ZC3H13

Summary

ZC3H13 (zinc finger CCCH-type containing 13, HGNC:20368) is a protein-coding gene on chromosome 13q14.13, encoding Zinc finger CCCH domain-containing protein 13 (Q5T200). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. It is a selective cancer dependency (DepMap: 30.5% of cell lines).

Enables RNA binding activity. Involved in mRNA processing. Located in nuclear speck. Part of RNA N6-methyladenosine methyltransferase complex.

Source: NCBI Gene 23091 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 220 total
• Cancer dependency (DepMap): dependent in 30.5% of screened cell lines
• MANE Select transcript: NM_001330564

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20368
Approved symbol	ZC3H13
Name	zinc finger CCCH-type containing 13
Location	13q14.13
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp434D1812, Xio
Ensembl gene	ENSG00000123200
Ensembl biotype	protein_coding
OMIM	616453
Entrez	23091

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 26 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000242848, ENST00000282007, ENST00000428921, ENST00000464597, ENST00000470308, ENST00000679008, ENST00000929085, ENST00000929086, ENST00000929087, ENST00000929088, ENST00000929089, ENST00000929090, ENST00000929091, ENST00000929092, ENST00000929094, ENST00000929095, ENST00000929096, ENST00000929097, ENST00000929098, ENST00000929099, ENST00000929100, ENST00000929101, ENST00000929102, ENST00000929103, ENST00000929104, ENST00000929105, ENST00000929106, ENST00000929107

RefSeq mRNA: 15 — MANE Select: NM_001330564 NM_001076788, NM_001330564, NM_001330565, NM_001330566, NM_001330567, NM_001382206, NM_001382207, NM_001382208, NM_001382209, NM_001382210, NM_001382211, NM_001382212, NM_001382213, NM_001382214, NM_015070

CCDS: CCDS81766, CCDS91804, CCDS9400

Canonical transcript exons

ENST00000679008 — 19 exons

Exon	Start	End
ENSE00001130342	45963842	45964042
ENSE00001130349	45965280	45965432
ENSE00001130365	45968748	45969971
ENSE00001180285	45954465	45957297
ENSE00001244878	45959483	45959646
ENSE00001244894	45967504	45968028
ENSE00001479355	46052404	46052746
ENSE00001596141	45970362	45970465
ENSE00001622638	46020449	46020557
ENSE00001668949	45975283	45975838
ENSE00001718452	46011415	46011554
ENSE00001722138	45988787	45989097
ENSE00001736769	46044955	46045064
ENSE00001757400	45985297	45985761
ENSE00001785865	45979813	45980004
ENSE00002204906	46042164	46042275
ENSE00003619090	46010348	46010505
ENSE00003664848	46003139	46003336
ENSE00003908294	46045391	46045516

Expression profiles

Bgee: expression breadth ubiquitous, 296 present calls, max score 97.47.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 45.5773 / max 4559.0289, expressed in 1813 samples.

FANTOM5 promoters (25 alternative TSS)

Promoter ID	TPM avg	Samples expressed
137154	33.1312	1812
137116	1.6344	737
137128	1.1444	341
137146	0.8259	331
137118	0.7962	272
137127	0.7947	297
137125	0.7146	296
137115	0.7052	323
137138	0.6287	262
137112	0.5951	250

