ZFP1

Summary

ZFP1 (ZFP1 zinc finger protein, HGNC:23328) is a protein-coding gene on chromosome 16q23.1, encoding Zinc finger protein 1 homolog (Q6P2D0). May be involved in transcriptional regulation.

This gene belongs to the zinc finger protein family. Some members of this family bind to DNA by zinc-mediated secondary structures called zinc fingers, and are involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms.

Source: NCBI Gene 162239 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 71 total
• MANE Select transcript: NM_153688

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23328
Approved symbol	ZFP1
Name	ZFP1 zinc finger protein
Location	16q23.1
Locus type	gene with protein product
Status	Approved
Aliases	PITA, FLJ34243, ZNF475
Ensembl gene	ENSG00000184517
Ensembl biotype	protein_coding
OMIM	617230
Entrez	162239

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 10 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000332307, ENST00000393430, ENST00000464850, ENST00000563356, ENST00000564989, ENST00000566105, ENST00000567481, ENST00000568079, ENST00000570010, ENST00000870669, ENST00000870670, ENST00000870671, ENST00000931429

RefSeq mRNA: 8 — MANE Select: NM_153688 NM_001318469, NM_001318471, NM_001318472, NM_001318473, NM_001318474, NM_001318475, NM_001318476, NM_153688

CCDS: CCDS10914, CCDS82012, CCDS82013

Canonical transcript exons

ENST00000570010 — 4 exons

Exon	Start	End
ENSE00002605879	75148524	75148643
ENSE00002620653	75169253	75172234
ENSE00003483571	75166770	75166896
ENSE00003634738	75152909	75152966

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 92.74.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.7677 / max 117.4642, expressed in 1746 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155016	11.7677	1746

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	92.74	gold quality
ganglionic eminence	UBERON:0004023	90.06	gold quality
ventricular zone	UBERON:0003053	87.88	gold quality
superior frontal gyrus	UBERON:0002661	87.13	gold quality
prefrontal cortex	UBERON:0000451	86.03	gold quality
primary visual cortex	UBERON:0002436	85.26	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.23	gold quality
frontal cortex	UBERON:0001870	84.14	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.71	gold quality
corpus callosum	UBERON:0002336	83.49	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	83.41	gold quality
cerebral cortex	UBERON:0000956	83.33	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.94	gold quality
anterior cingulate cortex	UBERON:0009835	82.49	gold quality
liver	UBERON:0002107	82.24	gold quality
islet of Langerhans	UBERON:0000006	82.23	gold quality
nucleus accumbens	UBERON:0001882	81.67	gold quality
right lobe of liver	UBERON:0001114	81.65	gold quality
amygdala	UBERON:0001876	81.28	gold quality
temporal lobe	UBERON:0001871	81.24	gold quality
caudate nucleus	UBERON:0001873	80.91	gold quality
right frontal lobe	UBERON:0002810	80.91	gold quality
endometrium	UBERON:0001295	80.88	gold quality
brain	UBERON:0000955	80.82	gold quality
putamen	UBERON:0001874	80.62	gold quality
smooth muscle tissue	UBERON:0001135	80.60	gold quality
Ammon’s horn	UBERON:0001954	80.53	gold quality
calcaneal tendon	UBERON:0003701	80.35	gold quality
skeletal muscle tissue	UBERON:0001134	80.25	gold quality
right coronary artery	UBERON:0001625	79.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.29

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

3 targets.

