ZC3H8

Summary

ZC3H8 (zinc finger CCCH-type containing 8, HGNC:30941) is a protein-coding gene on chromosome 2q14.1, encoding Zinc finger CCCH domain-containing protein 8 (Q8N5P1). Acts as a transcriptional repressor of the GATA3 promoter. It is a common-essential gene (DepMap: required in 90.8% of cancer cell lines).

Enables RNA binding activity. Involved in several processes, including positive regulation of thymocyte apoptotic process; regulation of DNA-templated transcription; and snRNA transcription. Located in Cajal body; euchromatin; and histone locus body. Part of transcription elongation factor complex.

Source: NCBI Gene 84524 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 7 total
• Cancer dependency (DepMap): dependent in 90.8% of screened cell lines (common-essential)
• MANE Select transcript: NM_032494

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30941
Approved symbol	ZC3H8
Name	zinc finger CCCH-type containing 8
Location	2q14.1
Locus type	gene with protein product
Status	Approved
Aliases	Fliz1
Ensembl gene	ENSG00000144161
Ensembl biotype	protein_coding
OMIM	621273
Entrez	84524

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 6 protein_coding, 3 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000409573, ENST00000464305, ENST00000466259, ENST00000474234, ENST00000476902, ENST00000495264, ENST00000866699, ENST00000866700, ENST00000866701, ENST00000924270, ENST00000957654

RefSeq mRNA: 1 — MANE Select: NM_032494 NM_032494

CCDS: CCDS46392

Canonical transcript exons

ENST00000409573 — 9 exons

Exon	Start	End
ENSE00001009521	112230903	112230950
ENSE00001579262	112254908	112255042
ENSE00001579413	112211529	112216468
ENSE00001587459	112231838	112231947
ENSE00002462855	112233260	112233371
ENSE00003463321	112234120	112234236
ENSE00003491463	112238315	112238528
ENSE00003518863	112250191	112250272
ENSE00003566309	112236562	112236695

Expression profiles

Bgee: expression breadth ubiquitous, 253 present calls, max score 96.06.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.5166 / max 229.6578, expressed in 1761 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
30143	17.5166	1761

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	96.06	gold quality
oocyte	CL:0000023	94.20	gold quality
buccal mucosa cell	CL:0002336	92.69	gold quality
Brodmann (1909) area 23	UBERON:0013554	91.19	gold quality
calcaneal tendon	UBERON:0003701	91.17	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.65	gold quality
endothelial cell	CL:0000115	88.54	gold quality
tendon	UBERON:0000043	87.95	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.02	gold quality
primary visual cortex	UBERON:0002436	86.77	gold quality
corpus callosum	UBERON:0002336	86.07	gold quality
body of pancreas	UBERON:0001150	86.00	gold quality
occipital lobe	UBERON:0002021	85.34	gold quality
muscle of leg	UBERON:0001383	85.15	gold quality
gastrocnemius	UBERON:0001388	85.06	gold quality
pituitary gland	UBERON:0000007	85.02	gold quality
colonic epithelium	UBERON:0000397	85.01	gold quality
skeletal muscle organ	UBERON:0014892	84.80	gold quality
cortical plate	UBERON:0005343	84.62	gold quality
middle temporal gyrus	UBERON:0002771	84.48	gold quality
sural nerve	UBERON:0015488	84.24	gold quality
hindlimb stylopod muscle	UBERON:0004252	84.21	gold quality
vastus lateralis	UBERON:0001379	84.12	gold quality
esophagus mucosa	UBERON:0002469	84.03	gold quality
embryo	UBERON:0000922	84.00	gold quality
ganglionic eminence	UBERON:0004023	84.00	gold quality
quadriceps femoris	UBERON:0001377	83.99	gold quality
cartilage tissue	UBERON:0002418	83.80	gold quality
tibialis anterior	UBERON:0001385	83.52	gold quality
muscle tissue	UBERON:0002385	83.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.62

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
GATA3	Repression

miRNA regulators (miRDB)

29 targeting ZC3H8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-4496	99.88	68.89	2236
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-147B-5P	99.45	70.62	2432
HSA-MIR-377-3P	99.37	70.18	1905
HSA-MIR-4311	99.31	70.47	3041
HSA-MIR-4738-3P	98.98	67.98	1846
HSA-MIR-224-3P	98.91	68.42	1815
HSA-MIR-522-3P	98.91	68.56	1817
HSA-MIR-29B-1-5P	98.86	68.35	1364
HSA-MIR-4477A	98.83	69.75	2952
HSA-MIR-513B-3P	98.76	68.12	1577
HSA-MIR-6512-5P	98.76	69.29	1195
HSA-MIR-4518	98.12	66.82	1030
HSA-MIR-18B-3P	98.05	65.55	595
HSA-MIR-4769-3P	97.95	68.17	1002
HSA-MIR-6817-5P	97.95	67.86	1026
HSA-MIR-3652	97.71	65.43	1890
HSA-MIR-1266-5P	97.71	66.92	1052
HSA-MIR-6782-3P	97.60	67.75	931
HSA-MIR-4430	97.47	65.61	1813
HSA-MIR-6500-3P	97.42	67.20	867
HSA-MIR-6826-5P	93.80	67.42	514

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 90.8% of screened cell lines, common-essential.

