XXYLT1-AS2

Summary

XXYLT1-AS2 (XXYLT1 antisense RNA 2, HGNC:41154) is a long non-coding RNA gene on chromosome 3q29.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41154
Approved symbol	XXYLT1-AS2
Name	XXYLT1 antisense RNA 2
Location	3q29
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230266
Ensembl biotype	lncRNA
Entrez	101410543
RNAcentral	URS000075AF6F — lncRNA, 859 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000426468, ENST00000447975

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000426468 — 2 exons

Exon	Start	End
ENSE00004172105	195147723	195148105
ENSE00004172106	195152257	195152858

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 76.81.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0756 / max 34.9268, expressed in 240 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
40681	0.8051	206
40683	0.1252	78
40682	0.0836	65
40680	0.0618	29

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	76.81	gold quality
stromal cell of endometrium	CL:0002255	75.75	gold quality
bone marrow cell	CL:0002092	69.69	silver quality
cortical plate	UBERON:0005343	69.33	gold quality
body of stomach	UBERON:0001161	68.50	gold quality
tonsil	UBERON:0002372	67.20	gold quality
stomach	UBERON:0000945	67.16	gold quality
monocyte	CL:0000576	67.00	gold quality
vermiform appendix	UBERON:0001154	66.40	gold quality
leukocyte	CL:0000738	66.35	gold quality
placenta	UBERON:0001987	65.21	gold quality
bone marrow	UBERON:0002371	64.78	gold quality
fundus of stomach	UBERON:0001160	64.42	gold quality
colonic epithelium	UBERON:0000397	64.30	silver quality
skeletal muscle tissue	UBERON:0001134	64.19	silver quality
lower esophagus muscularis layer	UBERON:0035833	63.86	gold quality
lower esophagus	UBERON:0013473	63.70	gold quality
mucosa of stomach	UBERON:0001199	63.51	gold quality
gall bladder	UBERON:0002110	62.83	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.35	gold quality
granulocyte	CL:0000094	62.09	gold quality
superior frontal gyrus	UBERON:0002661	61.37	gold quality
small intestine	UBERON:0002108	60.34	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.33	gold quality
muscle layer of sigmoid colon	UBERON:0035805	60.31	gold quality
rectum	UBERON:0001052	59.48	gold quality
esophagus	UBERON:0001043	59.30	gold quality
calcaneal tendon	UBERON:0003701	59.15	gold quality
intestine	UBERON:0000160	58.49	gold quality
blood	UBERON:0000178	58.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long noncoding RNA XXYLT1-AS2 regulates proliferation and adhesion by targeting the RNA binding protein FUS in HUVEC. (PMID:32171981)
• LncRNA XXYLT1-AS2 promotes tumor progression via autophagy inhibition through ubiquitinated degradation of TFEB in hepatocellular carcinoma. (PMID:37540409)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.