ZC3H18

Summary

ZC3H18 (zinc finger CCCH-type containing 18, HGNC:25091) is a protein-coding gene on chromosome 16q24.2, encoding Zinc finger CCCH domain-containing protein 18 (Q86VM9). It is a selective cancer dependency (DepMap: 73.7% of cell lines).

Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in RNA destabilization. Located in nuclear speck. Part of ribonucleoprotein complex.

Source: NCBI Gene 124245 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 182 total — 1 pathogenic
• Druggable target: yes — 1 molecules with ChEMBL bioactivity
• Cancer dependency (DepMap): dependent in 73.7% of screened cell lines
• MANE Select transcript: NM_144604

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25091
Approved symbol	ZC3H18
Name	zinc finger CCCH-type containing 18
Location	16q24.2
Locus type	gene with protein product
Status	Approved
Aliases	NHN1
Ensembl gene	ENSG00000158545
Ensembl biotype	protein_coding
Entrez	124245

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 17 protein_coding, 6 retained_intron

ENST00000301011, ENST00000452588, ENST00000563382, ENST00000564161, ENST00000564341, ENST00000565583, ENST00000566317, ENST00000566496, ENST00000566660, ENST00000567085, ENST00000568072, ENST00000569435, ENST00000867278, ENST00000867279, ENST00000867280, ENST00000867281, ENST00000929536, ENST00000929537, ENST00000929538, ENST00000967030, ENST00000967031, ENST00000967032, ENST00000967033

RefSeq mRNA: 2 — MANE Select: NM_144604 NM_001294340, NM_144604

CCDS: CCDS10967, CCDS73924

Canonical transcript exons

ENST00000301011 — 18 exons

Exon	Start	End
ENSE00001113653	88599791	88599948
ENSE00001113654	88570403	88570566
ENSE00001113660	88608934	88609051
ENSE00001113662	88598620	88598712
ENSE00001113671	88586600	88586684
ENSE00001120966	88598178	88598326
ENSE00001366026	88577110	88577726
ENSE00001885661	88631101	88631964
ENSE00002470017	88623958	88624062
ENSE00002480492	88627622	88627782
ENSE00002495146	88625202	88625267
ENSE00002498562	88622197	88622388
ENSE00002508148	88624602	88624745
ENSE00002522866	88623219	88623344
ENSE00003514896	88628758	88628854
ENSE00003559614	88611268	88611536
ENSE00003584956	88627920	88628119
ENSE00003611550	88630485	88630581

Expression profiles

Bgee: expression breadth ubiquitous, 243 present calls, max score 94.24.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 25.7214 / max 244.7140, expressed in 1815 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155536	23.4639	1812
155537	0.8848	602
155538	0.7451	377
208004	0.6276	393

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.24	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.83	gold quality
cerebellar hemisphere	UBERON:0002245	92.50	gold quality
cerebellar cortex	UBERON:0002129	92.36	gold quality
right testis	UBERON:0004534	92.26	gold quality
left testis	UBERON:0004533	92.19	gold quality
granulocyte	CL:0000094	91.74	gold quality
cerebellum	UBERON:0002037	91.48	gold quality
cardiac muscle of right atrium	UBERON:0003379	90.89	gold quality
spleen	UBERON:0002106	90.59	gold quality
right lobe of thyroid gland	UBERON:0001119	90.56	gold quality
testis	UBERON:0000473	90.10	gold quality
mucosa of transverse colon	UBERON:0004991	90.06	gold quality
vermiform appendix	UBERON:0001154	89.97	gold quality
apex of heart	UBERON:0002098	89.90	gold quality
lower esophagus muscularis layer	UBERON:0035833	89.85	gold quality
lower esophagus	UBERON:0013473	89.82	gold quality
body of uterus	UBERON:0009853	89.77	gold quality
muscle layer of sigmoid colon	UBERON:0035805	89.65	gold quality
bone marrow cell	CL:0002092	89.64	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	89.64	gold quality
small intestine Peyer’s patch	UBERON:0003454	89.59	gold quality
left lobe of thyroid gland	UBERON:0001120	89.56	gold quality
left uterine tube	UBERON:0001303	89.52	gold quality
ventricular zone	UBERON:0003053	89.48	gold quality
right ovary	UBERON:0002118	89.38	gold quality
gastrocnemius	UBERON:0001388	89.27	gold quality
upper lobe of left lung	UBERON:0008952	89.20	gold quality
ganglionic eminence	UBERON:0004023	89.10	gold quality
embryo	UBERON:0000922	89.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.59

