ZC3H7B

Summary

ZC3H7B (zinc finger CCCH-type containing 7B, HGNC:30869) is a protein-coding gene on chromosome 22q13.2, encoding Zinc finger CCCH domain-containing protein 7B (Q9UGR2). May be a specific regulator of miRNA biogenesis.

This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3.

Source: NCBI Gene 23264 — RefSeq curated summary.

At a glance

• GWAS associations: 22
• Clinical variants (ClinVar): 143 total
• MANE Select transcript: NM_017590

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30869
Approved symbol	ZC3H7B
Name	zinc finger CCCH-type containing 7B
Location	22q13.2
Locus type	gene with protein product
Status	Approved
Aliases	RoXaN, FLJ13787, DKFZp434K0920, KIAA1031
Ensembl gene	ENSG00000100403
Ensembl biotype	protein_coding
OMIM	618206
Entrez	23264

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 protein_coding, 1 retained_intron

ENST00000352645, ENST00000486331, ENST00000897616, ENST00000897617, ENST00000897618, ENST00000897619, ENST00000897620, ENST00000926343

RefSeq mRNA: 1 — MANE Select: NM_017590 NM_017590

CCDS: CCDS14013

Canonical transcript exons

ENST00000352645 — 23 exons

Exon	Start	End
ENSE00000655648	41339001	41339191
ENSE00000655656	41339816	41340137
ENSE00000655666	41341088	41341146
ENSE00000655675	41342529	41342628
ENSE00000655683	41343415	41343576
ENSE00000655685	41346003	41346208
ENSE00000655690	41348067	41348167
ENSE00000655697	41349120	41349301
ENSE00000655717	41355469	41355602
ENSE00000655723	41355757	41355862
ENSE00000655726	41355954	41356062
ENSE00000655728	41356343	41356476
ENSE00000655731	41356645	41356808
ENSE00000911293	41332171	41332227
ENSE00001243074	41351561	41351646
ENSE00001307363	41301525	41301772
ENSE00001309276	41357177	41360147
ENSE00001382058	41338313	41338355
ENSE00003478521	41327206	41327364
ENSE00003534385	41325564	41325597
ENSE00003546336	41330023	41330103
ENSE00003551094	41325721	41325918
ENSE00003628979	41320655	41320713

Expression profiles

Bgee: expression breadth ubiquitous, 281 present calls, max score 99.32.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 65.6698 / max 614.6223, expressed in 1821 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
192460	62.0600	1821
192459	2.4790	1224
192458	0.5883	326
192465	0.3302	146
192461	0.2124	78

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	99.32	gold quality
buccal mucosa cell	CL:0002336	99.22	gold quality
nipple	UBERON:0002030	98.99	gold quality
renal medulla	UBERON:0000362	98.95	gold quality
cardia of stomach	UBERON:0001162	98.95	gold quality
pylorus	UBERON:0001166	98.75	gold quality
superior surface of tongue	UBERON:0007371	98.60	gold quality
ventral tegmental area	UBERON:0002691	98.51	gold quality
sperm	CL:0000019	98.42	gold quality
trigeminal ganglion	UBERON:0001675	98.41	gold quality
dorsal root ganglion	UBERON:0000044	98.13	gold quality
superior vestibular nucleus	UBERON:0007227	98.07	gold quality
pericardium	UBERON:0002407	98.06	gold quality
saphenous vein	UBERON:0007318	98.06	gold quality
periodontal ligament	UBERON:0008266	98.01	gold quality
male germ cell	CL:0000015	97.99	gold quality
inferior vagus X ganglion	UBERON:0005363	97.94	gold quality
pharyngeal mucosa	UBERON:0000355	97.89	gold quality
visceral pleura	UBERON:0002401	97.58	gold quality
cervix squamous epithelium	UBERON:0006922	97.52	gold quality
trachea	UBERON:0003126	97.42	gold quality
vena cava	UBERON:0004087	97.28	gold quality
subthalamic nucleus	UBERON:0001906	97.25	gold quality
penis	UBERON:0000989	97.23	gold quality
body of tongue	UBERON:0011876	97.14	gold quality
mucosa of paranasal sinus	UBERON:0005030	97.05	gold quality
urethra	UBERON:0000057	97.03	gold quality
blood vessel layer	UBERON:0004797	97.03	gold quality
pons	UBERON:0000988	97.01	gold quality
tendon of biceps brachii	UBERON:0008188	96.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.73

