ZFAT-AS1

Summary

ZFAT-AS1 (ZFAT antisense RNA 1, HGNC:33992) is a long non-coding RNA gene on chromosome 8q24.22.

This gene encodes a small antisense RNA that may be involved in regulating the sense strand locus, zinc finger and AT hook domain containing. This RNA may play a role in B cell function. A single nucleotide polymorphism in the promoter of this gene is associated with an increased risk of autoimmune thyroid disease.

Source: NCBI Gene 594840 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33992
Approved symbol	ZFAT-AS1
Name	ZFAT antisense RNA 1
Location	8q24.22
Locus type	RNA, long non-coding
Status	Approved
Aliases	SAS-ZFAT, NCRNA00070
Ensembl gene	ENSG00000248492
Ensembl biotype	lncRNA
Entrez	594840
RNAcentral	URS0000323138 — lncRNA, 939 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000505776

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000505776 — 2 exons

Exon	Start	End
ENSE00002029143	134598071	134598575
ENSE00002072988	134600256	134600689

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 69.22.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	69.22	silver quality
cortical plate	UBERON:0005343	67.45	gold quality
liver	UBERON:0002107	65.29	silver quality
lung	UBERON:0002048	62.73	silver quality
hindlimb stylopod muscle	UBERON:0004252	61.43	gold quality
cortex of kidney	UBERON:0001225	58.03	gold quality
kidney	UBERON:0002113	56.33	gold quality
blood	UBERON:0000178	52.87	gold quality
monocyte	CL:0000576	52.38	silver quality
placenta	UBERON:0001987	51.22	gold quality
lymph node	UBERON:0000029	51.07	gold quality
calcaneal tendon	UBERON:0003701	49.78	silver quality
muscle of leg	UBERON:0001383	49.34	silver quality
prefrontal cortex	UBERON:0000451	49.18	gold quality
vermiform appendix	UBERON:0001154	48.39	gold quality
gastrocnemius	UBERON:0001388	47.51	silver quality
islet of Langerhans	UBERON:0000006	47.47	gold quality
adult mammalian kidney	UBERON:0000082	46.30	gold quality
thoracic mammary gland	UBERON:0005200	45.73	silver quality
heart	UBERON:0000948	45.49	gold quality
colon	UBERON:0001155	44.29	silver quality
lower esophagus muscularis layer	UBERON:0035833	43.96	gold quality
frontal cortex	UBERON:0001870	43.90	silver quality
esophagus mucosa	UBERON:0002469	43.86	silver quality
primary visual cortex	UBERON:0002436	43.84	silver quality
gall bladder	UBERON:0002110	43.79	silver quality
small intestine	UBERON:0002108	43.74	gold quality
body of pancreas	UBERON:0001150	43.18	silver quality
stomach	UBERON:0000945	42.90	silver quality
cerebral cortex	UBERON:0000956	42.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ZFAT

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.