ZBTB20-AS1

Summary

ZBTB20-AS1 (ZBTB20 antisense RNA 1, HGNC:40640) is a long non-coding RNA gene on chromosome 3q13.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40640
Approved symbol	ZBTB20-AS1
Name	ZBTB20 antisense RNA 1
Location	3q13.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000241560
Ensembl biotype	lncRNA
Entrez	100131117
RNAcentral	URS000075CF03 — lncRNA, 1719 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000460210, ENST00000467304, ENST00000475939, ENST00000487814, ENST00000496219, ENST00000651682, ENST00000654216, ENST00000657013, ENST00000657808, ENST00000659395, ENST00000659927, ENST00000801098, ENST00000801099

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000460210 — 4 exons

Exon	Start	End
ENSE00001815842	114366967	114367028
ENSE00001886543	114375794	114375836
ENSE00001903355	114366717	114366798
ENSE00001928964	114378970	114379178

Expression profiles

Bgee: expression breadth ubiquitous, 152 present calls, max score 94.23.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0823 / max 36.5379, expressed in 14 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
38000	0.0597	12
37999	0.0226	3

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	94.23	gold quality
left testis	UBERON:0004533	88.43	gold quality
right testis	UBERON:0004534	88.06	gold quality
testis	UBERON:0000473	85.06	gold quality
calcaneal tendon	UBERON:0003701	85.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.95	gold quality
tendon	UBERON:0000043	80.65	gold quality
adrenal tissue	UBERON:0018303	79.57	gold quality
colonic epithelium	UBERON:0000397	75.99	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.14	gold quality
sural nerve	UBERON:0015488	74.19	gold quality
bone marrow cell	CL:0002092	73.99	silver quality
tendon of biceps brachii	UBERON:0008188	73.81	silver quality
corpus callosum	UBERON:0002336	71.15	gold quality
granulocyte	CL:0000094	70.78	gold quality
upper arm skin	UBERON:0004263	67.78	gold quality
hindlimb stylopod muscle	UBERON:0004252	65.61	gold quality
kidney epithelium	UBERON:0004819	64.77	gold quality
nasal cavity epithelium	UBERON:0005384	63.49	gold quality
epithelial cell of pancreas	CL:0000083	63.44	gold quality
bone marrow	UBERON:0002371	63.01	silver quality
parotid gland	UBERON:0001831	62.68	gold quality
blood	UBERON:0000178	61.86	gold quality
tonsil	UBERON:0002372	59.63	gold quality
liver	UBERON:0002107	59.27	gold quality
ganglionic eminence	UBERON:0004023	59.17	gold quality
skin of hip	UBERON:0001554	59.11	silver quality
ventricular zone	UBERON:0003053	58.62	silver quality
descending thoracic aorta	UBERON:0002345	57.72	gold quality
myocardium	UBERON:0002349	57.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.55

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• ZBTB20-AS1 promoted Alzheimer’s disease progression through ZBTB20/GSK-3beta/Tau pathway. (PMID:36502636)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.