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

175 targeting ZC3H7B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-12121	99.99	66.64	255
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-106B-5P	99.88	74.72	2795

Literature-anchored findings (GeneRIF, showing 6)

• RoXaN is capable of interacting with NSP3 and eIF4G I in vivo and during rotavirus infection. Domains of interaction were mapped. (PMID:15047801)
• nuclear localization of PABP-C1 not only is dependent on the capacity of rotavirus NSP3 to interact with eIF4G but also requires the interaction of NSP3 with a specific region in RoXaN (PMID:18799579)
• Reverse transciptase-PCR with the ZC3H7B forward and BCOR reverse primer combinations confirmed the presence of a ZC3H7-BCOR chimeric transcript in both ESS carrying a der(22)t(X;22) but not in a control ESS with t(1;6) and the MEAF6-PHF1 fusion. (PMID:23580382)
• ZC3H7B-BCOR and MEAF6-PHF1 fusions occurred predominantly in S100 protein-negative and malignant ossifying fibromyxoid tumors. (PMID:24285434)
• The present study further expands the genetic spectrum of small blue round cell tumors, with 2 novel fusions, BCOR-MAML3 and ZC3H7B-BCOR, identified (PMID:26752546)
• we find that ESS with ZC3H7B-BCOR fusion constitutes a novel type of high-grade endometrial stromal sarcoma and shares significant morphologic overlap with myxoid leiomyosarcoma. (PMID:27631520)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	zc3h7bb	ENSDARG00000055930
danio_rerio	zc3h7ba	ENSDARG00000098540
mus_musculus	Zc3h7b	ENSMUSG00000022390
rattus_norvegicus	Zc3h7b	ENSRNOG00000055925

Paralogs (1): ZC3H7A (ENSG00000122299)

Protein

Protein identifiers

Zinc finger CCCH domain-containing protein 7B — Q9UGR2 (reviewed: Q9UGR2)

Alternative names: Rotavirus ‘X’-associated non-structural protein

All UniProt accessions (1): Q9UGR2

UniProt curated annotations — full annotation on UniProt →

Function. May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the ‘ATA(A/T)’ motif in the apical loop.

Subunit / interactions. (Microbial infection) Interacts (via LD motif) with rotavirus A NSP3 (via the coiled-coil region).

Subcellular location. Nucleus.

RefSeq proteins (1): NP_060060* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000571	Znf_CCCH	Domain
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR019734	TPR_rpt	Repeat
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR036855	Znf_CCCH_sf	Homologous_superfamily
IPR039691	ZC3H7A/B	Family

Pfam: PF00642, PF13181

UniProt features (26 total): sequence conflict 9, zinc finger region 5, repeat 3, modified residue 3, mutagenesis site 2, chain 1, short sequence motif 1, sequence variant 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UGR2-F1	70.24	0.25

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 217, 364, 367

Mutagenesis-validated functional residues (2):

Position	Phenotype
241–243	almost no effect on nsp3 binding.
252–254	complete loss of nsp3 binding.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 104 (showing top): TAATAAT_MIR126, TATTATA_MIR374, CACCAGC_MIR138, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, CAGCAGG_MIR370, BLALOCK_ALZHEIMERS_DISEASE_UP, TCCCCAC_MIR491, GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN, GAL_LEUKEMIC_STEM_CELL_UP, chr22q13, CAGCTTT_MIR320, GOMF_MIRNA_BINDING, LIU_COMMON_CANCER_GENES, CACTGCC_MIR34A_MIR34C_MIR449, LEE_DIFFERENTIATING_T_LYMPHOCYTE

GO Biological Process (2): post-transcriptional regulation of gene expression (GO:0010608), miRNA processing (GO:0035196)

