ZFC3H1

Summary

ZFC3H1 (zinc finger C3H1-type containing, HGNC:28328) is a protein-coding gene on chromosome 12q21.1, encoding Zinc finger C3H1 domain-containing protein (O60293). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. It is a selective cancer dependency (DepMap: 64.0% of cell lines).

Predicted to enable zinc ion binding activity. Predicted to be involved in RNA processing. Located in nucleus. Part of MTREC complex.

Source: NCBI Gene 196441 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 272 total — 2 likely-pathogenic
• Cancer dependency (DepMap): dependent in 64.0% of screened cell lines
• MANE Select transcript: NM_144982

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28328
Approved symbol	ZFC3H1
Name	zinc finger C3H1-type containing
Location	12q21.1
Locus type	gene with protein product
Status	Approved
Aliases	MGC23401, KIAA0546, CSRC2
Ensembl gene	ENSG00000133858
Ensembl biotype	protein_coding
OMIM	620956
Entrez	196441

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 6 retained_intron, 3 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000378743, ENST00000546475, ENST00000546606, ENST00000546771, ENST00000547398, ENST00000548100, ENST00000549407, ENST00000550712, ENST00000550963, ENST00000551487, ENST00000552037, ENST00000552994

RefSeq mRNA: 1 — MANE Select: NM_144982 NM_144982

CCDS: CCDS41813

Canonical transcript exons

ENST00000378743 — 35 exons

Exon	Start	End
ENSE00000911420	71614834	71614938
ENSE00000911421	71615206	71615316
ENSE00000911424	71620210	71620315
ENSE00000911425	71623360	71623597
ENSE00000911426	71624104	71624292
ENSE00000911427	71626260	71626446
ENSE00000911428	71627751	71627934
ENSE00000911429	71628918	71629037
ENSE00000911430	71629609	71629710
ENSE00001194725	71656885	71657301
ENSE00001302274	71619926	71620124
ENSE00001317255	71613335	71613435
ENSE00001334271	71630600	71630721
ENSE00001334272	71630823	71630954
ENSE00001334276	71631778	71631887
ENSE00001334280	71631972	71632514
ENSE00001334284	71632886	71633017
ENSE00001334287	71633264	71633438
ENSE00001334290	71634155	71634304
ENSE00001334291	71634704	71634825
ENSE00001334294	71635443	71635580
ENSE00001334295	71636490	71636654
ENSE00001334297	71636850	71637059
ENSE00001334298	71638418	71638515
ENSE00001334299	71642436	71642559
ENSE00001334301	71644095	71644318
ENSE00001334303	71644877	71645075
ENSE00001478591	71611058	71611097
ENSE00001478593	71611786	71611887
ENSE00001530932	71663013	71663848
ENSE00002412458	71609599	71610565
ENSE00003479568	71619315	71619409
ENSE00003531872	71610695	71610757
ENSE00003559968	71614535	71614700
ENSE00003656002	71647749	71647813

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 97.71.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.4340 / max 461.1191, expressed in 1803 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
132107	11.6002	1740
132108	5.6687	1650
132106	3.8997	1329
132105	0.2654	92

