ZDHHC18

Summary

ZDHHC18 (zDHHC palmitoyltransferase 18, HGNC:20712) is a protein-coding gene on chromosome 1p36.11, encoding Palmitoyltransferase ZDHHC18 (Q9NUE0). Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK.

Enables protein-cysteine S-palmitoyltransferase activity. Involved in negative regulation of cGAS/STING signaling pathway; negative regulation of innate immune response; and peptidyl-L-cysteine S-palmitoylation. Located in cytosol. Is active in Golgi apparatus.

Source: NCBI Gene 84243 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 47 total
• MANE Select transcript: NM_032283

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20712
Approved symbol	ZDHHC18
Name	zDHHC palmitoyltransferase 18
Location	1p36.11
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp667O2416
Ensembl gene	ENSG00000204160
Ensembl biotype	protein_coding
OMIM	620963
Entrez	84243

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000374141, ENST00000374142, ENST00000478902, ENST00000488397, ENST00000534643, ENST00000920892, ENST00000920893

RefSeq mRNA: 1 — MANE Select: NM_032283 NM_032283

CCDS: CCDS30650

Canonical transcript exons

ENST00000374142 — 8 exons

Exon	Start	End
ENSE00001462570	26853726	26857604
ENSE00001462573	26850558	26850606
ENSE00001462576	26852753	26852865
ENSE00001462580	26850301	26850438
ENSE00001462582	26848608	26848757
ENSE00001462584	26826688	26827139
ENSE00003557274	26832447	26832607
ENSE00003657240	26851129	26851231

Expression profiles

Bgee: expression breadth ubiquitous, 231 present calls, max score 96.63.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 43.8695 / max 2762.2297, expressed in 1811 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
1656	39.8662	1811
1659	1.1730	383
1663	0.7896	52
1658	0.7494	356
1657	0.6329	192
1664	0.3330	23
1662	0.3255	33

Top tissues by expression

275 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	96.63	gold quality
granulocyte	CL:0000094	94.63	gold quality
lower esophagus mucosa	UBERON:0035834	91.95	gold quality
spleen	UBERON:0002106	90.92	gold quality
secondary oocyte	CL:0000655	89.30	gold quality
stromal cell of endometrium	CL:0002255	89.23	gold quality
esophagus mucosa	UBERON:0002469	88.78	gold quality
lymph node	UBERON:0000029	88.75	gold quality
right hemisphere of cerebellum	UBERON:0014890	88.62	gold quality
vermiform appendix	UBERON:0001154	88.53	gold quality
gall bladder	UBERON:0002110	88.04	gold quality
bone marrow	UBERON:0002371	87.96	gold quality
minor salivary gland	UBERON:0001830	87.95	gold quality
cerebellar hemisphere	UBERON:0002245	87.94	gold quality
cortical plate	UBERON:0005343	87.92	gold quality
bone marrow cell	CL:0002092	87.87	gold quality
cerebellar cortex	UBERON:0002129	87.84	gold quality
rectum	UBERON:0001052	87.81	gold quality
leukocyte	CL:0000738	87.56	gold quality
right frontal lobe	UBERON:0002810	87.34	gold quality
monocyte	CL:0000576	86.92	gold quality
apex of heart	UBERON:0002098	86.87	gold quality
mononuclear cell	CL:0000842	86.82	gold quality
right lobe of liver	UBERON:0001114	86.79	gold quality
saliva-secreting gland	UBERON:0001044	86.76	gold quality
left lobe of thyroid gland	UBERON:0001120	86.71	gold quality
esophagus	UBERON:0001043	86.69	gold quality
mouth mucosa	UBERON:0003729	86.68	gold quality
right lobe of thyroid gland	UBERON:0001119	86.66	gold quality
smooth muscle tissue	UBERON:0001135	86.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.33