GO Molecular Function (5): RNA binding (GO:0003723), zinc ion binding (GO:0008270), miRNA binding (GO:0035198), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of gene expression	1
regulatory ncRNA processing	1
nucleic acid binding	1
transition metal ion binding	1
regulatory RNA binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1941 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZC3H7B	SH2D3C	Q8N5H7	825
ZC3H7B	CCNB3	Q8WWL7	726
ZC3H7B	NUTM2A	Q8IVF1	682
ZC3H7B	MEAF6	Q9HAF1	668
ZC3H7B	YWHAE	P29360	630
ZC3H7B	PHF1	O43189	628
ZC3H7B	JAZF1	Q86VZ6	623
ZC3H7B	EZHIP	Q86X51	611
ZC3H7B	NUTM2B	A6NNL0	603
ZC3H7B	PCGF1	Q9BSM1	593
ZC3H7B	MAML3	Q96JK9	588
ZC3H7B	MBTD1	Q05BQ5	575
ZC3H7B	NUTM2G	Q5VZR2	531
ZC3H7B	BCORL1	Q5H9F3	478
ZC3H7B	DUX4L2	P0CJ85	477

IntAct

35 interactions, top by confidence:

A	B	Type	Score
	ZC3H7B	psi-mi:“MI:0915”(physical association)	0.580
ZC3H7B		psi-mi:“MI:0915”(physical association)	0.580
ZC3H7B	EIF4G1	psi-mi:“MI:0915”(physical association)	0.570
N	NOP56	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
RPS3	ZNF316	psi-mi:“MI:0914”(association)	0.530
EIF4G1		psi-mi:“MI:0915”(physical association)	0.480
EIF4G1		psi-mi:“MI:0914”(association)	0.480
ZC3H7B	ZNF638	psi-mi:“MI:0915”(physical association)	0.400
ZC3H7B	DDX21	psi-mi:“MI:0915”(physical association)	0.400
HSP90AB1	ZC3H7B	psi-mi:“MI:0915”(physical association)	0.400
ZC3H7B	MLF1	psi-mi:“MI:0915”(physical association)	0.400
ZC3H7B	AARSD1	psi-mi:“MI:0915”(physical association)	0.400
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
N	IGF2BP3	psi-mi:“MI:0914”(association)	0.350
N	RBM47	psi-mi:“MI:0914”(association)	0.350
MYC		psi-mi:“MI:0914”(association)	0.350
HNRNPCL2	SMCHD1	psi-mi:“MI:0914”(association)	0.350
EEF1AKMT3	SMCHD1	psi-mi:“MI:0914”(association)	0.350

BioGRID (73): ZC3H7B (Affinity Capture-RNA), ZC3H7B (Affinity Capture-RNA), ZC3H7B (Affinity Capture-RNA), ZC3H7B (Affinity Capture-MS), ZC3H7B (Affinity Capture-RNA), ZC3H7B (Proximity Label-MS), ZC3H7B (Affinity Capture-MS), ZC3H7B (Affinity Capture-MS), ZC3H7B (Affinity Capture-MS), ZC3H7B (Protein-RNA), ZC3H7B (Protein-RNA), ZC3H7B (Protein-RNA), ZC3H7B (Protein-RNA), ZC3H7B (Proximity Label-MS), ZC3H7B (Proximity Label-MS)

ESM2 similar proteins: A0A0G2JV04, B0V207, D3Z8X7, D3ZFJ3, D3ZND0, F1LM81, G9CGD6, O00499, O08539, O08839, O12940, O60308, O60784, O75674, O88746, P42567, P55194, Q05DH4, Q0GNC1, Q0IHV1, Q27J81, Q3B7M3, Q3UN70, Q4KLN4, Q505K2, Q5FVK6, Q5T0F9, Q5U3K5, Q66HA5, Q68EF0, Q6P1N0, Q6P5E6, Q6P9Q4, Q6P9Q6, Q80V31, Q80V94, Q8BMI3, Q8BRN9, Q8K1A6, Q8R0H9

