ZC3H4

Summary

ZC3H4 (zinc finger CCCH-type containing 4, HGNC:17808) is a protein-coding gene on chromosome 19q13.32, encoding Zinc finger CCCH domain-containing protein 4 (Q9UPT8). RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs).

This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation.

Source: NCBI Gene 23211 — RefSeq curated summary.

At a glance

• GWAS associations: 50
• Clinical variants (ClinVar): 274 total
• MANE Select transcript: NM_015168

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17808
Approved symbol	ZC3H4
Name	zinc finger CCCH-type containing 4
Location	19q13.32
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1064
Ensembl gene	ENSG00000130749
Ensembl biotype	protein_coding
OMIM	619498
Entrez	23211

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 2 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000253048, ENST00000594019, ENST00000595341, ENST00000597069, ENST00000601973

RefSeq mRNA: 1 — MANE Select: NM_015168 NM_015168

CCDS: CCDS42582

Canonical transcript exons

ENST00000253048 — 15 exons

Exon	Start	End
ENSE00000895977	47069092	47069343
ENSE00000895978	47071778	47072121
ENSE00000895980	47072352	47072713
ENSE00000895983	47081513	47081622
ENSE00000895985	47082184	47082295
ENSE00000895987	47084345	47084455
ENSE00000895989	47085056	47085195
ENSE00001207487	47112424	47112589
ENSE00001207490	47113720	47113776
ENSE00001207496	47086384	47086538
ENSE00003120223	47064187	47067869
ENSE00003504603	47085318	47085414
ENSE00003542007	47094389	47094608
ENSE00003598986	47089967	47090189
ENSE00003673605	47093970	47094080

Expression profiles

Bgee: expression breadth ubiquitous, 293 present calls, max score 96.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 39.6417 / max 469.7928, expressed in 1825 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
181721	23.1769	1819
181727	6.8494	1712
181720	4.2014	1509
181726	2.4706	833
181719	1.6301	911
208875	0.7390	444
181725	0.5525	284
181716	0.0123	5
181715	0.0052	1
181714	0.0043	1

Top tissues by expression

297 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.86	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	95.63	gold quality
pancreatic ductal cell	CL:0002079	95.29	silver quality
inferior olivary complex	UBERON:0002127	93.97	gold quality
cervix squamous epithelium	UBERON:0006922	93.72	gold quality
mammary duct	UBERON:0001765	93.64	gold quality
epithelium of mammary gland	UBERON:0003244	93.60	gold quality
buccal mucosa cell	CL:0002336	92.98	gold quality
parotid gland	UBERON:0001831	92.72	gold quality
adult organism	UBERON:0007023	92.64	gold quality
epithelium of nasopharynx	UBERON:0001951	92.37	gold quality
visceral pleura	UBERON:0002401	92.37	gold quality
oviduct epithelium	UBERON:0004804	92.36	gold quality
parietal pleura	UBERON:0002400	92.19	gold quality
pleura	UBERON:0000977	91.84	gold quality
medial globus pallidus	UBERON:0002477	91.60	gold quality
cauda epididymis	UBERON:0004360	91.43	gold quality
trabecular bone tissue	UBERON:0002483	90.94	gold quality
middle temporal gyrus	UBERON:0002771	90.78	gold quality
globus pallidus	UBERON:0001875	90.72	gold quality
hair follicle	UBERON:0002073	90.70	gold quality
seminal vesicle	UBERON:0000998	90.61	gold quality
epithelium of esophagus	UBERON:0001976	90.50	gold quality
squamous epithelium	UBERON:0006914	90.44	gold quality
caput epididymis	UBERON:0004358	90.33	gold quality
esophagus squamous epithelium	UBERON:0006920	90.31	gold quality
penis	UBERON:0000989	90.21	gold quality
germinal epithelium of ovary	UBERON:0001304	89.89	gold quality
oral cavity	UBERON:0000167	89.71	gold quality
nipple	UBERON:0002030	89.67	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-7037	yes	95.65
E-ANND-3	yes	6.10
E-GEOD-124858	no	197.35