Top tissues by expression

302 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.47	gold quality
calcaneal tendon	UBERON:0003701	95.96	gold quality
secondary oocyte	CL:0000655	94.20	gold quality
tibia	UBERON:0000979	93.67	gold quality
corpus callosum	UBERON:0002336	93.58	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.25	gold quality
cranial nerve II	UBERON:0000941	92.95	gold quality
cauda epididymis	UBERON:0004360	92.92	gold quality
right lobe of liver	UBERON:0001114	92.85	gold quality
cortical plate	UBERON:0005343	92.77	gold quality
subthalamic nucleus	UBERON:0001906	92.51	gold quality
superficial temporal artery	UBERON:0001614	92.49	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	92.29	gold quality
embryo	UBERON:0000922	91.81	gold quality
blood vessel layer	UBERON:0004797	91.75	gold quality
lateral globus pallidus	UBERON:0002476	91.74	gold quality
corpus epididymis	UBERON:0004359	91.60	gold quality
parietal pleura	UBERON:0002400	91.55	gold quality
gluteal muscle	UBERON:0002000	91.49	gold quality
ganglionic eminence	UBERON:0004023	91.44	gold quality
caput epididymis	UBERON:0004358	91.37	gold quality
oocyte	CL:0000023	91.35	gold quality
pleura	UBERON:0000977	91.34	gold quality
liver	UBERON:0002107	91.33	gold quality
medulla oblongata	UBERON:0001896	91.21	gold quality
colonic epithelium	UBERON:0000397	91.18	gold quality
visceral pleura	UBERON:0002401	91.18	gold quality
superior vestibular nucleus	UBERON:0007227	91.11	gold quality
postcentral gyrus	UBERON:0002581	91.03	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	90.94	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-7606	no	347.97
E-CURD-112	no	2.19
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

101 targeting ZC3H13, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-4778-3P	99.93	70.40	1818
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778
HSA-MIR-302D-3P	99.89	71.25	1777
HSA-MIR-3681-3P	99.88	70.46	2254

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 30.5% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 9)

• This study identified ZC3H13 significantly associated loci with a biologically plausible role in schizophrenia. (PMID:24507884)
• The current study indicated that ZC3H13 may be an upstream regulator of Ras-ERK signaling pathway and suppressed invasion and proliferation of colorectal cancer. (PMID:30311220)
• ZC3H13-mediated N6-methyladenosine modification of PHF10 is impaired by fisetin which inhibits the DNA damage response in pancreatic cancer. (PMID:35033590)
• Downregulation of ZC3H13 by miR-362-3p/miR-425-5p is associated with a poor prognosis and adverse outcomes in hepatocellular carcinoma. (PMID:35278064)
• N(6)-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance. (PMID:35418160)
• Identification and validation of the N6-methyladenosine RNA methylation regulator ZC3H13 as a novel prognostic marker and potential target for hepatocellular carcinoma. (PMID:35582419)
• Enterovirus 71 VP1 promotes 5-HT release by upregulating the expression of ERICH3 and methyltransferase ZC3H13. (PMID:35660571)
• ZC3H13 reduced DUOX1-mediated ferroptosis in laryngeal squamous cell carcinoma cells through m6A-dependent modification. (PMID:37536262)
• ZC3H13 Accelerates Keloid Formation by Mediating N[6]-methyladenosine Modification of HIPK2. (PMID:37752292)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	zc3h13	ENSDARG00000037177
mus_musculus	Zc3h13	ENSMUSG00000022000
rattus_norvegicus	Zc3h13	ENSRNOG00000011237

Protein

Protein identifiers

Zinc finger CCCH domain-containing protein 13 — Q5T200 (reviewed: Q5T200)

All UniProt accessions (3): A0A087WX14, A0A7I2V4I5, Q5T200

UniProt curated annotations — full annotation on UniProt →

Function. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3’-UTR. Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation. In the WMM complex, anchors component of the MACOM subcomplex in the nucleus. Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B).

Subunit / interactions. Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. The MAC subcomplex is composed of METTL3 and METTL14. The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B). Also a component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, RBM15, BCLAF1 and THRAP3.

Subcellular location. Nucleus speckle. Nucleus. Nucleoplasm.

Similarity. Belongs to the ZC3H13 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q5T200-1	1	yes
Q5T200-2	2

RefSeq proteins (15): NP_001070256, NP_001317493, NP_001317494, NP_001317495, NP_001317496, NP_001369135, NP_001369136, NP_001369137, NP_001369138, NP_001369139, NP_001369140, NP_001369141, NP_001369142, NP_001369143, NP_055885 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000571	Znf_CCCH	Domain
IPR036855	Znf_CCCH_sf	Homologous_superfamily
IPR052824	m6A_RNA_Methylation_Regulator	Family

Pfam: PF00642

UniProt features (109 total): modified residue 55, compositionally biased region 26, helix 8, region of interest 4, strand 3, splice variant 3, coiled-coil region 2, cross-link 2, sequence conflict 2, chain 1, zinc finger region 1, turn 1, sequence variant 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7VF2	ELECTRON MICROSCOPY	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T200-F1	47.73	0.03

