XPO6

Summary

XPO6 (exportin 6, HGNC:19733) is a protein-coding gene on chromosome 16p12.1, encoding Exportin-6 (Q96QU8). Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.

The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Source: NCBI Gene 23214 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 134 total
• Druggable target: yes
• MANE Select transcript: NM_015171

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19733
Approved symbol	XPO6
Name	exportin 6
Location	16p12.1
Locus type	gene with protein product
Status	Approved
Aliases	KIAA0370, FLJ22519
Ensembl gene	ENSG00000169180
Ensembl biotype	protein_coding
OMIM	608411
Entrez	23214

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 18 protein_coding, 7 retained_intron, 5 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000304658, ENST00000561488, ENST00000562408, ENST00000563138, ENST00000564337, ENST00000564905, ENST00000565284, ENST00000565698, ENST00000566073, ENST00000566175, ENST00000567038, ENST00000567842, ENST00000568065, ENST00000569216, ENST00000569315, ENST00000569951, ENST00000569973, ENST00000570007, ENST00000570033, ENST00000570294, ENST00000573275, ENST00000573645, ENST00000574435, ENST00000864044, ENST00000864045, ENST00000917809, ENST00000917810, ENST00000917811, ENST00000917812, ENST00000917813, ENST00000917814, ENST00000959279

RefSeq mRNA: 2 — MANE Select: NM_015171 NM_001270940, NM_015171

CCDS: CCDS42135, CCDS59266

Canonical transcript exons

ENST00000304658 — 24 exons

Exon	Start	End
ENSE00000894427	28117318	28117462
ENSE00000894431	28106383	28106497
ENSE00000894432	28106043	28106214
ENSE00000894433	28104546	28104707
ENSE00000894434	28101847	28101945
ENSE00001138571	28107522	28107677
ENSE00001240103	28101458	28101688
ENSE00001240202	28156074	28156527
ENSE00001240225	28175898	28176095
ENSE00001302411	28097976	28098639
ENSE00001486703	28211366	28211965
ENSE00003480535	28146094	28146203
ENSE00003486261	28132334	28132403
ENSE00003496978	28112904	28113050
ENSE00003530652	28169750	28169909
ENSE00003534764	28180941	28181031
ENSE00003535147	28121670	28121762
ENSE00003565069	28135216	28135324
ENSE00003585617	28133841	28133933
ENSE00003596766	28125689	28125848
ENSE00003596825	28177220	28177332
ENSE00003618847	28166508	28166585
ENSE00003623040	28111817	28112006
ENSE00003657774	28152659	28152785

Expression profiles

Bgee: expression breadth ubiquitous, 294 present calls, max score 98.91.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.6588 / max 1433.0364, expressed in 1809 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
156875	21.3291	1805
156874	5.9126	1591
156873	0.6940	280
156871	0.3306	105
156872	0.1371	44
156866	0.0969	16
156870	0.0641	21
156867	0.0555	12
156868	0.0388	9

Top tissues by expression

298 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	98.91	gold quality
granulocyte	CL:0000094	98.29	gold quality
left testis	UBERON:0004533	98.16	gold quality
right testis	UBERON:0004534	98.11	gold quality
spleen	UBERON:0002106	98.10	gold quality
colonic epithelium	UBERON:0000397	98.01	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	97.71	gold quality
nerve	UBERON:0001021	97.56	gold quality
tibial nerve	UBERON:0001323	97.56	gold quality
upper lobe of left lung	UBERON:0008952	96.96	gold quality
right frontal lobe	UBERON:0002810	96.80	gold quality
ventricular zone	UBERON:0003053	96.79	gold quality
right lung	UBERON:0002167	96.78	gold quality
right lobe of thyroid gland	UBERON:0001119	96.71	gold quality
ganglionic eminence	UBERON:0004023	96.69	gold quality
cortical plate	UBERON:0005343	96.67	gold quality
adrenal tissue	UBERON:0018303	96.47	gold quality
spinal cord	UBERON:0002240	96.45	gold quality
testis	UBERON:0000473	96.44	gold quality
skin of leg	UBERON:0001511	96.43	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	96.41	gold quality
stromal cell of endometrium	CL:0002255	96.41	gold quality
adenohypophysis	UBERON:0002196	96.38	gold quality
left lobe of thyroid gland	UBERON:0001120	96.35	gold quality
caudate nucleus	UBERON:0001873	96.22	gold quality
skin of abdomen	UBERON:0001416	96.18	gold quality
small intestine Peyer’s patch	UBERON:0003454	96.18	gold quality
upper lobe of lung	UBERON:0008948	96.07	gold quality
left uterine tube	UBERON:0001303	96.04	gold quality
amygdala	UBERON:0001876	96.03	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.72
E-MTAB-9689	no	191.46
E-CURD-10	no	65.80

