ZC3H11A

Summary

ZC3H11A (zinc finger CCCH-type containing 11A, HGNC:29093) is a protein-coding gene on chromosome 1q32.1, encoding Zinc finger CCCH domain-containing protein 11A (O75152). Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells.

Enables RNA binding activity. Involved in poly(A)+ mRNA export from nucleus. Located in transcription export complex.

Source: NCBI Gene 9877 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 6 total
• Druggable target: yes
• MANE Select transcript: NM_001376342

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29093
Approved symbol	ZC3H11A
Name	zinc finger CCCH-type containing 11A
Location	1q32.1
Locus type	gene with protein product
Status	Approved
Aliases	KIAA0663
Ensembl gene	ENSG00000058673
Ensembl biotype	protein_coding
OMIM	613513
Entrez	9877

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 7 protein_coding, 6 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000332127, ENST00000367210, ENST00000367212, ENST00000367214, ENST00000432282, ENST00000453771, ENST00000461980, ENST00000466470, ENST00000480354, ENST00000488411, ENST00000492823, ENST00000495527, ENST00000638800, ENST00000639812, ENST00000640465

RefSeq mRNA: 43 — MANE Select: NM_001376342 NM_001319238, NM_001319239, NM_001350261, NM_001350262, NM_001350263, NM_001350264, NM_001350265, NM_001350266, NM_001376334, NM_001376335, NM_001376336, NM_001376337, NM_001376338, NM_001376339, NM_001376340, NM_001376341, NM_001376342, NM_001376343, NM_001376344, NM_001376345, NM_001376346, NM_001376347, NM_001376348, NM_001376349, NM_001376350, NM_001376351, NM_001376352, NM_001376353, NM_001376354, NM_001376355, NM_001376356, NM_001376357, NM_001376358, NM_001376359, NM_001376360, NM_001376361, NM_001376362, NM_001376363, NM_001376364, NM_001376365, NM_001376366, NM_001376367, NM_014827

CCDS: CCDS30978

Canonical transcript exons

ENST00000367210 — 18 exons

Exon	Start	End
ENSE00001319921	203852141	203854124
ENSE00003801256	203829451	203829654
ENSE00003801368	203840306	203840374
ENSE00003802606	203847184	203847687
ENSE00003802897	203829780	203829896
ENSE00003802923	203828299	203828422
ENSE00003803290	203848331	203848407
ENSE00003803332	203818570	203818689
ENSE00003804579	203816926	203817124
ENSE00003804796	203837966	203838064
ENSE00003805674	203851057	203851124
ENSE00003805978	203833791	203833853
ENSE00003807278	203850515	203850681
ENSE00003807498	203831661	203831771
ENSE00003808199	203830123	203830203
ENSE00003809351	203801575	203803016
ENSE00003810396	203849711	203850026
ENSE00003908581	203795623	203795794

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 97.29.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.2416 / max 164.2871, expressed in 1749 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
7943	6.4221	1715
7941	1.3429	641
7942	0.4766	215

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	97.29	gold quality
endometrium	UBERON:0001295	97.08	gold quality
lymph node	UBERON:0000029	96.29	gold quality
cerebellar hemisphere	UBERON:0002245	96.25	gold quality
cerebellar cortex	UBERON:0002129	96.24	gold quality
lower esophagus mucosa	UBERON:0035834	96.20	gold quality
cerebellum	UBERON:0002037	96.18	gold quality
calcaneal tendon	UBERON:0003701	96.15	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.01	gold quality
ventricular zone	UBERON:0003053	96.00	gold quality
skin of abdomen	UBERON:0001416	95.90	gold quality
zone of skin	UBERON:0000014	95.76	gold quality
pituitary gland	UBERON:0000007	95.67	gold quality
metanephros cortex	UBERON:0010533	95.65	gold quality
skin of leg	UBERON:0001511	95.60	gold quality
body of pancreas	UBERON:0001150	95.57	gold quality
spleen	UBERON:0002106	95.55	gold quality
small intestine Peyer’s patch	UBERON:0003454	95.52	gold quality
ganglionic eminence	UBERON:0004023	95.49	gold quality
adenohypophysis	UBERON:0002196	95.46	gold quality
thyroid gland	UBERON:0002046	95.42	gold quality
body of uterus	UBERON:0009853	95.42	gold quality
left lobe of thyroid gland	UBERON:0001120	95.35	gold quality
tonsil	UBERON:0002372	95.33	gold quality
endocervix	UBERON:0000458	95.32	gold quality
bone marrow	UBERON:0002371	95.31	gold quality
adrenal tissue	UBERON:0018303	95.29	gold quality
gastrocnemius	UBERON:0001388	95.26	gold quality
small intestine	UBERON:0002108	95.26	gold quality
myometrium	UBERON:0001296	95.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.36