Target	Regulation
CD74
ERVW-4
SLC11A1

Upstream regulators (CollecTRI, top): PRDM1, STAT1

miRNA regulators (miRDB)

100 targeting ZFP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-4713-3P	100.00	65.92	505
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-6857-5P	99.87	65.32	985
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-5010-3P	99.83	70.60	2357

Literature-anchored findings (GeneRIF, showing 1)

• ZFP1 is a biomarker related to poor prognosis and immunity in gastric cancer. (PMID:39261568)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp1	ENSMUSG00000055835
rattus_norvegicus	Zfp1	ENSRNOG00000019059

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein 1 homolog — Q6P2D0 (reviewed: Q6P2D0)

Alternative names: Zinc finger protein 475

All UniProt accessions (4): Q6P2D0, H3BM94, H3BV40, J3KNQ1

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in transcriptional regulation.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q6P2D0-1	1	yes
Q6P2D0-2	2

RefSeq proteins (8): NP_001305398, NP_001305400, NP_001305401, NP_001305402, NP_001305403, NP_001305404, NP_001305405, NP_710155* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (16 total): zinc finger region 8, cross-link 3, region of interest 2, chain 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6P2D0-F1	65.56	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 74, 114, 145

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 172 (showing top): GGAMTNNNNNTCCY_UNKNOWN, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_UP, IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM, MARSON_BOUND_BY_FOXP3_STIMULATED, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, SANSOM_APC_TARGETS, GEORGES_TARGETS_OF_MIR192_AND_MIR215, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, SWEET_LUNG_CANCER_KRAS_UP, WONG_ADULT_TISSUE_STEM_MODULE, GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, chr16q23, ESC_V6.5_UP_LATE.V1_DN

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

510 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZFP1	CASZ1	Q86V15	893
ZFP1	MYC	P01106	726
ZFP1	CDKN1A	P38936	605
ZFP1	PRDM2	Q13029	589
ZFP1	DOT1L	Q8TEK3	505
ZFP1	CIZ1	Q9ULV3	505
ZFP1	ZPR1	O75312	472
ZFP1	SPRR1B	P22528	470
ZFP1	COMMD9	Q9P000	455
ZFP1	GATM	P50440	445
ZFP1	TRMT11	Q7Z4G4	429
ZFP1	DIRAS1	O95057	427
ZFP1	KLK7	P49862	426
ZFP1	PLEKHF1	Q96S99	398
ZFP1	GEMIN5	Q8TEQ6	386
ZFP1	KLK6	Q92876	386

IntAct

88 interactions, top by confidence:

A	B	Type	Score
KRT31	HGS	psi-mi:“MI:0914”(association)	0.780
IPO8	TRIM28	psi-mi:“MI:0914”(association)	0.640
AKR1C2	AKR1C4	psi-mi:“MI:0914”(association)	0.640
ZFP1	MAP3K20	psi-mi:“MI:0915”(physical association)	0.600
ZFP1		psi-mi:“MI:0915”(physical association)	0.560
ZFP1	TSPYL2	psi-mi:“MI:0915”(physical association)	0.560
LDOC1	ZFP1	psi-mi:“MI:0915”(physical association)	0.560
KRT40	ZFP1	psi-mi:“MI:0915”(physical association)	0.560
ZFP1	CCDC125	psi-mi:“MI:0915”(physical association)	0.560
ZFP1	CEP70	psi-mi:“MI:0915”(physical association)	0.560
ZFP1	CARD10	psi-mi:“MI:0915”(physical association)	0.560
HAP1	ZFP1	psi-mi:“MI:0915”(physical association)	0.560
ZFP1	CRLF3	psi-mi:“MI:0915”(physical association)	0.560
MTUS2	ZFP1	psi-mi:“MI:0915”(physical association)	0.560
ZFP1	TBC1D1	psi-mi:“MI:0915”(physical association)	0.560
ZFP1	HOOK2	psi-mi:“MI:0915”(physical association)	0.560
GOLGA6L9	ZFP1	psi-mi:“MI:0915”(physical association)	0.560
CAVIN1	ZFP1	psi-mi:“MI:0915”(physical association)	0.560
POU6F2	ZFP1	psi-mi:“MI:0915”(physical association)	0.560
ZFP1	CEP19	psi-mi:“MI:0915”(physical association)	0.560
EMD	ZFP1	psi-mi:“MI:0915”(physical association)	0.560
ZNF250	ZFP1	psi-mi:“MI:0915”(physical association)	0.560
ZFP1	CIB3	psi-mi:“MI:0915”(physical association)	0.560
MFAP1	ZFP1	psi-mi:“MI:0915”(physical association)	0.560
ZFP1	TRIM41	psi-mi:“MI:0915”(physical association)	0.560
TRIM28	ZNF316	psi-mi:“MI:0914”(association)	0.530
TRIM28	ZNF320	psi-mi:“MI:0914”(association)	0.530
SERTAD4	POTEF	psi-mi:“MI:0914”(association)	0.530
WASHC3	WASH3P	psi-mi:“MI:0914”(association)	0.530