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

43 targeting XPO6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-1825	99.72	68.11	1089
HSA-MIR-4527	99.66	67.43	714
HSA-MIR-103A-1-5P	99.39	67.78	1545
HSA-MIR-103A-2-5P	99.39	67.72	1577
HSA-MIR-4786-3P	99.36	68.35	1390
HSA-MIR-584-3P	99.35	67.69	1082
HSA-MIR-1272	99.34	68.79	878
HSA-MIR-8085	99.28	67.56	2362
HSA-MIR-100-3P	99.20	67.33	672
HSA-MIR-146A-3P	99.13	68.99	1881
HSA-MIR-6770-5P	98.97	66.76	1853
HSA-MIR-3922-5P	98.77	66.53	1059
HSA-MIR-4773	98.35	67.30	1710
HSA-MIR-6842-3P	98.07	66.33	1325
HSA-MIR-6529-5P	97.85	66.47	673
HSA-MIR-3921	97.81	67.45	1431
HSA-MIR-3652	97.71	65.43	1890
HSA-MIR-4430	97.47	65.61	1813
HSA-MIR-7855-5P	97.39	67.18	925
HSA-MIR-2278	97.30	66.19	1130

Literature-anchored findings (GeneRIF, showing 6)

• identify exportin 6 (Exp6) as a novel family member from higher eukaryotes and show that it mediates nuclear export of profilin.actin complexes (PMID:14592989)
• Data suggest actin accumulation in senescent cells is due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation, resulting in decreased actin export via Exp6 inactivation. (PMID:21195711)
• potential prognostic biomarker for predicting prostate cancer recurrence [meta-analysis] (PMID:26709895)
• These results shed light on the crucial role of LN1 in quiescence and differentiation and how defects in the LN1/PI3K/XPO6/N-actin axis explain the loss of tissue homeostasis and growth control that contributes to malignant progression. (PMID:28591581)
• The XPO6 Exportin Mediates Herpes Simplex Virus 1 gM Nuclear Release Late in Infection. (PMID:32817212)
• Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1. (PMID:33596420)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	xpo6	ENSDARG00000041217
mus_musculus	Xpo6	ENSMUSG00000000131
rattus_norvegicus	Xpo6	ENSRNOG00000016722
drosophila_melanogaster	ebo	FBGN0266572

Protein

Protein identifiers

Exportin-6 — Q96QU8 (reviewed: Q96QU8)

Alternative names: Ran-binding protein 20

All UniProt accessions (10): Q96QU8, H3BMW9, H3BPG8, H3BR41, H3BRJ6, H3BRV5, H3BUP8, I3L0S8, I3L2D7, I3L2K0

UniProt curated annotations — full annotation on UniProt →

Function. Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.

Subunit / interactions. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with ACTB in a RanGTP-dependent manner.

Subcellular location. Nucleus. Cytoplasm.

