ZC2HC1C
gene geneOn this page
Summary
ZC2HC1C (zinc finger C2HC-type containing 1C, HGNC:20354) is a protein-coding gene on chromosome 14q24.3, encoding Zinc finger C2HC domain-containing protein 1C (Q53FD0).
Predicted to enable zinc ion binding activity.
Source: NCBI Gene 79696 — RefSeq curated summary.
At a glance
- Gene–disease (curated): neurodevelopmental disorder (Limited, GenCC)
- GWAS associations: 2
- Clinical variants (ClinVar): 74 total
- MANE Select transcript:
NM_024643
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:20354 |
| Approved symbol | ZC2HC1C |
| Name | zinc finger C2HC-type containing 1C |
| Location | 14q24.3 |
| Locus type | gene with protein product |
| Status | Approved |
| Ensembl gene | ENSG00000119703 |
| Ensembl biotype | protein_coding |
| Entrez | 79696 |
Gene structure
Transcript identifiers
Ensembl transcripts: 18 — 15 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay
ENST00000238686, ENST00000439583, ENST00000524913, ENST00000525046, ENST00000526130, ENST00000526748, ENST00000532198, ENST00000534151, ENST00000554763, ENST00000673663, ENST00000673981, ENST00000674017, ENST00000674086, ENST00000674094, ENST00000674097, ENST00000875427, ENST00000875428, ENST00000946640
RefSeq mRNA: 3 — MANE Select: NM_024643
NM_001042430, NM_001330191, NM_024643
CCDS: CCDS41972, CCDS45138, CCDS81829
Canonical transcript exons
ENST00000524913 — 3 exons
| Exon | Start | End |
|---|---|---|
| ENSE00001286339 | 75070555 | 75071911 |
| ENSE00002142361 | 75077532 | 75079988 |
| ENSE00002143226 | 75069641 | 75069749 |
Expression profiles
Bgee: expression breadth ubiquitous, 181 present calls, max score 95.34.
FANTOM5 (CAGE): breadth broad, TPM avg 1.4127 / max 246.2924, expressed in 542 samples.
FANTOM5 promoters (3 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 140601 | 1.1352 | 441 |
| 140599 | 0.2358 | 104 |
| 140600 | 0.0417 | 11 |
Top tissues by expression
285 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| left testis | UBERON:0004533 | 95.34 | gold quality |
| right testis | UBERON:0004534 | 94.96 | gold quality |
| testis | UBERON:0000473 | 92.96 | gold quality |
| adult organism | UBERON:0007023 | 88.68 | gold quality |
| right uterine tube | UBERON:0001302 | 88.22 | gold quality |
| bronchial epithelial cell | CL:0002328 | 87.16 | gold quality |
| epithelium of bronchus | UBERON:0002031 | 85.08 | gold quality |
| corpus epididymis | UBERON:0004359 | 83.97 | gold quality |
| bronchus | UBERON:0002185 | 83.51 | gold quality |
| male germ line stem cell (sensu Vertebrata) in testis | CL:0000089 ∩ UBERON:0000473 | 82.25 | gold quality |
| olfactory segment of nasal mucosa | UBERON:0005386 | 80.42 | gold quality |
| apex of heart | UBERON:0002098 | 79.88 | gold quality |
| right lobe of thyroid gland | UBERON:0001119 | 79.66 | gold quality |
| cauda epididymis | UBERON:0004360 | 78.60 | gold quality |
| right lobe of liver | UBERON:0001114 | 78.17 | gold quality |
| left lobe of thyroid gland | UBERON:0001120 | 78.14 | gold quality |
| adenohypophysis | UBERON:0002196 | 78.05 | gold quality |
| sperm | CL:0000019 | 78.04 | gold quality |
| male germ cell | CL:0000015 | 77.54 | gold quality |
| thyroid gland | UBERON:0002046 | 77.35 | gold quality |
| pituitary gland | UBERON:0000007 | 77.03 | gold quality |