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (57): 1453, 1456, 1466, 64, 77, 198, 207, 209, 211, 237, 238, 242, 263, 265, 316, 318, 325, 328, 354, 364 …

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 126 (showing top): WEI_MYCN_TARGETS_WITH_E_BOX, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, GOBP_RNA_SPLICING, GOBP_MAINTENANCE_OF_CELL_NUMBER, GOBP_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, RIGGI_EWING_SARCOMA_PROGENITOR_UP, chr13q14, TGGAAA_NFAT_Q4_01, GOCC_NUCLEAR_SPECK, GOCC_TRANSFERASE_COMPLEX, GOCC_NUCLEAR_BODY, GOCC_RIBONUCLEOPROTEIN_GRANULE, GOCC_METHYLTRANSFERASE_COMPLEX, SCGGAAGY_ELK1_02

GO Biological Process (3): mRNA processing (GO:0006397), RNA splicing (GO:0008380), regulation of stem cell population maintenance (GO:2000036)

GO Molecular Function (4): RNA binding (GO:0003723), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (4): nucleus (GO:0005634), nucleoplasm (GO:0005654), nuclear speck (GO:0016607), RNA N6-methyladenosine methyltransferase complex (GO:0036396)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
mRNA metabolic process	1
stem cell population maintenance	1
regulation of developmental process	1
regulation of multicellular organismal process	1
nucleic acid binding	1
transition metal ion binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
nuclear ribonucleoprotein granule	1
methyltransferase complex	1

Protein interactions and networks

STRING

2152 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZC3H13	WTAP	Q15007	998
ZC3H13	VIRMA	Q69YN4	998
ZC3H13	CBLL1	Q75N03	998
ZC3H13	METTL3	Q86U44	998
ZC3H13	RBM15B	Q8NDT2	998
ZC3H13	RBM15	Q96T37	998
ZC3H13	METTL14	Q9HCE5	998
ZC3H13	METTL16	Q86W50	997
ZC3H13	ZCCHC4	Q9H5U6	946
ZC3H13	YTHDC1	Q96MU7	934
ZC3H13	METTL5	Q9NRN9	924
ZC3H13	YTHDC2	Q9H6S0	896
ZC3H13	ALKBH5	Q6P6C2	891
ZC3H13	YTHDF1	Q9BYJ9	885
ZC3H13	YTHDF2	Q9Y5A9	854

IntAct

85 interactions, top by confidence:

A	B	Type	Score
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
ZC3H18	AQR	psi-mi:“MI:0914”(association)	0.530
EZH1	EPOP	psi-mi:“MI:0914”(association)	0.530
CHD8	ACOT7	psi-mi:“MI:0914”(association)	0.500
ZC3H13	PTGES3	psi-mi:“MI:0915”(physical association)	0.400
ZC3H13	RAB34	psi-mi:“MI:0915”(physical association)	0.400
ZC3H13	PDCD11	psi-mi:“MI:0915”(physical association)	0.400
ZC3H13	YWHAZ	psi-mi:“MI:0915”(physical association)	0.400
THOC1	TARS3	psi-mi:“MI:0914”(association)	0.350
MZT1	ZC3H18	psi-mi:“MI:0914”(association)	0.350
ID1	TCF3	psi-mi:“MI:0914”(association)	0.350
KIF26B	CASK	psi-mi:“MI:0914”(association)	0.350
CBR1	DENND3	psi-mi:“MI:0914”(association)	0.350
METTL3	TUBAL3	psi-mi:“MI:0914”(association)	0.350
WTAP	DDX39A	psi-mi:“MI:0914”(association)	0.350
METTL14	HMGB1P1	psi-mi:“MI:0914”(association)	0.350
METTL3	TRIM28	psi-mi:“MI:0914”(association)	0.350
METTL14	TRIM28	psi-mi:“MI:0914”(association)	0.350
WTAP	TRIM28	psi-mi:“MI:0914”(association)	0.350
VIRMA	WTAP	psi-mi:“MI:0914”(association)	0.350
CLK3	USP9Y	psi-mi:“MI:0914”(association)	0.350
CBLL2	SRSF10	psi-mi:“MI:0914”(association)	0.350
GAN	ZMYM3	psi-mi:“MI:0914”(association)	0.350
YWHAG	C1orf226	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
DDOST	ATL3	psi-mi:“MI:0914”(association)	0.350
OST4	ATL3	psi-mi:“MI:0914”(association)	0.350
RNF40	HNRNPR	psi-mi:“MI:0914”(association)	0.350
YWHAG	FOXO6	psi-mi:“MI:0914”(association)	0.350

