ZFAND6

Summary

ZFAND6 (zinc finger AN1-type containing 6, HGNC:30164) is a protein-coding gene on chromosome 15q25.1, encoding AN1-type zinc finger protein 6 (Q6FIF0). Involved in regulation of TNF induced NF-kappa-B activation and apoptosis.

Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in cellular response to tumor necrosis factor; negative regulation of apoptotic process; and regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol.

Source: NCBI Gene 54469 — RefSeq curated summary.

At a glance

• GWAS associations: 11
• Clinical variants (ClinVar): 29 total
• MANE Select transcript: NM_019006

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30164
Approved symbol	ZFAND6
Name	zinc finger AN1-type containing 6
Location	15q25.1
Locus type	gene with protein product
Status	Approved
Aliases	ZFAND5B, AWP1
Ensembl gene	ENSG00000086666
Ensembl biotype	protein_coding
OMIM	610183
Entrez	54469

Gene structure

Transcript identifiers

Ensembl transcripts: 158 — 155 protein_coding, 3 retained_intron

ENST00000261749, ENST00000557793, ENST00000557983, ENST00000558087, ENST00000558272, ENST00000558390, ENST00000558494, ENST00000558688, ENST00000558724, ENST00000558997, ENST00000559157, ENST00000559775, ENST00000559835, ENST00000560228, ENST00000560392, ENST00000560470, ENST00000560976, ENST00000561012, ENST00000561017, ENST00000561060, ENST00000564367, ENST00000613266, ENST00000616533, ENST00000618205, ENST00000891381, ENST00000891382, ENST00000891383, ENST00000891384, ENST00000891385, ENST00000891386, ENST00000891387, ENST00000891388, ENST00000891389, ENST00000891390, ENST00000891391, ENST00000891392, ENST00000891393, ENST00000891394, ENST00000891395, ENST00000891396, ENST00000891397, ENST00000891398, ENST00000891399, ENST00000891400, ENST00000891401, ENST00000891402, ENST00000891403, ENST00000891404, ENST00000891405, ENST00000891406, ENST00000891407, ENST00000891408, ENST00000891409, ENST00000891410, ENST00000891411, ENST00000891412, ENST00000891413, ENST00000891414, ENST00000891415, ENST00000891416, ENST00000891417, ENST00000891418, ENST00000891419, ENST00000891420, ENST00000891421, ENST00000891422, ENST00000891423, ENST00000891424, ENST00000891425, ENST00000891426, ENST00000891427, ENST00000891428, ENST00000891429, ENST00000891430, ENST00000891431, ENST00000891432, ENST00000891433, ENST00000891434, ENST00000891435, ENST00000891436, ENST00000891437, ENST00000891438, ENST00000891439, ENST00000891440, ENST00000891441, ENST00000891442, ENST00000914160, ENST00000914161, ENST00000914162, ENST00000914163, ENST00000914164, ENST00000914165, ENST00000914166, ENST00000914167, ENST00000914168, ENST00000914169, ENST00000914170, ENST00000914171, ENST00000914172, ENST00000914173, ENST00000914174, ENST00000914175, ENST00000914176, ENST00000914177, ENST00000914178, ENST00000914179, ENST00000914180, ENST00000914181, ENST00000914182, ENST00000914183, ENST00000914184, ENST00000914185, ENST00000914186, ENST00000914187, ENST00000914188, ENST00000914189, ENST00000914191, ENST00000914192, ENST00000914193, ENST00000914195, ENST00000914196, ENST00000914197, ENST00000914198, ENST00000914199, ENST00000914200, ENST00000961407, ENST00000961408, ENST00000961409, ENST00000961410, ENST00000961411, ENST00000961412, ENST00000961413, ENST00000961414, ENST00000961415, ENST00000961416, ENST00000961417, ENST00000961418, ENST00000961419, ENST00000961420, ENST00000961421, ENST00000961422, ENST00000961423, ENST00000961424, ENST00000961425, ENST00000961426, ENST00000961427, ENST00000961428, ENST00000961429, ENST00000961430, ENST00000961431, ENST00000961432, ENST00000961433, ENST00000961434, ENST00000961435, ENST00000961436, ENST00000961437, ENST00000961438, ENST00000961439

