ZDHHC21

Summary

ZDHHC21 (zDHHC palmitoyltransferase 21, HGNC:20750) is a protein-coding gene on chromosome 9p22.3, encoding Palmitoyltransferase ZDHHC21 (Q8IVQ6). Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates.

Enables protein-cysteine S-palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in Golgi apparatus and plasma membrane.

Source: NCBI Gene 340481 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 53 total
• MANE Select transcript: NM_178566

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20750
Approved symbol	ZDHHC21
Name	zDHHC palmitoyltransferase 21
Location	9p22.3
Locus type	gene with protein product
Status	Approved
Aliases	HSPC097, DNZ1, DHHC21
Ensembl gene	ENSG00000175893
Ensembl biotype	protein_coding
OMIM	614605
Entrez	340481

Gene structure

Transcript identifiers

Ensembl transcripts: 39 — 34 protein_coding, 3 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000380916, ENST00000497966, ENST00000850565, ENST00000850566, ENST00000850567, ENST00000850568, ENST00000850569, ENST00000850570, ENST00000899578, ENST00000899579, ENST00000899580, ENST00000899581, ENST00000899582, ENST00000899583, ENST00000899584, ENST00000899585, ENST00000899586, ENST00000899587, ENST00000899588, ENST00000899589, ENST00000899590, ENST00000899591, ENST00000899592, ENST00000899593, ENST00000899594, ENST00000899595, ENST00000899596, ENST00000928204, ENST00000961810, ENST00000961811, ENST00000961812, ENST00000961813, ENST00000961814, ENST00000961815, ENST00000961816, ENST00000961817, ENST00000961818, ENST00000961819, ENST00000961820

RefSeq mRNA: 14 — MANE Select: NM_178566 NM_001354118, NM_001354119, NM_001354120, NM_001354121, NM_001354122, NM_001354123, NM_001354124, NM_001354125, NM_001354126, NM_001354127, NM_001354128, NM_001354129, NM_001354130, NM_178566

CCDS: CCDS6475

Canonical transcript exons

ENST00000380916 — 10 exons

Exon	Start	End
ENSE00001314876	14658749	14658887
ENSE00001334892	14680033	14680162
ENSE00001596278	14690337	14690385
ENSE00004282127	14619639	14619682
ENSE00004282134	14639896	14640012
ENSE00004282138	14662215	14662326
ENSE00004282144	14611071	14619098
ENSE00004282146	14674187	14674385
ENSE00004282148	14693229	14693432
ENSE00004282152	14672830	14672928

Expression profiles

Bgee: expression breadth ubiquitous, 245 present calls, max score 91.93.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.8664 / max 162.8225, expressed in 1609 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
100032	5.7995	1533
100033	1.8855	837
100025	0.1458	20
100027	0.0357	6

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
epithelial cell of pancreas	CL:0000083	91.93	gold quality
endothelial cell	CL:0000115	90.25	gold quality
Brodmann (1909) area 23	UBERON:0013554	89.93	gold quality
calcaneal tendon	UBERON:0003701	89.91	gold quality
esophagus squamous epithelium	UBERON:0006920	88.96	gold quality
oviduct epithelium	UBERON:0004804	88.36	gold quality
middle temporal gyrus	UBERON:0002771	88.21	gold quality
gingival epithelium	UBERON:0001949	88.12	gold quality
gingiva	UBERON:0001828	87.26	gold quality
tendon	UBERON:0000043	85.94	gold quality
corpus epididymis	UBERON:0004359	85.55	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.18	gold quality
caput epididymis	UBERON:0004358	85.13	gold quality
primary visual cortex	UBERON:0002436	84.94	gold quality
occipital lobe	UBERON:0002021	84.14	gold quality
adrenal tissue	UBERON:0018303	83.87	gold quality
corpus callosum	UBERON:0002336	83.74	gold quality
medial globus pallidus	UBERON:0002477	83.28	gold quality
jejunal mucosa	UBERON:0000399	83.10	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.85	gold quality
esophagus mucosa	UBERON:0002469	82.61	gold quality
cerebellum	UBERON:0002037	82.56	gold quality
Brodmann (1909) area 46	UBERON:0006483	82.54	gold quality
cerebellar cortex	UBERON:0002129	82.48	gold quality
right hemisphere of cerebellum	UBERON:0014890	82.48	gold quality
cerebellar hemisphere	UBERON:0002245	82.44	gold quality
oral cavity	UBERON:0000167	82.32	gold quality
cerebellar vermis	UBERON:0004720	82.01	gold quality
lower esophagus mucosa	UBERON:0035834	82.00	gold quality
visceral pleura	UBERON:0002401	81.90	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.99
E-MTAB-8271	no	217.97

