ZDHHC6

Summary

ZDHHC6 (zDHHC palmitoyltransferase 6, HGNC:19160) is a protein-coding gene on chromosome 10q25.2, encoding Palmitoyltransferase ZDHHC6 (Q9H6R6). Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC.

Enables palmitoyltransferase activity and protein-cysteine S-stearoyltransferase activity. Involved in positive regulation of mitochondrial fusion; protein palmitoylation; and protein stearoylation. Located in endoplasmic reticulum.

Source: NCBI Gene 64429 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 61 total
• MANE Select transcript: NM_022494

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19160
Approved symbol	ZDHHC6
Name	zDHHC palmitoyltransferase 6
Location	10q25.2
Locus type	gene with protein product
Status	Approved
Aliases	ZNF376, FLJ21952
Ensembl gene	ENSG00000023041
Ensembl biotype	protein_coding
OMIM	618715
Entrez	64429

Gene structure

Transcript identifiers

Ensembl transcripts: 54 — 38 protein_coding, 8 retained_intron, 6 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined

ENST00000369404, ENST00000369405, ENST00000471035, ENST00000482410, ENST00000626395, ENST00000681964, ENST00000682006, ENST00000682055, ENST00000682143, ENST00000682182, ENST00000682195, ENST00000682267, ENST00000682441, ENST00000682616, ENST00000682731, ENST00000682807, ENST00000682839, ENST00000683319, ENST00000683491, ENST00000683505, ENST00000683895, ENST00000684173, ENST00000684234, ENST00000684507, ENST00000684617, ENST00000684741, ENST00000876815, ENST00000876816, ENST00000876817, ENST00000876818, ENST00000876819, ENST00000876820, ENST00000876821, ENST00000876822, ENST00000876823, ENST00000876825, ENST00000876827, ENST00000876830, ENST00000876832, ENST00000876833, ENST00000876834, ENST00000876835, ENST00000876836, ENST00000876837, ENST00000914120, ENST00000914121, ENST00000914122, ENST00000914123, ENST00000962556, ENST00000962557, ENST00000962558, ENST00000962559, ENST00000962560, ENST00000962561

RefSeq mRNA: 9 — MANE Select: NM_022494 NM_001303134, NM_001351082, NM_001351083, NM_001351084, NM_001351085, NM_001351086, NM_001363544, NM_001411066, NM_022494

CCDS: CCDS7574, CCDS76335, CCDS86144, CCDS91345

Canonical transcript exons

ENST00000369405 — 11 exons

Exon	Start	End
ENSE00000811892	112434297	112434464
ENSE00000811893	112438336	112438389
ENSE00000811894	112440534	112440695
ENSE00000811895	112442192	112442351
ENSE00000811896	112443515	112443606
ENSE00001368652	112446705	112446914
ENSE00001449965	112430300	112430907
ENSE00001449967	112445170	112445650
ENSE00003466494	112432376	112432521
ENSE00003569075	112432240	112432286
ENSE00003669563	112433240	112433281

Expression profiles

Bgee: expression breadth ubiquitous, 285 present calls, max score 99.13.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 23.9115 / max 201.6748, expressed in 1817 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111434	12.3047	1799
111435	9.5776	1781
111432	0.7171	404
111433	0.6930	413
111437	0.4167	187
111436	0.2023	76

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
renal glomerulus	UBERON:0000074	99.13	gold quality
metanephric glomerulus	UBERON:0004736	99.05	gold quality
jejunal mucosa	UBERON:0000399	96.85	gold quality
cortex of kidney	UBERON:0001225	96.20	gold quality
metanephros	UBERON:0000081	96.03	gold quality
kidney epithelium	UBERON:0004819	95.84	gold quality
metanephros cortex	UBERON:0010533	95.80	gold quality
duodenum	UBERON:0002114	95.75	gold quality
rectum	UBERON:0001052	95.62	gold quality
right uterine tube	UBERON:0001302	95.57	gold quality
small intestine Peyer’s patch	UBERON:0003454	95.18	gold quality
right ovary	UBERON:0002118	94.79	gold quality
granulocyte	CL:0000094	94.78	gold quality
adult mammalian kidney	UBERON:0000082	94.74	gold quality
left ovary	UBERON:0002119	94.64	gold quality
mucosa of stomach	UBERON:0001199	94.56	gold quality
small intestine	UBERON:0002108	94.47	gold quality
tibial nerve	UBERON:0001323	94.29	gold quality
lymph node	UBERON:0000029	94.26	gold quality
body of pancreas	UBERON:0001150	94.24	gold quality
gall bladder	UBERON:0002110	94.23	gold quality
spleen	UBERON:0002106	94.20	gold quality
minor salivary gland	UBERON:0001830	94.10	gold quality
endometrium	UBERON:0001295	93.92	gold quality
body of uterus	UBERON:0009853	93.85	gold quality
transverse colon	UBERON:0001157	93.82	gold quality
ileal mucosa	UBERON:0000331	93.73	gold quality
kidney	UBERON:0002113	93.73	gold quality
right lung	UBERON:0002167	93.67	gold quality
calcaneal tendon	UBERON:0003701	93.66	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	30.20
E-ANND-3	yes	6.27