RefSeq mRNA: 10 — MANE Select: NM_019006 NM_001242911, NM_001242912, NM_001242913, NM_001242914, NM_001242915, NM_001242916, NM_001242917, NM_001242918, NM_001242919, NM_019006

CCDS: CCDS10313, CCDS58395

Canonical transcript exons

ENST00000261749 — 7 exons

Exon	Start	End
ENSE00001025055	80122700	80122800
ENSE00001218509	80098416	80098578
ENSE00001343702	80131180	80131293
ENSE00001855325	80137480	80138393
ENSE00002558150	80059676	80059809
ENSE00003688955	80120328	80120498
ENSE00003790486	80121712	80121820

Expression profiles

Bgee: expression breadth ubiquitous, 139 present calls, max score 99.05.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.1529 / max 466.0614, expressed in 1817 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
147974	27.0211	1813
147975	3.7365	1312
147980	3.3137	1255
147976	2.4967	1342
147973	0.5653	312
147977	0.0195	7

Top tissues by expression

139 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	99.05	gold quality
right testis	UBERON:0004534	98.06	gold quality
left testis	UBERON:0004533	97.96	gold quality
testis	UBERON:0000473	97.91	gold quality
bone marrow cell	CL:0002092	97.84	gold quality
endometrium	UBERON:0001295	97.74	gold quality
bone marrow	UBERON:0002371	97.53	gold quality
tonsil	UBERON:0002372	97.39	gold quality
skeletal muscle tissue	UBERON:0001134	97.23	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.01	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	97.00	gold quality
colonic epithelium	UBERON:0000397	96.97	gold quality
smooth muscle tissue	UBERON:0001135	96.94	gold quality
gastrocnemius	UBERON:0001388	96.91	gold quality
skeletal muscle organ	UBERON:0014892	96.89	gold quality
muscle of leg	UBERON:0001383	96.88	gold quality
right adrenal gland cortex	UBERON:0035827	96.80	gold quality
lymph node	UBERON:0000029	96.79	gold quality
adrenal tissue	UBERON:0018303	96.77	gold quality
rectum	UBERON:0001052	96.73	gold quality
monocyte	CL:0000576	96.69	gold quality
islet of Langerhans	UBERON:0000006	96.66	gold quality
leukocyte	CL:0000738	96.64	gold quality
right adrenal gland	UBERON:0001233	96.61	gold quality
adrenal gland	UBERON:0002369	96.49	gold quality
left adrenal gland	UBERON:0001234	96.47	gold quality
left adrenal gland cortex	UBERON:0035825	96.45	gold quality
liver	UBERON:0002107	96.32	gold quality
uterus	UBERON:0000995	96.28	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	96.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

78 targeting ZFAND6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-3121-3P	99.82	71.96	3630

Literature-anchored findings (GeneRIF, showing 6)

• The AN1 domain of AWP1 mediated the functional interaction with tumor necrosis factor receptor-associated factor 2, and the A20 domain was responsible for the negative regulation of nuclear factor kappaB activation. (PMID:21810480)
• ZFAND6 was identified as a type 2 diabetes susceptibility gene. ZFAND6 plays a role in insulin secretion in vitro. (PMID:28580277)
• By observing the data obtained from the isothermal titration calorimetry assay, both of the human proteins (KRCC1 and ZFAND6) were demonstrated to bind to their respective Toxoplasma gondii SAG1 and SAG2 proteins. (PMID:29351065)
• Genetic Variants of HNF4A, WFS1, DUSP9, FTO, and ZFAND6 Genes Are Associated with Prediabetes Susceptibility and Inflammatory Markers in the Saudi Arabian Population. (PMID:36980809)
• EIF4A3-induced circZFAND6 promotes breast cancer proliferation and metastasis through the miR-647/FASN axis. (PMID:37127184)
• Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India. (PMID:37738238)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfand6	ENSMUSG00000030629
rattus_norvegicus	Zfand6	ENSRNOG00000013506