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	97.71	gold quality
male germ cell	CL:0000015	96.62	gold quality
lower esophagus mucosa	UBERON:0035834	96.30	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.36	gold quality
cerebellar hemisphere	UBERON:0002245	95.27	gold quality
cerebellar cortex	UBERON:0002129	95.14	gold quality
vagina	UBERON:0000996	94.97	gold quality
small intestine Peyer’s patch	UBERON:0003454	94.94	gold quality
buccal mucosa cell	CL:0002336	94.79	gold quality
right ovary	UBERON:0002118	94.61	gold quality
body of pancreas	UBERON:0001150	94.57	gold quality
right lung	UBERON:0002167	94.55	gold quality
left ovary	UBERON:0002119	94.48	gold quality
spleen	UBERON:0002106	94.30	gold quality
skin of abdomen	UBERON:0001416	94.17	gold quality
tibial nerve	UBERON:0001323	94.12	gold quality
esophagus mucosa	UBERON:0002469	94.11	gold quality
right uterine tube	UBERON:0001302	94.00	gold quality
cerebellum	UBERON:0002037	94.00	gold quality
skin of leg	UBERON:0001511	93.96	gold quality
body of uterus	UBERON:0009853	93.93	gold quality
upper lobe of left lung	UBERON:0008952	93.89	gold quality
ectocervix	UBERON:0012249	93.78	gold quality
endocervix	UBERON:0000458	93.73	gold quality
minor salivary gland	UBERON:0001830	93.73	gold quality
transverse colon	UBERON:0001157	93.68	gold quality
monocyte	CL:0000576	93.64	gold quality
mononuclear cell	CL:0000842	93.63	gold quality
colonic epithelium	UBERON:0000397	93.49	gold quality
left lobe of thyroid gland	UBERON:0001120	93.43	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-11011	no	424.94
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): GLI2

miRNA regulators (miRDB)

143 targeting ZFC3H1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-607	99.97	73.62	5593

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 64.0% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 7)

• ZFC3H1 participates in the transcriptional activation of IL-8. (PMID:25268596)
• The described is the mRNA degradation poly(A) tail exosome targeting (PAXT) connection, which comprises the ZFC3H1 Zn-knuckle protein as a central link between MTR4 and the nuclear poly(A)-binding protein PABPN1. (PMID:27871484)
• a critical role for Mtr4/ZFC3H1 in nuclear surveillance of naturally unstable lncRNAs to prevent their accumulation, transport to the cytoplasm, and resultant disruption of protein synthesis (PMID:28733371)
• These results establish ZFC3H1 as a central nuclear polyadenylated (+) RNA retention factor, counteracting nuclear export activity. (PMID:29768216)
• Zinc finger C3H1 domain-containing protein (ZFC3H1) evaluates the prognosis and treatment of prostate adenocarcinoma (PRAD): A study based on TCGA data. (PMID:34514952)
• Zinc finger C3H1-type containing serves as a novel prognostic biomarker in human pan-cancer. (PMID:35131366)
• PAPgamma associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs. (PMID:37875486)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfc3h1	ENSMUSG00000034163
rattus_norvegicus	Zfc3h1	ENSRNOG00000053060

Protein

Protein identifiers

Zinc finger C3H1 domain-containing protein — O60293 (reviewed: O60293)

Alternative names: Coiled-coil domain-containing protein 131, Proline/serine-rich coiled-coil protein 2

All UniProt accessions (2): G3V1X1, O60293

UniProt curated annotations — full annotation on UniProt →

Function. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters.

Subunit / interactions. Component of the poly(A) tail exosome targeting (PAXT) complex made of accessory factors, such as PABPN1, ZFC3H1 and MTREX, and which directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. Co-localizes with component of the CBC-ARS2 (CBCA) complex. Binds to RNA exosome components. Interacts with NCBP1/CBP80, ZC3H18, MTREX and PABPN1 in a RNase-insensitive manner, and with PABPC4, PABPC1 and ZC3H14 in a RNase-sensitive manner.

Subcellular location. Nucleus.

Isoforms (3)

UniProt ID	Names	Canonical?
O60293-1	1	yes
O60293-2	2
O60293-4	4

RefSeq proteins (1): NP_659419* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003107	HAT	Repeat
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR019607	Putative_zinc-finger_domain	Domain
IPR039278	Red1	Family

Pfam: PF10650

UniProt features (68 total): modified residue 23, compositionally biased region 19, repeat 7, region of interest 6, coiled-coil region 5, splice variant 3, sequence variant 2, initiator methionine 1, chain 1, zinc finger region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O60293-F1	58.75	0.01

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (23): 2, 15, 28, 34, 128, 251, 352, 383, 662, 714, 717, 719, 766, 805, 809, 948, 949, 953, 998, 1046 …

