ZDHHC11B

Summary

ZDHHC11B (zDHHC palmitoyltransferase 11B (putative), HGNC:32962) is a protein-coding gene on chromosome 5p15.33, encoding Probable palmitoyltransferase ZDHHC11B (P0C7U3). Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes.

Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Predicted to be located in endosome membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum.

Source: NCBI Gene 653082 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 5 total — 1 likely-pathogenic
• MANE Select transcript: NM_001351303

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32962
Approved symbol	ZDHHC11B
Name	zDHHC palmitoyltransferase 11B (putative)
Location	5p15.33
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000206077
Ensembl biotype	protein_coding
Entrez	653082

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 4 protein_coding, 2 nonsense_mediated_decay, 2 retained_intron

ENST00000508859, ENST00000522356, ENST00000622126, ENST00000651083, ENST00000651221, ENST00000651714, ENST00000652055, ENST00000962634

RefSeq mRNA: 1 — MANE Select: NM_001351303 NM_001351303

CCDS: CCDS87287

Canonical transcript exons

ENST00000508859 — 14 exons

Exon	Start	End
ENSE00002082626	766698	766919
ENSE00002103995	710355	712282
ENSE00003565060	716801	716865
ENSE00003841230	730434	730468
ENSE00003844672	767392	767524
ENSE00003845003	768835	768930
ENSE00003845609	733752	733839
ENSE00003846925	741594	741628
ENSE00003847016	754998	755099
ENSE00003847867	751133	751257
ENSE00003848086	745183	745298
ENSE00003849291	748404	748559
ENSE00003849679	784668	784729
ENSE00003850806	755966	756144

Expression profiles

Bgee: expression breadth ubiquitous, 136 present calls, max score 98.17.

FANTOM5 (CAGE): breadth broad, TPM avg 2.8217 / max 268.9793, expressed in 362 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
60733	2.7205	356
60732	0.1012	52

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar vermis	UBERON:0004720	98.17	gold quality
quadriceps femoris	UBERON:0001377	97.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.97	gold quality
cerebellar hemisphere	UBERON:0002245	96.92	gold quality
cerebellar cortex	UBERON:0002129	96.91	gold quality
cerebellum	UBERON:0002037	96.90	gold quality
right uterine tube	UBERON:0001302	96.74	gold quality
Ammon’s horn	UBERON:0001954	93.89	gold quality
putamen	UBERON:0001874	93.84	gold quality
primary visual cortex	UBERON:0002436	93.80	gold quality
right frontal lobe	UBERON:0002810	93.59	gold quality
caudate nucleus	UBERON:0001873	93.35	gold quality
superior frontal gyrus	UBERON:0002661	93.16	gold quality
amygdala	UBERON:0001876	92.84	gold quality
temporal lobe	UBERON:0001871	92.83	gold quality
nucleus accumbens	UBERON:0001882	92.71	gold quality
apex of heart	UBERON:0002098	92.35	gold quality
right atrium auricular region	UBERON:0006631	92.32	gold quality
brain	UBERON:0000955	92.28	gold quality
Brodmann (1909) area 9	UBERON:0013540	92.28	gold quality
adenohypophysis	UBERON:0002196	92.20	gold quality
hypothalamus	UBERON:0001898	92.11	gold quality
substantia nigra	UBERON:0002038	91.98	gold quality
pituitary gland	UBERON:0000007	91.91	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.74	gold quality
spinal cord	UBERON:0002240	91.73	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	91.55	gold quality
anterior cingulate cortex	UBERON:0009835	91.03	gold quality
cerebral cortex	UBERON:0000956	90.78	gold quality
mucosa of stomach	UBERON:0001199	90.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.85

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• First, MYC downregulates miR-150 to unleash MYB from the miR-150-mediated repression. Second, MYC induces ZDHHC11 and ZDHHC11B that further ensures the maintenance of high MYB levels (PMID:28331227)
• ZDHHC11B is decreased in lung adenocarcinoma and inhibits tumorigenesis via regulating epithelial-mesenchymal transition. (PMID:37434393)

Cross-species orthologs

12 orthologs

Organism	Symbol	Gene ID
danio_rerio	zdhhc11	ENSDARG00000076202
mus_musculus	Zdhhc11	ENSMUSG00000069189
rattus_norvegicus	Zdhhc11	ENSRNOG00000039743
drosophila_melanogaster	Dnz1	FBGN0027453
drosophila_melanogaster	CG1407	FBGN0033474
drosophila_melanogaster	CG17287	FBGN0034202
caenorhabditis_elegans	dhhc-7	WBGENE00007637
caenorhabditis_elegans	dhhc-12	WBGENE00010323
caenorhabditis_elegans	dhhc-2	WBGENE00012948
caenorhabditis_elegans		WBGENE00014075
caenorhabditis_elegans		WBGENE00016620
caenorhabditis_elegans		WBGENE00020066