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

128 targeting ZC3H4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-3162-3P	100.00	65.37	363
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-219A-5P	99.91	73.36	735
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-4753-3P	99.90	71.03	3786

Literature-anchored findings (GeneRIF, showing 4)

• A first exon termination checkpoint preferentially suppresses extragenic transcription. (PMID:33767452)
• ZC3H4 controls termination of extragenic transcription in human and mouse cells. Cells depleted of ZC3H4 show greatly enhanced synthesis of long and spliced extragenic transcripts. (PMID:33767452)
• ZC3H4 restricts non-coding transcription in human cells. (PMID:33913806)
• ZWC complex-mediated SPT5 phosphorylation suppresses divergent antisense RNA transcription at active gene promoters. (PMID:35325203)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	zc3h4	ENSDARG00000078355
mus_musculus	Zc3h4	ENSMUSG00000059273
rattus_norvegicus	Zc3h4	ENSRNOG00000015229

Paralogs (2): ZC3H8 (ENSG00000144161), ZC3H6 (ENSG00000188177)

Protein

Protein identifiers

Zinc finger CCCH domain-containing protein 4 — Q9UPT8 (reviewed: Q9UPT8)

All UniProt accessions (2): Q9UPT8, M0QY97

UniProt curated annotations — full annotation on UniProt →

Function. RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs). LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein. Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome. The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs.

Subunit / interactions. Interacts with WDR82.

Subcellular location. Chromosome.

Similarity. Belongs to the suppressor of sable family.

RefSeq proteins (1): NP_055983* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000571	Znf_CCCH	Domain
IPR036855	Znf_CCCH_sf	Homologous_superfamily
IPR041367	Znf-CCCH_4	Domain
IPR045124	Su(sable)-like	Family
IPR054361	Znf-CCCH_ZC3H4/6/8	Domain

Pfam: PF00642, PF18044, PF22623

UniProt features (72 total): compositionally biased region 33, modified residue 20, region of interest 5, zinc finger region 3, sequence variant 3, coiled-coil region 2, strand 2, helix 2, chain 1, turn 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2CQE	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UPT8-F1	51.04	0.01

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (20): 72, 75, 76, 92, 94, 155, 601, 807, 808, 904, 907, 908, 1104, 1106, 1108, 1110, 1114, 1118, 1269, 1275

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9930044	Nuclear RNA decay

MSigDB gene sets: 0 (showing top):

GO Biological Process (6): DNA-templated transcription termination (GO:0006353), negative regulation of DNA-templated transcription, elongation (GO:0032785), nuclear RNA surveillance (GO:0071027), lncRNA catabolic process (GO:0110064), negative regulation of lncRNA transcription (GO:0140744), negative regulation of DNA-templated transcription (GO:0045892)

GO Molecular Function (6): RNA binding (GO:0003723), zinc ion binding (GO:0008270), promoter-specific chromatin binding (GO:1990841), chromatin binding (GO:0003682), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (4): nucleus (GO:0005634), nucleoplasm (GO:0005654), chromosome (GO:0005694), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Metabolism of RNA	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	2
negative regulation of DNA-templated transcription	2
binding	2
cellular anatomical structure	2
RNA biosynthetic process	1
DNA-templated transcription elongation	1
regulation of DNA-templated transcription elongation	1
nucleus	1
RNA surveillance	1
RNA catabolic process	1
lncRNA transcription	1
regulation of lncRNA transcription	1
regulation of DNA-templated transcription	1
negative regulation of RNA biosynthetic process	1
nucleic acid binding	1
transition metal ion binding	1
chromatin binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular membraneless organelle	1
cytoplasm	1

Protein interactions and networks

STRING

1606 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZC3H4	WDR82	Q6UXN9	660
ZC3H4	METTL5	Q9NRN9	586
ZC3H4	TMEM160	Q9NX00	579
ZC3H4	WTAP	Q15007	522
ZC3H4	VIRMA	Q69YN4	522
ZC3H4	ZC3H13	Q5T200	519
ZC3H4	NCBP3	Q53F19	514
ZC3H4	YAE1	Q9NRH1	504
ZC3H4	METTL14	Q9HCE5	490
ZC3H4	RBM15	Q96T37	489
ZC3H4	METTL3	Q86U44	488
ZC3H4	QPCTL	Q9NXS2	479
ZC3H4	MED13L	Q71F56	465
ZC3H4	WDFY3	Q8IZQ1	445
ZC3H4	V9GXZ4	V9GXZ4	432