| mucosa of paranasal sinus | UBERON:0005030 | 76.67 | silver quality |
| caput epididymis | UBERON:0004358 | 75.98 | gold quality |
| body of pancreas | UBERON:0001150 | 75.97 | gold quality |
| heart left ventricle | UBERON:0002084 | 75.97 | gold quality |
| mucosa of transverse colon | UBERON:0004991 | 75.95 | gold quality |
| islet of Langerhans | UBERON:0000006 | 75.57 | gold quality |
| cardiac ventricle | UBERON:0002082 | 75.36 | gold quality |
| gastrocnemius | UBERON:0001388 | 75.20 | gold quality |
| pancreas | UBERON:0001264 | 74.60 | gold quality |
Single-cell (SCXA)
Detected in 1 experiment(s), a significant marker in 1.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | yes | 3.57 |
Regulation
Is transcription factor: no
miRNA regulators (miRDB)
101 targeting ZC2HC1C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-4692 | 100.00 | 67.32 | 2066 |
| HSA-MIR-3925-3P | 100.00 | 69.95 | 1237 |
| HSA-MIR-4514 | 99.99 | 67.10 | 1870 |
| HSA-MIR-196A-1-3P | 99.99 | 72.15 | 2772 |
| HSA-MIR-1184 | 99.99 | 68.19 | 1458 |
| HSA-MIR-548P | 99.98 | 72.25 | 3784 |
| HSA-MIR-1468-3P | 99.96 | 72.74 | 3797 |
| HSA-MIR-6778-3P | 99.96 | 67.29 | 2693 |
| HSA-MIR-5195-3P | 99.92 | 70.92 | 1877 |
| HSA-MIR-145-5P | 99.92 | 71.13 | 1836 |
| HSA-MIR-6499-3P | 99.90 | 66.38 | 1212 |
| HSA-MIR-3919 | 99.87 | 69.45 | 2489 |
| HSA-MIR-12119 | 99.87 | 68.35 | 1653 |
| HSA-MIR-4728-5P | 99.85 | 69.39 | 4718 |
| HSA-MIR-6785-5P | 99.82 | 68.68 | 4428 |
| HSA-MIR-6817-3P | 99.79 | 68.35 | 2126 |
| HSA-MIR-548AG | 99.77 | 69.25 | 1492 |
| HSA-MIR-3156-3P | 99.76 | 66.72 | 939 |
| HSA-MIR-149-3P | 99.72 | 68.22 | 3963 |
| HSA-MIR-518A-5P | 99.70 | 69.01 | 2209 |
| HSA-MIR-527 | 99.70 | 69.01 | 2209 |
| HSA-MIR-548AI | 99.69 | 69.24 | 1494 |
| HSA-MIR-548BA | 99.69 | 69.14 | 1514 |
| HSA-MIR-570-5P | 99.69 | 69.24 | 1494 |
| HSA-MIR-6883-5P | 99.69 | 68.05 | 3785 |
| HSA-MIR-5004-5P | 99.68 | 66.63 | 1294 |
| HSA-MIR-7-5P | 99.67 | 70.53 | 1809 |
| HSA-MIR-10394-5P | 99.65 | 66.83 | 1852 |
| HSA-MIR-1205 | 99.65 | 66.76 | 1826 |
| HSA-MIR-7156-5P | 99.64 | 68.81 | 1369 |
Literature-anchored findings (GeneRIF, showing 1)
- Screening of candidate genes at GLC3B and GLC3C loci in Chinese primary congenital glaucoma patients with targeted next generation sequencing. (PMID:36193031)
Cross-species orthologs
3 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| danio_rerio | zc2hc1c | ENSDARG00000070526 |
| mus_musculus | Zc2hc1c | ENSMUSG00000045064 |
| rattus_norvegicus | Zc2hc1c | ENSRNOG00000027115 |
Protein
Protein identifiers
Zinc finger C2HC domain-containing protein 1C — Q53FD0 (reviewed: Q53FD0)
All UniProt accessions (5): Q53FD0, A0A669KB15, E9PMG6, H0YE08, J3KMY6
UniProt curated annotations — full annotation on UniProt →
Similarity. Belongs to the ZC2HC1 family.
Isoforms (2)
| UniProt ID | Names | Canonical? |
|---|---|---|
| Q53FD0-1 | 1 | yes |
| Q53FD0-2 | 2 |
RefSeq proteins (3): NP_001035895, NP_001317120, NP_078919* (*=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR026104 | ZNF_C2HC_dom_1C | Family |
| IPR049899 | Znf_C2HC_C3H | Domain |
UniProt features (15 total): binding site 4, region of interest 3, compositionally biased region 3, chain 1, zinc finger region 1, splice variant 1, sequence conflict 1, coiled-coil region 1
Structure
Experimental structures (PDB)
0 structures.