Paralogs (17): ZDHHC6 (ENSG00000023041), ZDHHC15 (ENSG00000102383), ZDHHC2 (ENSG00000104219), ZDHHC4 (ENSG00000136247), ZDHHC7 (ENSG00000153786), ZDHHC1 (ENSG00000159714), ZDHHC12 (ENSG00000160446), ZDHHC3 (ENSG00000163812), ZDHHC19 (ENSG00000163958), ZDHHC14 (ENSG00000175048), ZDHHC21 (ENSG00000175893), ZDHHC22 (ENSG00000177108), ZDHHC20 (ENSG00000180776), ZDHHC23 (ENSG00000184307), ZDHHC9 (ENSG00000188706), ZDHHC11 (ENSG00000188818), ZDHHC18 (ENSG00000204160)

Protein

Protein identifiers

Probable palmitoyltransferase ZDHHC11B — P0C7U3 (reviewed: P0C7U3)

Alternative names: Zinc finger DHHC domain-containing protein 11B

All UniProt accessions (5): P0C7U3, A0A494BZX9, A0A494C0T6, A0A494C1T0, A0A7P0TA36

UniProt curated annotations — full annotation on UniProt →

Function. Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes. May play a role in cell proliferation.

Subcellular location. Membrane.

Domain organisation. The DHHC domain is required for palmitoyltransferase activity.

Similarity. Belongs to the DHHC palmitoyltransferase family.

RefSeq proteins (1): NP_001338232* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001594	Palmitoyltrfase_DHHC	Domain
IPR039859	PFA4/ZDH16/20/ERF2-like	Family

Pfam: PF01529

Catalyzed reactions (Rhea), 1 shown:

• L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA (RHEA:36683)

UniProt features (14 total): transmembrane region 5, sequence variant 3, compositionally biased region 2, chain 1, active site 1, domain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0C7U3-F1	79.81	0.63

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 155 (s-palmitoyl cysteine intermediate)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 21 (showing top): GOBP_PROTEIN_TARGETING, GOBP_PROTEIN_TARGETING_TO_MEMBRANE, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE, GOBP_DEFENSE_RESPONSE_TO_VIRUS, GOBP_LOCALIZATION_WITHIN_MEMBRANE, GOBP_RESPONSE_TO_VIRUS, GOMF_S_ACYLTRANSFERASE_ACTIVITY, GOMF_PALMITOYLTRANSFERASE_ACTIVITY, GOMF_ACYLTRANSFERASE_ACTIVITY, NFKBIA_TARGET_GENES, DESCARTES_MAIN_FETAL_PDE1C_ACSM3_POSITIVE_CELLS, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION, GOBP_ANTIVIRAL_INNATE_IMMUNE_RESPONSE, MYOCD_TARGET_GENES

GO Biological Process (2): protein targeting to membrane (GO:0006612), antiviral innate immune response (GO:0140374)

GO Molecular Function (4): protein-cysteine S-palmitoyltransferase activity (GO:0019706), palmitoyltransferase activity (GO:0016409), transferase activity (GO:0016740), acyltransferase activity (GO:0016746)

GO Cellular Component (3): endoplasmic reticulum (GO:0005783), Golgi apparatus (GO:0005794), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	2
endomembrane system	2
intracellular membrane-bounded organelle	2
protein targeting	1
establishment of protein localization to membrane	1
innate immune response	1
defense response to virus	1
palmitoyltransferase activity	1
protein-cysteine S-acyltransferase activity	1
acyltransferase activity, transferring groups other than amino-acyl groups	1
catalytic activity	1
transferase activity	1
cellular anatomical structure	1

Protein interactions and networks

STRING

192 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZDHHC11B	SPDYE11	P0DTA3	576
ZDHHC11B	TMEM170A	Q8WVE7	507
ZDHHC11B	ZDHHC13	Q8IUH4	490
ZDHHC11B	BTBD6	Q96KE9	477
ZDHHC11B	ZDHHC3	Q9NYG2	433
ZDHHC11B	ZDHHC24	Q6UX98	431
ZDHHC11B	PGPEP1	Q9NXJ5	417
ZDHHC11B	ZDHHC22	Q8N966	416
ZDHHC11B	RCCD1	A6NED2	382
ZDHHC11B	ZFP30	Q9Y2G7	348
ZDHHC11B	PPT1	P50897	332
ZDHHC11B	CELA3B	P08861	329
ZDHHC11B	ZNF512	Q96ME7	323
ZDHHC11B	CLPTM1L	Q96KA5	313
ZDHHC11B	SUPT4H1	P63272	306

IntAct

0 interactions, top by confidence:

BioGRID (1): ZDHHC11B (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4IDP3, A0A0R4IF99, A0PK84, B0S5D5, E7F021, E7F587, F1Q7H8, F1QAM1, F1QGD2, F1QHM7, F1QX91, F1QXD3, F1RE57, O74384, P0C7U3, P42836, Q06551, Q0VC89, Q2TGI8, Q2TGJ4, Q500Z2, Q58DT3, Q5BLG4, Q5FVR1, Q5FWL7, Q5M757, Q5W0Z9, Q5Y5T1, Q5Y5T3, Q6CPU8, Q6DHI1, Q6FSS4, Q6FW70, Q750R7, Q75AW7, Q7XA86, Q8BGJ0, Q8I0G4, Q8VYP5, Q91WU6