Paralogs (2): ZFAND5 (ENSG00000107372), ZFAND3 (ENSG00000156639)

Protein

Protein identifiers

AN1-type zinc finger protein 6 — Q6FIF0 (reviewed: Q6FIF0)

Alternative names: Associated with PRK1 protein, Zinc finger A20 domain-containing protein 3

All UniProt accessions (12): Q6FIF0, H0YK21, H0YK54, H0YLR2, H0YME2, H0YMG0, H0YMR5, H3BM82, H3BMJ5, H3BP46, H3BPX9, H3BT16

UniProt curated annotations — full annotation on UniProt →

Function. Involved in regulation of TNF induced NF-kappa-B activation and apoptosis. Involved in modulation of ‘Lys-48’-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes.

Subunit / interactions. Interacts with PKN1. Interacts with TRAF2. Interacts with mono- and polyubiquitin. Interacts with PEX6. Interacts with PEX5 (Cys-linked ubiquitinated).

Subcellular location. Cytoplasm.

Tissue specificity. Widely expressed with high level in heart, skeletal muscle, liver, kidney and placenta.

Domain organisation. The A20-type zinc finger domain mediates regulation of NF-kappa-B activity. The AN1-type zinc finger domain mediates association with TRAF2.

Isoforms (2)

UniProt ID	Names	Canonical?
Q6FIF0-1	1	yes
Q6FIF0-2	2

RefSeq proteins (10): NP_001229840, NP_001229841, NP_001229842, NP_001229843, NP_001229844, NP_001229845, NP_001229846, NP_001229847, NP_001229848, NP_061879* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000058	Znf_AN1	Domain
IPR002653	Znf_A20	Domain
IPR035896	AN1-like_Znf	Homologous_superfamily
IPR050652	AN1_A20_ZnFinger	Family

Pfam: PF01428, PF01754

UniProt features (27 total): binding site 12, sequence conflict 4, compositionally biased region 4, zinc finger region 2, modified residue 2, chain 1, splice variant 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6FIF0-F1	72.62	0.38

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (12): 30; 33; 149; 152; 163; 165; 170; 173; 179; 181; 14; 18

Post-translational modifications (2): 49, 204

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9033241	Peroxisomal protein import

MSigDB gene sets: 178 (showing top): GOBP_RESPONSE_TO_PEPTIDE, MODULE_151, GOBP_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION, GOBP_PROTEIN_TARGETING, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, CATTTCA_MIR203, BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS, AACTTT_UNKNOWN, COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_DN, BURTON_ADIPOGENESIS_10, DOUGLAS_BMI1_TARGETS_UP, ZHANG_BREAST_CANCER_PROGENITORS_UP, YAMAZAKI_TCEB3_TARGETS_DN, GOBP_RESPONSE_TO_TUMOR_NECROSIS_FACTOR, HOXA4_Q2

GO Biological Process (6): protein targeting to peroxisome (GO:0006625), apoptotic process (GO:0006915), protein transport (GO:0015031), negative regulation of apoptotic process (GO:0043066), regulation of canonical NF-kappaB signal transduction (GO:0043122), cellular response to tumor necrosis factor (GO:0071356)

GO Molecular Function (5): DNA binding (GO:0003677), zinc ion binding (GO:0008270), polyubiquitin modification-dependent protein binding (GO:0031593), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): cytosol (GO:0005829), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Protein localization	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
protein targeting	1
establishment of protein localization to peroxisome	1
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
apoptotic process	1
regulation of apoptotic process	1
negative regulation of programmed cell death	1
canonical NF-kappaB signal transduction	1
regulation of intracellular signal transduction	1
response to tumor necrosis factor	1
cellular response to cytokine stimulus	1
nucleic acid binding	1
transition metal ion binding	1
modification-dependent protein binding	1
binding	1
cation binding	1
cytoplasm	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