Diamond homologs: A4K2V0, A6HD62, D7REX8, F4IRM4, F4JTI1, F4K487, O13754, O14217, O35814, O48802, O54981, O94826, P23231, P31948, P33313, P38825, P53041, P53042, Q07617, Q28IV3, Q2U919, Q32PZ3, Q38931, Q3KRD5, Q3ZBR5, Q3ZBZ8, Q43207, Q496Y0, Q4R8N7, Q54DA8, Q54IP0, Q5RAP0, Q5U2X2, Q5VJS5, Q5ZHY5, Q60676, Q60864, Q68F64, Q68FQ7, Q6DGE9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

143 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	119
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3793 predictions. Top by Δscore:

Variant	Effect	Δscore
22:41301641:G:GT	donor_gain	1.0000
22:41320653:A:AG	acceptor_gain	1.0000
22:41320654:G:GG	acceptor_gain	1.0000
22:41320654:GA:G	acceptor_gain	1.0000
22:41320714:G:GG	donor_gain	1.0000
22:41325597:GG:G	donor_loss	1.0000
22:41325598:GT:G	donor_loss	1.0000
22:41325599:T:G	donor_loss	1.0000
22:41325916:ATGG:A	donor_loss	1.0000
22:41325917:TGGT:T	donor_loss	1.0000
22:41325919:G:GG	donor_gain	1.0000
22:41325919:GTGA:G	donor_loss	1.0000
22:41325920:T:G	donor_loss	1.0000
22:41327200:T:TA	acceptor_gain	1.0000
22:41327201:G:A	acceptor_gain	1.0000
22:41327201:GGCA:G	acceptor_loss	1.0000
22:41327202:GCA:G	acceptor_loss	1.0000
22:41327203:CA:C	acceptor_loss	1.0000
22:41327204:A:AG	acceptor_gain	1.0000
22:41327204:AG:A	acceptor_gain	1.0000
22:41327204:AGG:A	acceptor_gain	1.0000
22:41327204:AGGGC:A	acceptor_loss	1.0000
22:41327205:G:GA	acceptor_gain	1.0000
22:41327205:GG:G	acceptor_gain	1.0000
22:41327205:GGG:G	acceptor_gain	1.0000
22:41327205:GGGC:G	acceptor_gain	1.0000
22:41327205:GGGCC:G	acceptor_gain	1.0000
22:41327320:G:GT	donor_gain	1.0000
22:41327361:CCAC:C	donor_gain	1.0000
22:41327362:CAC:C	donor_gain	1.0000

AlphaMissense

6455 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:41325737:T:C	L35P	1.000
22:41325749:T:C	L39P	1.000
22:41325760:G:C	G43R	1.000
22:41342593:T:C	F421S	1.000
22:41342604:T:C	C425R	1.000
22:41342605:G:A	C425Y	1.000
22:41342605:G:T	C425F	1.000
22:41342606:C:G	C425W	1.000
22:41342613:T:A	C428S	1.000
22:41342613:T:C	C428R	1.000
22:41342614:G:A	C428Y	1.000
22:41342614:G:C	C428S	1.000
22:41342615:C:G	C428W	1.000
22:41343462:T:A	C449S	1.000
22:41343462:T:C	C449R	1.000
22:41343463:G:C	C449S	1.000
22:41343464:C:G	C449W	1.000
22:41343513:T:A	W466R	1.000
22:41343513:T:C	W466R	1.000
22:41343525:C:G	R470G	1.000
22:41343549:T:C	F478L	1.000
22:41343550:T:C	F478S	1.000
22:41343550:T:G	F478C	1.000
22:41343551:C:A	F478L	1.000
22:41343551:C:G	F478L	1.000
22:41343556:G:A	G480D	1.000
22:41343561:T:G	Y482D	1.000
22:41343570:T:A	C485S	1.000
22:41343570:T:C	C485R	1.000
22:41343570:T:G	C485G	1.000