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

58 targeting ZDHHC6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-7162-3P	99.89	68.16	1682
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-448	99.79	72.37	2103
HSA-MIR-26A-5P	99.78	73.52	2303
HSA-MIR-26B-5P	99.78	73.51	2305
HSA-MIR-498-5P	99.76	69.64	1807
HSA-MIR-548A-3P	99.76	70.58	3524
HSA-MIR-148A-3P	99.74	73.77	1700
HSA-MIR-148B-3P	99.74	73.75	1700
HSA-MIR-152-3P	99.74	73.75	1703
HSA-MIR-4465	99.71	72.56	2096
HSA-MIR-10394-5P	99.65	66.83	1852
HSA-MIR-1205	99.65	66.76	1826
HSA-MIR-6134	99.63	65.68	1537
HSA-MIR-7106-5P	99.53	67.47	3574
HSA-MIR-136-5P	99.50	67.26	1153

Literature-anchored findings (GeneRIF, showing 3)

• Data show that palmitoyl acyltransferases DHHC5, DHHC6, and DHHC8 appear to be S-acylated on three cysteine residues within a novel CCX(7-13)C(S/T) motif downstream of a conserved Asp-His-His-Cys cysteine-rich domain. (PMID:19801377)
• DHHC6 knockdown using shRNA in stably transfected cell lines led to decreased expression of the IP3R and impaired IP3R-dependent Ca(2+) flux. (PMID:25368151)
• human ZDHHC6, which modifies key proteins of the endoplasmic reticulum, is controlled by an upstream palmitoyltransferase, ZDHHC16, revealing the first palmitoylation cascade. (PMID:28826475)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	zdhhc6	ENSDARG00000075721
mus_musculus	Zdhhc6	ENSMUSG00000024982
rattus_norvegicus	Zdhhc6	ENSRNOG00000036576
drosophila_melanogaster	CG4483	FBGN0035970
drosophila_melanogaster	CG5196	FBGN0038039
caenorhabditis_elegans		WBGENE00008606

Paralogs (17): ZDHHC15 (ENSG00000102383), ZDHHC2 (ENSG00000104219), ZDHHC4 (ENSG00000136247), ZDHHC7 (ENSG00000153786), ZDHHC1 (ENSG00000159714), ZDHHC12 (ENSG00000160446), ZDHHC3 (ENSG00000163812), ZDHHC19 (ENSG00000163958), ZDHHC14 (ENSG00000175048), ZDHHC21 (ENSG00000175893), ZDHHC22 (ENSG00000177108), ZDHHC20 (ENSG00000180776), ZDHHC23 (ENSG00000184307), ZDHHC9 (ENSG00000188706), ZDHHC11 (ENSG00000188818), ZDHHC18 (ENSG00000204160), ZDHHC11B (ENSG00000206077)

Protein

Protein identifiers

Palmitoyltransferase ZDHHC6 — Q9H6R6 (reviewed: Q9H6R6)

Alternative names: Stearoyltransferase ZDHHC6, Transmembrane protein H4, Zinc finger DHHC domain-containing protein 6, Zinc finger protein 376

All UniProt accessions (9): A0A0D9SEX5, A0A804HJ40, A0A804HJ80, A0A804HJC7, Q9H6R6, A0A804HJK5, A0A804HKZ7, A0A804HL63, A0A804HL82

UniProt curated annotations — full annotation on UniProt →

Function. Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum. Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation.

Subunit / interactions. Homooligomerizes. Interacts with SELENOK.

Subcellular location. Endoplasmic reticulum membrane.

Post-translational modifications. Palmitoylated at 3 different sites by ZDHHC16. The combination of the different palmitoylation events strongly affects the quaternary assembly of ZDHHC6, its localization, stability and function. Palmitoylation at Cys-328 accelerates the turnover of ZDHHC6. Depalmitoylated by LYPLA2.

Domain organisation. The DHHC domain is required for palmitoyltransferase activity. The C-terminal di-lysine motif confers endoplasmic reticulum localization.

