ZBED3-AS1

Summary

ZBED3-AS1 (ZBED3 antisense RNA 1, HGNC:44188) is a long non-coding RNA gene on chromosome 5q13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44188
Approved symbol	ZBED3-AS1
Name	ZBED3 antisense RNA 1
Location	5q13.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc13728
Ensembl gene	ENSG00000250802
Ensembl biotype	lncRNA
Entrez	728723
RNAcentral	URS0002617A61 — lncRNA, 2175 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 47 — 47 lncRNA

ENST00000502433, ENST00000503969, ENST00000504506, ENST00000505918, ENST00000507749, ENST00000508401, ENST00000511547, ENST00000512001, ENST00000512213, ENST00000513406, ENST00000513591, ENST00000514114, ENST00000514288, ENST00000514640, ENST00000514905, ENST00000515356, ENST00000515419, ENST00000642217, ENST00000642277, ENST00000642398, ENST00000643269, ENST00000643365, ENST00000643465, ENST00000643603, ENST00000643819, ENST00000643848, ENST00000643894, ENST00000643974, ENST00000644015, ENST00000644131, ENST00000644426, ENST00000644460, ENST00000645070, ENST00000645136, ENST00000645183, ENST00000645374, ENST00000645459, ENST00000645509, ENST00000646307, ENST00000646594, ENST00000646603, ENST00000646705, ENST00000646953, ENST00000647045, ENST00000647364, ENST00000731888, ENST00000731889

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000502433 — 6 exons

Exon	Start	End
ENSE00002036823	77098655	77098747
ENSE00002037884	77139261	77139303
ENSE00002046255	77087487	77087619
ENSE00002074650	77105656	77105689
ENSE00002076569	77086801	77086904
ENSE00002088001	77118320	77118521

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 90.06.

FANTOM5 (CAGE): breadth broad, TPM avg 2.0439 / max 110.3421, expressed in 664 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
57173	1.1344	505
57179	0.2713	35
57176	0.2286	105
57174	0.1712	89
57177	0.0904	27
57178	0.0822	24
57175	0.0657	34

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	90.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.97	gold quality
sural nerve	UBERON:0015488	80.19	gold quality
right lobe of thyroid gland	UBERON:0001119	79.40	gold quality
left lobe of thyroid gland	UBERON:0001120	78.81	gold quality
omental fat pad	UBERON:0010414	78.61	gold quality
peritoneum	UBERON:0002358	78.50	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	78.24	gold quality
thyroid gland	UBERON:0002046	78.11	gold quality
adipose tissue of abdominal region	UBERON:0007808	77.30	gold quality
ventricular zone	UBERON:0003053	77.00	gold quality
adrenal tissue	UBERON:0018303	75.88	gold quality
left uterine tube	UBERON:0001303	75.75	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.73	gold quality
adenohypophysis	UBERON:0002196	75.17	gold quality
fallopian tube	UBERON:0003889	74.87	gold quality
spinal cord	UBERON:0002240	74.78	gold quality
oviduct epithelium	UBERON:0004804	74.60	gold quality
ganglionic eminence	UBERON:0004023	74.33	gold quality
body of uterus	UBERON:0009853	74.05	gold quality
pituitary gland	UBERON:0000007	72.89	gold quality
subcutaneous adipose tissue	UBERON:0002190	72.50	gold quality
islet of Langerhans	UBERON:0000006	71.96	gold quality
amygdala	UBERON:0001876	71.67	gold quality
bone marrow cell	CL:0002092	71.64	silver quality
cortical plate	UBERON:0005343	71.60	gold quality
hypothalamus	UBERON:0001898	71.29	gold quality
metanephros cortex	UBERON:0010533	71.28	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.01	gold quality
corpus callosum	UBERON:0002336	71.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.89

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Lnc13728 facilitates human mesenchymal stem cell adipogenic differentiation via positive regulation of ZBED3 and downregulation of the WNT/beta-catenin pathway. (PMID:33712067)
• Implication of lncRNA ZBED3-AS1 downregulation in acquired resistance to Temozolomide and glycolysis in glioblastoma. (PMID:36462734)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.