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ZBED6

miRNA regulators (miRDB)

123 targeting ZC3H11A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4481	100.00	66.42	1669
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502

Literature-anchored findings (GeneRIF, showing 3)

• PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. (PMID:22928037)
• Knockout of ZC3H11A in HeLa cells demonstrated that several nuclear-replicating viruses are dependent on ZC3H11A for efficient growth whereas cytoplasmic replicating viruses are not. ZC3H11A binds to short purine-rich ribonucleotide stretches in cellular and adenoviral transcripts. ZC3H11A is important for maintaining nuclear export of mRNAs during stress. Several nuclear-replicating viruses take advantage of this. (PMID:29610341)
• The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts. (PMID:37356722)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	zc3h11a	ENSDARG00000009754
mus_musculus	Zc3h11a	ENSMUSG00000102976
rattus_norvegicus		ENSRNOG00000066862
rattus_norvegicus		ENSRNOG00000075060
rattus_norvegicus		ENSRNOG00000085640

Paralogs (3): C12orf50 (ENSG00000165805), ZC3H11C (ENSG00000214558), ZC3H11B (ENSG00000215817)

Protein

Protein identifiers

Zinc finger CCCH domain-containing protein 11A — O75152 (reviewed: O75152)

All UniProt accessions (5): O75152, A0A1W2PPR9, C9J0L0, E9PBY7, E9PQ61

UniProt curated annotations — full annotation on UniProt →

Function. Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells. Binds RNA. (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export. May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA.

Subunit / interactions. Interacts with TREX complex components THOC2, DDX39 and POLDIP3; the interactions are ATP-dependent. Interacts with PABPN1; this interaction retains ZC3H11A in nuclear speckles. Interacts with KPNA3.

Subcellular location. Nucleus. Nucleus speckle.

Induction. By heat shock treatment.

RefSeq proteins (43): NP_001306167, NP_001306168, NP_001337190, NP_001337191, NP_001337192, NP_001337193, NP_001337194, NP_001337195, NP_001363263, NP_001363264, NP_001363265, NP_001363266, NP_001363267, NP_001363268, NP_001363269, NP_001363270, NP_001363271, NP_001363272, NP_001363273, NP_001363274, NP_001363275, NP_001363276, NP_001363277, NP_001363278, NP_001363279, NP_001363280, NP_001363281, NP_001363282, NP_001363283, NP_001363284, NP_001363285, NP_001363286, NP_001363287, NP_001363288, NP_001363289, NP_001363290, NP_001363291, NP_001363292, NP_001363293, NP_001363294, NP_001363295, NP_001363296, NP_055642 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000571	Znf_CCCH	Domain
IPR041686	Znf-CCCH_3	Domain

Pfam: PF15663

UniProt features (44 total): compositionally biased region 8, modified residue 7, sequence conflict 7, region of interest 6, cross-link 5, mutagenesis site 5, zinc finger region 3, chain 1, coiled-coil region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75152-F1	57.05	0.10

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (12): 108, 132, 149, 171, 290, 321, 370, 114, 124, 140, 478, 619

Mutagenesis-validated functional residues (5):

Position	Phenotype
8	loss of interaction with pabpn1, loss of localization to nuclear speckles and strong reduction in the binding to viral t
37	reduced interaction with pabpn1, decreased localization to nuclear speckles and reduced binding to viral transcripts. lo
66	loss of interaction with pabpn1, loss of localization to nuclear speckles and reduced binding to viral transcripts. loss
286–301	no effect on nuclear localization. loss of nuclear localization; when associated with 661-v–k-699 del.
661–699	no effect on nuclear localization. loss of nuclear localization; when associated with 286-a–a-301.