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

490 targeting ZDHHC21, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-5692B	100.00	71.32	2622

Literature-anchored findings (GeneRIF, showing 3)

• the DHHC-7 and -21 proteins are novel targets to selectively inhibit membrane sex steroid receptor localization and function (PMID:22031296)
• We show that knockdown of ZDHHC21 leads to reduced levels of platelet endothelial cell adhesion molecule-1 at the cell surface. (PMID:22496122)
• The palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML. (PMID:37216691)

Cross-species orthologs

12 orthologs

Organism	Symbol	Gene ID
danio_rerio	zdhhc21	ENSDARG00000110709
mus_musculus	Zdhhc21	ENSMUSG00000028403
rattus_norvegicus	Zdhhc21	ENSRNOG00000074898
drosophila_melanogaster	Dnz1	FBGN0027453
drosophila_melanogaster	CG1407	FBGN0033474
drosophila_melanogaster	CG17287	FBGN0034202
caenorhabditis_elegans	dhhc-7	WBGENE00007637
caenorhabditis_elegans	dhhc-12	WBGENE00010323
caenorhabditis_elegans	dhhc-2	WBGENE00012948
caenorhabditis_elegans		WBGENE00014075
caenorhabditis_elegans		WBGENE00016620
caenorhabditis_elegans		WBGENE00020066

Paralogs (17): ZDHHC6 (ENSG00000023041), ZDHHC15 (ENSG00000102383), ZDHHC2 (ENSG00000104219), ZDHHC4 (ENSG00000136247), ZDHHC7 (ENSG00000153786), ZDHHC1 (ENSG00000159714), ZDHHC12 (ENSG00000160446), ZDHHC3 (ENSG00000163812), ZDHHC19 (ENSG00000163958), ZDHHC14 (ENSG00000175048), ZDHHC22 (ENSG00000177108), ZDHHC20 (ENSG00000180776), ZDHHC23 (ENSG00000184307), ZDHHC9 (ENSG00000188706), ZDHHC11 (ENSG00000188818), ZDHHC18 (ENSG00000204160), ZDHHC11B (ENSG00000206077)

Protein

Protein identifiers

Palmitoyltransferase ZDHHC21 — Q8IVQ6 (reviewed: Q8IVQ6)

Alternative names: DHHC domain-containing cysteine-rich protein 21, Zinc finger DHHC domain-containing protein 21

All UniProt accessions (1): Q8IVQ6

UniProt curated annotations — full annotation on UniProt →

Function. Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor. Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Also has a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK.

Subcellular location. Golgi apparatus membrane. Golgi apparatus. cis-Golgi network membrane. Cell membrane.

Tissue specificity. Widely expressed.

Domain organisation. The DHHC domain is required for palmitoyltransferase activity.

Similarity. Belongs to the DHHC palmitoyltransferase family.

RefSeq proteins (14): NP_001341047, NP_001341048, NP_001341049, NP_001341050, NP_001341051, NP_001341052, NP_001341053, NP_001341054, NP_001341055, NP_001341056, NP_001341057, NP_001341058, NP_001341059, NP_848661* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001594	Palmitoyltrfase_DHHC	Domain
IPR039859	PFA4/ZDH16/20/ERF2-like	Family

Pfam: PF01529

Catalyzed reactions (Rhea), 1 shown:

• L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA (RHEA:36683)

UniProt features (12 total): topological domain 5, transmembrane region 4, chain 1, domain 1, active site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IVQ6-F1	87.81	0.63

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 120 (s-palmitoyl cysteine intermediate)

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-203615	eNOS activation
R-HSA-9009391	Extra-nuclear estrogen signaling