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

69 targeting ZDHHC18, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-26A-5P	99.78	73.52	2303
HSA-MIR-26B-5P	99.78	73.51	2305
HSA-MIR-4517	99.76	69.19	1867
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-4465	99.71	72.56	2096
HSA-MIR-548AU-3P	99.70	68.22	1373
HSA-MIR-7161-5P	99.68	68.92	1592
HSA-MIR-6512-3P	99.65	66.07	1468
HSA-MIR-6720-5P	99.65	66.22	1459
HSA-MIR-548U	99.65	67.78	1463
HSA-MIR-24-3P	99.59	69.97	1934
HSA-MIR-4310	99.59	68.84	2527
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-762	99.58	66.61	1994

Cross-species orthologs

14 orthologs

Organism	Symbol	Gene ID
danio_rerio	zdhhc18a	ENSDARG00000069807
danio_rerio	zdhhc18b	ENSDARG00000105034
mus_musculus	Zdhhc18	ENSMUSG00000037553
rattus_norvegicus	Zdhhc18	ENSRNOG00000058156
drosophila_melanogaster	Dnz1	FBGN0027453
drosophila_melanogaster	CG1407	FBGN0033474
drosophila_melanogaster	CG17287	FBGN0034202
caenorhabditis_elegans	dhhc-7	WBGENE00007637
caenorhabditis_elegans	dhhc-12	WBGENE00010323
caenorhabditis_elegans	dhhc-2	WBGENE00012948
caenorhabditis_elegans		WBGENE00014075
caenorhabditis_elegans		WBGENE00016620
caenorhabditis_elegans		WBGENE00020066
caenorhabditis_elegans	dhhc-11	WBGENE00020694

Paralogs (17): ZDHHC6 (ENSG00000023041), ZDHHC15 (ENSG00000102383), ZDHHC2 (ENSG00000104219), ZDHHC4 (ENSG00000136247), ZDHHC7 (ENSG00000153786), ZDHHC1 (ENSG00000159714), ZDHHC12 (ENSG00000160446), ZDHHC3 (ENSG00000163812), ZDHHC19 (ENSG00000163958), ZDHHC14 (ENSG00000175048), ZDHHC21 (ENSG00000175893), ZDHHC22 (ENSG00000177108), ZDHHC20 (ENSG00000180776), ZDHHC23 (ENSG00000184307), ZDHHC9 (ENSG00000188706), ZDHHC11 (ENSG00000188818), ZDHHC11B (ENSG00000206077)

Protein

Protein identifiers

Palmitoyltransferase ZDHHC18 — Q9NUE0 (reviewed: Q9NUE0)

Alternative names: DHHC domain-containing cysteine-rich protein 18, Zinc finger DHHC domain-containing protein 18

All UniProt accessions (3): E9PJS3, Q9NUE0, H0YEN1

UniProt curated annotations — full annotation on UniProt →

Function. Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK. Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS. May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling.

Subcellular location. Golgi apparatus membrane.

Tissue specificity. Widely expressed.

Domain organisation. The DHHC domain is required for palmitoyltransferase activity.

Similarity. Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NUE0-1	1	yes
Q9NUE0-2	2

RefSeq proteins (1): NP_115659* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001594	Palmitoyltrfase_DHHC	Domain
IPR039859	PFA4/ZDH16/20/ERF2-like	Family

Pfam: PF01529

Catalyzed reactions (Rhea), 1 shown:

• L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA (RHEA:36683)

UniProt features (19 total): topological domain 5, transmembrane region 4, compositionally biased region 3, region of interest 2, chain 1, domain 1, active site 1, modified residue 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NUE0-F1	81.50	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 222 (s-palmitoyl cysteine intermediate)

Post-translational modifications (1): 19

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 174 (showing top): GOBP_LIPOPROTEIN_METABOLIC_PROCESS, GOBP_PROTEIN_TARGETING, GOBP_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE, GOBP_PEPTIDYL_CYSTEINE_MODIFICATION, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS, GOBP_REGULATION_OF_IMMUNE_RESPONSE, GOBP_PROTEIN_TARGETING_TO_MEMBRANE, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, FOSTER_TOLERANT_MACROPHAGE_DN, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP, GOBP_LIPOPROTEIN_BIOSYNTHETIC_PROCESS, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN, GOBP_REGULATION_OF_RESPONSE_TO_STRESS

