ZEB2-AS1

Summary

ZEB2-AS1 (ZEB2 antisense RNA 1, HGNC:37149) is a long non-coding RNA gene on chromosome 2q22.3.

This gene produces a spliced long non-coding RNA which is a natural antisense transcript corresponding to the 5’ UTR of zinc finger E-box binding homeobox 2 (ZEB2). It is thought that this transcript may be involved in the regulation of ZEB2 expression, and may play a role in the progression of bladder cancer.

Source: NCBI Gene 100303491 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37149
Approved symbol	ZEB2-AS1
Name	ZEB2 antisense RNA 1
Location	2q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	ZEB2NAT
Ensembl gene	ENSG00000238057
Ensembl biotype	lncRNA
Entrez	100303491
RNAcentral	URS00005A7900 — lncRNA, 430 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 19 lncRNA

ENST00000421083, ENST00000427278, ENST00000428623, ENST00000595109, ENST00000595449, ENST00000602006, ENST00000608361, ENST00000609376, ENST00000609819, ENST00000609842, ENST00000610265, ENST00000610937, ENST00000647603, ENST00000648698, ENST00000648781, ENST00000649923, ENST00000650024, ENST00000823977, ENST00000823978

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421083 — 3 exons

Exon	Start	End
ENSE00001608025	144520215	144520285
ENSE00003710902	144519836	144520110
ENSE00004232804	144520754	144520905

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 96.13.

FANTOM5 (CAGE): breadth broad, TPM avg 3.6558 / max 251.3459, expressed in 478 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
22859	1.0280	159
22858	0.8876	175
22864	0.8710	134
22863	0.2811	67
22857	0.2695	127
22865	0.2109	79
22862	0.0940	33
22860	0.0137	7

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	96.13	gold quality
monocyte	CL:0000576	92.29	gold quality
corpus callosum	UBERON:0002336	92.14	gold quality
bone marrow cell	CL:0002092	91.47	gold quality
leukocyte	CL:0000738	91.41	gold quality
bone marrow	UBERON:0002371	90.53	gold quality
calcaneal tendon	UBERON:0003701	89.78	gold quality
adrenal tissue	UBERON:0018303	87.74	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.15	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.55	gold quality
colonic epithelium	UBERON:0000397	81.67	gold quality
sural nerve	UBERON:0015488	80.55	gold quality
substantia nigra	UBERON:0002038	79.22	gold quality
blood	UBERON:0000178	77.70	gold quality
prefrontal cortex	UBERON:0000451	76.76	gold quality
cortical plate	UBERON:0005343	76.60	gold quality
Ammon’s horn	UBERON:0001954	76.40	gold quality
spleen	UBERON:0002106	75.94	gold quality
left adrenal gland cortex	UBERON:0035825	75.23	gold quality
lung	UBERON:0002048	75.06	gold quality
amygdala	UBERON:0001876	74.93	gold quality
right coronary artery	UBERON:0001625	74.91	gold quality
temporal lobe	UBERON:0001871	74.90	gold quality
frontal cortex	UBERON:0001870	74.67	gold quality
tibial nerve	UBERON:0001323	74.55	gold quality
adrenal gland	UBERON:0002369	74.50	gold quality
right adrenal gland cortex	UBERON:0035827	74.39	gold quality
left adrenal gland	UBERON:0001234	74.20	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.87	gold quality
omental fat pad	UBERON:0010414	73.77	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	8.35
E-ANND-3	yes	4.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 18)

• the current study demonstrated that the downregulation of ZEB2AS1 was associated with decreased tumor growth and metastasis in Hepatocellular carcinoma (HCC) by the regulation of the expression levels of epithelial mesenchymal transition-induced markers. In conclusion, lncRNA ZEB2AS1 may be used as a valuable biomarker in patients with HCC. (PMID:27748842)
• In hepatocellular carcinoma cells, expression of ZEB2 antisense RNA 1 (ZEB2-AS1) is altered by hepatitis B virus X protein (HBx). Inhibition of ZEB2-AS1 can compensate for the epithelial-mesenchymal transition (EMT) phenotype and reverse the expression of EMT markers regulated by hepatitis B virus X protein (HBx). (PMID:29258558)
• HMGB1 was identified as a down-stream target of miR-204. The miR-204/HMGB1 axis mediated ZEB2-AS1’s effect on pancreatic cancer. (PMID:29753015)
• ZEB2-AS1 promotes the tumorigenesis of gastric carcinoma that is related to the upregulation of ZEB2 and the activation of the Wnt/beta-catenin pathway. (PMID:30635820)
• lncRNA-ZEB2-AS1 expression is associated with clinicopathologic features and short survival of breast cancer patients. (PMID:30825262)
• Overexpression of ZEB2-AS1 promotes epithelial-to-mesenchymal transition and metastasis by stabilizing ZEB2 mRNA in head neck squamous cell carcinoma. (PMID:30950191)
• The expression of lncRNA ZEB2-AS1 in gastric cancer tissues is significantly higher than in cancer-adjacent tissues. Patients with highly expressed lncRNA ZEB2-AS1 have a poor prognosis, and knockdown of lncRNA ZEB2-AS1 in AGS cells inhibits cell proliferation, invasion and metastasis, and promotes apoptosis. (PMID:31128021)
• The decreased lncRNA ZEB2-AS1 in pre-eclampsia controls the trophoblastic cell line HTR-8/SVneo’s invasive and migratory abilities via the miR-149/PGF axis. (PMID:31148230)
• Effect and mechanism of long non-coding RNA ZEB2-AS1 in the occurrence and development of colon cancer. (PMID:31698657)
• ZEB2-AS1 Accelerates Epithelial/Mesenchymal Transition Through miR-1205/CRKL Pathway in Colorectal Cancer. (PMID:31755734)
• Knockdown of ZEB2-AS1 inhibits cell invasion and induces apoptosis in colorectal cancer. (PMID:32277632)
• IL-6 stimulates lncRNA ZEB2-AS1 to aggravate the progression of non-small cell lung cancer through activating STAT1. (PMID:32329850)
• ZEB2-AS1 regulates the expression of TAB3 and promotes the development of colon cancer by adsorbing microRNA-188. (PMID:32373954)
• Long noncoding RNA ZEB2AS1 affects cell proliferation and apoptosis via the miR1225p/PLK1 axis in acute myeloid leukemia. (PMID:32700753)
• The Long Noncoding RNA ZEB2-AS1 Contributes to Proliferation and Epithelial-to-Mesenchymal Transition of Osteosarcoma. (PMID:33085924)
• Knockdown of lncRNA ZEB2NAT suppresses epithelial mesenchymal transition, metastasis and proliferation in breast cancer cells. (PMID:34418470)
• Differential gene expression of BCL-2, ZEB2-AS1 and BALR-2 in prostate cancer and benign prostatic hyperplasia. (PMID:34866225)
• Clinical significance of long non-coding RNA ZEB2-AS1 and EMT-related markers in ductal and lobular breast cancer. (PMID:37088469)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.