YPEL5

Summary

YPEL5 (yippee like 5, HGNC:18329) is a protein-coding gene on chromosome 2p23.1, encoding Protein yippee-like 5 (P62699). Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. It is a selective cancer dependency (DepMap: 74.8% of cell lines).

Predicted to enable metal ion binding activity. Predicted to be involved in cell population proliferation. Part of ubiquitin ligase complex.

Source: NCBI Gene 51646 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 13 total
• Cancer dependency (DepMap): dependent in 74.8% of screened cell lines
• MANE Select transcript: NM_016061

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18329
Approved symbol	YPEL5
Name	yippee like 5
Location	2p23.1
Locus type	gene with protein product
Status	Approved
Aliases	CGI-127
Ensembl gene	ENSG00000119801
Ensembl biotype	protein_coding
OMIM	609726
Entrez	51646

Gene structure

Transcript identifiers

Ensembl transcripts: 40 — 35 protein_coding, 5 protein_coding_CDS_not_defined

ENST00000261353, ENST00000379519, ENST00000379520, ENST00000402003, ENST00000402708, ENST00000470120, ENST00000482474, ENST00000490211, ENST00000492439, ENST00000495673, ENST00000871629, ENST00000871630, ENST00000871631, ENST00000871632, ENST00000871633, ENST00000871634, ENST00000871635, ENST00000871636, ENST00000871637, ENST00000871638, ENST00000871639, ENST00000871640, ENST00000871641, ENST00000921992, ENST00000921993, ENST00000921994, ENST00000921995, ENST00000921996, ENST00000921997, ENST00000956321, ENST00000956322, ENST00000956323, ENST00000956324, ENST00000956325, ENST00000956326, ENST00000956327, ENST00000956328, ENST00000956329, ENST00000956330, ENST00000956331

RefSeq mRNA: 4 — MANE Select: NM_016061 NM_001127399, NM_001127400, NM_001127401, NM_016061

CCDS: CCDS1771

Canonical transcript exons

ENST00000261353 — 3 exons

Exon	Start	End
ENSE00001078558	30158619	30160533
ENSE00001875716	30147007	30147062
ENSE00003557435	30156628	30156792

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 99.93.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 135.8607 / max 4732.9545, expressed in 1821 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
19553	81.3501	1797
19552	53.7982	1815
202146	0.2090	84
19556	0.1013	29
19554	0.0817	20
19557	0.0803	31
19558	0.0764	30
202147	0.0648	28
19555	0.0581	15
19562	0.0409	15

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	99.93	gold quality
oocyte	CL:0000023	99.88	gold quality
endothelial cell	CL:0000115	99.52	gold quality
amniotic fluid	UBERON:0000173	99.34	gold quality
middle temporal gyrus	UBERON:0002771	99.10	gold quality
sperm	CL:0000019	99.04	gold quality
palpebral conjunctiva	UBERON:0001812	98.95	gold quality
Brodmann (1909) area 23	UBERON:0013554	98.76	gold quality
bone marrow	UBERON:0002371	98.75	gold quality
eye	UBERON:0000970	98.72	gold quality
renal glomerulus	UBERON:0000074	98.66	gold quality
monocyte	CL:0000576	98.62	gold quality
mononuclear cell	CL:0000842	98.62	gold quality
metanephric glomerulus	UBERON:0004736	98.60	gold quality
male germ cell	CL:0000015	98.56	gold quality
leukocyte	CL:0000738	98.48	gold quality
pons	UBERON:0000988	98.23	gold quality
upper leg skin	UBERON:0004262	98.13	gold quality
bone marrow cell	CL:0002092	98.11	gold quality
germinal epithelium of ovary	UBERON:0001304	98.10	gold quality
pigmented layer of retina	UBERON:0001782	98.07	gold quality
nephron tubule	UBERON:0001231	98.06	gold quality
retina	UBERON:0000966	98.04	gold quality
hair follicle	UBERON:0002073	98.01	gold quality
superior frontal gyrus	UBERON:0002661	98.00	gold quality
parietal pleura	UBERON:0002400	97.97	gold quality
visceral pleura	UBERON:0002401	97.92	gold quality
kidney epithelium	UBERON:0004819	97.91	gold quality
pleura	UBERON:0000977	97.90	gold quality
postcentral gyrus	UBERON:0002581	97.89	gold quality

Single-cell (SCXA)

Detected in 9 experiment(s), a significant marker in 7.