IntAct

138 interactions, top by confidence:

A	B	Type	Score
MED21	MED19	psi-mi:“MI:0914”(association)	0.880
CAPN1	CAPNS1	psi-mi:“MI:0914”(association)	0.840
CSNK2B	NMT2	psi-mi:“MI:0914”(association)	0.660
CSNK2A2	PES1	psi-mi:“MI:0914”(association)	0.640
MRPS27	MRPS14	psi-mi:“MI:0914”(association)	0.640
MRPS6	STAT5A	psi-mi:“MI:0914”(association)	0.550
KSR2	POLR3A	psi-mi:“MI:0914”(association)	0.530
RSPH9	EIF3H	psi-mi:“MI:0914”(association)	0.530
PDGFB	DKC1	psi-mi:“MI:0914”(association)	0.530
WDR82	SETD1A	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
ZFP41	LRP4	psi-mi:“MI:0914”(association)	0.530
CAPN13	SFSWAP	psi-mi:“MI:0914”(association)	0.530
EZH1	EPOP	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
MRPS17	MRPS22	psi-mi:“MI:0914”(association)	0.530
MRPS18B	MRPS14	psi-mi:“MI:0914”(association)	0.530
MRPS18C	MRPS14	psi-mi:“MI:0914”(association)	0.530
MRPS26	MRPS10	psi-mi:“MI:0914”(association)	0.530
MRPS34	MRPS12	psi-mi:“MI:0914”(association)	0.530
NIFK	RSL1D1	psi-mi:“MI:0914”(association)	0.530
RPL13	RRP8	psi-mi:“MI:0914”(association)	0.530
RPLP0	GTPBP10	psi-mi:“MI:0914”(association)	0.530
SRSF3	CASC3	psi-mi:“MI:0914”(association)	0.530
CPSF6	DDX39A	psi-mi:“MI:0914”(association)	0.480
RBM45	HNRNPDL	psi-mi:“MI:0914”(association)	0.460
H3C1	SMCHD1	psi-mi:“MI:2364”(proximity)	0.410
ZC3H4	H2BC21	psi-mi:“MI:0915”(physical association)	0.400
ZC3H4	HMGN3	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (196): ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS), ZC3H4 (Affinity Capture-MS)

ESM2 similar proteins: A0JNI5, A2AJT4, A2AQ19, A4IFB1, B1H1X4, D3ZTQ1, O43290, P35269, Q05519, Q12872, Q13435, Q3THK3, Q3UJB0, Q3UQU0, Q3USH5, Q4V7C9, Q53F19, Q568R1, Q5EA53, Q5HZB6, Q5PQQ2, Q5R539, Q5RAD5, Q5XIW8, Q5ZM19, Q66I22, Q6AY96, Q6DDA4, Q6GLZ8, Q6INH5, Q6ZPZ3, Q8BZR9, Q8CFC7, Q8K194, Q8N2M8, Q8N5F7, Q8TF01, Q8VHI6, Q8WVK2, Q923D5

Diamond homologs: P61129, Q6ZPZ3, Q8BYK8, Q8N5P1, Q9JJ48, Q9UPT8, Q9LTS7, P22293

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 194 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Maturation of hRSV A proteins	5	29.5×	2e-05
Mitochondrial translation	15	16.0×	6e-12
Mitochondrial translation initiation	15	14.8×	1e-11
Mitochondrial translation elongation	15	14.8×	1e-11
SARS-CoV-1 modulates host translation machinery	6	14.4×	8e-05
Mitochondrial ribosome-associated quality control	15	14.3×	1e-11
Mitochondrial translation termination	15	12.8×	7e-11
Eukaryotic Translation Initiation	5	12.0×	1e-03