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9930044	Nuclear RNA decay

MSigDB gene sets: 193 (showing top): FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP, AAGCAAT_MIR137, TAATAAT_MIR126, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, TGCACTT_MIR519C_MIR519B_MIR519A, MORF_SNRP70, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, CATTTCA_MIR203, chr12q21, AAAGGGA_MIR204_MIR211, NIKOLSKY_BREAST_CANCER_12Q13_Q21_AMPLICON, TGAGATT_MIR216, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P, ATAACCT_MIR154, AGTCAGC_MIR345

GO Biological Process (1): RNA processing (GO:0006396)

GO Molecular Function (3): zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (4): obsolete extracellular space (GO:0005615), nucleus (GO:0005634), nucleoplasm (GO:0005654), MTREC complex (GO:1990477)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Metabolism of RNA	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
gene expression	1
RNA biosynthetic process	1
primary metabolic process	1
transition metal ion binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
nuclear protein-containing complex	1

Protein interactions and networks

STRING

1292 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZFC3H1	PABPN1	Q86U42	977
ZFC3H1	MTREX	P42285	930
ZFC3H1	RBM7	Q9Y580	821
ZFC3H1	ZCCHC8	Q6NZY4	812
ZFC3H1	SRRT	Q9BXP5	770
ZFC3H1	ZCCHC7	Q8N3Z6	716
ZFC3H1	NRDE2	Q9H7Z3	709
ZFC3H1	RBM26	Q5T8P6	667
ZFC3H1	RBM27	Q9P2N5	622
ZFC3H1	ALYREF	Q86V81	615
ZFC3H1	TENT4B	Q8NDF8	607
ZFC3H1	EXOSC10	Q01780	585
ZFC3H1	EXOSC3	Q9NQT5	551
ZFC3H1	DIS3	Q9Y2L1	546
ZFC3H1	EXOSC4	Q9NPD3	505

IntAct

123 interactions, top by confidence:

A	B	Type	Score
BUB3	ZNF207	psi-mi:“MI:0914”(association)	0.690
C1D	ZFC3H1	psi-mi:“MI:0914”(association)	0.640
EXOSC5	ZFC3H1	psi-mi:“MI:0914”(association)	0.640
SLC39A5	FAM171A2	psi-mi:“MI:0914”(association)	0.640
EXOSC7	ZFC3H1	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
PAPOLG	ZFC3H1	psi-mi:“MI:0914”(association)	0.530
EXOSC4	ZFC3H1	psi-mi:“MI:0914”(association)	0.530
ZFC3H1	HNRNPCL1	psi-mi:“MI:0914”(association)	0.530
MPHOSPH6	ZFC3H1	psi-mi:“MI:0914”(association)	0.530
RPL13	RRP8	psi-mi:“MI:0914”(association)	0.530
CPSF6	DDX39A	psi-mi:“MI:0914”(association)	0.480
ZFC3H1	RPL36	psi-mi:“MI:0915”(physical association)	0.400
ZFC3H1	H1-2	psi-mi:“MI:0915”(physical association)	0.400
ZFC3H1	H1-4	psi-mi:“MI:0915”(physical association)	0.400
ZFC3H1	H1-5	psi-mi:“MI:0915”(physical association)	0.400
NINL	ZFC3H1	psi-mi:“MI:0915”(physical association)	0.370
ZFC3H1	CCDC85B	psi-mi:“MI:0915”(physical association)	0.370
BUB1B	NDC80	psi-mi:“MI:0914”(association)	0.350
THOC1	TARS3	psi-mi:“MI:0914”(association)	0.350
Ddb1		psi-mi:“MI:0914”(association)	0.350
ZFC3H1	UNC119B	psi-mi:“MI:0914”(association)	0.350