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

22 targeting ZC3H18, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-3617-5P	99.75	69.41	1968
HSA-MIR-641	99.75	69.35	1975
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-7152-5P	99.60	69.33	2094
HSA-MIR-4505	99.27	67.81	2678
HSA-MIR-5787	99.22	67.86	2628
HSA-MIR-6815-3P	99.13	68.98	1530
HSA-MIR-4742-3P	98.73	69.82	1803
HSA-MIR-644A	96.02	66.52	786
HSA-MIR-4524B-3P	95.52	64.12	964
HSA-MIR-3672	94.46	65.67	646
HSA-MIR-6864-3P	94.46	65.97	625
HSA-MIR-604	93.13	64.42	299

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 73.7% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 3)

• examination of ZC3H18 function, by genome-wide analyses, demonstrated its impact on transcription of a subset of protein-coding genes. This activity requires the CBC-interacting domain of the protein, with some genes being also dependent on the NEXT- and/or histone-interacting domains. (PMID:29298432)
• ZC3H18 copy number losses could contribute to homologous recombination defects in high-grade serous ovarian cancers. (PMID:31604914)
• NCBP3 positively impacts mRNA biogenesis. (PMID:32960271)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	zc3h18	ENSDARG00000062506
mus_musculus	Zc3h18	ENSMUSG00000017478
rattus_norvegicus	Zc3h18	ENSRNOG00000028501
drosophila_melanogaster	CG1677	FBGN0029941
drosophila_melanogaster	CG31601	FBGN0051601

Paralogs (2): PPP1R10 (ENSG00000204569), PRR3 (ENSG00000204576)

Protein

Protein identifiers

Zinc finger CCCH domain-containing protein 18 — Q86VM9 (reviewed: Q86VM9)

Alternative names: Nuclear protein NHN1

All UniProt accessions (6): E7ERS3, Q86VM9, H3BP01, H3BPD0, H3BRH3, H3BRN6

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Interacts with ZFC3H1 in a RNase-insensitive manner.

Subcellular location. Nucleus.

RefSeq proteins (2): NP_001281269, NP_653205* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000571	Znf_CCCH	Domain
IPR036855	Znf_CCCH_sf	Homologous_superfamily
IPR041367	Znf-CCCH_4	Domain
IPR052647	Zinc_finger_CCCH-type	Family

Pfam: PF18044

UniProt features (65 total): modified residue 27, compositionally biased region 22, cross-link 6, coiled-coil region 3, region of interest 2, sequence variant 2, chain 1, zinc finger region 1, sequence conflict 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
9T3X	ELECTRON MICROSCOPY	2.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86VM9-F1	53.22	0.05

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (33): 1, 6, 34, 46, 53, 59, 67, 74, 78, 83, 95, 109, 110, 118, 162, 173, 179, 487, 532, 534 …

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9930044	Nuclear RNA decay

MSigDB gene sets: 91 (showing top): GOBP_MACROMOLECULE_CATABOLIC_PROCESS, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, NIKOLSKY_BREAST_CANCER_16Q24_AMPLICON, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS, TGIF_01, ATTCTTT_MIR186, AACTTT_UNKNOWN, CREB_Q3, PTF1BETA_Q6, REACTOME_METABOLISM_OF_RNA, GOCC_NUCLEAR_SPECK, GOCC_NUCLEAR_BODY

GO Biological Process (1): RNA destabilization (GO:0050779)

