ZFHX2-AS1

Summary

ZFHX2-AS1 (ZFHX2 antisense RNA 1, HGNC:52658) is a long non-coding RNA gene on chromosome 14q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52658
Approved symbol	ZFHX2-AS1
Name	ZFHX2 antisense RNA 1
Location	14q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LncZFHX2
Ensembl gene	ENSG00000157306
Ensembl biotype	lncRNA
OMIM	617833
Entrez	109729160
RNAcentral	URS00005EB21E — lncRNA, 2322 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 3 lncRNA, 3 retained_intron

ENST00000553985, ENST00000554403, ENST00000556354, ENST00000556613, ENST00000557568, ENST00000726280

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000553985 — 3 exons

Exon	Start	End
ENSE00002479331	23514236	23514416
ENSE00002490673	23512817	23512873
ENSE00002531815	23558695	23560778

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 81.62.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5755 / max 106.6818, expressed in 100 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
138935	0.5755	100
138932	0.3399	102
138934	0.0984	44
138933	0.0155	9

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	81.62	gold quality
cerebellum	UBERON:0002037	81.33	gold quality
cerebellar cortex	UBERON:0002129	81.30	gold quality
cerebellar hemisphere	UBERON:0002245	81.30	gold quality
granulocyte	CL:0000094	80.71	gold quality
prostate gland	UBERON:0002367	80.70	gold quality
sural nerve	UBERON:0015488	80.20	gold quality
temporal lobe	UBERON:0001871	80.00	gold quality
amygdala	UBERON:0001876	79.87	gold quality
anterior cingulate cortex	UBERON:0009835	79.27	gold quality
prefrontal cortex	UBERON:0000451	79.18	gold quality
mucosa of transverse colon	UBERON:0004991	79.05	gold quality
left lobe of thyroid gland	UBERON:0001120	78.90	gold quality
superior frontal gyrus	UBERON:0002661	78.85	gold quality
frontal cortex	UBERON:0001870	78.83	gold quality
thyroid gland	UBERON:0002046	78.82	gold quality
right lobe of thyroid gland	UBERON:0001119	78.77	gold quality
lower esophagus mucosa	UBERON:0035834	78.71	gold quality
right frontal lobe	UBERON:0002810	78.54	gold quality
right lobe of liver	UBERON:0001114	78.38	gold quality
body of stomach	UBERON:0001161	78.18	gold quality
tonsil	UBERON:0002372	78.00	gold quality
fundus of stomach	UBERON:0001160	77.94	gold quality
left ovary	UBERON:0002119	77.79	gold quality
cerebral cortex	UBERON:0000956	77.71	gold quality
brain	UBERON:0000955	77.61	gold quality
primary visual cortex	UBERON:0002436	77.59	gold quality
right adrenal gland cortex	UBERON:0035827	77.54	gold quality
cortex of kidney	UBERON:0001225	77.47	gold quality
pituitary gland	UBERON:0000007	77.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.51

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.