BioGRID (66): ZFP1 (Affinity Capture-MS), ZFP1 (Affinity Capture-MS), ZFP1 (Affinity Capture-MS), ZFP1 (Affinity Capture-MS), ZFP1 (Affinity Capture-MS), ZFP1 (Affinity Capture-MS), ZFP1 (Affinity Capture-MS), ZFP1 (Affinity Capture-MS), ZFP1 (Affinity Capture-MS), ZFP1 (Two-hybrid), ZFP1 (Two-hybrid), ZFP1 (Two-hybrid), ZFP1 (Two-hybrid), ZFP1 (Two-hybrid), ZFP1 (Two-hybrid)

ESM2 similar proteins: A0JPL0, A3KN36, A7MBI1, A8MT65, B2RXC5, D3ZVT0, P08042, P21506, P51508, P52738, Q02525, Q06730, Q12901, Q2KI58, Q2M218, Q2M3W8, Q2M3X9, Q2VY69, Q49AA0, Q4R6J4, Q4V8A8, Q5FWF6, Q5HY98, Q5RB33, Q5RC79, Q5REF1, Q5T5D7, Q5VIY5, Q61967, Q6P2D0, Q6ZN11, Q86XU0, Q86Y25, Q8N782, Q8N859, Q8NB42, Q8TF39, Q8TF47, Q8WXB4, Q95K49

Diamond homologs: A0JPL0, A2VDP4, A6QLU5, A6QPT6, A8MQ14, A8MUZ8, A8MWA4, B1APH4, B2RXC5, E9PYI1, E9Q8G5, O75290, O94892, P08042, P0CH99, P0CI00, P17014, P17025, P17030, P17031, P17032, P17098, P21506, P51508, P51523, P51786, P51814, P52736, P52738, Q02525, Q03923, Q03936, Q06730, Q06732, Q0VCB0, Q13401, Q14587, Q16587, Q2M218, Q2M3X9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

71 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	62
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1075 predictions. Top by Δscore:

Variant	Effect	Δscore
16:75148645:T:A	donor_loss	1.0000
16:75152907:A:AG	acceptor_gain	1.0000
16:75152908:G:GA	acceptor_gain	1.0000
16:75152908:GTT:G	acceptor_gain	1.0000
16:75152908:GTTCT:G	acceptor_gain	1.0000
16:75166893:GTGG:G	donor_gain	1.0000
16:75152902:A:AG	acceptor_gain	0.9900
16:75152904:TCCA:T	acceptor_loss	0.9900
16:75152906:CAGTT:C	acceptor_loss	0.9900
16:75152908:G:A	acceptor_loss	0.9900
16:75152908:GT:G	acceptor_gain	0.9900
16:75152908:GTTC:G	acceptor_gain	0.9900
16:75152964:CAGGT:C	donor_loss	0.9900
16:75152965:AGG:A	donor_loss	0.9900
16:75152967:GT:G	donor_loss	0.9900
16:75152968:TGAGT:T	donor_loss	0.9900
16:75152969:GAGTT:G	donor_loss	0.9900
16:75169251:A:AG	acceptor_gain	0.9900
16:75169252:G:GG	acceptor_gain	0.9900
16:75169252:GAA:G	acceptor_gain	0.9900
16:75169252:GAAGT:G	acceptor_gain	0.9900
5:122151777:A:AG	acceptor_gain	0.9900
5:122151778:G:GG	acceptor_gain	0.9900
16:75149258:G:GA	donor_gain	0.9800
16:75149268:G:GG	donor_gain	0.9800
16:75166723:T:G	acceptor_gain	0.9800
16:75169245:A:AG	acceptor_gain	0.9800
5:122129649:GCTC:G	donor_gain	0.9800
5:122151776:CAGA:C	acceptor_loss	0.9800
5:122151777:A:AT	acceptor_loss	0.9800