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	15	14.6×	9e-11
negative regulation of translation	11	12.1×	6e-07
positive regulation of transcription elongation by RNA polymerase II	7	11.8×	3e-04
cytoplasmic translation	11	11.4×	8e-07
regulation of alternative mRNA splicing, via spliceosome	8	11.0×	1e-04
translation	17	9.8×	8e-10
mRNA processing	14	6.2×	1e-05
RNA splicing	12	6.0×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

274 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	198
Likely benign	28
Benign	24

Top pathogenic / likely-pathogenic (0)

SpliceAI

2673 predictions. Top by Δscore:

Variant	Effect	Δscore
19:47067866:TCAC:T	acceptor_gain	1.0000
19:47067867:CAC:C	acceptor_gain	1.0000
19:47067867:CACC:C	acceptor_gain	1.0000
19:47067868:AC:A	acceptor_gain	1.0000
19:47067869:CC:C	acceptor_gain	1.0000
19:47067869:CCT:C	acceptor_loss	1.0000
19:47067870:C:CC	acceptor_gain	1.0000
19:47069094:T:A	donor_gain	1.0000
19:47069109:T:TA	donor_gain	1.0000
19:47072349:CACC:C	donor_loss	1.0000
19:47072350:A:T	donor_loss	1.0000
19:47072351:C:CA	donor_loss	1.0000
19:47072711:CAT:C	acceptor_gain	1.0000
19:47072713:TCTG:T	acceptor_loss	1.0000
19:47072714:C:CC	acceptor_gain	1.0000
19:47072715:T:G	acceptor_loss	1.0000
19:47072720:G:C	acceptor_gain	1.0000
19:47072720:G:GC	acceptor_gain	1.0000
19:47072722:G:C	acceptor_gain	1.0000
19:47072722:G:GC	acceptor_gain	1.0000
19:47081607:T:C	acceptor_gain	1.0000
19:47081610:C:CT	acceptor_gain	1.0000
19:47081620:C:CT	acceptor_gain	1.0000
19:47081627:A:C	acceptor_gain	1.0000
19:47082207:G:C	donor_gain	1.0000
19:47084339:CCTTA:C	donor_loss	1.0000
19:47084340:CTT:C	donor_loss	1.0000
19:47084341:TTA:T	donor_loss	1.0000
19:47084342:T:TG	donor_loss	1.0000
19:47084343:A:AC	donor_gain	1.0000

AlphaMissense

8511 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:47066365:A:C	F1301L	1.000
19:47066365:A:T	F1301L	1.000
19:47066367:A:G	F1301L	1.000
19:47066384:T:C	D1295G	1.000
19:47066386:G:C	F1294L	1.000
19:47066386:G:T	F1294L	1.000
19:47066388:A:G	F1294L	1.000
19:47066395:A:C	F1291L	1.000
19:47066395:A:T	F1291L	1.000
19:47066396:A:G	F1291S	1.000
19:47066397:A:G	F1291L	1.000
19:47067333:A:G	W979R	1.000
19:47067333:A:T	W979R	1.000
19:47067855:A:G	W805R	1.000
19:47067855:A:T	W805R	1.000
19:47072397:A:C	I586S	1.000
19:47072397:A:T	I586N	1.000
19:47072402:A:C	F584L	1.000
19:47072402:A:T	F584L	1.000
19:47072403:A:G	F584S	1.000
19:47072404:A:G	F584L	1.000
19:47072406:A:G	L583S	1.000
19:47072607:A:T	L516H	1.000
19:47072611:C:G	G515R	1.000
19:47072616:C:T	G513D	1.000
19:47072617:C:G	G513R	1.000
19:47072634:A:T	L507Q	1.000
19:47072643:A:C	I504S	1.000
19:47072643:A:G	I504T	1.000
19:47072643:A:T	I504N	1.000

dbSNP variants (sampled 300 via entrez): RS1000018053 (19:47115330 T>C), RS1000034897 (19:47064809 A>C), RS1000102632 (19:47073942 C>T), RS1000106520 (19:47065055 T>C,G), RS1000147515 (19:47111123 C>G,T), RS1000159918 (19:47089119 T>C), RS1000258808 (19:47091808 G>A,T), RS1000294811 (19:47081177 G>A), RS1000295391 (19:47091960 G>A), RS1000384030 (19:47068929 G>C), RS1000387021 (19:47105438 T>C), RS1000484049 (19:47112186 A>G), RS1000542865 (19:47096936 C>T), RS1000576374 (19:47092900 C>A,T), RS1000600009 (19:47076325 G>GCGCA,GCGCACA,GCGCACACA,GCGCACACACGCACA,GCGCGCACA)