MSigDB gene sets: 294 (showing top): GOBP_ENDOTHELIAL_CELL_DEVELOPMENT, GOBP_EPITHELIUM_DEVELOPMENT, YAATNRNNNYNATT_UNKNOWN, ACTACCT_MIR196A_MIR196B, GOBP_CIRCULATORY_SYSTEM_PROCESS, STAEGE_EWING_FAMILY_TUMOR, RORA1_01, GOBP_LIPOPROTEIN_METABOLIC_PROCESS, GOBP_EPITHELIAL_CELL_DEVELOPMENT, NKX25_02, GOBP_PROTEIN_TARGETING, GOBP_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION, GOBP_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION, LANG_MYB_FAMILY_TARGETS, TGACCTY_ERR1_Q2

GO Biological Process (9): hair follicle development (GO:0001942), regulation of vascular associated smooth muscle contraction (GO:0003056), protein targeting to membrane (GO:0006612), peptidyl-L-cysteine S-palmitoylation (GO:0018230), nitric oxide metabolic process (GO:0046209), sebaceous gland development (GO:0048733), adrenergic receptor signaling pathway (GO:0071875), regulation of establishment of endothelial barrier (GO:1903140), regulation of leukocyte adhesion to arterial endothelial cell (GO:1904997)

GO Molecular Function (5): palmitoyltransferase activity (GO:0016409), protein-cysteine S-palmitoyltransferase activity (GO:0019706), protein binding (GO:0005515), transferase activity (GO:0016740), acyltransferase activity (GO:0016746)

GO Cellular Component (5): Golgi membrane (GO:0000139), endoplasmic reticulum (GO:0005783), Golgi apparatus (GO:0005794), plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Metabolism of nitric oxide: NOS3 activation and regulation	1
ESR-mediated signaling	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	2
endomembrane system	2
intracellular membrane-bounded organelle	2
hair cycle process	1
anatomical structure development	1
skin epidermis development	1
regulation of smooth muscle contraction	1
vascular associated smooth muscle contraction	1
regulation of vasoconstriction	1
protein targeting	1
establishment of protein localization to membrane	1
peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	1
protein palmitoylation	1
reactive nitrogen species metabolic process	1
skin development	1
gland development	1
adrenergic receptor activity	1
G protein-coupled receptor signaling pathway	1
establishment of endothelial barrier	1
regulation of endothelial cell development	1
leukocyte adhesion to arterial endothelial cell	1
regulation of leukocyte adhesion to vascular endothelial cell	1
acyltransferase activity, transferring groups other than amino-acyl groups	1
palmitoyltransferase activity	1
protein-cysteine S-acyltransferase activity	1
binding	1
catalytic activity	1
transferase activity	1
Golgi apparatus	1
bounding membrane of organelle	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

510 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZDHHC21	MPDZ	O75970	592
ZDHHC21	NHLRC3	Q5JS37	570
ZDHHC21	LNX1	Q8TBB1	548
ZDHHC21	ESR1	P03372	538
ZDHHC21	NFIB	O00712	520
ZDHHC21	PRR14L	Q5THK1	517
ZDHHC21	GLDC	P23378	504
ZDHHC21	RCC2	Q9P258	491
ZDHHC21	ZDHHC16	Q969W1	474
ZDHHC21	ZDHHC13	Q8IUH4	472
ZDHHC21	TYRP1	P17643	464
ZDHHC21	ZDHHC6	Q9H6R6	441
ZDHHC21	ABHD17B	Q5VST6	426
ZDHHC21	FREM1	Q5H8C1	425
ZDHHC21	PPIP5K2	O43314	418

IntAct

55 interactions, top by confidence:

A	B	Type	Score
ZDHHC21	CHODL	psi-mi:“MI:0915”(physical association)	0.560
ZDHHC21	TRIM59	psi-mi:“MI:0915”(physical association)	0.560
ZDHHC21	TMEM167B	psi-mi:“MI:0915”(physical association)	0.560
RNASEK	ZDHHC21	psi-mi:“MI:0915”(physical association)	0.560
PGRMC2	ZDHHC21	psi-mi:“MI:0915”(physical association)	0.560
MUC1	ZDHHC21	psi-mi:“MI:0915”(physical association)	0.560
ZDHHC21	ELOVL4	psi-mi:“MI:0915”(physical association)	0.560
ZDHHC21	FAM210B	psi-mi:“MI:0915”(physical association)	0.560
AQP6	ZDHHC21	psi-mi:“MI:0915”(physical association)	0.560
ZDHHC21	MTERF3	psi-mi:“MI:0915”(physical association)	0.560
ZDHHC21	ERGIC3	psi-mi:“MI:0915”(physical association)	0.560
SLC7A1	TMEM223	psi-mi:“MI:0914”(association)	0.530
C3AR1	TMEM120B	psi-mi:“MI:0914”(association)	0.530
SLC22A9	GPR89A	psi-mi:“MI:0914”(association)	0.530
	ZDHHC21	psi-mi:“MI:0915”(physical association)	0.370
CCL1	ZDHHC21	psi-mi:“MI:0915”(physical association)	0.370
ZDHHC21	CREB3	psi-mi:“MI:0915”(physical association)	0.370
ADGRE5	TMEM223	psi-mi:“MI:0914”(association)	0.350
DPEP1	TMEM120B	psi-mi:“MI:0914”(association)	0.350
SLC22A9	GPR89A	psi-mi:“MI:0914”(association)	0.350
TSPAN5	KLHL2	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350
CHRNA4	TMEM223	psi-mi:“MI:0914”(association)	0.350

BioGRID (29): ZDHHC21 (Two-hybrid), ZDHHC21 (Affinity Capture-MS), ZDHHC21 (Affinity Capture-MS), ZDHHC21 (Affinity Capture-MS), ZDHHC21 (Affinity Capture-MS), ZDHHC21 (Affinity Capture-MS), ZDHHC21 (Affinity Capture-MS), ZDHHC21 (Two-hybrid), ZDHHC21 (Two-hybrid), ZDHHC21 (Two-hybrid), ZDHHC21 (Two-hybrid), ZDHHC21 (Two-hybrid), ZDHHC21 (Two-hybrid), ZDHHC21 (Two-hybrid), MUC1 (Two-hybrid)

ESM2 similar proteins: A0A0R4IF99, A2VDT6, B1H1H3, B8A4F0, E7F021, E7F587, E7F6D7, F1Q7H8, F1QAM1, F1QGD2, F1QHM7, F1QXD3, F1RE57, O14345, O74384, P42836, Q06551, Q2HJ95, Q2TGJ4, Q2TGK3, Q500Z2, Q5BLG4, Q5FWL7, Q5M757, Q5RB84, Q5REH2, Q6C7D1, Q6CPU8, Q6CQB5, Q6DHI1, Q6FSS4, Q6FW70, Q75AW7, Q7XA86, Q8BGJ0, Q8IVQ6, Q8R173, Q8VYP5, Q91WU6, Q923G5

Diamond homologs: A2VDT6, B1H1H3, Q5RB84, Q8IVQ6, Q9D270

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	30
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2340 predictions. Top by Δscore:

Variant	Effect	Δscore
9:14619637:A:AC	donor_gain	1.0000
9:14619638:C:CC	donor_gain	1.0000
9:14619638:CAT:C	donor_gain	1.0000
9:14619638:CATAT:C	donor_gain	1.0000
9:14639887:TATAC:T	donor_loss	1.0000
9:14639888:ATACT:A	donor_loss	1.0000
9:14639889:TACT:T	donor_loss	1.0000
9:14639890:ACTTA:A	donor_loss	1.0000
9:14639891:CT:C	donor_loss	1.0000
9:14639892:TTACT:T	donor_loss	1.0000
9:14639893:TACT:T	donor_loss	1.0000
9:14639894:A:AC	donor_gain	1.0000
9:14639894:ACTG:A	donor_loss	1.0000
9:14639895:C:CA	donor_gain	1.0000
9:14639895:CT:C	donor_gain	1.0000
9:14639895:CTG:C	donor_gain	1.0000
9:14639895:CTGT:C	donor_gain	1.0000
9:14639895:CTGTG:C	donor_gain	1.0000
9:14640012:CCTAA:C	acceptor_loss	1.0000
9:14640014:T:C	acceptor_loss	1.0000
9:14693225:TCA:T	donor_loss	1.0000
9:14693226:CA:C	donor_loss	1.0000
9:14693227:A:AC	donor_gain	1.0000
9:14693228:C:CC	donor_gain	1.0000
9:14693228:CCGT:C	donor_gain	1.0000
9:14619630:TATAC:T	donor_loss	0.9900
9:14619631:ATAC:A	donor_loss	0.9900
9:14619632:TACTT:T	donor_loss	0.9900
9:14619633:ACT:A	donor_loss	0.9900
9:14619634:C:CG	donor_loss	0.9900

