ZEB1-AS1

Summary

ZEB1-AS1 (ZEB1 antisense RNA 1, HGNC:42354) is a long non-coding RNA gene on chromosome 10p11.22.

This locus produces long non-coding RNA that is transcribed from a shared bi-directional promoter with zinc finger E-box binding homeobox 1 (ZEB1). This transcript binds lysine methyltransferase 2A and promotes histone modifications that are thought to promote expression of ZEB1. Expression of this gene is correlated with tumor progression. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 220930 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42354
Approved symbol	ZEB1-AS1
Name	ZEB1 antisense RNA 1
Location	10p11.22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237036
Ensembl biotype	lncRNA
Entrez	220930
RNAcentral	URS000075AC83 — lncRNA, 2232 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000423714, ENST00000424191, ENST00000441257, ENST00000450834, ENST00000605946, ENST00000606250, ENST00000606286, ENST00000607166, ENST00000607455, ENST00000656575, ENST00000659795, ENST00000702065, ENST00000805106, ENST00000805107, ENST00000805108, ENST00000805109, ENST00000805110

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000423714 — 2 exons

Exon	Start	End
ENSE00001619448	31318452	31318540
ENSE00001742812	31319515	31319881

Expression profiles

Bgee: expression breadth ubiquitous, 190 present calls, max score 86.15.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.4294 / max 59.4992, expressed in 1429 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
108962	2.9027	1252
108963	0.5267	312

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	86.15	gold quality
ventricular zone	UBERON:0003053	85.94	gold quality
secondary oocyte	CL:0000655	84.78	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.33	gold quality
ganglionic eminence	UBERON:0004023	83.62	gold quality
sural nerve	UBERON:0015488	82.76	gold quality
colonic epithelium	UBERON:0000397	82.64	gold quality
body of uterus	UBERON:0009853	81.61	gold quality
calcaneal tendon	UBERON:0003701	81.09	gold quality
ascending aorta	UBERON:0001496	80.90	gold quality
thoracic aorta	UBERON:0001515	80.80	gold quality
thymus	UBERON:0002370	80.70	gold quality
left testis	UBERON:0004533	80.67	gold quality
apex of heart	UBERON:0002098	80.60	gold quality
right testis	UBERON:0004534	80.47	gold quality
endocervix	UBERON:0000458	80.12	gold quality
descending thoracic aorta	UBERON:0002345	79.92	gold quality
stromal cell of endometrium	CL:0002255	79.77	gold quality
left coronary artery	UBERON:0001626	79.31	gold quality
aorta	UBERON:0000947	79.28	gold quality
hindlimb stylopod muscle	UBERON:0004252	79.13	gold quality
testis	UBERON:0000473	79.12	gold quality
tibial nerve	UBERON:0001323	78.77	gold quality
popliteal artery	UBERON:0002250	78.47	gold quality
tibial artery	UBERON:0007610	78.44	gold quality
ectocervix	UBERON:0012249	78.37	gold quality
muscle layer of sigmoid colon	UBERON:0035805	78.15	gold quality
right coronary artery	UBERON:0001625	77.64	gold quality
cartilage tissue	UBERON:0002418	77.59	gold quality
adenohypophysis	UBERON:0002196	77.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.93

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 35)