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187	mRNA 3’-end processing
R-HSA-73856	RNA Polymerase II Transcription Termination

MSigDB gene sets: 186 (showing top): ATACCTC_MIR202, MAZ_Q6, GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP, YY1_Q6, EFC_Q6, GOBP_NUCLEAR_TRANSPORT, MARTINEZ_RB1_TARGETS_UP, ONKEN_UVEAL_MELANOMA_UP, YY1_02, REACTOME_MRNA_3_END_PROCESSING, REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, ATTCTTT_MIR186, DODD_NASOPHARYNGEAL_CARCINOMA_UP, RYTTCCTG_ETS2_B

GO Biological Process (2): poly(A)+ mRNA export from nucleus (GO:0016973), mRNA transport (GO:0051028)

GO Molecular Function (4): RNA binding (GO:0003723), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (4): nucleoplasm (GO:0005654), nuclear speck (GO:0016607), transcription export complex (GO:0000346), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Transport of Mature Transcript to Cytoplasm	1
Processing of Capped Intron-Containing Pre-mRNA	1
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mRNA export from nucleus	1
RNA transport	1
nucleic acid binding	1
transition metal ion binding	1
binding	1
cation binding	1
nuclear lumen	1
cellular anatomical structure	1
nuclear ribonucleoprotein granule	1
nuclear protein-containing complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1368 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZC3H11A	ZBED6	P86452	980
ZC3H11A	THOC2	Q8NI27	647
ZC3H11A	SARNP	P82979	640
ZC3H11A	THOC5	Q13769	624
ZC3H11A	FYTTD1	Q96QD9	615
ZC3H11A	NCBP3	Q53F19	580
ZC3H11A	THOC6	Q86W42	579
ZC3H11A	THOC1	Q96FV9	575
ZC3H11A	DDX39A	O00148	566
ZC3H11A	THOC3	Q96J01	566
ZC3H11A	PRRC2C	Q9Y520	543
ZC3H11A	SNRPE	P08578	428
ZC3H11A	CHTOP	Q9Y3Y2	420
ZC3H11A	EDF1	O60869	412
ZC3H11A	NFAT5	O94916	406

IntAct

185 interactions, top by confidence:

A	B	Type	Score
ZC3H11A	MLH1	psi-mi:“MI:0915”(physical association)	0.870
MLH1	ZC3H11A	psi-mi:“MI:0915”(physical association)	0.870
SARNP	DDX39A	psi-mi:“MI:0914”(association)	0.740
KBTBD7	METTL15	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
NCBP2	KPNA3	psi-mi:“MI:0914”(association)	0.640
NCBP1	KPNA3	psi-mi:“MI:0914”(association)	0.640
SF3B1	SAP18	psi-mi:“MI:0914”(association)	0.640
SARNP	ZC3H11A	psi-mi:“MI:0914”(association)	0.610
XAGE1A	THAP12	psi-mi:“MI:0914”(association)	0.530
GSPT2	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
IER2	KPNA3	psi-mi:“MI:0914”(association)	0.530
ZC3H18	AQR	psi-mi:“MI:0914”(association)	0.530
NCBP3	SAP18	psi-mi:“MI:0914”(association)	0.530
ELAVL2	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
PAIP2B	CASC3	psi-mi:“MI:0914”(association)	0.530
ZC3H11A	FOXM1	psi-mi:“MI:0915”(physical association)	0.500
CPSF6	DDX39A	psi-mi:“MI:0914”(association)	0.480