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-Q53FD0-F1 | 61.23 | 0.16 |
Functional residue map
Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.
Ligand- & substrate-binding residues (4): 394; 406; 410; 391
Function
Pathways and Gene Ontology
Reactome pathways
0 pathways
MSigDB gene sets: 112 (showing top):
CMYB_01, CAGCAGG_MIR370, chr14q24, TGANTCA_AP1_C, GNF2_CCNA1, NRF2_Q4, AACTTT_UNKNOWN, LEE_LIVER_CANCER_E2F1_DN, CART1_01, AACTGGA_MIR145, NFE2_01, ACACTCC_MIR122A, LEE_LIVER_CANCER_MYC_TGFA_DN, LEE_LIVER_CANCER_MYC_DN, DODD_NASOPHARYNGEAL_CARCINOMA_DN
GO Biological Process (0):
GO Molecular Function (3): zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)
GO Cellular Component (0):
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| transition metal ion binding | 1 |
| binding | 1 |
| cation binding | 1 |
Protein interactions and networks
STRING
626 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| ZC2HC1C | OR5T1 | Q8NG75 | 571 |
| ZC2HC1C | RPS6KL1 | Q9Y6S9 | 544 |
| ZC2HC1C | MLH3 | P49751 | 449 |
| ZC2HC1C | OR2W1 | Q9Y3N9 | 447 |
| ZC2HC1C | VWA3A | A6NCI4 | 446 |
| ZC2HC1C | NEK9 | Q8TD19 | 442 |
| ZC2HC1C | C5orf34 | Q96MH7 | 433 |
| ZC2HC1C | MEDAG | Q5VYS4 | 433 |
| ZC2HC1C | ZNF557 | Q8N988 | 432 |
| ZC2HC1C | SERPINB11 | Q96P15 | 432 |
| ZC2HC1C | MIER2 | Q8N344 | 431 |
| ZC2HC1C | ZNF721 | Q8TF20 | 417 |
| ZC2HC1C | CCDC32 | Q9BV29 | 397 |
| ZC2HC1C | ZNF358 | Q9NW07 | 392 |
| ZC2HC1C | PAMR1 | Q6UXH9 | 386 |
IntAct
70 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| KRT15 | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.670 |
| ZC2HC1C | MTUS2 | psi-mi:“MI:0915”(physical association) | 0.670 |
| TFIP11 | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.670 |
| ZC2HC1C | KRT15 | psi-mi:“MI:0915”(physical association) | 0.670 |
| ZC2HC1C | TFIP11 | psi-mi:“MI:0915”(physical association) | 0.670 |
| MTUS2 | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.670 |
| PNMA1 | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.600 |
| ZC2HC1C | PNMA1 | psi-mi:“MI:0915”(physical association) | 0.600 |
| ZC2HC1C | FSD2 | psi-mi:“MI:0915”(physical association) | 0.560 |
| GFAP | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.560 |
| TRIM27 | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZC2HC1C | SFN | psi-mi:“MI:0915”(physical association) | 0.560 |
| TRIM23 | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.560 |
| TRAF2 | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.560 |
| TRAF1 | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.560 |
| KRT40 | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.560 |
| BANP | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZC2HC1C | CBY2 | psi-mi:“MI:0915”(physical association) | 0.560 |
| HOOK2 | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.560 |
| CCDC136 | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.560 |
| ZC2HC1C | SPAG5 | psi-mi:“MI:0915”(physical association) | 0.560 |
| RABGEF1 | ZC2HC1C | psi-mi:“MI:0915”(physical association) | 0.560 |
BioGRID (110): ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid), ZC2HC1C (Two-hybrid)
ESM2 similar proteins: A0A1I8MUL8, A0A1L8H8C0, A0A1L8HFX9, A2AG58, A2AJT9, B9UYK6, C5IY45, E9Q309, E9Q4F7, O94687, P0DW16, P31629, P61129, P78332, P97868, Q01613, Q08D57, Q09JY9, Q17QQ9, Q27IV2, Q2T9M9, Q498L0, Q4R731, Q53FD0, Q5F3P8, Q5JSZ5, Q5LJZ2, Q5PPL1, Q5R6I3, Q5SW79, Q5T481, Q5VT06, Q62504, Q66J90, Q6IMN6, Q6P9P0, Q6UB99, Q7Z6E9, Q865B7, Q8BYK8
Diamond homologs: A4FUE7, Q22122, Q32KN7, Q53FD0, Q5PPV5, Q5REC0, Q5TFG8, Q618K0, Q6AYP4, Q7SXT7, Q8BJH1, Q8CCG1, Q96GY0, Q9BGW4, Q9D534, Q5R498
SIGNOR signaling
0 interactions.
