ZBTB40-IT1

Summary

ZBTB40-IT1 (ZBTB40 intronic transcript 1, HGNC:41493) is a long non-coding RNA gene on chromosome 1p36.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41493
Approved symbol	ZBTB40-IT1
Name	ZBTB40 intronic transcript 1
Location	1p36.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237200
Ensembl biotype	lncRNA
OMIM	618485
Entrez	100874345
RNAcentral	URS0000174377 — lncRNA, 273 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000438551

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000438551 — 2 exons

Exon	Start	End
ENSE00001716935	22519606	22519708
ENSE00001765639	22517474	22517643

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 81.47.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right coronary artery	UBERON:0001625	81.47	gold quality
corpus callosum	UBERON:0002336	79.29	gold quality
left coronary artery	UBERON:0001626	78.82	gold quality
ascending aorta	UBERON:0001496	78.00	gold quality
thoracic aorta	UBERON:0001515	77.91	gold quality
descending thoracic aorta	UBERON:0002345	77.79	gold quality
cortical plate	UBERON:0005343	77.54	gold quality
calcaneal tendon	UBERON:0003701	76.89	gold quality
bone marrow cell	CL:0002092	76.62	gold quality
gall bladder	UBERON:0002110	76.39	gold quality
bone marrow	UBERON:0002371	75.17	gold quality
mucosa of stomach	UBERON:0001199	74.60	gold quality
popliteal artery	UBERON:0002250	74.58	gold quality
tibial artery	UBERON:0007610	74.56	gold quality
ganglionic eminence	UBERON:0004023	74.17	gold quality
hindlimb stylopod muscle	UBERON:0004252	73.81	gold quality
right ovary	UBERON:0002118	73.72	gold quality
left ovary	UBERON:0002119	73.60	gold quality
monocyte	CL:0000576	73.40	gold quality
prostate gland	UBERON:0002367	73.08	gold quality
ovary	UBERON:0000992	73.07	gold quality
right adrenal gland cortex	UBERON:0035827	72.78	gold quality
endocervix	UBERON:0000458	72.72	gold quality
body of uterus	UBERON:0009853	72.62	gold quality
myometrium	UBERON:0001296	72.43	gold quality
right adrenal gland	UBERON:0001233	72.39	gold quality
colonic epithelium	UBERON:0000397	72.27	gold quality
vagina	UBERON:0000996	71.82	gold quality
upper lobe of left lung	UBERON:0008952	71.72	gold quality
skin of leg	UBERON:0001511	71.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• study discovers the critical role of ZBTB40 and lncRNA ZBTB40-IT1 in bone metabolism, and provides a mechanistic basis for osteoporosis GWAS lead SNPs rs34920465 and rs6426749. (PMID:30661131)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.