AlphaMissense

2724 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:75169771:T:C	F221L	0.999
16:75169773:C:A	F221L	0.999
16:75169773:C:G	F221L	0.999
16:75169790:T:C	L227P	0.999
16:75169855:T:C	F249L	0.999
16:75169857:C:A	F249L	0.999
16:75169857:C:G	F249L	0.999
16:75170191:T:C	F361L	0.999
16:75170193:C:A	F361L	0.999
16:75170193:C:G	F361L	0.999
16:75170275:T:C	F389L	0.999
16:75170277:T:A	F389L	0.999
16:75170277:T:G	F389L	0.999
16:75169939:T:C	F277L	0.998
16:75169941:T:A	F277L	0.998
16:75169941:T:G	F277L	0.998
16:75169958:T:C	L283P	0.998
16:75170042:T:C	L311P	0.998
16:75170126:T:C	L339P	0.998
16:75170225:G:C	R372P	0.998
16:75169800:T:A	H230Q	0.997
16:75169800:T:G	H230Q	0.997
16:75169802:A:C	Q231P	0.997
16:75169874:T:C	L255P	0.997
16:75169968:C:A	H286Q	0.997
16:75169968:C:G	H286Q	0.997
16:75170054:A:C	Q315P	0.997
16:75170107:T:C	F333L	0.997
16:75170109:T:A	F333L	0.997
16:75170109:T:G	F333L	0.997

dbSNP variants (sampled 300 via entrez): RS1000068594 (16:75154179 G>A,T), RS1000083076 (16:75141748 A>C), RS1000148973 (16:75148470 C>A,G), RS1000179135 (16:75127065 T>C), RS1000228112 (16:75131535 G>A), RS1000269076 (16:75162377 G>A,T), RS1000284932 (16:75122540 G>A), RS1000322517 (16:75166058 A>G), RS1000412207 (16:75148557 C>CA), RS1000436101 (16:75136552 A>G), RS1000467084 (16:75118600 C>T), RS1000584335 (16:75117595 G>A,C), RS1000592617 (16:75139627 G>A,T), RS1000625267 (16:75144123 T>G), RS1000650239 (16:75171182 C>A,T)

Disease associations

OMIM: gene MIM:617230 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST002553_10	Pancreatic cancer	1.000000e-10
GCST004860_122	Alcoholic chronic pancreatitis	4.000000e-09
GCST004860_124	Alcoholic chronic pancreatitis	8.000000e-07
GCST004860_136	Alcoholic chronic pancreatitis	2.000000e-06
GCST004860_62	Alcoholic chronic pancreatitis	5.000000e-06
GCST90002382_445	Eosinophil percentage of white cells	2.000000e-10
GCST90002388_172	Lymphocyte count	4.000000e-13

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007991	eosinophil percentage of leukocytes
EFO:0004587	lymphocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, increases methylation	3
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	decreases expression	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
dorsomorphin	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Acrolein	decreases expression, increases abundance, affects cotreatment	1
Air Pollutants	affects cotreatment, decreases expression, increases abundance	1
Doxorubicin	decreases expression	1
Formaldehyde	decreases expression	1
Ozone	affects cotreatment, decreases expression, increases abundance	1
Phthalic Acids	decreases methylation	1
Urethane	decreases expression	1
Copper Sulfate	decreases expression	1
Particulate Matter	increases expression	1
Volatile Organic Compounds	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.