BioGRID (248): ZFC3H1 (Two-hybrid), ZFC3H1 (Two-hybrid), ZFC3H1 (Two-hybrid), ZFC3H1 (Two-hybrid), ZFC3H1 (Two-hybrid), ZFC3H1 (Two-hybrid), ZFC3H1 (Two-hybrid), KHDRBS2 (Two-hybrid), CCDC57 (Two-hybrid), ZFC3H1 (Two-hybrid), ZFC3H1 (Affinity Capture-MS), ZFC3H1 (Affinity Capture-MS), ZFC3H1 (Affinity Capture-MS), ZFC3H1 (Two-hybrid), ZFC3H1 (Two-hybrid)

ESM2 similar proteins: A0A1B0GTU1, A2AUY4, B7ZS37, D3Z8Y2, D4A4L4, D4A666, E1B7L7, O46385, O60293, O75152, O95425, P0DQW0, Q08AZ1, Q3KQW7, Q3U1C4, Q3UH68, Q3ZC82, Q4G0F8, Q4V9H5, Q5F3Z9, Q5NBX1, Q5REG6, Q5ZJJ1, Q5ZM88, Q61464, Q62394, Q68FE9, Q6NZF1, Q6PJT7, Q6ZQ03, Q6ZU65, Q76L83, Q7TMD5, Q8BHZ4, Q8BJ05, Q8BLG0, Q8BZ32, Q8C9B9, Q8CCJ9, Q8K298

Diamond homologs: O60293, Q9UTR8

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 143 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	5	34.1×	1e-05
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	5	34.1×	1e-05
Nuclear RNA decay	7	23.2×	1e-06
ATF4 activates genes in response to endoplasmic reticulum stress	5	21.9×	1e-04
mRNA 3’-end processing	8	16.9×	1e-06
mRNA Polyadenylation	13	12.3×	6e-09
mRNA Splicing	10	11.8×	1e-06
Processing of Capped Intron-Containing Pre-mRNA	13	11.5×	9e-09

GO biological processes:

GO term	Partners	Fold	FDR
mRNA transport	6	13.1×	7e-04
RNA processing	7	12.7×	2e-04
mRNA splicing, via spliceosome	15	11.3×	3e-09
cytoplasmic translation	7	10.7×	5e-04
regulation of alternative mRNA splicing, via spliceosome	5	10.1×	6e-03
negative regulation of translation	6	9.7×	2e-03
rRNA processing	8	9.4×	3e-04
RNA splicing	12	8.8×	5e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

272 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	2
Uncertain significance	213
Likely benign	6
Benign	8

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
599528	NM_144982.5(ZFC3H1):c.5885T>C (p.Leu1962Pro)	Likely pathogenic
599529	NM_144982.5(ZFC3H1):c.947G>A (p.Arg316His)	Likely pathogenic

SpliceAI

5101 predictions. Top by Δscore:

Variant	Effect	Δscore
12:71610694:CAT:C	donor_gain	1.0000
12:71610696:T:TA	donor_gain	1.0000
12:71610700:T:A	donor_gain	1.0000
12:71611784:A:AC	donor_gain	1.0000
12:71611785:C:CC	donor_gain	1.0000
12:71612219:T:A	donor_gain	1.0000
12:71613329:TCTTA:T	donor_loss	1.0000
12:71613330:CTTA:C	donor_loss	1.0000
12:71613331:TTA:T	donor_loss	1.0000
12:71613332:TACC:T	donor_loss	1.0000
12:71613333:ACC:A	donor_loss	1.0000
12:71614533:AC:A	donor_gain	1.0000
12:71614534:CC:C	donor_gain	1.0000
12:71614701:C:CC	acceptor_gain	1.0000
12:71614832:A:AC	donor_gain	1.0000
12:71614833:C:CC	donor_gain	1.0000
12:71623355:CTTA:C	donor_loss	1.0000
12:71623356:TTA:T	donor_loss	1.0000
12:71623357:TACC:T	donor_loss	1.0000
12:71623358:ACCT:A	donor_loss	1.0000
12:71623359:CCTT:C	donor_gain	1.0000
12:71626246:T:C	donor_gain	1.0000
12:71626254:ACT:A	donor_loss	1.0000
12:71626255:CTC:C	donor_loss	1.0000
12:71626256:TCAC:T	donor_loss	1.0000
12:71626257:C:CG	donor_loss	1.0000
12:71626258:A:AC	donor_gain	1.0000
12:71626258:ACAGT:A	donor_gain	1.0000
12:71626259:C:CA	donor_gain	1.0000
12:71626259:CA:C	donor_gain	1.0000