Diamond homologs: E7EZI4, E7F4Z4, P0C7U3, Q14AK4, Q8R0N9, Q8WTX9, Q9H8X9, Q8L5Y5, A0A0R4IQZ2, A0PK84, A5WVX9, B8A4F0, C8VCL4, E9PTT0, F1QAM1, F1QHM7, F1QX91, O60069, P0CS66, P0CS67, Q03289, Q04629, Q09701, Q10L01, Q2TGI8, Q2TGJ4, Q2TGK3, Q4I8B6, Q4IA62, Q4P6L3, Q4R690, Q4WZL8, Q4X251, Q550R7, Q552M6, Q554E7, Q58DT3, Q59QL0, Q5ADN9, Q5B0V6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

5 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	0
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
624532	GRCh37/hg19 5p15.33(chr5:52186-4163906)x1	Likely pathogenic

SpliceAI

2686 predictions. Top by Δscore:

Variant	Effect	Δscore
5:730425:CGAA:C	donor_gain	1.0000
5:730432:A:AC	donor_gain	1.0000
5:730432:AC:A	donor_gain	1.0000
5:730433:C:CC	donor_gain	1.0000
5:730433:CC:C	donor_gain	1.0000
5:745179:GTACC:G	donor_loss	1.0000
5:745181:A:C	donor_loss	1.0000
5:745182:C:CA	donor_loss	1.0000
5:745221:T:A	donor_gain	1.0000
5:745294:GGCCT:G	acceptor_gain	1.0000
5:745295:GCCT:G	acceptor_gain	1.0000
5:745296:CCTC:C	acceptor_gain	1.0000
5:745297:CT:C	acceptor_gain	1.0000
5:745299:C:CC	acceptor_gain	1.0000
5:745299:CTGG:C	acceptor_loss	1.0000
5:745300:T:A	acceptor_loss	1.0000
5:748402:A:AC	donor_gain	1.0000
5:748403:C:CC	donor_gain	1.0000
5:748403:CT:C	donor_gain	1.0000
5:712283:C:CC	acceptor_gain	0.9900
5:716880:C:CT	acceptor_gain	0.9900
5:716881:A:T	acceptor_gain	0.9900
5:730424:A:AC	donor_gain	0.9900
5:730425:C:CC	donor_gain	0.9900
5:730429:CTT:C	donor_loss	0.9900
5:730431:TACCC:T	donor_loss	0.9900
5:745192:T:TA	donor_gain	0.9900
5:745226:A:AC	donor_gain	0.9900
5:745227:C:CC	donor_gain	0.9900
5:748398:ACATA:A	donor_loss	0.9900

AlphaMissense

2441 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:755048:G:C	F151L	0.976
5:755048:G:T	F151L	0.976
5:755050:A:G	F151L	0.976
5:755989:G:C	F126L	0.949
5:755989:G:T	F126L	0.949
5:755991:A:G	F126L	0.949
5:756002:A:G	I122T	0.948
5:755081:G:C	H140Q	0.947
5:755081:G:T	H140Q	0.947
5:755084:T:A	K139N	0.943
5:755084:T:G	K139N	0.943
5:755978:C:G	C130S	0.924
5:755979:A:T	C130S	0.924
5:755067:T:A	N145I	0.919
5:756002:A:C	I122S	0.917
5:745283:G:A	T267I	0.915
5:755987:C:G	C127S	0.914
5:755988:A:T	C127S	0.914
5:755061:C:G	C147S	0.910
5:755062:A:T	C147S	0.910
5:755063:C:A	K146N	0.910
5:755063:C:G	K146N	0.910
5:755083:G:C	H140D	0.902
5:755987:C:T	C127Y	0.898
5:755066:A:C	N145K	0.894
5:755066:A:T	N145K	0.894
5:756028:G:C	F113L	0.886
5:756028:G:T	F113L	0.886
5:756030:A:G	F113L	0.886
5:756002:A:T	I122N	0.879

dbSNP variants (sampled 300 via entrez): RS1000423341 (5:724995 A>G), RS1000734327 (5:773928 C>A,G,T), RS1000784782 (5:745819 C>T), RS1000859682 (5:747043 T>C), RS1001104322 (5:772546 G>A), RS1001330191 (5:718488 A>G), RS1001915534 (5:741679 C>T), RS1001933478 (5:714283 C>G,T), RS1002137059 (5:767462 A>G), RS1002428484 (5:715863 C>T), RS1002706807 (5:761660 T>A,C), RS1002738103 (5:762883 A>C), RS1002866476 (5:732961 G>C), RS1002884611 (5:710063 T>G), RS1002944259 (5:785030 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST90020029_1127	Waist circumference adjusted for body mass index	7.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
di-n-butylphosphoric acid	affects expression	1
clothianidin	decreases expression	1
abrine	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Okadaic Acid	increases expression	1
S-Nitrosoglutathione	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.