AlphaMissense

1766 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:14662222:A:G	C120R	1.000
9:14662223:G:C	H119Q	1.000
9:14662223:G:T	H119Q	1.000
9:14662226:A:C	H118Q	1.000
9:14662226:A:T	H118Q	1.000
9:14662228:G:C	H118D	1.000
9:14662262:A:C	C106W	1.000
9:14662264:A:G	C106R	1.000
9:14662265:G:C	H105Q	1.000
9:14662265:G:T	H105Q	1.000
9:14662270:G:C	H104D	1.000
9:14662296:C:G	C95S	1.000
9:14662297:A:T	C95S	1.000
9:14662306:A:G	C92R	1.000
9:14619031:A:G	W245R	0.999
9:14619031:A:T	W245R	0.999
9:14658848:A:C	F135L	0.999
9:14658848:A:T	F135L	0.999
9:14658849:A:C	F135C	0.999
9:14658849:A:G	F135S	0.999
9:14658850:A:G	F135L	0.999
9:14658860:A:C	N131K	0.999
9:14658860:A:T	N131K	0.999
9:14658870:C:A	G128V	0.999
9:14658870:C:T	G128D	0.999
9:14658871:C:G	G128R	0.999
9:14658873:A:T	V127D	0.999
9:14658875:A:C	C126W	0.999
9:14658876:C:A	C126F	0.999
9:14658876:C:G	C126S	0.999

dbSNP variants (sampled 300 via entrez): RS1000020482 (9:14619106 A>G), RS1000029637 (9:14651486 C>A), RS1000051852 (9:14618865 G>A), RS1000063008 (9:14656550 A>G), RS1000069335 (9:14595289 A>T), RS1000078438 (9:14642747 A>C), RS1000089138 (9:14660914 T>G), RS1000092173 (9:14690295 T>C), RS1000124170 (9:14618647 A>G,T), RS1000167420 (9:14674260 A>G), RS1000170784 (9:14611728 G>A,C), RS1000178183 (9:14604078 G>C), RS1000194152 (9:14606848 A>C), RS1000201879 (9:14611519 G>C), RS1000202681 (9:14680611 TAA>T)

Disease associations

OMIM: gene MIM:614605 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST001474_3	Hypothyroidism	7.000000e-06
GCST001523_41	Visceral adipose tissue adjusted for BMI	7.000000e-06
GCST008829_11	Neuritic plaque	8.000000e-06
GCST009391_1330	Metabolite levels	8.000000e-06
GCST010482_3	Cardiovascular death or myocardial infarction in response to clopidogrel treatment	6.000000e-06
GCST011768_5	Schizophrenia	7.000000e-09
GCST011769_3	Schizophrenia	1.000000e-09
GCST90000047_193	Age at first sexual intercourse	6.000000e-11

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0006798	neuritic plaque measurement
EFO:0010361	lysophosphatidylcholine 18:2 measurement
EFO:0006919	cardiovascular event measurement
EFO:0009749	age at first sexual intercourse measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

41 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases methylation, increases expression	4
bisphenol A	decreases expression, affects cotreatment	2
sodium arsenite	increases expression	2
entinostat	decreases expression, affects cotreatment	2
aristolochic acid I	decreases expression	1
urushiol	increases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
cinnamaldehyde	increases expression	1
cobaltous chloride	decreases expression	1
manganese chloride	increases abundance, increases expression	1
nickel sulfate	decreases expression	1
vanadyl sulfate	decreases expression	1
avobenzone	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	affects cotreatment, decreases expression	1
Irinotecan	decreases expression	1
Vorinostat	increases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	increases abundance, increases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Succimer	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Estradiol	affects cotreatment, decreases expression	1
Indomethacin	decreases expression, affects cotreatment	1
Manganese	increases abundance, increases expression	1
Methyl Methanesulfonate	decreases expression	1
Polychlorinated Biphenyls	affects expression	1
Quercetin	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TY87	HAP1 ZDHHC21 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.