Similarity. Belongs to the exportin family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96QU8-1	1	yes
Q96QU8-2	2

RefSeq proteins (2): NP_001257869, NP_055986* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001494	Importin-beta_N	Domain
IPR011989	ARM-like	Homologous_superfamily
IPR013598	Exportin-1/Importin-b-like	Domain
IPR016024	ARM-type_fold	Homologous_superfamily
IPR040016	XPO6	Family

Pfam: PF03810, PF08389

UniProt features (14 total): modified residue 6, sequence conflict 3, initiator methionine 1, chain 1, sequence variant 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96QU8-F1	87.11	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 2, 199, 201, 204, 208, 224

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 196 (showing top): AHRARNT_01, MORF_MTA1, GCM_GSPT1, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, MORF_CDK2, MORF_HDAC2, GOMF_GTPASE_BINDING, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, NFKB_Q6, GOBP_NUCLEAR_TRANSPORT, WEI_MYCN_TARGETS_WITH_E_BOX, NFKB_C, MORF_RAF1, GATA3_01, MORF_FANCG

GO Biological Process (4): protein export from nucleus (GO:0006611), intracellular protein transport (GO:0006886), nucleocytoplasmic transport (GO:0006913), protein transport (GO:0015031)

GO Molecular Function (3): nuclear export signal receptor activity (GO:0005049), small GTPase binding (GO:0031267), protein binding (GO:0005515)

GO Cellular Component (7): nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytoplasm (GO:0005737), cytosol (GO:0005829), plasma membrane (GO:0005886), protein-containing complex (GO:0032991)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
nuclear export	2
intracellular protein localization	2
nuclear lumen	2
intracellular protein transport	1
protein transport	1
intracellular transport	1
nuclear transport	1
transport	1
establishment of protein localization	1
nucleocytoplasmic carrier activity	1
GTPase binding	1
binding	1
intracellular membrane-bounded organelle	1
intracellular membraneless organelle	1
intracellular anatomical structure	1
cytoplasm	1
membrane	1
cell periphery	1
cellular_component	1

Protein interactions and networks

STRING

1958 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
XPO6	PFN1	P07737	990
XPO6	PFN4	Q8NHR9	954
XPO6	PFN3	P60673	952
XPO6	IPO9	Q96P70	828
XPO6	XPO4	Q9C0E2	820
XPO6	XPO7	Q9UIA9	805
XPO6	ACTB	P02570	794
XPO6	CSE1L	P55060	770
XPO6	XPOT	O43592	668
XPO6	CFL2	Q9Y281	667
XPO6	CFL1	P23528	667
XPO6	XPO5	Q9HAV4	650
XPO6	XPO1	O14980	632
XPO6	TMTC3	Q6ZXV5	614
XPO6	IPO4	Q8TEX9	591

IntAct

105 interactions, top by confidence:

A	B	Type	Score
NUP62	XPO6	psi-mi:“MI:0915”(physical association)	0.670
XPO6	NUP62	psi-mi:“MI:0915”(physical association)	0.670
SCN2B	EXOC5	psi-mi:“MI:0914”(association)	0.640
ILVBL	COG7	psi-mi:“MI:0914”(association)	0.640
STK4	STRN	psi-mi:“MI:0914”(association)	0.610
NPY2R	RTL8C	psi-mi:“MI:0914”(association)	0.530
NCR3LG1	FAM171A2	psi-mi:“MI:0914”(association)	0.530
FCGRT	GOLIM4	psi-mi:“MI:0914”(association)	0.530
CD83	BTAF1	psi-mi:“MI:0914”(association)	0.530
VSIG2	TTI1	psi-mi:“MI:0914”(association)	0.530
CD274	TTI1	psi-mi:“MI:0914”(association)	0.530
CA14	EXOC5	psi-mi:“MI:0914”(association)	0.530
ILVBL	EIF2B5	psi-mi:“MI:0914”(association)	0.530
ILVBL	SLC33A1	psi-mi:“MI:0914”(association)	0.530
CD40	EXOC5	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
SLC30A4	OPA1	psi-mi:“MI:0914”(association)	0.530
RASSF1	MAP1B	psi-mi:“MI:0914”(association)	0.530
XPO6	SLC27A2	psi-mi:“MI:0915”(physical association)	0.400
ORF4	DNM1L	psi-mi:“MI:0914”(association)	0.350
SIGLECL1	KIAA1324L	psi-mi:“MI:0914”(association)	0.350
LYPD3	CLASP2	psi-mi:“MI:0914”(association)	0.350
FPR2	GPR89A	psi-mi:“MI:0914”(association)	0.350
VIPR1	GPR89A	psi-mi:“MI:0914”(association)	0.350
PVR	QSOX1	psi-mi:“MI:0914”(association)	0.350