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zc3h8	ENSMUSG00000027387
rattus_norvegicus	Zc3h8	ENSRNOG00000017647
caenorhabditis_elegans		WBGENE00020827

Paralogs (2): ZC3H4 (ENSG00000130749), ZC3H6 (ENSG00000188177)

Protein

Protein identifiers

Zinc finger CCCH domain-containing protein 8 — Q8N5P1 (reviewed: Q8N5P1)

All UniProt accessions (1): Q8N5P1

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5’-AGGTCTC-3’ sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.

Subunit / interactions. Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via C-terminus domain).

Subcellular location. Nucleus.

Domain organisation. The N-terminal region and all three C3H1-type zinc fingers are necessary to induce transcriptional repression.

RefSeq proteins (1): NP_115883* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000571	Znf_CCCH	Domain
IPR036855	Znf_CCCH_sf	Homologous_superfamily
IPR045124	Su(sable)-like	Family
IPR054361	Znf-CCCH_ZC3H4/6/8	Domain

Pfam: PF00642, PF18345, PF22623

UniProt features (20 total): modified residue 6, zinc finger region 3, region of interest 3, compositionally biased region 3, sequence conflict 2, chain 1, cross-link 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N5P1-F1	67.70	0.14

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (7): 22, 32, 59, 63, 77, 83, 43

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-6807505	RNA polymerase II transcribes snRNA genes

MSigDB gene sets: 182 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_UP, GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_UP, GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GOBP_REGULATION_OF_CELL_ACTIVATION, GOBP_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS, GOBP_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT, TGCGCANK_UNKNOWN, GOBP_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS, GOBP_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS, GOBP_T_CELL_HOMEOSTASIS, GOBP_LYMPHOCYTE_HOMEOSTASIS, GOBP_TRANSCRIPTION_BY_RNA_POLYMERASE_III, GOBP_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS, GOBP_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION, GOBP_CELL_CELL_ADHESION

GO Biological Process (10): apoptotic process (GO:0006915), negative regulation of T cell differentiation in thymus (GO:0033085), snRNA transcription by RNA polymerase II (GO:0042795), snRNA transcription by RNA polymerase III (GO:0042796), T cell homeostasis (GO:0043029), negative regulation of DNA-templated transcription (GO:0045892), positive regulation of transcription by RNA polymerase III (GO:0045945), response to antibiotic (GO:0046677), positive regulation of thymocyte apoptotic process (GO:0070245), negative regulation of transcription by RNA polymerase II (GO:0000122)

GO Molecular Function (6): RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding (GO:0001162), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), RNA binding (GO:0003723), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (8): chromatin (GO:0000785), euchromatin (GO:0000791), nucleus (GO:0005634), nucleoplasm (GO:0005654), transcription elongation factor complex (GO:0008023), Cajal body (GO:0015030), nuclear body (GO:0016604), histone locus body (GO:0035363)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transcription by RNA polymerase II	2
snRNA transcription	2
transcription by RNA polymerase III	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
cellular anatomical structure	2
nucleoplasm	2
nuclear ribonucleoprotein granule	2
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
T cell differentiation in thymus	1
regulation of T cell differentiation in thymus	1
negative regulation of T cell differentiation	1
lymphocyte homeostasis	1
DNA-templated transcription	1
regulation of DNA-templated transcription	1
negative regulation of RNA biosynthetic process	1
regulation of transcription by RNA polymerase III	1
positive regulation of DNA-templated transcription	1
response to chemical	1
positive regulation of T cell apoptotic process	1
thymocyte apoptotic process	1
regulation of thymocyte apoptotic process	1
regulation of transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
intronic transcription regulatory region sequence-specific DNA binding	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
nucleic acid binding	1
transition metal ion binding	1
binding	1
cation binding	1
chromosome	1
chromatin	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
nuclear protein-containing complex	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1378 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZC3H8	ICE1	Q9Y2F5	878
ZC3H8	ICE2	Q659A1	834
ZC3H8	ELL	P55199	781
ZC3H8	SMIM12	Q96EX1	525
ZC3H8	SUB1	P53999	501
ZC3H8	DPY19L3	Q6ZPD9	494
ZC3H8	SYNE1	Q8NF91	483
ZC3H8	LRRC40	Q9H9A6	480
ZC3H8	PRPSAP1	Q14558	477
ZC3H8	CMTM4	Q8IZR5	475
ZC3H8	TMEM87B	Q96K49	470
ZC3H8	MNMIP1	A4FU49	470
ZC3H8	LEPROTL1	O95214	466
ZC3H8	PPP1R3G	B7ZBB8	459
ZC3H8	NLRP13	Q86W25	452