Disease & clinical
Clinical variants and AI predictions
ClinVar
74 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 0 |
| Likely pathogenic | 0 |
| Uncertain significance | 61 |
| Likely benign | 9 |
| Benign | 0 |
Top pathogenic / likely-pathogenic (0)
SpliceAI
3634 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 14:75087231:C:CC | acceptor_gain | 1.0000 |
| 14:75097267:TTAT:T | acceptor_gain | 1.0000 |
| 14:75100988:TCA:T | donor_loss | 1.0000 |
| 14:75100989:CA:C | donor_loss | 1.0000 |
| 14:75100990:A:AC | donor_gain | 1.0000 |
| 14:75100991:C:CC | donor_gain | 1.0000 |
| 14:75100991:C:CT | donor_loss | 1.0000 |
| 14:75100991:CCAT:C | donor_gain | 1.0000 |
| 14:75101149:TCGCT:T | acceptor_gain | 1.0000 |
| 14:75101150:CGCT:C | acceptor_gain | 1.0000 |
| 14:75101150:CGCTC:C | acceptor_gain | 1.0000 |
| 14:75101152:CT:C | acceptor_gain | 1.0000 |
| 14:75101152:CTCTG:C | acceptor_loss | 1.0000 |
| 14:75101153:TCTG:T | acceptor_gain | 1.0000 |
| 14:75101154:C:A | acceptor_loss | 1.0000 |
| 14:75101154:C:CC | acceptor_gain | 1.0000 |
| 14:75101154:C:G | acceptor_gain | 1.0000 |
| 14:75101155:T:A | acceptor_loss | 1.0000 |
| 14:75101166:C:CT | acceptor_gain | 1.0000 |
| 14:75101167:A:T | acceptor_gain | 1.0000 |
| 14:75101650:AACTT:A | donor_loss | 1.0000 |
| 14:75101651:ACTTA:A | donor_loss | 1.0000 |
| 14:75101652:CTTA:C | donor_loss | 1.0000 |
| 14:75101653:TTAC:T | donor_loss | 1.0000 |
| 14:75101654:TACC:T | donor_loss | 1.0000 |
| 14:75101655:A:AC | donor_gain | 1.0000 |
| 14:75101655:AC:A | donor_gain | 1.0000 |
| 14:75101655:ACCA:A | donor_loss | 1.0000 |
| 14:75101655:ACCAT:A | donor_gain | 1.0000 |
| 14:75101656:C:CG | donor_gain | 1.0000 |
AlphaMissense
3001 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 14:75071834:T:C | F421L | 0.996 |
| 14:75071836:T:A | F421L | 0.996 |
| 14:75071836:T:G | F421L | 0.996 |
| 14:75071760:G:C | R396P | 0.991 |
| 14:75071759:C:A | R396S | 0.990 |
| 14:75071766:T:C | F398S | 0.988 |
| 14:75071789:C:G | H406D | 0.983 |
| 14:75071835:T:G | F421C | 0.983 |
| 14:75071791:C:A | H406Q | 0.982 |
| 14:75071791:C:G | H406Q | 0.982 |
| 14:75071766:T:G | F398C | 0.981 |
| 14:75071744:T:C | C391R | 0.980 |
| 14:75071765:T:C | F398L | 0.978 |
| 14:75071767:C:A | F398L | 0.978 |
| 14:75071767:C:G | F398L | 0.978 |
| 14:75071801:T:A | C410S | 0.978 |
| 14:75071802:G:C | C410S | 0.978 |
| 14:75071827:G:C | R418S | 0.978 |
| 14:75071827:G:T | R418S | 0.978 |
| 14:75071861:G:C | G430R | 0.977 |
| 14:75071744:T:A | C391S | 0.976 |
| 14:75071745:G:C | C391S | 0.976 |
| 14:75071754:G:A | C394Y | 0.976 |
| 14:75077558:G:C | W455C | 0.976 |
| 14:75077558:G:T | W455C | 0.976 |
| 14:75071753:T:A | C394S | 0.975 |
| 14:75071754:G:C | C394S | 0.975 |
| 14:75071801:T:C | C410R | 0.975 |
| 14:75071803:C:G | C410W | 0.975 |