AlphaMissense

13076 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:71627781:A:G	L1367P	1.000
12:71630845:A:G	C1194R	1.000
12:71630869:A:G	C1186R	1.000
12:71632417:A:G	L972P	1.000
12:71636887:A:G	L633P	1.000
12:71636890:A:G	L632P	1.000
12:71636899:C:G	R629P	1.000
12:71636902:A:G	L628P	1.000
12:71644134:G:C	F488L	1.000
12:71644134:G:T	F488L	1.000
12:71644135:A:C	F488C	1.000
12:71644135:A:G	F488S	1.000
12:71644136:A:G	F488L	1.000
12:71644138:C:G	R487P	1.000
12:71644165:A:G	L478P	1.000
12:71644171:C:G	R476P	1.000
12:71645020:A:G	L379P	1.000
12:71645029:A:G	L376P	1.000
12:71645035:A:G	L374P	1.000
12:71657184:A:G	L239P	1.000
12:71610703:A:G	W1942R	0.999
12:71610703:A:T	W1942R	0.999
12:71611793:A:G	W1908R	0.999
12:71611793:A:T	W1908R	0.999
12:71614613:A:C	C1816W	0.999
12:71614615:A:G	C1816R	0.999
12:71626297:G:T	A1427D	0.999
12:71626298:C:G	A1427P	0.999
12:71626354:A:G	L1408P	0.999
12:71626358:A:C	Y1407D	0.999

dbSNP variants (sampled 300 via entrez): RS1000002241 (12:71645514 T>C,G), RS1000034723 (12:71645170 T>C), RS1000047184 (12:71629814 T>C), RS1000055415 (12:71640194 G>A,C), RS1000066041 (12:71619477 GAAA>G,GAA,GAAAA), RS1000119192 (12:71642841 T>A), RS1000317736 (12:71632819 T>C,G), RS1000409901 (12:71613909 A>G), RS1000426607 (12:71638280 C>A), RS1000549378 (12:71626724 C>T), RS1000592359 (12:71650118 G>A), RS1000647884 (12:71631195 C>A,G), RS1000662477 (12:71651520 T>G), RS1000736271 (12:71656044 G>C,T), RS1000757913 (12:71638793 C>A)

Disease associations

OMIM: gene MIM:620956 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST010796_3125	Electrocardiogram morphology (amplitude at temporal datapoints)	4.000000e-09
GCST010796_3176	Electrocardiogram morphology (amplitude at temporal datapoints)	7.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004327	electrocardiography

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, decreases expression	2
sodium arsenite	increases expression, affects cotreatment, increases abundance	2
Arsenic	affects cotreatment, increases abundance, increases expression, affects expression	2
Formaldehyde	increases expression	2
Nickel	increases expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
bisphenol F	decreases expression, affects cotreatment	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
beta-lapachone	decreases expression	1
coumarin	affects phosphorylation	1
methacrylaldehyde	increases oxidation, increases abundance, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
ICG 001	decreases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
bisphenol S	affects cotreatment, decreases expression	1
Resveratrol	increases expression, affects cotreatment	1
Acrolein	increases abundance, affects cotreatment, increases oxidation	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Atrazine	increases expression	1
Caffeine	affects phosphorylation	1
Cisplatin	decreases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Ivermectin	decreases expression	1
Ozone	affects cotreatment, increases oxidation, increases abundance	1
Plant Extracts	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.