GO Molecular Function (6): RNA binding (GO:0003723), zinc ion binding (GO:0008270), protein-macromolecule adaptor activity (GO:0030674), mRNA cap binding complex binding (GO:0140262), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (5): nucleoplasm (GO:0005654), nuclear speck (GO:0016607), protein-containing complex (GO:0032991), ribonucleoprotein complex (GO:1990904), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Metabolism of RNA	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA catabolic process	1
positive regulation of catabolic process	1
regulation of RNA stability	1
positive regulation of RNA metabolic process	1
nucleic acid binding	1
transition metal ion binding	1
protein binding	1
molecular adaptor activity	1
protein-containing complex binding	1
binding	1
cation binding	1
nuclear lumen	1
cellular anatomical structure	1
nuclear ribonucleoprotein granule	1
cellular_component	1
protein-containing complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

2971 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZC3H18	THOC2	Q8NI27	713
ZC3H18	SLAIN2	Q9P270	528
ZC3H18	ZCCHC8	Q6NZY4	512
ZC3H18	ALYREF	Q86V81	509
ZC3H18	RBM7	Q9Y580	475
ZC3H18	SLBP	Q14493	466
ZC3H18	MTREX	P42285	413
ZC3H18	NCBP1	Q09161	397
ZC3H18	SRRT	Q9BXP5	393
ZC3H18	ZFC3H1	O60293	380
ZC3H18	LEMD2	Q8NC56	358
ZC3H18	TTC14	Q96N46	349
ZC3H18	PHAX	Q9H814	348
ZC3H18	FRYL	O94915	347
ZC3H18	NCBP2	P52298	325
ZC3H18	TMEM132D	Q14C87	325

IntAct

229 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
ZC3H18	E	psi-mi:“MI:0915”(physical association)	0.660
CARNMT1	NUP42	psi-mi:“MI:0914”(association)	0.640
NCBP2	KPNA3	psi-mi:“MI:0914”(association)	0.640
CAMKV	AP3B1	psi-mi:“MI:0914”(association)	0.640
SF3B1	SAP18	psi-mi:“MI:0914”(association)	0.640
BCOR	CBX4	psi-mi:“MI:0914”(association)	0.530
PCGF1	CBX4	psi-mi:“MI:0914”(association)	0.530
PTGER3	PIK3R2	psi-mi:“MI:0914”(association)	0.530
ERMAP	AP3B1	psi-mi:“MI:0914”(association)	0.530
GSPT2	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
RSBN1	SETD1A	psi-mi:“MI:0914”(association)	0.530
ZC3H18	AQR	psi-mi:“MI:0914”(association)	0.530
ZNF816	LRP4	psi-mi:“MI:0914”(association)	0.530
ZNF214	LRP4	psi-mi:“MI:0914”(association)	0.530
E	AP3B1	psi-mi:“MI:0914”(association)	0.530
SUPT5H	POLR2D	psi-mi:“MI:0914”(association)	0.530
JPH4	ZSWIM8	psi-mi:“MI:0914”(association)	0.530
EPB41L1	AP3B1	psi-mi:“MI:0914”(association)	0.530
EPB41L3	AP3B1	psi-mi:“MI:0914”(association)	0.530
ELAVL2	IGF2BP3	psi-mi:“MI:0914”(association)	0.530

BioGRID (1141): ZC3H18 (Affinity Capture-RNA), ZC3H18 (Affinity Capture-RNA), ZC3H18 (Affinity Capture-MS), ZC3H18 (Affinity Capture-MS), ZC3H18 (Affinity Capture-MS), ZC3H18 (Affinity Capture-MS), ZC3H18 (Affinity Capture-MS), ZC3H18 (Affinity Capture-MS), RNPS1 (Co-fractionation), RPL6 (Co-fractionation), RTF1 (Co-fractionation), SLC3A2 (Co-fractionation), SRRM2 (Co-fractionation), ZC3H18 (Co-fractionation), ZC3H18 (Co-fractionation)

ESM2 similar proteins: A2A6A1, B0BN49, B0QZF7, D2H526, E1BB50, E9PYH6, E9Q4F7, E9Q6J5, F1Q8W0, O15047, O88453, P30414, P30415, Q01538, Q14AX6, Q17QQ9, Q27450, Q3KPW4, Q3UMU9, Q4V8I5, Q505I5, Q5BKY9, Q5SW79, Q5VZP5, Q62417, Q66648, Q66PJ3, Q6A065, Q6P9P0, Q6UB99, Q7TQC7, Q7Z4V5, Q80U49, Q86VM9, Q8BYK8, Q8C5W0, Q8CFC2, Q8NEY8, Q8R0F5, Q8R2M2