BioGRID (125): NUP62 (Two-hybrid), XPO6 (Reconstituted Complex), XPO6 (Affinity Capture-MS), XPO6 (Affinity Capture-MS), XPO6 (Affinity Capture-MS), XPO6 (Affinity Capture-MS), XPO6 (Affinity Capture-MS), NUP62 (Two-hybrid), XPO6 (Affinity Capture-MS), XPO6 (Affinity Capture-MS), XPO6 (Co-fractionation), XPO6 (Co-fractionation), XPO6 (Co-fractionation), XPO6 (Co-fractionation), XPO6 (Co-fractionation)

ESM2 similar proteins: A4FUD6, A4QNE0, B5KFI0, F1Q8X5, O35841, P40763, P42224, P42227, P52631, P70398, Q19S50, Q3ZBE1, Q5R644, Q5R8I6, Q5R8N4, Q5RCC1, Q5RCR8, Q5XI83, Q6DFZ1, Q6DV79, Q6NRC7, Q6NRL4, Q6QI06, Q6R327, Q7SXV1, Q7Z3J2, Q8BHL5, Q8BIK4, Q8BPU7, Q8BWQ6, Q8CIB5, Q8CIQ7, Q8IWV8, Q8IWZ6, Q8IZD9, Q8K0F1, Q8K2G4, Q8R5L3, Q924Z6, Q92538

Diamond homologs: Q53I77, Q6NTZ5, Q8QHJ8, Q924Z6, Q96QU8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 123 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	6	13.0×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

134 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	100
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

5312 predictions. Top by Δscore:

Variant	Effect	Δscore
16:28101451:T:A	donor_gain	1.0000
16:28101684:ATCTT:A	acceptor_gain	1.0000
16:28101686:CTT:C	acceptor_gain	1.0000
16:28101687:TT:T	acceptor_gain	1.0000
16:28101689:C:CC	acceptor_gain	1.0000
16:28101842:CTTA:C	donor_loss	1.0000
16:28101843:TTA:T	donor_loss	1.0000
16:28101844:TACC:T	donor_loss	1.0000
16:28101845:A:AC	donor_gain	1.0000
16:28101845:ACCT:A	donor_loss	1.0000
16:28101846:C:CC	donor_gain	1.0000
16:28101943:AGCC:A	acceptor_loss	1.0000
16:28101944:GCCTA:G	acceptor_loss	1.0000
16:28101945:CCT:C	acceptor_loss	1.0000
16:28101946:C:CA	acceptor_loss	1.0000
16:28101946:C:CC	acceptor_gain	1.0000
16:28101947:T:G	acceptor_loss	1.0000
16:28104541:GTTA:G	donor_loss	1.0000
16:28104544:A:C	donor_loss	1.0000
16:28104703:GGACG:G	acceptor_gain	1.0000
16:28104704:GACG:G	acceptor_gain	1.0000
16:28104705:ACG:A	acceptor_gain	1.0000
16:28104706:CG:C	acceptor_gain	1.0000
16:28104706:CGC:C	acceptor_gain	1.0000
16:28104707:GCT:G	acceptor_loss	1.0000
16:28104708:C:CC	acceptor_gain	1.0000
16:28104708:C:G	acceptor_loss	1.0000
16:28106038:CCTAC:C	donor_loss	1.0000
16:28106040:TACC:T	donor_loss	1.0000
16:28106042:C:CT	donor_loss	1.0000