Disease associations

OMIM: gene MIM:619498 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

50 associations (top):

Study	Trait	p-value
GCST000830_18	Body mass index	2.000000e-12
GCST001762_797	Obesity-related traits	2.000000e-06
GCST002783_109	Body mass index	3.000000e-10
GCST002783_197	Body mass index	5.000000e-15
GCST002783_352	Body mass index	6.000000e-16
GCST002783_592	Body mass index	7.000000e-09
GCST004065_102	Waist circumference	8.000000e-08
GCST004065_99	Waist circumference	2.000000e-10
GCST004066_97	Hip circumference	2.000000e-08
GCST004495_85	BMI (adjusted for smoking behaviour)	1.000000e-12
GCST004495_86	BMI (adjusted for smoking behaviour)	1.000000e-09
GCST004497_63	Body mass index (joint analysis main effects and smoking interaction)	1.000000e-13
GCST004497_64	Body mass index (joint analysis main effects and smoking interaction)	4.000000e-11
GCST004498_29	BMI in smokers	1.000000e-06
GCST004498_30	BMI in smokers	2.000000e-06
GCST004499_78	BMI in non-smokers	2.000000e-09
GCST004499_79	BMI in non-smokers	4.000000e-07
GCST004557_116	Body mass index	7.000000e-08
GCST004557_121	Body mass index	2.000000e-09
GCST004557_171	Body mass index	3.000000e-07
GCST004557_249	Body mass index	3.000000e-09
GCST004558_112	Body mass index (joint analysis main effects and physical activity interaction)	8.000000e-07
GCST004558_119	Body mass index (joint analysis main effects and physical activity interaction)	1.000000e-09
GCST004558_184	Body mass index (joint analysis main effects and physical activity interaction)	5.000000e-07
GCST004558_31	Body mass index (joint analysis main effects and physical activity interaction)	2.000000e-09
GCST004559_113	Body mass index in physically active individuals	1.000000e-06
GCST004559_3	Body mass index in physically active individuals	5.000000e-08
GCST004601_193	Red blood cell count	2.000000e-13
GCST004604_43	Hematocrit	3.000000e-11
GCST004615_126	Hemoglobin concentration	3.000000e-10

EFO canonical traits (18, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0004730	hormone measurement
EFO:0004318	smoking behavior
EFO:0008002	physical activity measurement
EFO:0004305	erythrocyte count
EFO:0004348	hematocrit
EFO:0004509	hemoglobin measurement
EFO:0004530	triglyceride measurement
EFO:0004574	total cholesterol measurement
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004341	body fat distribution
EFO:0006781	coffee consumption measurement
EFO:0000195	metabolic syndrome
EFO:0004614	apolipoprotein A 1 measurement
EFO:0004918	age at diagnosis
EFO:0009819	comparative body size at age 10, self-reported
EFO:0007986	reticulocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

54 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cisplatin	decreases expression, affects expression	3
bisphenol A	decreases expression	2
sodium arsenite	decreases expression, increases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	2
GSK-J4	decreases expression	1
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
urushiol	decreases expression	1
2,4,6-tribromophenol	decreases expression	1
decabromobiphenyl ether	decreases expression	1
trichostatin A	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
butyraldehyde	decreases expression	1
tetrabromobisphenol A	decreases expression	1
perfluorooctanoic acid	decreases expression	1
ferrous chloride	decreases expression	1
coumarin	affects phosphorylation	1
isobutyl alcohol	affects cotreatment, decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
perfluoro-n-nonanoic acid	decreases expression	1
perfluorohexanesulfonic acid	decreases expression	1
ICG 001	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
Decitabine	affects expression	1
Acetaminophen	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Ethanol	affects cotreatment, decreases expression, increases abundance	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D9VY	Ubigene HEK293 ZC3H4 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.