Experiment	Marker?	Max mean expression
E-GEOD-111727	yes	3152.59
E-MTAB-9467	yes	1893.49
E-MTAB-6678	yes	1432.07
E-GEOD-135922	yes	35.32
E-CURD-88	yes	32.51
E-MTAB-9067	yes	11.97
E-CURD-89	no	4383.84
E-MTAB-7606	no	641.69
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

134 targeting YPEL5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-1193	100.00	65.93	529
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-6768-5P	99.92	67.36	1942

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 74.8% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 5)

• YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. (PMID:20580816)
• results indicate that SCN-iPS cells provide a useful disease model for SCN, and the activation of the Wnt3a/beta-catenin pathway may offer a novel therapy for SCN with ELANE mutation (PMID:23382248)
• YPEL5 silencing enhanced the induction of IFNB1 by pattern recognition receptors and phosphorylation of TBK1/IKBKE kinases, whereas co-immunoprecipitation experiments revealed that YPEL5 interacted physically with IKBKE. (PMID:27705791)
• results demonstrate the functional conservation between yeast Moh1 and human YPEL5, and their involvement in mitochondria-dependent apoptosis induced by DNA damage (PMID:28173693)
• METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5. (PMID:33411363)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	ypel5	ENSDARG00000088929
mus_musculus	Ypel5	ENSMUSG00000039770
rattus_norvegicus	Ypel5	ENSRNOG00000026742
drosophila_melanogaster	Ype	FBGN0288857
caenorhabditis_elegans		WBGENE00015250
caenorhabditis_elegans		WBGENE00015251

Paralogs (10): L2HGDH (ENSG00000087299), YPEL3 (ENSG00000090238), PDPR (ENSG00000090857), YPEL1 (ENSG00000100027), FOXRED1 (ENSG00000110074), SARDH (ENSG00000123453), DMGDH (ENSG00000132837), AMT (ENSG00000145020), YPEL4 (ENSG00000166793), YPEL2 (ENSG00000175155)

Protein

Protein identifiers

Protein yippee-like 5 — P62699 (reviewed: P62699)

All UniProt accessions (1): P62699

UniProt curated annotations — full annotation on UniProt →

Function. Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for normal cell proliferation.

Subunit / interactions. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with RANBP9 and RANBP10.

Subcellular location. Nucleus. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Spindle pole. Midbody.

Similarity. Belongs to the yippee family.

RefSeq proteins (4): NP_001120871, NP_001120872, NP_001120873, NP_057145* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004910	Yippee/Mis18/Cereblon	Domain
IPR034751	Yippee	Domain
IPR039058	Yippee_fam	Family

Pfam: PF03226

UniProt features (22 total): strand 9, binding site 4, helix 3, turn 3, chain 1, domain 1, modified residue 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
8QBN	ELECTRON MICROSCOPY	3.2
9RSD	ELECTRON MICROSCOPY	3.38
9RSC	ELECTRON MICROSCOPY	3.42

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P62699-F1	93.24	0.85

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 17; 20; 73; 76

Post-translational modifications (1): 118

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-6798695	Neutrophil degranulation

MSigDB gene sets: 316 (showing top): KOBAYASHI_EGFR_SIGNALING_24HR_UP, REACTOME_INNATE_IMMUNE_SYSTEM, GOCC_SECRETORY_GRANULE, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, IVANOVA_HEMATOPOIESIS_MATURE_CELL, CAGCTG_AP4_Q5, CCATCCA_MIR432, GOCC_MICROTUBULE_ORGANIZING_CENTER, MISSIAGLIA_REGULATED_BY_METHYLATION_UP, GTGTTGA_MIR505, ODONNELL_TARGETS_OF_MYC_AND_TFRC_UP, BACH2_01, GOCC_CENTROSOME, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5

GO Biological Process (1): cell population proliferation (GO:0008283)

GO Molecular Function (2): metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (11): ubiquitin ligase complex (GO:0000151), extracellular region (GO:0005576), nucleus (GO:0005634), centrosome (GO:0005813), midbody (GO:0030496), mitotic spindle pole (GO:0097431), tertiary granule lumen (GO:1904724), ficolin-1-rich granule lumen (GO:1904813), spindle pole (GO:0000922), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Innate Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
intracellular organelle lumen	2
cellular process	1
cation binding	1
binding	1
intracellular protein-containing complex	1
transferase complex	1
intracellular membrane-bounded organelle	1
centriole	1
microtubule organizing center	1
spindle pole	1
mitotic spindle	1
tertiary granule	1
ficolin-1-rich granule	1
spindle	1
intracellular anatomical structure	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1254 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
YPEL5	RANBP10	Q6VN20	839
YPEL5	WDR26	Q9H7D7	760
YPEL5	RANBP9	Q96S59	721
YPEL5	MKLN1	Q9UL63	719
YPEL5	MAEA	Q7L5Y9	697
YPEL5	GID8	Q9NWU2	691
YPEL5	GID4	Q8IVV7	689
YPEL5	RMND5B	Q96G75	676
YPEL5	ARMC8	Q8IUR7	674
YPEL5	RMND5A	Q9H871	608
YPEL5	FAM162B	Q5T6X4	542
YPEL5	TMEM167A	Q8TBQ9	502
YPEL5	HEXD	Q8WVB3	462
YPEL5	UBE2H	P37286	460
YPEL5	LCLAT1	Q6UWP7	447