GO Biological Process (8): protein targeting to membrane (GO:0006612), intracellular protein localization (GO:0008104), peptidyl-L-cysteine S-palmitoylation (GO:0018230), innate immune response (GO:0045087), negative regulation of innate immune response (GO:0045824), negative regulation of cGAS/STING signaling pathway (GO:0160049), immune system process (GO:0002376), cGAS/STING signaling pathway (GO:0140896)

GO Molecular Function (4): palmitoyltransferase activity (GO:0016409), protein-cysteine S-palmitoyltransferase activity (GO:0019706), transferase activity (GO:0016740), acyltransferase activity (GO:0016746)

GO Cellular Component (5): Golgi membrane (GO:0000139), endoplasmic reticulum (GO:0005783), Golgi apparatus (GO:0005794), cytosol (GO:0005829), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	3
endomembrane system	2
intracellular membrane-bounded organelle	2
cellular anatomical structure	2
protein targeting	1
establishment of protein localization to membrane	1
macromolecule localization	1
peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	1
protein palmitoylation	1
immune response	1
defense response to symbiont	1
negative regulation of response to biotic stimulus	1
negative regulation of defense response	1
negative regulation of response to external stimulus	1
innate immune response	1
regulation of innate immune response	1
negative regulation of immune response	1
negative regulation of cytoplasmic pattern recognition receptor signaling pathway	1
cGAS/STING signaling pathway	1
biological_process	1
cytoplasmic pattern recognition receptor signaling pathway	1
acyltransferase activity, transferring groups other than amino-acyl groups	1
palmitoyltransferase activity	1
protein-cysteine S-acyltransferase activity	1
catalytic activity	1
transferase activity	1
Golgi apparatus	1
bounding membrane of organelle	1

Protein interactions and networks

STRING

620 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZDHHC18	ZDHHC22	Q8N966	510
ZDHHC18	FAM110A	Q9BQ89	475
ZDHHC18	LYPLA2	O95372	414
ZDHHC18	PPT2	Q9UMR5	411
ZDHHC18	LYPLA1	O75608	402
ZDHHC18	GOLGA7	Q7Z5G4	394
ZDHHC18	TMEM86A	Q8N2M4	372
ZDHHC18	KCTD3	Q9Y597	366
ZDHHC18	ZDHHC24	Q6UX98	349
ZDHHC18	ZDHHC13	Q8IUH4	347
ZDHHC18	PALM	O75781	324
ZDHHC18	TEKT4	Q8WW24	319
ZDHHC18	PPT1	P50897	317
ZDHHC18	ZDHHC17	Q8IUH5	316
ZDHHC18	RNF144A	P50876	315

IntAct

57 interactions, top by confidence:

A	B	Type	Score
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
IPPK	TMEM223	psi-mi:“MI:0914”(association)	0.530
KLRG2	GXYLT2	psi-mi:“MI:0914”(association)	0.530
IL13RA2	METTL15	psi-mi:“MI:0914”(association)	0.530
GDPD5	GOLIM4	psi-mi:“MI:0914”(association)	0.530
SPINT2	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
ZNRF4	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
ASGR2	MT-CO1	psi-mi:“MI:0914”(association)	0.530
IL9R	RETSAT	psi-mi:“MI:0914”(association)	0.530
PCDHAC2	TMEM223	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM120B	psi-mi:“MI:0914”(association)	0.530
SLC1A5	GPR89A	psi-mi:“MI:0914”(association)	0.530
TPCN2	AP3B1	psi-mi:“MI:0914”(association)	0.530
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
UPK1A	TMEM223	psi-mi:“MI:0914”(association)	0.350
ADGRE5	TMEM223	psi-mi:“MI:0914”(association)	0.350
PCDHAC2	TMEM223	psi-mi:“MI:0914”(association)	0.350
DLK2	SLC22A23	psi-mi:“MI:0914”(association)	0.350
TPCN2	DDX11L8	psi-mi:“MI:0914”(association)	0.350
SLC1A5	GPR89A	psi-mi:“MI:0914”(association)	0.350
GPM6A	HAX1	psi-mi:“MI:0914”(association)	0.350
SLC34A2	SYNGR2	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350