dbSNP variants (sampled 300 via entrez): RS1000010921 (22:41357628 G>A,C), RS1000023413 (22:41349876 A>G), RS1000043465 (22:41357922 C>A,G), RS1000076835 (22:41351730 A>T), RS1000097745 (22:41327341 C>T), RS1000152653 (22:41312442 A>C,G), RS1000154049 (22:41325175 G>A,C), RS1000277535 (22:41331967 G>A), RS1000295923 (22:41344092 C>T), RS1000401912 (22:41330187 G>A,T), RS1000449778 (22:41318104 C>T), RS1000464987 (22:41337846 G>A), RS1000555280 (22:41314984 A>G), RS1000574608 (22:41335065 A>C), RS1000716843 (22:41359559 G>A,C)

Disease associations

OMIM: gene MIM:618206 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

22 associations (top):

Study	Trait	p-value
GCST004521_55	Autism spectrum disorder or schizophrenia	9.000000e-09
GCST004600_123	Eosinophil percentage of white cells	2.000000e-09
GCST004617_47	Eosinophil percentage of granulocytes	5.000000e-11
GCST004623_46	Neutrophil percentage of granulocytes	1.000000e-12
GCST004624_33	Sum eosinophil basophil counts	5.000000e-10
GCST004785_25	Vitiligo	3.000000e-15
GCST004946_20	Schizophrenia	1.000000e-12
GCST005232_52	Neuroticism	3.000000e-18
GCST006803_24	Schizophrenia	6.000000e-13
GCST007709_158	General factor of neuroticism	9.000000e-10
GCST007932_101	Medication use (thyroid preparations)	9.000000e-09
GCST010002_83	Refractive error	2.000000e-27
GCST010133_13	Lamb consumption	3.000000e-08
GCST010143_2	Meat-related diet	4.000000e-08
GCST010989_166	Body size at age 10	8.000000e-09
GCST011124_12	Caffeine consumption from tea	2.000000e-10
GCST011702_1	Smoking cessation	1.000000e-08
GCST90002381_449	Eosinophil count	6.000000e-22
GCST90002382_513	Eosinophil percentage of white cells	2.000000e-21
GCST90002388_272	Lymphocyte count	2.000000e-29
GCST90020025_1735	Waist-to-hip ratio adjusted for BMI	2.000000e-08
GCST90020027_404	Waist-hip index	8.000000e-09

EFO canonical traits (13, from GWAS)

EFO ID	Trait name
EFO:0007991	eosinophil percentage of leukocytes
EFO:0007996	eosinophil percentage of granulocytes
EFO:0007994	neutrophil percentage of granulocytes
EFO:0004842	eosinophil count
EFO:0005090	basophil count
EFO:0007660	neuroticism measurement
EFO:0009933	Thyroid preparation use measurement
EFO:0008111	diet measurement
EFO:0009819	comparative body size at age 10, self-reported
EFO:0010091	tea consumption measurement
EFO:0004319	smoking cessation
EFO:0004587	lymphocyte count
EFO:0007788	BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases methylation, increases expression, increases methylation	3
trichostatin A	affects expression, increases expression	2
sodium arsenite	decreases expression, increases expression	2
Valproic Acid	affects expression, decreases expression, increases methylation	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
dicrotophos	increases expression	1
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
mono-(2-ethylhexyl)phthalate	increases abundance, increases methylation	1
cobaltous chloride	decreases expression	1
corosolic acid	increases expression	1
abrine	increases expression	1
(+)-JQ1 compound	decreases expression	1
Arsenic Trioxide	increases expression	1
Acetaminophen	decreases expression	1
Cadmium	increases abundance, increases expression	1
Caffeine	increases phosphorylation	1
Diethylhexyl Phthalate	increases abundance, increases methylation	1
Doxorubicin	decreases expression	1
Formaldehyde	increases expression	1
Ivermectin	decreases expression	1
Ribonucleotides	affects binding	1
Silicon Dioxide	decreases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Triiodothyronine	decreases expression	1
Aflatoxin B1	increases methylation	1
Antirheumatic Agents	increases expression	1
Cadmium Chloride	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.