BioGRID (265): ZC3H11A (Affinity Capture-MS), ZC3H11A (Affinity Capture-MS), ZC3H11A (Affinity Capture-MS), ZC3H11A (Affinity Capture-MS), ZC3H11A (Affinity Capture-MS), ZC3H11A (Affinity Capture-MS), ZC3H11A (Affinity Capture-MS), ZC3H11A (Two-hybrid), ZC3H11A (Affinity Capture-MS), ZC3H11A (Affinity Capture-MS), ZC3H11A (Affinity Capture-MS), ZC3H11A (Affinity Capture-MS), ZC3H11A (Affinity Capture-MS), ZC3H11A (Affinity Capture-MS), ZC3H11A (Affinity Capture-MS)

ESM2 similar proteins: A0A1B0GTU1, A2AUY4, B7ZS37, D3Z8Y2, D4A4L4, D4A666, E1B7L7, O46385, O60293, O75152, O95425, P0DQW0, Q08AZ1, Q3KQW7, Q3U1C4, Q3UH68, Q3ZC82, Q4G0F8, Q4V9H5, Q5F3Z9, Q5NBX1, Q5REG6, Q5ZJJ1, Q5ZM88, Q61464, Q62394, Q68FE9, Q6NZF1, Q6PJT7, Q6ZQ03, Q6ZU65, Q76L83, Q7TMD5, Q8BHZ4, Q8BJ05, Q8BLG0, Q8BZ32, Q8C9B9, Q8CCJ9, Q8K298

Diamond homologs: A0A1B0GTU1, O75152, P0DQW0, Q32KY7, Q4R731, Q5REG6, Q5ZJJ1, Q6AYU0, Q6NZF1, Q8NA57, Q6K977

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
ZC3H11A	“up-regulates activity”	“TREX complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 198 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Transport of Mature Transcript to Cytoplasm	14	39.8×	3e-18
mRNA 3’-end processing	22	32.3×	3e-26
RNA Polymerase II Transcription Termination	18	29.5×	1e-20
Transport of Mature mRNA derived from an Intron-Containing Transcript	22	25.0×	1e-23
Processing of Capped Intron-Containing Pre-mRNA	34	20.9×	8e-34
mRNA Splicing	24	19.7×	4e-23
mRNA Polyadenylation	29	19.0×	2e-27
mRNA Splicing - Major Pathway	42	17.1×	2e-38

GO biological processes:

GO term	Partners	Fold	FDR
RNA export from nucleus	6	31.7×	2e-06
negative regulation of mRNA splicing, via spliceosome	7	30.3×	4e-07
regulation of mRNA splicing, via spliceosome	6	30.1×	3e-06
mRNA export from nucleus	17	28.4×	4e-18
alternative mRNA splicing, via spliceosome	7	26.7×	7e-07
positive regulation of transcription by RNA polymerase III	5	26.4×	7e-05
U2-type prespliceosome assembly	7	24.7×	1e-06
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	8	21.2×	5e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

6 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	2
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3006 predictions. Top by Δscore:

Variant	Effect	Δscore
1:203795749:G:GT	donor_gain	1.0000
1:203801627:GT:G	donor_gain	1.0000
1:203816921:TTTA:T	acceptor_loss	1.0000
1:203816922:TTA:T	acceptor_loss	1.0000
1:203816923:TA:T	acceptor_loss	1.0000
1:203816924:A:AG	acceptor_gain	1.0000
1:203816924:A:C	acceptor_loss	1.0000
1:203816925:G:GG	acceptor_gain	1.0000
1:203816925:G:GT	acceptor_loss	1.0000
1:203817019:G:GT	donor_gain	1.0000
1:203817084:G:GT	donor_gain	1.0000
1:203817125:G:GG	donor_gain	1.0000
1:203818566:ACAG:A	acceptor_gain	1.0000
1:203818567:CAG:C	acceptor_loss	1.0000
1:203818568:A:AG	acceptor_gain	1.0000
1:203818568:A:AT	acceptor_loss	1.0000
1:203818568:AG:A	acceptor_gain	1.0000
1:203818568:AGG:A	acceptor_gain	1.0000
1:203818568:AGGGT:A	acceptor_gain	1.0000
1:203818569:G:A	acceptor_gain	1.0000
1:203818569:G:GT	acceptor_gain	1.0000
1:203818569:GGG:G	acceptor_gain	1.0000
1:203818569:GGGT:G	acceptor_gain	1.0000
1:203818569:GGGTG:G	acceptor_gain	1.0000
1:203818685:TTGAT:T	donor_gain	1.0000
1:203818686:TGAT:T	donor_gain	1.0000
1:203818687:GAT:G	donor_gain	1.0000
1:203818687:GATG:G	donor_gain	1.0000
1:203818688:AT:A	donor_gain	1.0000
1:203818689:TGTA:T	donor_loss	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000050843 (1:203840605 A>T), RS1000067608 (1:203834155 C>A,T), RS1000116443 (1:203852625 G>A), RS1000116729 (1:203818780 T>A), RS1000181035 (1:203811834 T>C), RS1000196772 (1:203805891 A>G), RS1000212804 (1:203846971 C>T), RS1000273857 (1:203852966 A>C,G), RS1000352734 (1:203846208 G>A), RS1000412682 (1:203846569 T>A,C), RS1000485729 (1:203813478 A>T), RS1000529494 (1:203810722 T>A), RS1000580159 (1:203813842 A>G), RS1000599083 (1:203807201 T>G), RS1000686170 (1:203847994 T>A)

Disease associations

OMIM: gene MIM:613513 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002537_1	Breast cancer	9.000000e-09
GCST006661_122	Male-pattern baldness	1.000000e-15
GCST006661_16	Male-pattern baldness	2.000000e-13
GCST006661_4	Male-pattern baldness	8.000000e-14

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067018 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.83	Kd	148.8	nM	CHEMBL3752910
6.83	ED50	148.8	nM	CHEMBL3752910
5.41	Kd	3881	nM	CHEMBL5653589
5.41	ED50	3881	nM	CHEMBL5653589

PubChem BioAssay actives

2 with measured affinity, of 4 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149806: Binding affinity to human ZC3H11A incubated for 45 mins by Kinobead based pull down assay	kd	0.1488	uM
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149806: Binding affinity to human ZC3H11A incubated for 45 mins by Kinobead based pull down assay	kd	3.8807	uM

CTD chemical–gene interactions

41 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression, increases expression	2
aristolochic acid I	decreases expression	1
bisphenol F	affects cotreatment, increases expression	1
TAK-243	decreases sumoylation	1
geldanamycin	increases expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
bisphenol A	decreases expression, increases methylation	1
trichostatin A	decreases expression	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	affects binding, decreases reaction	1
coumarin	affects phosphorylation	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	increases reaction, affects binding	1
K 7174	increases expression	1
bisphenol S	affects cotreatment, decreases expression	1
Rosiglitazone	decreases reaction, increases expression	1
Pioglitazone	decreases reaction, increases expression	1
Arsenic Trioxide	decreases expression	1
Troglitazone	decreases reaction, increases expression	1
Vorinostat	decreases expression	1
Acrolein	decreases expression, increases abundance, affects cotreatment	1
Air Pollutants	affects cotreatment, decreases expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Caffeine	affects phosphorylation	1
Dexamethasone	affects cotreatment, increases expression, decreases expression	1
Endosulfan	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Indomethacin	affects cotreatment, increases expression, decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652848	Binding	Binding affinity to human ZC3H11A incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A8B4	SEES3-1V human ZC3H11A, clone1	Embryonic stem cell	Male
CVCL_A8B5	SEES3-1V human ZC3H11A, clone2	Embryonic stem cell	Male
CVCL_A8B6	SEES3-1V human ZC3H11A, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.