Diamond homologs: Q0P678, Q1LUE5, Q6TQE1, Q86VM9

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 209 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Transport of Mature Transcript to Cytoplasm	10	26.2×	1e-10
mRNA Splicing	29	22.0×	3e-29
RNA Polymerase II Transcription Termination	13	19.7×	4e-12
mRNA 3’-end processing	14	19.0×	9e-13
Processing of Capped Intron-Containing Pre-mRNA	32	18.1×	2e-29
mRNA Polyadenylation	29	17.6×	3e-26
mRNA Splicing - Minor Pathway	11	17.0×	2e-09
mRNA Splicing - Major Pathway	43	16.2×	4e-38

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of mRNA splicing, via spliceosome	7	28.7×	5e-07
U2-type prespliceosome assembly	8	26.7×	8e-08
mRNA cis splicing, via spliceosome	5	26.5×	9e-05
mRNA splice site recognition	6	25.8×	1e-05
positive regulation of transcription by RNA polymerase III	5	25.0×	1e-04
regulation of mRNA splicing, via spliceosome	5	23.7×	1e-04
alternative mRNA splicing, via spliceosome	6	21.6×	3e-05
RNA splicing, via transesterification reactions	5	16.7×	7e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

182 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	146
Likely benign	10
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
267482	Single allele	Pathogenic

SpliceAI

3618 predictions. Top by Δscore:

Variant	Effect	Δscore
16:88570502:G:T	donor_gain	1.0000
16:88570533:G:T	donor_gain	1.0000
16:88570562:CTGAG:C	donor_loss	1.0000
16:88570563:TGAGG:T	donor_loss	1.0000
16:88570567:G:T	donor_loss	1.0000
16:88577104:TTGCA:T	acceptor_loss	1.0000
16:88577105:TGCAG:T	acceptor_loss	1.0000
16:88577106:GCAG:G	acceptor_loss	1.0000
16:88577107:CAGA:C	acceptor_loss	1.0000
16:88577108:A:AG	acceptor_gain	1.0000
16:88577108:A:G	acceptor_loss	1.0000
16:88577109:G:GT	acceptor_gain	1.0000
16:88577109:G:T	acceptor_loss	1.0000
16:88577109:GA:G	acceptor_gain	1.0000
16:88577109:GAA:G	acceptor_gain	1.0000
16:88577109:GAAC:G	acceptor_gain	1.0000
16:88577109:GAACC:G	acceptor_gain	1.0000
16:88577724:GAC:G	donor_gain	1.0000
16:88577727:G:GG	donor_gain	1.0000
16:88586593:GTTTC:G	acceptor_loss	1.0000
16:88586594:TTTCA:T	acceptor_loss	1.0000
16:88586595:TTCA:T	acceptor_loss	1.0000
16:88586596:TCA:T	acceptor_loss	1.0000
16:88586597:CA:C	acceptor_loss	1.0000
16:88586598:A:AG	acceptor_gain	1.0000
16:88586598:AG:A	acceptor_gain	1.0000
16:88586598:AGGAT:A	acceptor_gain	1.0000
16:88586599:G:GG	acceptor_gain	1.0000
16:88586599:GG:G	acceptor_gain	1.0000
16:88586599:GGA:G	acceptor_gain	1.0000

AlphaMissense

6171 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:88577506:T:C	L128P	1.000
16:88586610:T:C	L205P	1.000
16:88586618:G:C	G208R	1.000
16:88586666:T:A	C224S	1.000
16:88586666:T:C	C224R	1.000
16:88586667:G:A	C224Y	1.000
16:88586667:G:C	C224S	1.000
16:88586667:G:T	C224F	1.000
16:88586668:C:G	C224W	1.000
16:88586672:T:C	F226L	1.000
16:88586673:T:C	F226S	1.000
16:88586673:T:G	F226C	1.000
16:88586674:C:A	F226L	1.000
16:88586674:C:G	F226L	1.000
16:88586675:T:C	F227L	1.000
16:88586677:C:A	F227L	1.000
16:88586677:C:G	F227L	1.000
16:88598183:T:A	C232S	1.000
16:88598183:T:C	C232R	1.000
16:88598183:T:G	C232G	1.000
16:88598184:G:A	C232Y	1.000
16:88598184:G:C	C232S	1.000
16:88598184:G:T	C232F	1.000
16:88598185:T:G	C232W	1.000
16:88598189:T:A	W234R	1.000
16:88598189:T:C	W234R	1.000
16:88598191:G:C	W234C	1.000
16:88598191:G:T	W234C	1.000
16:88598201:T:A	C238S	1.000
16:88598201:T:C	C238R	1.000