IntAct

125 interactions, top by confidence:

A	B	Type	Score
ARMC8	HTRA2	psi-mi:“MI:0914”(association)	0.750
RANBP9	YPEL5	psi-mi:“MI:0914”(association)	0.640
PRG2	YPEL5	psi-mi:“MI:0914”(association)	0.640
CCDC120	AIP	psi-mi:“MI:0914”(association)	0.640
GID8	HTRA2	psi-mi:“MI:0914”(association)	0.610
YPEL5	PSMA1	psi-mi:“MI:0915”(physical association)	0.560
TRAF5	YPEL5	psi-mi:“MI:0915”(physical association)	0.560
YPEL5	SHC3	psi-mi:“MI:0915”(physical association)	0.560
MAPKBP1	YPEL5	psi-mi:“MI:0915”(physical association)	0.560
YPEL5	DDIT4L	psi-mi:“MI:0915”(physical association)	0.560
GSC2	YPEL5	psi-mi:“MI:0915”(physical association)	0.560
YPEL5	PFDN5	psi-mi:“MI:0915”(physical association)	0.560
YPEL5	CTDSP1	psi-mi:“MI:0915”(physical association)	0.560
YPEL5	PLAGL2	psi-mi:“MI:0915”(physical association)	0.560
YPEL5	ZNF655	psi-mi:“MI:0915”(physical association)	0.560
PSMA1	YPEL5	psi-mi:“MI:0915”(physical association)	0.560
JPH4	ZSWIM8	psi-mi:“MI:0914”(association)	0.530
EMILIN3	ZZEF1	psi-mi:“MI:0914”(association)	0.530
CBFA2T3	CBFA2T2	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
GNLY	YPEL5	psi-mi:“MI:0914”(association)	0.530
PIGT	ZNF609	psi-mi:“MI:0914”(association)	0.530
EFHC2	YPEL5	psi-mi:“MI:0914”(association)	0.510
RANBP10	HTRA2	psi-mi:“MI:0914”(association)	0.510
RANBP9	DDX5	psi-mi:“MI:0914”(association)	0.510
RMND5B	PSMA7	psi-mi:“MI:0914”(association)	0.510
WDR26	HTRA2	psi-mi:“MI:0914”(association)	0.510

BioGRID (112): YPEL5 (Affinity Capture-MS), YPEL5 (Affinity Capture-MS), YPEL5 (Affinity Capture-MS), YPEL5 (Affinity Capture-MS), YPEL5 (Affinity Capture-MS), YPEL5 (Affinity Capture-MS), YPEL5 (Affinity Capture-MS), YPEL5 (Affinity Capture-MS), YPEL5 (Affinity Capture-MS), YPEL5 (Affinity Capture-MS), YPEL5 (Affinity Capture-MS), RANBP10 (Affinity Capture-MS), WDR26 (Affinity Capture-MS), YPEL5 (Affinity Capture-MS), ARMC8 (Affinity Capture-MS)

ESM2 similar proteins: A7ZMP8, A8A0X0, A9MFH4, A9N292, B1IPF3, B1LDV3, B1XGN8, B4T3Y1, B4TGC8, B4TUA8, B5F860, B5FJF9, B5YQ71, B6IBJ9, B7L6Q3, B7LQ21, B7M1J2, B7MAY9, B7MVQ9, B7N5B4, B7NSZ8, B7USF8, C4ZZD4, C5BR54, P0A746, P0A747, P0A748, P38191, P59234, P62699, P62700, P65449, P65450, Q0T4Y5, Q0TH50, Q2V3E2, Q321R4, Q3Z2B6, Q3ZBE7, Q4R4Q6

Diamond homologs: A6QPH8, O44440, O60688, P38191, P59234, P61236, P61237, P62699, P62700, Q2V3E2, Q2YDI3, Q3ZBE7, Q4R4Q6, Q5RDN9, Q5RDU7, Q5XID5, Q65Z54, Q65Z55, Q65Z56, Q65Z57, Q65Z58, Q65Z59, Q65Z93, Q65Z95, Q6NWI4, Q8S5M8, Q96NS1, Q96QA6, Q9C777, Q9DG42, Q9ESC7, Q9FN32, Q9LY56, Q9SR97, Q9T096, Q9U3G6, Q9URW3, Q9W2X7, Q9XZF0