BioGRID (201): ZC3H13 (Affinity Capture-MS), ZC3H13 (Affinity Capture-MS), ZC3H13 (Affinity Capture-MS), ZC3H13 (Co-fractionation), ZC3H13 (Co-fractionation), ZC3H13 (Synthetic Lethality), ZC3H13 (Biochemical Activity), ZC3H13 (Biochemical Activity), ZC3H13 (Affinity Capture-MS), ZC3H13 (Affinity Capture-MS), ZC3H13 (Affinity Capture-MS), ZC3H13 (Affinity Capture-MS), ZC3H13 (Affinity Capture-MS), ZC3H13 (Affinity Capture-MS), ZC3H13 (Affinity Capture-MS)

ESM2 similar proteins: A2AR02, A6QLS2, B0BN49, B5DE93, D2H526, E1BB50, E9Q5K9, E9Q784, O35986, O55035, O74418, P30414, P30415, Q13427, Q14AX6, Q19QU3, Q27450, Q3KPW4, Q3MJK5, Q3UC65, Q4R626, Q4V8I5, Q4V9W2, Q505I5, Q5BKY9, Q5R580, Q5R8J6, Q5RJP9, Q5T200, Q5U2S0, Q5VTL8, Q5XHJ5, Q5ZLM8, Q6AXY7, Q6P7Y3, Q7L4I2, Q80SY5, Q8N9E0, Q8N9Q2, Q8R0F5

Diamond homologs: E9Q784, Q5T200

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 117 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Transport of Mature Transcript to Cytoplasm	6	30.4×	2e-06
mRNA 3’-end processing	10	26.2×	3e-10
Transport of Mature mRNA derived from an Intron-Containing Transcript	10	20.3×	3e-09
Processing of Capped Intron-Containing Pre-mRNA	17	18.6×	7e-15
mRNA Splicing	12	17.6×	3e-10
RNA Polymerase II Transcription Termination	6	17.6×	4e-05
mRNA Splicing - Minor Pathway	5	14.9×	7e-04
mRNA Splicing - Major Pathway	17	12.4×	3e-12

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of mRNA splicing, via spliceosome	5	39.9×	2e-05
RNA splicing, via transesterification reactions	5	32.5×	4e-05
regulation of alternative mRNA splicing, via spliceosome	9	22.9×	3e-08
mRNA export from nucleus	5	15.4×	1e-03
mRNA splicing, via spliceosome	14	13.4×	6e-10
mRNA processing	15	12.3×	6e-10
RNA splicing	10	9.2×	2e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

220 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	193
Likely benign	10
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3094 predictions. Top by Δscore:

Variant	Effect	Δscore
13:45964043:C:CC	acceptor_gain	1.0000
13:45965275:GTTAC:G	donor_loss	1.0000
13:45965277:TACCT:T	donor_loss	1.0000
13:45965278:A:AT	donor_loss	1.0000
13:45965279:C:CT	donor_loss	1.0000
13:45965428:TCCTG:T	acceptor_gain	1.0000
13:45965429:CCTG:C	acceptor_loss	1.0000
13:45965429:CCTGC:C	acceptor_gain	1.0000
13:45965430:CTG:C	acceptor_gain	1.0000
13:45965432:GC:G	acceptor_loss	1.0000
13:45965433:C:CC	acceptor_gain	1.0000
13:45965433:CTA:C	acceptor_loss	1.0000
13:45965434:T:G	acceptor_loss	1.0000
13:45965437:A:C	acceptor_gain	1.0000
13:45967373:T:TA	donor_gain	1.0000
13:45967499:CTCA:C	donor_loss	1.0000
13:45967500:TCA:T	donor_loss	1.0000
13:45967501:CACCT:C	donor_loss	1.0000
13:45967502:A:AC	donor_gain	1.0000
13:45967502:ACCTT:A	donor_gain	1.0000
13:45967503:C:CA	donor_loss	1.0000
13:45967503:C:CC	donor_gain	1.0000
13:45967503:CCTT:C	donor_gain	1.0000
13:45967503:CCTTC:C	donor_gain	1.0000
13:45970356:GCTTA:G	donor_loss	1.0000
13:45970357:CTTAC:C	donor_loss	1.0000
13:45970358:TTA:T	donor_loss	1.0000
13:45970359:TA:T	donor_loss	1.0000
13:45970360:A:AC	donor_gain	1.0000
13:45970360:AC:A	donor_loss	1.0000