• lncRNA ZEB1-AS1 was associated with tumor progression and could be an independent prognostic factor for esophageal squamous cell carcinoma patients. (PMID:26617942)
• Glioma patients with high ZEB1-AS1 levels had poor prognoses. ZEB1-AS1 functioned as an important regulator of migration and invasion via activating epithelial to mesenchymal transition. (PMID:27589728)
• study revealed a novel regulatory mechanism between ZEB1-AS1, miR-200s, and ZEB1. The interplay between ZEB1-AS1 and miR-200s contributes to osteosarcoma cell proliferation and migration, and targeting this interplay could be a promising strategy for osteosarcoma treatment. (PMID:28075045)
• these findings indicated that ZEB1-AS1 plays regulatory roles in bladder cancer and it may become a novel molecular biomarker of prognosis and therapy in bladder cancer. (PMID:28445936)
• Upregulation of ZEB1-AS1 colorectal cancer promotes cell proliferation and inhibits cell apoptosis. In addition, cell cycle inhibitory protein p15 participates in the oncogenic function of ZEB1-AS1. Collectively, ZEB1-AS1 has asignificant effect on colorectal cancer pathological process and serves as a valuable prognostic biomarker for colorectal cancer. (PMID:28618933)
• Studied role of lncRNA ZEB1 antisense 1 in prostate cancer epigenetic processes and ZEB1 expression. (PMID:28830551)
• Studied the role of ZEB1-AS1, and it’s association with IL-11, in promoting STAT3 activation in B-lymphoblastic leukemia. (PMID:28861713)
• colorectal cancer (CRC) patients of the high ZEB1-AS1 expression group had a poorer prognosis and a significantly lower survival rate than those of the low expression group, and Cox regression analysis indicated that ZEB1-AS1 expression and metastasis were independent predictors of poor prognosis. (PMID:28967064)
• High Levels of ZEB1-AS1 expression is associated with gastric cancer (PMID:29113674)
• LncRNA ZEB1-AS1 is highly expressed in gastric cancer tissues and cells, promoting cell migration and neoplasm metastasis. (PMID:29771411)
• Extracellular vesicles deliver lncZEB1 to esophageal cancer cells, promoting esophageal cancer cell proliferation by upregulating the expression of downstream ZEB1. (PMID:29771414)
• High expression of ZEB1-AS1 was associated with advanced clinicopathological characteristics, and ZEB1-AS1expression may be a potential prognostic biomarker in human cancer. (PMID:29778540)
• High expression of lncRNA ZEB1-AS1 was an unfavorable predictor of cancer prognosis in terms of OS, DFS, RFS, tumor differentiation, depth of invasion, clinical stage, organ metastasis and lymph node metastasis and the expression of lncRNA ZEB1-AS1 might be used as a promising prognostic biomarker for cancer. (PMID:29885321)
• miR-181a-5p targets not only protein-coding genes but also the lncRNA ZEB1-AS1. (PMID:29886791)
• ZEB1-AS1 can promote cell proliferation and migration of non-small cell lung carcinoma cells by silencing ID1 expression. (PMID:30626729)
• we found that ZEB1-AS1 is a downstream target of TGF-beta1 and is involved in its regulatory mechanism on cell migration and invasion by affecting miR-200b/FSCN1 axis in bladder cancer cells (PMID:30823924)
• the present findings suggest that ZEB1 antisense RNA 1 is an independent prognostic factor for patients with advanced gastric cancer receiving chemotherapy. (PMID:31072267)
• the data from the present study demonstrated that ZEB1AS1 induced bladder cancer metastasis via an AUF1mediated translation activation of ZEB1 mRNA mechanism. (PMID:31115480)
• Whole transcriptome analysis reveals correlation of long noncoding RNA ZEB1-AS1 with invasive profile in melanoma. (PMID:31383874)
• LncRNA ZEB1-AS1 down-regulation suppresses the proliferation and invasion by inhibiting ZEB1 expression in oesophageal squamous cell carcinoma. (PMID:31638344)
• ZEB1-AS1 promotes PAK2 expression by sponging miR-455-3p, thus facilitating colon adenocarcinoma cell growth and metastasis. (PMID:31828845)
• ZEB1 induced-upregulation of long noncoding RNA ZEB1-AS1 facilitates the progression of triple negative breast cancer by binding with ELAVL1 to maintain the stability of ZEB1 mRNA. (PMID:31922280)
• LncRNA ZEB1-AS1 facilitates ox-LDL-induced damage of HCtAEC cells (PMID:31962131)
• Long noncoding RNA ZEB1AS1 predicts a poor prognosis and promotes cancer progression through the miR200a/ZEB1 signaling pathway in intrahepatic cholangiocarcinoma. (PMID:32236578)
• Downregulation of lncRNA ZEB1-AS1 Represses Cell Proliferation, Migration, and Invasion Through Mediating PI3K/AKT/mTOR Signaling by miR-342-3p/CUL4B Axis in Prostate Cancer. (PMID:32275162)
• LncRNA ZEB1-AS1 promotes pancreatic cancer progression by regulating miR-505-3p/TRIB2 axis. (PMID:32513531)
• Clinical value of long noncoding RNA ZEB1 anti-sense1 in cancer patients: A meta-analysis. (PMID:32756112)
• Long noncoding RNA ZEB1-AS1 affects paclitaxel and cisplatin resistance by regulating MMP19 in epithelial ovarian cancer cells. (PMID:33151424)
• Long non-coding RNA ZEB1-AS1 promotes proliferation and metastasis of hepatocellular carcinoma cells by targeting miR-299-3p/E2F1 axis. (PMID:33788950)
• Exosomes-Mediated LncRNA ZEB1-AS1 Facilitates Cell Injuries by miR-590-5p/ETS1 Axis Through the TGF-beta/Smad Pathway in Oxidized Low-density Lipoprotein-induced Human Umbilical Vein Endothelial Cells. (PMID:33818551)
• LncRNA ZEB1-AS1 regulates hepatocellular carcinoma progression by targeting miR-23c. (PMID:33865414)
• Identification of a novel pathway in sporadic Amyotrophic Lateral Sclerosis mediated by the long non-coding RNA ZEB1-AS1. (PMID:36736597)
• A review on the role of ZEB1-AS1 in human disorders. (PMID:37120907)
• Long noncoding RNA ZEB1-AS1 attenuates ferroptosis of gastric cancer cells through modulating miR-429/BGN axis. (PMID:37128782)
• ZEB1-AS1 mediates bone metastasis through targeting miR-320b/BMPR1A axis in lung cancer. (PMID:38783645)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.