BioGRID (102): ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS), ZDHHC18 (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4IF99, B3DN87, E7EZI4, E7F4Z4, E7FH11, E9QCD3, F1Q7H8, F1QHM7, F1R013, O74384, O80685, P0C7U3, P59267, P59268, Q06551, Q0VC89, Q0WQK2, Q14AK4, Q2TGJ1, Q2TGJ4, Q3EBC2, Q4I1J3, Q4WN54, Q58DA8, Q5BLG4, Q5PNZ1, Q5R5J8, Q5W0Z9, Q5Y5T1, Q5Y5T2, Q5Y5T3, Q6C890, Q6DR03, Q76IC6, Q7ZVN4, Q8BGJ0, Q8BQQ1, Q8I0G4, Q8IYP9, Q8IZN3

Diamond homologs: A0A0R4IDP3, A2CEX1, A2VEY9, A5WVX9, B3DN87, C8VCL4, E1BLT8, E7F021, E7F587, E7FBS9, E7FH11, E9PTT0, E9QCD3, F1Q7H8, F1QAM1, F1QHM7, F1QX91, F1QXD3, F1R013, F1RE57, J9VJ99, O60069, O74384, O80685, P42836, P59267, P59268, Q04629, Q0VC89, Q10L01, Q2TGJ1, Q2TGJ4, Q2TGK3, Q2THW7, Q2THW8, Q2THW9, Q2THX0, Q2THX1, Q4R690, Q4WZL8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	38
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1268 predictions. Top by Δscore:

Variant	Effect	Δscore
1:26827138:GA:G	donor_gain	1.0000
1:26827140:G:GG	donor_gain	1.0000
1:26832445:A:AG	acceptor_gain	1.0000
1:26832446:G:GG	acceptor_gain	1.0000
1:26832446:GCT:G	acceptor_gain	1.0000
1:26832603:GATCG:G	donor_gain	1.0000
1:26832604:A:G	donor_gain	1.0000
1:26848604:TCAG:T	acceptor_loss	1.0000
1:26848605:CA:C	acceptor_loss	1.0000
1:26848606:A:AG	acceptor_gain	1.0000
1:26848606:A:C	acceptor_loss	1.0000
1:26848607:G:GA	acceptor_gain	1.0000
1:26848607:GA:G	acceptor_gain	1.0000
1:26848607:GAC:G	acceptor_gain	1.0000
1:26848607:GACA:G	acceptor_gain	1.0000
1:26848607:GACAA:G	acceptor_gain	1.0000
1:26848754:GTGG:G	donor_gain	1.0000
1:26848755:TGG:T	donor_gain	1.0000
1:26848756:GG:G	donor_gain	1.0000
1:26848756:GGG:G	donor_gain	1.0000
1:26848757:GG:G	donor_gain	1.0000
1:26848758:G:GG	donor_gain	1.0000
1:26848758:GT:G	donor_loss	1.0000
1:26850434:GTTGC:G	donor_gain	1.0000
1:26850437:GC:G	donor_gain	1.0000
1:26850439:G:GG	donor_gain	1.0000
1:26827135:TTTGA:T	donor_gain	0.9900
1:26827136:TTGA:T	donor_gain	0.9900
1:26827136:TTGAG:T	donor_loss	0.9900
1:26827137:TGA:T	donor_gain	0.9900

