ZFHX4-AS1

Summary

ZFHX4-AS1 (ZFHX4 antisense RNA 1, HGNC:44165) is a long non-coding RNA gene on chromosome 8q21.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44165
Approved symbol	ZFHX4-AS1
Name	ZFHX4 antisense RNA 1
Location	8q21.13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000253661
Ensembl biotype	lncRNA
Entrez	100192378
RNAcentral	URS000075CAFC — lncRNA, 1724 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 27 lncRNA

ENST00000518143, ENST00000521894, ENST00000522357, ENST00000522961, ENST00000523977, ENST00000663063, ENST00000663655, ENST00000666902, ENST00000669823, ENST00000689032, ENST00000692896, ENST00000814135, ENST00000814136, ENST00000814137, ENST00000814138, ENST00000814139, ENST00000814140, ENST00000814141, ENST00000814142, ENST00000814143, ENST00000814144, ENST00000814145, ENST00000814146, ENST00000814147, ENST00000814148, ENST00000814149, ENST00000814150

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000518143 — 5 exons

Exon	Start	End
ENSE00002098809	76672827	76673033
ENSE00002114853	76616322	76616451
ENSE00002120786	76615153	76615319
ENSE00004214869	76610963	76612027
ENSE00004214871	76683052	76683338

Expression profiles

Bgee: expression breadth ubiquitous, 169 present calls, max score 85.34.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2345 / max 54.2742, expressed in 491 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
93643	0.5892	277
93642	0.2608	118
93644	0.1951	103
93645	0.1894	84

Top tissues by expression

226 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	85.34	gold quality
gingival epithelium	UBERON:0001949	82.47	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.76	gold quality
mucosa of paranasal sinus	UBERON:0005030	81.35	gold quality
lower lobe of lung	UBERON:0008949	80.21	silver quality
germinal epithelium of ovary	UBERON:0001304	78.46	gold quality
calcaneal tendon	UBERON:0003701	77.86	gold quality
superficial temporal artery	UBERON:0001614	77.02	gold quality
ganglionic eminence	UBERON:0004023	76.60	gold quality
nucleus accumbens	UBERON:0001882	75.33	gold quality
putamen	UBERON:0001874	74.48	gold quality
vastus lateralis	UBERON:0001379	73.86	gold quality
amygdala	UBERON:0001876	73.70	gold quality
quadriceps femoris	UBERON:0001377	73.60	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	73.55	gold quality
hypothalamus	UBERON:0001898	73.21	gold quality
caudate nucleus	UBERON:0001873	73.19	gold quality
biceps brachii	UBERON:0001507	73.10	gold quality
substantia nigra	UBERON:0002038	72.68	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.51	gold quality
anterior cingulate cortex	UBERON:0009835	71.59	gold quality
gingiva	UBERON:0001828	71.45	gold quality
spinal cord	UBERON:0002240	71.22	gold quality
midbrain	UBERON:0001891	70.21	gold quality
right frontal lobe	UBERON:0002810	69.54	gold quality
temporal lobe	UBERON:0001871	69.35	gold quality
muscle of leg	UBERON:0001383	69.32	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.21	gold quality
Ammon’s horn	UBERON:0001954	69.18	gold quality
prefrontal cortex	UBERON:0000451	69.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• our findings reveal that lncRNA ZFHX4-AS1 silencing exerts an inhibitory effect on breast cancer development by suppressing the activation of the Hippo signaling pathway via FAT4. (PMID:30546116)
• An Integrative Analysis Revealing ZFHX4-AS1 as a Novel Prognostic Biomarker Correlated with Immune Infiltrates in Ovarian Cancer. (PMID:35795530)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.