AlphaMissense

7416 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:28125789:C:G	D556H	1.000
16:28125794:A:G	L554P	1.000
16:28125804:G:C	H551D	1.000
16:28133898:G:C	S493R	1.000
16:28133898:G:T	S493R	1.000
16:28133900:T:G	S493R	1.000
16:28146167:A:G	W421R	1.000
16:28146167:A:T	W421R	1.000
16:28152669:G:T	T405K	1.000
16:28152735:A:G	L383P	1.000
16:28152739:G:C	H382D	1.000
16:28152759:A:G	L375P	1.000
16:28156140:A:G	L344P	1.000
16:28156215:A:G	L319P	1.000
16:28156236:G:T	A312D	1.000
16:28156396:A:G	W259R	1.000
16:28156396:A:T	W259R	1.000
16:28156404:A:G	L256P	1.000
16:28169875:A:G	L147P	1.000
16:28169878:C:T	G146E	1.000
16:28169879:C:A	G146W	1.000
16:28169879:C:G	G146R	1.000
16:28169879:C:T	G146R	1.000
16:28175937:C:A	W122C	1.000
16:28175937:C:G	W122C	1.000
16:28175939:A:G	W122R	1.000
16:28175939:A:T	W122R	1.000
16:28175947:C:G	R119P	1.000
16:28175950:C:T	G118E	1.000
16:28175951:C:G	G118R	1.000

dbSNP variants (sampled 300 via entrez): RS1000020262 (16:28136887 A>G), RS1000045684 (16:28103280 AATGCATGTGAAACTC>A), RS1000054161 (16:28181253 T>C), RS1000057066 (16:28151423 C>T), RS1000124293 (16:28161293 G>A), RS1000145464 (16:28194423 A>T), RS1000145486 (16:28102047 T>C), RS1000177320 (16:28161598 A>G), RS1000182554 (16:28179690 C>T), RS1000216367 (16:28110821 G>C), RS1000261071 (16:28154207 C>T), RS1000264138 (16:28111277 C>G), RS1000273128 (16:28130703 A>T), RS1000278588 (16:28211716 C>G), RS1000327052 (16:28141918 C>T)

Disease associations

OMIM: gene MIM:608411 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST010002_111	Refractive error	3.000000e-09
GCST010241_84	Apolipoprotein A1 levels	3.000000e-13
GCST011742_22	Triglyceride levels in HIV infection	6.000000e-07
GCST011742_8	Triglyceride levels in HIV infection	6.000000e-07
GCST90002393_267	Monocyte count	2.000000e-13
GCST90011900_123	Serum alkaline phosphatase levels	1.000000e-08

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004614	apolipoprotein A 1 measurement
EFO:0004530	triglyceride measurement
EFO:0005091	monocyte count
EFO:0004533	alkaline phosphatase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066255 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.18	Kd	654.3	nM	CHEMBL5653589
6.18	ED50	654.3	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149788: Binding affinity to human XPO6 incubated for 45 mins by Kinobead based pull down assay	kd	0.6543	uM

CTD chemical–gene interactions

47 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, decreases methylation, decreases expression	2
Air Pollutants	affects expression, affects cotreatment, increases abundance, increases oxidation	2
Estradiol	increases expression	2
Ozone	increases oxidation, increases abundance, affects expression, affects cotreatment	2
Cyclosporine	increases expression	2
GSK-J4	increases expression	1
bisphenol F	affects cotreatment, decreases expression	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	increases abundance, affects cotreatment, increases oxidation	1
beta-lapachone	increases expression	1
methylparaben	increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
beta-methylcholine	affects expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
cylindrospermopsin	increases expression	1
abrine	increases expression	1
bisphenol S	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Zoledronic Acid	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants, Occupational	affects expression	1
Benzo(a)pyrene	increases methylation	1
Caffeine	affects phosphorylation	1
Cisplatin	decreases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Folic Acid	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652830	Binding	Binding affinity to human XPO6 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.