| 14:75071802:G:A | C410Y | 0.974 |
dbSNP variants (sampled 300 via entrez): RS1000008765 (14:75076708 T>C), RS1000060993 (14:75077105 T>C), RS1000300669 (14:75074258 T>C), RS1000336708 (14:75070589 C>A,T), RS1000686640 (14:75078954 G>C), RS1000738359 (14:75079319 G>GA), RS1001273923 (14:75068177 G>A), RS1001737679 (14:75074896 T>C), RS1002023672 (14:75073020 TCCC>T), RS1002275324 (14:75072022 C>T), RS1002351165 (14:75078423 A>G), RS1002405040 (14:75078754 T>G), RS1002740591 (14:75076273 T>G), RS1002775717 (14:75068894 G>C), RS1002958151 (14:75075086 C>T)
Disease associations
OMIM: gene `` | disease phenotypes:
GenCC curated gene-disease
| Disease | Classification | Inheritance |
|---|---|---|
| neurodevelopmental disorder | Limited | Autosomal recessive |
Mondo (1): neurodevelopmental disorder (MONDO:0700092)
Orphanet (0):
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
2 associations (top):
| Study | Trait | p-value |
|---|---|---|
| GCST006940_131 | Neurociticism | 1.000000e-13 |
| GCST010002_156 | Refractive error | 7.000000e-25 |
EFO canonical traits (1, from GWAS)
| EFO ID | Trait name |
|---|---|
| EFO:0007660 | neuroticism measurement |
MeSH disease descriptors (1)
| Descriptor | Name | Tree numbers |
|---|---|---|
| D065886 | Neurodevelopmental Disorders | F03.625 |
Drugs & pharmacology
Drug and pharmacology data
Is drug target: no
PharmGKB: 1 entry (VIP=true, CPIC=false)
CTD chemical–gene interactions
23 total (human), top 23 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| bisphenol A | decreases methylation, increases expression | 2 |
| dicrotophos | decreases expression | 1 |
| methylmercuric chloride | decreases expression | 1 |
| S-(1,2-dichlorovinyl)cysteine | affects response to substance, increases expression | 1 |
| abrine | increases expression | 1 |
| bisphenol S | decreases methylation | 1 |
| jinfukang | increases expression | 1 |
| (+)-JQ1 compound | decreases expression | 1 |
| Temozolomide | decreases expression | 1 |
| Sunitinib | decreases expression | 1 |
| Air Pollutants | increases abundance, increases expression | 1 |
| Benzo(a)pyrene | decreases methylation | 1 |
| Cadmium | decreases expression, increases abundance | 1 |
| Doxorubicin | decreases expression | 1 |
| Lipopolysaccharides | affects response to substance, increases expression | 1 |
| Quercetin | decreases expression | 1 |
| Smoke | decreases expression | 1 |
| Tobacco Smoke Pollution | decreases expression | 1 |
| Cyclosporine | decreases expression | 1 |
| Cadmium Chloride | decreases expression, increases abundance | 1 |
| Okadaic Acid | increases expression | 1 |
| Copper Sulfate | decreases expression | 1 |
| Particulate Matter | increases abundance, increases expression | 1 |
Clinical trials (associated diseases)
202 trials via MONDO — disease-level, not drug-specific.