AlphaMissense

2517 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:26832554:G:A	G148E	1.000
1:26848691:T:A	C194S	1.000
1:26848691:T:C	C194R	1.000
1:26848692:G:A	C194Y	1.000
1:26848692:G:C	C194S	1.000
1:26848692:G:T	C194F	1.000
1:26848693:C:G	C194W	1.000
1:26848700:T:A	C197S	1.000
1:26848700:T:C	C197R	1.000
1:26848701:G:A	C197Y	1.000
1:26848701:G:C	C197S	1.000
1:26848701:G:T	C197F	1.000
1:26848702:C:G	C197W	1.000
1:26848712:C:G	R201G	1.000
1:26848730:C:A	H207N	1.000
1:26848730:C:G	H207D	1.000
1:26848732:C:A	H207Q	1.000
1:26848732:C:G	H207Q	1.000
1:26848733:T:A	C208S	1.000
1:26848733:T:C	C208R	1.000
1:26848734:G:A	C208Y	1.000
1:26848734:G:C	C208S	1.000
1:26848734:G:T	C208F	1.000
1:26848735:C:G	C208W	1.000
1:26848742:T:C	C211R	1.000
1:26848743:G:A	C211Y	1.000
1:26848746:A:T	D212V	1.000
1:26848750:C:A	N213K	1.000
1:26848750:C:G	N213K	1.000
1:26848751:T:A	C214S	1.000

dbSNP variants (sampled 300 via entrez): RS1000017581 (1:26830142 T>C), RS1000054474 (1:26834942 C>A,T), RS1000095457 (1:26825549 T>C), RS1000104672 (1:26834502 G>T), RS1000225394 (1:26836118 A>C,G), RS1000235369 (1:26828623 T>C), RS1000398699 (1:26854121 C>T), RS1000519077 (1:26847044 C>T), RS1000539806 (1:26826752 G>A,C,T), RS1000574336 (1:26829421 C>T), RS1000652531 (1:26841592 C>A), RS1000683191 (1:26835883 C>G), RS1000755310 (1:26836200 C>T), RS1000762348 (1:26846931 C>T), RS1000770926 (1:26854513 G>A)

Disease associations

OMIM: gene MIM:620963 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST004250_25	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)	1.000000e-07
GCST007267_99	Systolic blood pressure	1.000000e-09
GCST007611_16	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy)	6.000000e-12
GCST007615_1	C-reactive protein levels	5.000000e-10
GCST007615_5	C-reactive protein levels	5.000000e-11
GCST008059_209	Estimated glomerular filtration rate	2.000000e-08
GCST90002394_131	Monocyte percentage of white cells	2.000000e-31
GCST90013406_246	Liver enzyme levels (alkaline phosphatase)	1.000000e-19

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0007965	response to combination chemotherapy
EFO:0006335	systolic blood pressure
EFO:0004458	C-reactive protein measurement
EFO:0007989	monocyte percentage of leukocytes
EFO:0004533	alkaline phosphatase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

41 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium Chloride	increases palmitoylation, decreases expression, increases expression, decreases reaction, increases abundance	4
bisphenol A	decreases methylation, affects expression, affects cotreatment	2
sodium arsenite	increases expression	2
Cadmium	increases palmitoylation, decreases expression, decreases reaction, increases abundance	2
Aflatoxin B1	decreases methylation, increases expression	2
Particulate Matter	increases methylation, decreases expression, increases abundance	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
beta-lapachone	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
2-bromopalmitate	increases abundance, increases palmitoylation, decreases reaction	1
zinc chromate	decreases expression, increases abundance	1
cupric chloride	increases expression	1
nickel sulfate	increases expression	1
evodiamine	increases expression	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	decreases expression, increases abundance	1
CGP 52608	affects binding, increases reaction	1
K 7174	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Acetaminophen	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Vehicle Emissions	decreases expression, increases abundance	1
Caffeine	affects phosphorylation	1
Doxorubicin	decreases expression	1
N-Nitrosopyrrolidine	increases expression	1
Ozone	affects expression, increases abundance	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TY78	HAP1 ZDHHC18 (-) 1	Cancer cell line	Male
CVCL_TY79	HAP1 ZDHHC18 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.