Similarity. Belongs to the DHHC palmitoyltransferase family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H6R6-1	1	yes
Q9H6R6-2	2

RefSeq proteins (9): NP_001290063, NP_001338011, NP_001338012, NP_001338013, NP_001338014, NP_001338015, NP_001350473, NP_001397995, NP_071939* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001452	SH3_domain	Domain
IPR001594	Palmitoyltrfase_DHHC	Domain
IPR039859	PFA4/ZDH16/20/ERF2-like	Family

Pfam: PF01529, PF07653

Catalyzed reactions (Rhea), 2 shown:

• L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA (RHEA:36683)
• L-cysteinyl-[protein] + octadecanoyl-CoA = S-octadecanoyl-L-cysteinyl-[protein] + CoA (RHEA:59740)

UniProt features (32 total): mutagenesis site 7, sequence conflict 6, topological domain 5, transmembrane region 4, lipid moiety-binding region 3, domain 2, chain 1, short sequence motif 1, active site 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H6R6-F1	86.57	0.68

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 129 (s-palmitoyl cysteine intermediate)

Post-translational modifications (3): 328, 329, 343

Mutagenesis-validated functional residues (7):

Position	Phenotype
328–329	abolishes palmitoylation, leading to impaired homooligomeization and decreased catalytic activity; when associated with
343	abolishes palmitoylation, leading to impaired homooligomeization and decreased catalytic activity; when associated with
409	does not affect localization to the endoplasmic reticulum.
410	impaired localization to the endoplasmic reticulum.
411	impaired localization to the endoplasmic reticulum.
412	does not affect localization to the endoplasmic reticulum.
413	does not affect localization to the endoplasmic reticulum.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 156 (showing top): TSENG_IRS1_TARGETS_UP, AAGCCAT_MIR135A_MIR135B, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_PROTEIN_TARGETING, GOBP_PROTEIN_TARGETING_TO_MEMBRANE, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE, GOBP_LOCALIZATION_WITHIN_MEMBRANE, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, MCCLUNG_COCAIN_REWARD_4WK, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, BENPORATH_OCT4_TARGETS, GRYDER_PAX3FOXO1_TOP_ENHANCERS, chr10q25, VANHARANTA_UTERINE_FIBROID_WITH_7Q_DELETION_UP

GO Biological Process (2): protein targeting to membrane (GO:0006612), intracellular signal transduction (GO:0035556)

GO Molecular Function (6): palmitoyltransferase activity (GO:0016409), protein-cysteine S-palmitoyltransferase activity (GO:0019706), protein-cysteine S-stearoyltransferase activity (GO:0140439), protein binding (GO:0005515), transferase activity (GO:0016740), acyltransferase activity (GO:0016746)

GO Cellular Component (4): endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), Golgi apparatus (GO:0005794), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein-cysteine S-acyltransferase activity	2
cytoplasm	2
endomembrane system	2
intracellular membrane-bounded organelle	2
protein targeting	1
establishment of protein localization to membrane	1
intracellular anatomical structure	1
signal transduction	1
acyltransferase activity, transferring groups other than amino-acyl groups	1
palmitoyltransferase activity	1
binding	1
catalytic activity	1
transferase activity	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
cellular anatomical structure	1

Protein interactions and networks

STRING

544 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZDHHC6	SELENOK	Q9Y6D0	893
ZDHHC6	ZDHHC13	Q8IUH4	697
ZDHHC6	GOLGA7	Q7Z5G4	610
ZDHHC6	LYPLA2	O95372	560
ZDHHC6	TECTB	Q96PL2	523
ZDHHC6	VTI1A	Q96AJ9	507
ZDHHC6	ACSL5	Q9ULC5	506
ZDHHC6	ZDHHC4	Q9NPG8	505
ZDHHC6	PPT1	P50897	504
ZDHHC6	LYPLA1	O75608	490
ZDHHC6	ZDHHC17	Q8IUH5	488
ZDHHC6	NHLRC2	Q8NBF2	460
ZDHHC6	CCDC186	Q7Z3E2	460
ZDHHC6	ZDHHC24	Q6UX98	456
ZDHHC6	PLEKHS1	Q5SXH7	456

IntAct

60 interactions, top by confidence:

A	B	Type	Score
LRRC32	SMPD2	psi-mi:“MI:0914”(association)	0.640
POMK	LRP5	psi-mi:“MI:0914”(association)	0.640
KLRG2	GXYLT2	psi-mi:“MI:0914”(association)	0.530
POMK	TMEM120B	psi-mi:“MI:0914”(association)	0.530
C3AR1	TMEM120B	psi-mi:“MI:0914”(association)	0.530
CD226	MEN1	psi-mi:“MI:0914”(association)	0.530
WBP1	EXTL3	psi-mi:“MI:0914”(association)	0.530
TSPAN2	TSPAN3	psi-mi:“MI:0914”(association)	0.530
PLVAP	SMPD2	psi-mi:“MI:0914”(association)	0.530
TSPAN5	SC5D	psi-mi:“MI:0914”(association)	0.530
STS	GJA1	psi-mi:“MI:0914”(association)	0.530
CD63	LGALS8	psi-mi:“MI:0914”(association)	0.530
IL27RA	AP1G2	psi-mi:“MI:0914”(association)	0.530
CD44	PDPK1	psi-mi:“MI:0914”(association)	0.530
ADAM10	ZDHHC6	psi-mi:“MI:0407”(direct interaction)	0.440
CLDN17	ZDHHC6	psi-mi:“MI:0915”(physical association)	0.400
SNRNP70	ZDHHC6	psi-mi:“MI:0915”(physical association)	0.400
ZDHHC6		psi-mi:“MI:0915”(physical association)	0.370
	ZDHHC6	psi-mi:“MI:0915”(physical association)	0.370
CCL1	ZDHHC6	psi-mi:“MI:0915”(physical association)	0.370
	TMEM223	psi-mi:“MI:0914”(association)	0.350
POMK	ESYT2	psi-mi:“MI:0914”(association)	0.350
EPHA7	MYO1B	psi-mi:“MI:0914”(association)	0.350
EPHB2	BANF1	psi-mi:“MI:0914”(association)	0.350

BioGRID (77): ZDHHC6 (Affinity Capture-RNA), ZDHHC6 (Affinity Capture-RNA), ZDHHC6 (Affinity Capture-MS), ZDHHC6 (Affinity Capture-MS), ZDHHC6 (Affinity Capture-MS), ZDHHC6 (Affinity Capture-MS), ZDHHC6 (Affinity Capture-MS), ZDHHC6 (Affinity Capture-MS), ZDHHC6 (Affinity Capture-MS), ZDHHC6 (Affinity Capture-MS), ZDHHC6 (Affinity Capture-MS), ZDHHC6 (Affinity Capture-MS), ZDHHC6 (Affinity Capture-MS), ZDHHC6 (Affinity Capture-MS), ZDHHC6 (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4IF99, B8A4F0, E7F587, E7F6D7, F1Q7H8, F1QHM7, F1QX91, F1QXD3, F1RE57, O14345, O74384, P0C7U3, P42836, Q06551, Q0VC89, Q10L01, Q14AK4, Q2HJ95, Q2TGJ4, Q3EBC2, Q4R7E2, Q4WN54, Q58CU4, Q5BC23, Q5BLG4, Q5FWL7, Q5REH2, Q5W0Z9, Q5Y5T1, Q5Y5T3, Q6BLY8, Q6CG20, Q6CUB5, Q6DHI1, Q6FSS4, Q750R7, Q75AW7, Q76IC6, Q7XA86, Q8BGJ0

Diamond homologs: E7F6D7, Q2HJ95, Q4PE27, Q4R7E2, Q4WC37, Q5BD15, Q5REH2, Q969W1, Q9CPV7, Q9H6R6, Q6BLY8, Q9ESG8, J9VJ99, O14345, P0CS68, P0CS69, Q12006, Q86A83, A0A0R4IDP3, A0A0R4IF99, B8A4F0, E7F587, F1Q7H8, F1QXD3, F1R013, F1RE57, P0CS66, P0CS67, Q10L01, Q2TGK3, Q4WZL8, Q552M6, Q58CU4, Q58DT3, Q5ADN9, Q5B433, Q6BHT4, Q6C4W5, Q6DHI1, Q6FSS4

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 81 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
epidermal growth factor receptor signaling pathway	5	17.4×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

61 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	0
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

2353 predictions. Top by Δscore:

Variant	Effect	Δscore
10:112425336:A:AG	acceptor_gain	1.0000
10:112425336:AGAAT:A	acceptor_gain	1.0000
10:112425337:G:GA	acceptor_gain	1.0000
10:112425337:GA:G	acceptor_gain	1.0000
10:112425337:GAAT:G	acceptor_gain	1.0000
10:112425337:GAATG:G	acceptor_gain	1.0000
10:112425435:G:GT	donor_gain	1.0000
10:112425436:G:GT	donor_gain	1.0000
10:112432372:TTAC:T	donor_loss	1.0000
10:112432373:TACC:T	donor_loss	1.0000
10:112432374:A:AC	donor_gain	1.0000
10:112432374:A:C	donor_loss	1.0000
10:112432374:AC:A	donor_gain	1.0000
10:112432375:C:CT	donor_gain	1.0000
10:112432375:CC:C	donor_gain	1.0000
10:112432529:CAG:C	acceptor_gain	1.0000
10:112432530:A:T	acceptor_gain	1.0000
10:112433239:CA:C	donor_gain	1.0000
10:112433239:CACTT:C	donor_gain	1.0000
10:112443613:A:T	acceptor_gain	1.0000
10:112447463:GCCTG:G	donor_gain	1.0000
10:112425337:GAA:G	acceptor_gain	0.9900
10:112425469:G:T	donor_gain	0.9900
10:112425479:CGGG:C	donor_loss	0.9900
10:112425480:GG:G	donor_gain	0.9900
10:112425481:GG:G	donor_gain	0.9900
10:112425481:GGT:G	donor_loss	0.9900
10:112425482:GT:G	donor_loss	0.9900
10:112425483:T:A	donor_loss	0.9900
10:112426255:T:G	acceptor_gain	0.9900

AlphaMissense

2737 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:112442279:G:C	F144L	1.000
10:112442279:G:T	F144L	1.000
10:112442281:A:G	F144L	1.000
10:112442306:A:C	C135W	1.000
10:112442320:A:G	W131R	1.000
10:112442320:A:T	W131R	1.000
10:112442324:A:C	C129W	1.000
10:112442325:C:T	C129Y	1.000
10:112442326:A:G	C129R	1.000
10:112442327:G:C	H128Q	1.000
10:112442327:G:T	H128Q	1.000
10:112442329:G:C	H128D	1.000
10:112442330:A:C	H127Q	1.000
10:112442330:A:T	H127Q	1.000
10:112442332:G:C	H127D	1.000
10:112442334:T:A	D126V	1.000
10:112442334:T:G	D126A	1.000
10:112442335:C:G	D126H	1.000
10:112443529:G:C	C115W	1.000
10:112443530:C:G	C115S	1.000
10:112443530:C:T	C115Y	1.000
10:112443531:A:G	C115R	1.000
10:112443531:A:T	C115S	1.000
10:112443532:G:C	H114Q	1.000
10:112443532:G:T	H114Q	1.000
10:112443534:G:C	H114D	1.000
10:112443537:G:C	H113D	1.000
10:112443550:C:A	K108N	1.000
10:112443550:C:G	K108N	1.000
10:112430887:A:G	W387R	0.999

dbSNP variants (sampled 300 via entrez): RS1000017846 (10:112424036 T>C,G), RS1000033978 (10:112447241 G>A,T), RS1000352319 (10:112444770 A>T), RS1000355422 (10:112427579 G>C), RS1000384943 (10:112444394 CTTTATAG>C), RS1000407957 (10:112427931 T>A), RS1000411159 (10:112440793 A>G), RS1000689173 (10:112426117 T>C,G), RS1000718159 (10:112445988 C>T), RS1000825096 (10:112426445 A>C), RS1001067276 (10:112438423 C>T), RS1001093584 (10:112438845 A>G), RS1001173364 (10:112440498 T>A,C), RS1001236926 (10:112439275 A>G), RS1001391107 (10:112432485 A>G)

Disease associations

OMIM: gene MIM:618715 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST008949_1	High chromosomal aberration frequency (chromosome type) in genotoxic compound exposure	3.000000e-06
GCST009391_1695	Metabolite levels	4.000000e-06
GCST90002379_84	Basophil count	2.000000e-09

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0009861	chromosome-type aberration frequency
EFO:0010344	cholesteryl ester 18:1 measurement
EFO:0005090	basophil count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — 2.3.1.- Acyltransferases

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	3
aristolochic acid I	decreases expression	1
sodium arsenite	affects methylation	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
deguelin	decreases expression	1
(+)-JQ1 compound	decreases expression	1
Arsenic Trioxide	increases expression	1
Leflunomide	decreases expression	1
Acetaminophen	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Coumestrol	increases expression	1
Doxorubicin	decreases expression	1
Ozone	affects expression, increases abundance	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Cyclosporine	increases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2LP	Abcam HeLa ZDHHC6 KO	Cancer cell line	Female
CVCL_TZ02	HAP1 ZDHHC6 (-) 1	Cancer cell line	Male
CVCL_TZ03	HAP1 ZDHHC6 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.