862 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZFAND6	PEX6	Q13608	840
ZFAND6	ZBED3	Q96IU2	706
ZFAND6	HHEX	Q03014	627
ZFAND6	PKN1	Q16512	615
ZFAND6	CDKAL1	Q5VV42	612
ZFAND6	TSPAN8	P19075	588
ZFAND6	PAX6	P26367	586
ZFAND6	CDC34	P49427	578
ZFAND6	KLF14	Q8TD94	570
ZFAND6	PEX1	O43933	552
ZFAND6	FTO	Q9C0B1	550
ZFAND6	ARAP1	Q96P48	543
ZFAND6	IGF2BP2	Q9Y6M1	542
ZFAND6	CDC123	O75794	507
ZFAND6	ZFAND3	Q9H8U3	498

IntAct

16 interactions, top by confidence:

A	B	Type	Score
ZFAND6	TRAF2	psi-mi:“MI:0914”(association)	0.810
TRAF2	ZFAND6	psi-mi:“MI:0915”(physical association)	0.810
ZFAND6	TRAF2	psi-mi:“MI:0915”(physical association)	0.810
ZFAND6	TRAF5	psi-mi:“MI:0915”(physical association)	0.560
RAD23A	ZFAND6	psi-mi:“MI:0915”(physical association)	0.560
TRAF2	TMEM178B	psi-mi:“MI:0914”(association)	0.350
DNM2	ZFAND6	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (40): ZFAND6 (Two-hybrid), ZFAND6 (Two-hybrid), CDV3 (Co-fractionation), CIRBP (Co-fractionation), GSS (Co-fractionation), HNRNPA3 (Co-fractionation), NONO (Co-fractionation), TXLNG (Co-fractionation), TRAF2 (Affinity Capture-MS), BIRC2 (Affinity Capture-MS), ZFAND6 (Reconstituted Complex), ZFAND6 (Positive Genetic), ZFAND6 (Affinity Capture-MS), RAD23A (Two-hybrid), ZFAND6 (Protein-peptide)

ESM2 similar proteins: A2VE56, A6QPH9, I3LHS8, O08781, O14545, O54836, P0C6S7, Q14CM0, Q3SZY7, Q3U2E2, Q497H0, Q4R3D6, Q4R970, Q58D05, Q5F3F2, Q5FWF5, Q5R7S6, Q5RDJ2, Q5U2M7, Q5VT97, Q66J85, Q68FE8, Q69Z69, Q6DGF4, Q6FIF0, Q6N043, Q6P2K3, Q70EL2, Q7Z6G8, Q8BIZ1, Q8IWR0, Q8K214, Q8K387, Q8N7W2, Q8N9Z9, Q8NA31, Q8ND82, Q8QFX1, Q91YD3, Q96B23

Diamond homologs: A2YEZ6, A2Z2J6, A3BDI8, A3C039, B5DF11, D3Z3C6, O49663, O76080, O88878, P0C282, Q0DJC7, Q3EA33, Q3SZY7, Q5JLA7, Q5JN07, Q5R7S6, Q69LE0, Q6DGF4, Q6FIF0, Q6H754, Q6H7P8, Q6NNI8, Q6Z541, Q7Y1W9, Q84PD8, Q852K5, Q852K6, Q852K8, Q86XD8, Q8H0X0, Q942F8, Q94B40, Q9DCH6, Q9H8U3, Q9LHJ8, Q9SJM6, Q9STJ9, Q9SZ69, Q9ZNU9, O18973

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

29 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	18
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1805 predictions. Top by Δscore:

Variant	Effect	Δscore
15:80120322:TTTCA:T	acceptor_loss	1.0000
15:80120323:TTCA:T	acceptor_loss	1.0000
15:80120324:TCA:T	acceptor_loss	1.0000
15:80120325:CAGGT:C	acceptor_loss	1.0000
15:80120327:GGT:G	acceptor_gain	1.0000
15:80120327:GGTGT:G	acceptor_gain	1.0000
15:80120433:GTTC:G	donor_gain	1.0000
15:80120438:G:GG	donor_gain	1.0000
15:80120497:TGGT:T	donor_loss	1.0000
15:80120499:GTAA:G	donor_loss	1.0000
15:80120500:T:G	donor_loss	1.0000
15:80122698:A:AG	acceptor_gain	1.0000
15:80122699:G:GA	acceptor_gain	1.0000
15:80122699:GCCCT:G	acceptor_gain	1.0000
15:80122799:GG:G	donor_gain	1.0000
15:80122800:GG:G	donor_gain	1.0000
15:80131178:A:AG	acceptor_gain	1.0000
15:80131179:G:GG	acceptor_gain	1.0000
15:80131274:G:GT	donor_gain	1.0000
15:80059807:CAG:C	donor_loss	0.9900
15:80059808:AGGT:A	donor_loss	0.9900
15:80059809:GGTGA:G	donor_loss	0.9900
15:80059810:G:A	donor_loss	0.9900
15:80059811:T:A	donor_loss	0.9900
15:80071022:G:GT	donor_gain	0.9900
15:80075793:T:G	acceptor_gain	0.9900
15:80085130:GGGGA:G	donor_gain	0.9900
15:80085131:GGGAG:G	donor_gain	0.9900
15:80085132:G:T	donor_gain	0.9900
15:80098577:GT:G	donor_gain	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000040394 (15:80074955 A>G), RS1000043693 (15:80090904 C>T), RS1000109405 (15:80117592 G>A,T), RS1000119848 (15:80117265 C>A), RS1000143688 (15:80126600 T>A,G), RS1000218866 (15:80074000 A>G), RS1000259512 (15:80129137 A>G), RS1000286422 (15:80069560 C>G,T), RS1000302054 (15:80107413 T>A), RS1000306637 (15:80128924 T>C), RS1000360399 (15:80069698 G>C), RS1000362141 (15:80135208 C>T), RS1000362677 (15:80091139 T>C), RS1000391836 (15:80063738 A>G), RS1000410874 (15:80101954 G>C)

Disease associations

OMIM: gene MIM:610183 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

11 associations (top):

Study	Trait	p-value
GCST000712_9	Type 2 diabetes	2.000000e-09
GCST004619_121	Reticulocyte fraction of red cells	3.000000e-12
GCST004622_134	Reticulocyte count	8.000000e-14
GCST005973_12	White blood cell count	3.000000e-16
GCST005975_20	Eosinophil count	2.000000e-10
GCST005977_15	Monocyte count	3.000000e-08
GCST90002385_61	High light scatter reticulocyte count	3.000000e-33
GCST90002386_601	High light scatter reticulocyte percentage of red cells	2.000000e-29
GCST90002387_9	Immature fraction of reticulocytes	4.000000e-17
GCST90002405_345	Reticulocyte count	2.000000e-28
GCST90002406_394	Reticulocyte fraction of red cells	2.000000e-24

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007986	reticulocyte count
EFO:0004842	eosinophil count
EFO:0005091	monocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases abundance, increases expression	3
bisphenol A	decreases expression	2
trichostatin A	affects expression, increases expression	2
Acetaminophen	increases expression	2
Arsenic	decreases expression, increases abundance, increases expression	2
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
testosterone undecanoate	affects cotreatment, decreases expression	1
beta-lapachone	increases expression	1
arsenite	affects binding, increases reaction	1
zinc chromate	increases abundance, increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	decreases expression, affects cotreatment	1
chromium hexavalent ion	increases abundance, increases expression	1
K 7174	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Vehicle Emissions	increases expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Diazinon	increases methylation	1
Estradiol	decreases expression	1
Formaldehyde	decreases expression	1
Gold	decreases expression	1
Lead	affects splicing	1
Plant Extracts	affects cotreatment, increases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	increases expression	1
Levonorgestrel	affects cotreatment, decreases expression	1
Cadmium Chloride	increases expression	1
Copper Sulfate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.