| Trial | Phase | Status | Title |
|---|---|---|---|
| NCT04586348 | PHASE4 | UNKNOWN | Prenatal Iodine Supplementation and Early Childhood Neurodevelopment |
| NCT04873115 | PHASE4 | UNKNOWN | Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties, |
| NCT02559102 | PHASE3 | COMPLETED | Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants |
| NCT02757079 | PHASE3 | COMPLETED | Study of the Efficacy and Safety of NPC-15 for Sleep Disorders of Children With Neurodevelopmental Disorders |
| NCT06915480 | PHASE3 | RECRUITING | Reducing Missed Appointments |
| NCT07377032 | PHASE3 | RECRUITING | TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders |
| NCT02909959 | PHASE2 | COMPLETED | Sulforaphane for the Treatment of Young Men With Autism Spectrum Disorder |
| NCT06081348 | PHASE2 | RECRUITING | Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders |
| NCT06352372 | PHASE2 | COMPLETED | Safety and Efficacy of tPBM for Epileptiform Activity in Autism |
| NCT00503191 | PHASE1 | COMPLETED | NeuroModulation Technique Treatment of Autism |
| NCT04475848 | PHASE1 | COMPLETED | A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO6953958 in Healthy Participants |
| NCT06300398 | PHASE1 | COMPLETED | IAMA-6 Oral Dose Study in Healthy Adults |
| NCT01783041 | PHASE2/PHASE3 | COMPLETED | Effect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants |
| NCT05767385 | PHASE2/PHASE3 | RECRUITING | Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior |
| NCT05675098 | EARLY_PHASE1 | NOT_YET_RECRUITING | Central Nervous System Stimulants and Physical Function in Children With Cerebral Palsy |
| NCT00783783 | Not specified | COMPLETED | CYP2D6 Pharmacogenetics in Risperidone-Treated Children |
| NCT01778504 | Not specified | RECRUITING | Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders |
| NCT01850784 | Not specified | UNKNOWN | High Energy Formula Feeding in Infants With Congenital Heart Disease |
| NCT01922791 | Not specified | COMPLETED | Nutrition and Pregnancy Intervention Study |
| NCT01942525 | Not specified | UNKNOWN | Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants |
| NCT02003170 | Not specified | COMPLETED | Etiology and Early Diagnosis of Neurodevelopmental Disorders |
| NCT02118649 | Not specified | ACTIVE_NOT_RECRUITING | Enhancing Behavior and Brain Response to Visual Targets Using a Computer Game |
| NCT02557191 | Not specified | TERMINATED | Biomarkers, Neurodevelopment and Preterm Infants |
| NCT02690675 | Not specified | COMPLETED | Iron Supplement Effect on Child Development |
| NCT02694003 | Not specified | COMPLETED | Better Nights, Better Days for Children With Neurodevelopment Disorders |
| NCT02792894 | Not specified | COMPLETED | Family Networks (FaNs) for Children With Developmental Disorders and Delays |
| NCT02871674 | Not specified | UNKNOWN | Good Night Project: Behavioural Sleep Interventions for Children With ADHD: A Randomised Controlled Trial |
| NCT02887157 | Not specified | COMPLETED | Analyzing Retinal Microanatomy in ROP |
| NCT02898298 | Not specified | COMPLETED | Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder |
| NCT02912780 | Not specified | UNKNOWN | Introduction of Microsystems in a Level 3 Neonatal Intensive Care Unit |
| NCT03023293 | Not specified | COMPLETED | n-3 PUFAs, Irisin and Maternal Glucose Metabolism From Pregnancy to Postpartum |
| NCT03023644 | Not specified | COMPLETED | Improving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention Study |
| NCT03032991 | Not specified | UNKNOWN | Early Biomarkers of Neurodevelopment in Offspring of Diabetic Mothers |
| NCT03088189 | Not specified | TERMINATED | Effect of Parental Peri-conceptional Vitamin B12 Supplementation on Infant Neurocognitive Development in Offspring |
| NCT03096028 | Not specified | COMPLETED | Developmental Origins of Mental Health Disorders |
| NCT03148782 | Not specified | COMPLETED | Brain Plasticity Underlying Acquisition of New Organizational Skills in Children-R61 Phase |
| NCT03172104 | Not specified | COMPLETED | Neurobehavioural Development of Infants Born <30 Weeks Gestational Age Between Birth and Five Years of Age |
| NCT03222375 | Not specified | RECRUITING | SQUED™ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism |
| NCT03229928 | Not specified | COMPLETED | Clinical Testing of a Real-Time Behavior Measurement Tool: Measuring Outcomes for CHAnge |
| NCT03232489 | Not specified | UNKNOWN | Study for the Evaluation of the Feasibility of Applying Advanced MRI Scanning in Pediatric Clinical Practice |
Related Atlas pages
- Associated diseases: neurodevelopmental disorder