AlphaMissense

10952 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:45959531:G:C	C1596W	1.000
13:45959533:A:G	C1596R	1.000
13:45964016:A:G	W1500R	1.000
13:45964016:A:T	W1500R	1.000
13:45965345:A:G	L1469P	1.000
13:45965360:A:T	I1464N	1.000
13:45969343:C:A	W1067C	1.000
13:45969343:C:G	W1067C	1.000
13:45969345:A:G	W1067R	1.000
13:45969345:A:T	W1067R	1.000
13:46011464:A:G	L180P	1.000
13:46011473:A:G	L177S	1.000
13:46011482:T:G	Q174P	1.000
13:46011485:A:C	I173R	1.000
13:46011485:A:G	I173T	1.000
13:46011485:A:T	I173K	1.000
13:46011491:T:G	Q171P	1.000
13:46011494:C:G	R170P	1.000
13:46011495:G:T	R170S	1.000
13:46011512:A:G	L164S	1.000
13:46045011:A:C	C57W	1.000
13:46045012:C:G	C57S	1.000
13:46045012:C:T	C57Y	1.000
13:46045013:A:G	C57R	1.000
13:46045013:A:T	C57S	1.000
13:46045029:G:C	C51W	1.000
13:46045030:C:G	C51S	1.000
13:46045030:C:T	C51Y	1.000
13:46045031:A:G	C51R	1.000
13:46045031:A:T	C51S	1.000

dbSNP variants (sampled 300 via entrez): RS1000000690 (13:45961196 CAT>C), RS1000019695 (13:46007735 T>C), RS1000031261 (13:45957385 A>G), RS1000046731 (13:46054357 T>C), RS1000071825 (13:45991660 T>C,G), RS1000092028 (13:46004464 C>T), RS1000153169 (13:46048161 T>C), RS1000194252 (13:46038105 A>G), RS1000233024 (13:45988022 T>C,G), RS1000241711 (13:45954782 TGTA>T), RS1000244151 (13:45987714 C>A,T), RS1000263412 (13:45976881 A>G), RS1000279352 (13:46046208 T>C), RS1000286118 (13:46048337 G>A), RS1000290231 (13:46039734 T>C)

Disease associations

OMIM: gene MIM:616453 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003134_12	Cerebrospinal fluid clusterin levels	5.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Valproic Acid	decreases expression, decreases methylation	2
FR900359	affects phosphorylation	1
TAK-243	decreases sumoylation	1
triphenyl phosphate	affects expression	1
nickel sulfate	decreases expression	1
coumarin	decreases phosphorylation	1
pentanal	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	decreases methylation	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	affects response to substance	1
Acetaminophen	decreases expression	1
Arsenic	increases expression	1
Caffeine	affects phosphorylation	1
Carmustine	affects response to substance	1
Cisplatin	decreases expression	1
Enzyme Inhibitors	increases O-linked glycosylation, decreases activity	1
Formaldehyde	decreases expression	1
Indomethacin	decreases expression	1
Ivermectin	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Quercetin	decreases phosphorylation	1
Ribonucleotides	affects binding	1
Sodium Dodecyl Sulfate	increases expression	1
Dronabinol	increases expression	1
Thiram	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_F1QI	HyCyte HGC-27 KO-hZC3H13	Cancer cell line	Sex unspecified

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.