074:C:G	C32S	0.958
1:168542075:A:G	C32R	0.958
1:168542075:A:T	C32S	0.958
1:168541070:C:G	W76S	0.955
1:168542035:A:T	I45N	0.954
1:168541070:C:A	W76L	0.952
1:168541090:A:C	C69W	0.952
1:168541071:A:C	W76G	0.951
1:168541106:C:G	R64P	0.948
1:168541103:C:A	G65V	0.946
1:168542074:C:T	C32Y	0.941
1:168541068:C:A	V77L	0.939
1:168541068:C:G	V77L	0.939
1:168541996:A:T	V58E	0.939

dbSNP variants (sampled 300 via entrez): RS1000316518 (1:168540317 C>T), RS1000352527 (1:168544963 A>G), RS1000807092 (1:168544821 A>C), RS1001918384 (1:168544349 A>C), RS1001970622 (1:168544098 T>A), RS1002926599 (1:168543084 C>T), RS1002977227 (1:168542795 G>A), RS1004433099 (1:168542556 C>A,T), RS1004832223 (1:168542747 A>C,T), RS1005429752 (1:168541844 T>C), RS1005897724 (1:168541694 A>G), RS1006260357 (1:168545570 G>C), RS1006327446 (1:168545393 C>A), RS1006719656 (1:168541309 T>C,G), RS1006847552 (1:168540897 G>A,C,T)

Disease associations

OMIM: gene MIM:604828 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002945_1	Emphysema imaging phenotypes	3.000000e-07
GCST002945_21	Emphysema imaging phenotypes	1.000000e-06
GCST004748_62	Lung cancer	2.000000e-07
GCST004750_93	Squamous cell lung carcinoma	3.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007626	emphysema imaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
GSK-J4	decreases expression	1
triphenyl phosphate	affects expression	1
decabromobiphenyl ether	affects expression	1
sodium arsenite	increases expression	1
3-chlorophenol	increases expression	1
di-n-butylphosphoric acid	affects expression	1
MT19c compound	decreases expression	1
Panobinostat	affects cotreatment, affects expression	1
Benzo(a)pyrene	increases methylation	1
Calcitriol	increases expression	1
Cisplatin	affects cotreatment, affects expression	1
Diuron	decreases expression	1
Estradiol	decreases expression, affects cotreatment	1
Pentachlorophenol	decreases expression	1
Progesterone	affects cotreatment, decreases expression	1
Valproic Acid	decreases methylation	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.