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 110 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Regulation of pyruvate metabolism	8	64.3×	8e-11
Pyruvate metabolism	5	28.7×	2e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

13 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	9
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

540 predictions. Top by Δscore:

Variant	Effect	Δscore
2:30147059:CAGGG:C	donor_loss	1.0000
2:30147060:AGGGT:A	donor_loss	1.0000
2:30147061:GG:G	donor_gain	1.0000
2:30147062:GG:G	donor_gain	1.0000
2:30147062:GGT:G	donor_loss	1.0000
2:30147063:G:GG	donor_gain	1.0000
2:30148303:G:GT	donor_gain	1.0000
2:30158615:TTA:T	acceptor_loss	1.0000
2:30158618:G:A	acceptor_loss	1.0000
2:30158618:GGTA:G	acceptor_gain	1.0000
2:30147059:CAGG:C	donor_gain	0.9900
2:30147060:AGG:A	donor_gain	0.9900
2:30147061:GGG:G	donor_gain	0.9900
2:30156626:A:AG	acceptor_gain	0.9900
2:30156627:G:GG	acceptor_gain	0.9900
2:30156790:AAGG:A	donor_loss	0.9900
2:30156793:G:GG	donor_loss	0.9900
2:30158617:AG:A	acceptor_gain	0.9900
2:30158618:GG:G	acceptor_gain	0.9900
2:30158618:GGT:G	acceptor_gain	0.9900
2:30147058:TCAGG:T	donor_gain	0.9800
2:30147063:G:T	donor_gain	0.9800
2:30147064:T:A	donor_loss	0.9800
2:30155849:GCCTT:G	acceptor_gain	0.9800
2:30156622:TCCTA:T	acceptor_gain	0.9800
2:30156623:CCTAG:C	acceptor_gain	0.9800
2:30156624:CTAGG:C	acceptor_gain	0.9800
2:30156625:TAGG:T	acceptor_gain	0.9800
2:30156626:AG:A	acceptor_gain	0.9800
2:30156626:AGG:A	acceptor_gain	0.9800

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000094465 (2:30147199 C>A), RS1000136868 (2:30158240 A>G), RS1000474197 (2:30154044 A>G), RS1000525914 (2:30153878 A>C), RS1001031987 (2:30160712 A>G), RS1001072368 (2:30159515 A>C), RS1001216701 (2:30150148 T>A,C), RS1001475870 (2:30155224 A>G), RS1001528294 (2:30154939 A>G), RS1001746933 (2:30149636 C>G,T), RS1002333913 (2:30155159 A>C), RS1002519634 (2:30156245 A>T), RS1002585840 (2:30150675 C>T), RS1003077466 (2:30146662 C>T), RS1003108679 (2:30146836 C>G,T)

Disease associations

OMIM: gene MIM:609726 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST008644_20	Celiac disease and Rheumatoid arthritis	2.000000e-08
GCST009363_55	Triglyceride levels x short total sleep time interaction (2df test)	1.000000e-08
GCST011346_12	Total cholesterol levels	4.000000e-09
GCST011347_14	Low density lipoprotein cholesterol levels	4.000000e-08

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004530	triglyceride measurement
EFO:0004574	total cholesterol measurement
EFO:0004611	low density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

74 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression, decreases expression, increases abundance	5
(+)-JQ1 compound	decreases expression, increases expression	3
Air Pollutants	affects cotreatment, increases abundance, increases expression, affects expression, decreases expression	3
Estradiol	decreases expression	3
Valproic Acid	affects expression, decreases expression, increases expression	3
bisphenol F	affects cotreatment, increases methylation, increases expression	2
cobaltous chloride	increases expression	2
Ozone	affects cotreatment, increases expression, increases abundance, affects expression	2
Tetrachlorodibenzodioxin	increases expression	2
Tobacco Smoke Pollution	increases expression	2
Tretinoin	increases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression, increases expression	2
Cadmium Chloride	increases expression	2
Genistein	decreases expression	2
GSK-J4	increases expression	1
afuresertib	increases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
bisphenol A	decreases expression	1
hydroxyhydroquinone	increases expression	1
arsenite	affects binding, increases reaction	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
chloropicrin	increases expression	1
monomethylarsonous acid	increases expression	1
K 7174	increases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.