IntAct

90 interactions, top by confidence:

A	B	Type	Score
LARP7	CCNT1	psi-mi:“MI:0914”(association)	0.850
H1-1	RRP8	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
SNRPA1	U2SURP	psi-mi:“MI:0914”(association)	0.640
ZNF764	ZNF316	psi-mi:“MI:0914”(association)	0.640
H1-6	ZNF724	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
E4F1	ZBTB24	psi-mi:“MI:0914”(association)	0.530
ZCRB1	DKC1	psi-mi:“MI:0914”(association)	0.530
RPS3	ZNF316	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
ZC3H8	RSL1D1	psi-mi:“MI:0914”(association)	0.530
RPS2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
H1-1	SURF6	psi-mi:“MI:0914”(association)	0.530
THUMPD1	YBX1	psi-mi:“MI:0914”(association)	0.530
LIN28B	ELAVL2	psi-mi:“MI:0914”(association)	0.530
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RSL1D1	METAP1	psi-mi:“MI:0914”(association)	0.530
CSNK2A1	ZC3H8	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
ZC3H8	H3-4	psi-mi:“MI:0915”(physical association)	0.400
ZC3H8		psi-mi:“MI:0915”(physical association)	0.370
NLRP3	PHRF1	psi-mi:“MI:0914”(association)	0.350
Tyw3	PPP6C	psi-mi:“MI:0914”(association)	0.350
KSR1	FAM168B	psi-mi:“MI:0914”(association)	0.350
k8	RGL2	psi-mi:“MI:0914”(association)	0.350

BioGRID (109): ZC3H8 (Affinity Capture-MS), ZC3H8 (Affinity Capture-MS), ZC3H8 (Affinity Capture-MS), LARP7 (Affinity Capture-MS), THUMPD1 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), ZCRB1 (Affinity Capture-MS), C8orf33 (Affinity Capture-MS), TUBA8 (Affinity Capture-MS), SF3B2 (Affinity Capture-MS), ZC3H8 (Affinity Capture-MS), ZC3H8 (Affinity Capture-MS), THUMPD1 (Affinity Capture-MS), TUBA8 (Affinity Capture-MS), ZC3H8 (Affinity Capture-MS)

ESM2 similar proteins: A5WW08, D3ZND0, D4A7V9, E1C760, E7EXT2, F7AEX0, O57589, P09926, P51612, Q01831, Q07617, Q07G43, Q08288, Q0VBD2, Q15527, Q28E45, Q28EG9, Q2YDS5, Q3KQ71, Q5D1Z3, Q5EAW4, Q5I0E6, Q5RDL2, Q5RET9, Q5RHY1, Q5U4Z3, Q5ZJF6, Q6AYK5, Q6DE94, Q6DFQ2, Q6IQ49, Q6XV80, Q7L590, Q7T293, Q7ZVP1, Q7ZZ00, Q80Y44, Q80ZX8, Q8BG17, Q8BVE8

Diamond homologs: P61129, Q6ZPZ3, Q8BYK8, Q8N5P1, Q9JJ48, Q9UPT8, Q9LTS7, P22293

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 112 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Eukaryotic Translation Initiation	7	32.7×	3e-08
Cap-dependent Translation Initiation	7	32.7×	3e-08
SARS-CoV-1 modulates host translation machinery	7	32.7×	3e-08
Eukaryotic Translation Elongation	7	29.5×	6e-08
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	7	28.8×	6e-08
Nonsense-Mediated Decay (NMD)	8	28.2×	7e-09
rRNA processing in the nucleus and cytosol	10	24.4×	2e-10
SARS-CoV-2 modulates host translation machinery	7	23.8×	3e-07

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	12	21.6×	2e-10
ribosomal large subunit biogenesis	5	21.5×	3e-04
ribosomal small subunit biogenesis	8	17.7×	3e-06
negative regulation of translation	7	13.3×	9e-05
RNA processing	6	12.8×	6e-04
rRNA processing	9	12.4×	7e-06
translation	12	12.0×	1e-07
RNA splicing	10	8.6×	3e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

7 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	3
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2213 predictions. Top by Δscore:

Variant	Effect	Δscore
2:112234107:CA:C	donor_gain	1.0000
2:112234163:C:A	donor_gain	1.0000
2:112235857:AGTGG:A	donor_gain	1.0000
2:112236566:T:TA	donor_gain	1.0000
2:112236693:CAG:C	acceptor_gain	1.0000
2:112236696:C:CC	acceptor_gain	1.0000
2:112238524:CTAAA:C	acceptor_gain	1.0000
2:112238529:C:CC	acceptor_gain	1.0000
2:112250189:A:AC	donor_gain	1.0000
2:112250190:C:CC	donor_gain	1.0000
2:112231953:CCAAG:C	acceptor_gain	0.9900
2:112231954:CAAG:C	acceptor_gain	0.9900
2:112233316:CA:C	donor_gain	0.9900
2:112234106:A:AC	donor_gain	0.9900
2:112234107:C:CC	donor_gain	0.9900
2:112234131:T:A	donor_gain	0.9900
2:112234150:A:AC	donor_gain	0.9900
2:112234151:C:CC	donor_gain	0.9900
2:112234162:T:A	donor_gain	0.9900
2:112234236:CCTT:C	acceptor_gain	0.9900
2:112236556:CAATA:C	donor_loss	0.9900
2:112236557:AATAC:A	donor_loss	0.9900
2:112236558:ATACC:A	donor_loss	0.9900
2:112236559:TA:T	donor_loss	0.9900
2:112236561:CC:C	donor_loss	0.9900
2:112236563:T:TA	donor_gain	0.9900
2:112236692:GCAG:G	acceptor_gain	0.9900
2:112236693:CAGC:C	acceptor_gain	0.9900
2:112236695:GCTA:G	acceptor_loss	0.9900
2:112236697:T:C	acceptor_loss	0.9900

AlphaMissense

1952 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:112233317:A:G	C226R	1.000
2:112233361:C:G	C211S	1.000
2:112233362:A:T	C211S	1.000
2:112231883:A:C	F266L	0.999
2:112231883:A:T	F266L	0.999
2:112231885:A:G	F266L	0.999
2:112231889:G:C	C264W	0.999
2:112231890:C:G	C264S	0.999
2:112231890:C:T	C264Y	0.999
2:112231891:A:G	C264R	0.999
2:112231891:A:T	C264S	0.999
2:112231908:C:G	C258S	0.999
2:112231909:A:G	C258R	0.999
2:112231909:A:T	C258S	0.999
2:112231924:G:C	H253D	0.999
2:112231934:A:C	C249W	0.999
2:112231935:C:A	C249F	0.999
2:112231935:C:G	C249S	0.999
2:112231935:C:T	C249Y	0.999
2:112231936:A:G	C249R	0.999
2:112231936:A:T	C249S	0.999
2:112233275:A:G	C240R	0.999
2:112233291:A:C	C234W	0.999
2:112233292:C:G	C234S	0.999
2:112233292:C:T	C234Y	0.999
2:112233293:A:G	C234R	0.999
2:112233293:A:T	C234S	0.999
2:112233309:A:C	F228L	0.999
2:112233309:A:T	F228L	0.999
2:112233311:A:G	F228L	0.999

dbSNP variants (sampled 300 via entrez): RS1000029067 (2:112214182 A>G), RS1000213601 (2:112230368 T>C), RS1000225168 (2:112243963 T>C), RS1000278159 (2:112251435 A>G), RS1000304748 (2:112237037 G>A), RS1000325434 (2:112246717 G>T), RS1000339991 (2:112216163 A>G), RS1000343936 (2:112223840 T>TAATC), RS1000461246 (2:112245898 C>A,T), RS1000462440 (2:112216636 A>G), RS1000501391 (2:112232489 TTATAA>T), RS1000565640 (2:112230635 T>C), RS1000607336 (2:112225310 G>A), RS1000614092 (2:112252928 G>A), RS1000788182 (2:112218677 CAT>C)

Disease associations

OMIM: gene MIM:621273 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	increases expression	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, increases methylation	1
trichostatin A	increases expression	1
beta-lapachone	increases expression	1
sodium arsenite	decreases expression	1
aflatoxin B2	decreases methylation	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	increases reaction, affects binding	1
perfluoro-n-nonanoic acid	increases expression	1
2-palmitoylglycerol	increases expression	1
K 7174	increases expression	1
MT19c compound	increases expression	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Air Pollutants	increases abundance, increases expression	1
Atrazine	decreases expression	1
Cisplatin	increases expression	1
Doxorubicin	increases expression	1
Ethyl Methanesulfonate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Nickel	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
Sodium Dodecyl Sulfate	decreases expression	1
T-2 Toxin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.