dbSNP variants (sampled 300 via entrez): RS1000072044 (16:88573547 T>G), RS1000077952 (16:88591407 T>G), RS1000129377 (16:88569497 T>A,C), RS1000192329 (16:88631580 C>T), RS1000223768 (16:88620842 A>T), RS1000229817 (16:88597884 T>C), RS1000250377 (16:88627236 A>G), RS1000304406 (16:88627082 G>A,C), RS1000317096 (16:88581036 C>T), RS1000322433 (16:88571590 C>G,T), RS1000329421 (16:88593303 C>T), RS1000329528 (16:88575828 G>A), RS1000336143 (16:88604596 G>C), RS1000383251 (16:88593445 A>C,G), RS1000402179 (16:88573342 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (1): 16q24.3 microdeletion syndrome (MONDO:0016838)

Orphanet (1): 16q24.3 microdeletion syndrome (Orphanet:261250)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST003479_9	Hair color	1.000000e-07
GCST008154_28	Trunk fat mass	4.000000e-06
GCST010396_212	Gut microbiota (bacterial taxa, hurdle binary method)	4.000000e-06
GCST90002392_515	Mean corpuscular volume	2.000000e-10
GCST90002394_505	Monocyte percentage of white cells	9.000000e-12
GCST90002397_720	Mean spheric corpuscular volume	1.000000e-09
GCST90002399_275	Neutrophil percentage of white cells	5.000000e-12
GCST90002400_193	Plateletcrit	1.000000e-11
GCST90002402_477	Platelet count	5.000000e-13
GCST90011899_11	Aspartate aminotransferase levels	1.000000e-10

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0007874	gut microbiome measurement
EFO:0007989	monocyte percentage of leukocytes
EFO:0007990	neutrophil percentage of leukocytes
EFO:0007985	platelet crit
EFO:0004309	platelet count
EFO:0004736	aspartate aminotransferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5725041 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 1,538 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

Molecule	Name	Phase	Patents
CHEMBL1232461	MOLIBRESIB	2	1,538

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
8.09	Kd	8.216	nM	CHEMBL5653589
8.09	ED50	8.216	nM	CHEMBL5653589
7.52	IC50	30	nM	MOLIBRESIB
7.47	Kd	34	nM	MOLIBRESIB

PubChem BioAssay actives

3 with measured affinity, of 9 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149807: Binding affinity to human ZC3H18 incubated for 45 mins by Kinobead based pull down assay	kd	0.0082	uM
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide	2178521: Inhibition of ZC3H18 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	ic50	0.0300	uM

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression, decreases expression, affects cotreatment, increases abundance	4
Air Pollutants	affects expression, increases abundance, increases expression	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
TAK-243	affects sumoylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
beta-lapachone	decreases expression	1
butyraldehyde	decreases expression	1
manganese chloride	increases abundance, increases expression	1
cupric chloride	increases expression	1
nickel sulfate	increases expression	1
coumarin	affects phosphorylation	1
cylindrospermopsin	increases expression	1
abrine	increases expression	1
bisphenol S	affects expression	1
Sunitinib	increases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Atrazine	increases expression	1
Benzo(a)pyrene	increases methylation	1
Caffeine	affects phosphorylation	1
Cisplatin	decreases expression	1
Doxorubicin	decreases expression	1
Manganese	increases abundance, increases expression	1
Ozone	affects expression, increases abundance	1
Quercetin	decreases phosphorylation	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases methylation	1

ChEMBL screening assays

8 unique, capped per target: 8 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652849	Binding	Binding affinity to human ZC3H18 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.