ZFP2

Summary

ZFP2 (ZFP2 zinc finger protein, HGNC:26138) is a protein-coding gene on chromosome 5q35.3, encoding Zinc finger protein ZFP2 (Q6ZN57). Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

Source: NCBI Gene 80108 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 82 total
• MANE Select transcript: NM_030613

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26138
Approved symbol	ZFP2
Name	ZFP2 zinc finger protein
Location	5q35.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ21628, ZNF751
Ensembl gene	ENSG00000198939
Ensembl biotype	protein_coding
Entrez	80108

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 26 protein_coding

ENST00000361362, ENST00000520301, ENST00000520660, ENST00000520805, ENST00000523286, ENST00000896567, ENST00000896568, ENST00000896569, ENST00000896570, ENST00000896571, ENST00000896572, ENST00000896573, ENST00000896574, ENST00000896575, ENST00000896576, ENST00000896577, ENST00000896578, ENST00000916756, ENST00000916757, ENST00000916758, ENST00000916759, ENST00000916760, ENST00000916761, ENST00000960763, ENST00000960764, ENST00000960765

RefSeq mRNA: 1 — MANE Select: NM_030613 NM_030613

CCDS: CCDS4440

Canonical transcript exons

ENST00000361362 — 5 exons

Exon	Start	End
ENSE00001419935	178931237	178933212
ENSE00001425671	178916565	178916710
ENSE00001430074	178912584	178912719
ENSE00001432484	178912982	178913071
ENSE00002134632	178895913	178895974

Expression profiles

Bgee: expression breadth ubiquitous, 173 present calls, max score 88.85.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2642 / max 57.4145, expressed in 556 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
60533	1.2642	556

Top tissues by expression

270 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.85	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.44	gold quality
cortical plate	UBERON:0005343	77.51	gold quality
cerebellar hemisphere	UBERON:0002245	76.10	gold quality
cerebellar cortex	UBERON:0002129	76.03	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.46	gold quality
cerebellum	UBERON:0002037	74.40	gold quality
ventricular zone	UBERON:0003053	74.36	gold quality
mucosa of stomach	UBERON:0001199	73.70	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.83	gold quality
ganglionic eminence	UBERON:0004023	72.82	gold quality
lower esophagus	UBERON:0013473	72.78	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.58	gold quality
body of uterus	UBERON:0009853	72.56	gold quality
muscle layer of sigmoid colon	UBERON:0035805	72.55	gold quality
right frontal lobe	UBERON:0002810	72.05	gold quality
tibial artery	UBERON:0007610	71.46	gold quality
popliteal artery	UBERON:0002250	71.45	gold quality
right coronary artery	UBERON:0001625	71.19	gold quality
right uterine tube	UBERON:0001302	71.16	gold quality
right ovary	UBERON:0002118	71.08	gold quality
pigmented layer of retina	UBERON:0001782	71.01	gold quality
anterior cingulate cortex	UBERON:0009835	70.95	gold quality
cingulate cortex	UBERON:0003027	70.86	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.83	gold quality
left ovary	UBERON:0002119	70.58	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	70.46	gold quality
left uterine tube	UBERON:0001303	70.34	gold quality
prefrontal cortex	UBERON:0000451	70.26	gold quality
endocervix	UBERON:0000458	70.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.63

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

34 targeting ZFP2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-4320	99.75	65.80	793
HSA-MIR-4428	99.73	66.41	1733
HSA-MIR-1179	99.71	68.70	1040
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-199A-5P	99.51	69.71	1107
HSA-MIR-199B-5P	99.51	69.74	1098
HSA-MIR-12132	99.47	68.90	1341
HSA-MIR-519D-5P	99.41	69.30	2057
HSA-MIR-3191-5P	99.24	66.52	1722
HSA-MIR-593-3P	99.22	67.28	1327
HSA-MIR-664A-3P	99.22	71.08	2696
HSA-MIR-4528	99.18	69.77	1936
HSA-MIR-4424	98.91	70.33	1145
HSA-MIR-382-3P	98.83	67.10	1074
HSA-MIR-7977	98.65	66.18	2590
HSA-MIR-12125	98.59	67.54	1044
HSA-MIR-3145-5P	98.57	67.83	900
HSA-MIR-1237-3P	98.55	67.65	1423
HSA-MIR-4684-5P	98.29	67.99	1650
HSA-MIR-490-3P	97.79	65.54	606
HSA-MIR-4456	97.50	64.88	1678
HSA-MIR-4640-5P	97.42	66.33	1543
HSA-MIR-5187-3P	97.28	67.10	1037
HSA-MIR-4726-5P	97.24	65.67	1299

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp2	ENSMUSG00000049321
rattus_norvegicus	Zfp2	ENSRNOG00000030750

Paralogs (176): ZNF195 (ENSG00000005801), ZNF112 (ENSG00000062370), ZNF275 (ENSG00000063587), ZNF37A (ENSG00000075407), ZNF510 (ENSG00000081386), ZNF506 (ENSG00000081665), ZNF268 (ENSG00000090612), MZF1 (ENSG00000099326), ZNF629 (ENSG00000102870), ZNF175 (ENSG00000105497), ZNF85 (ENSG00000105750), ZFP30 (ENSG00000120784), ZNF45 (ENSG00000124459), ZNF391 (ENSG00000124613), ZNF436 (ENSG00000125945), ZNF484 (ENSG00000127081), ZNF835 (ENSG00000127903), ZNF780B (ENSG00000128000), ZSCAN10 (ENSG00000130182), ZNF317 (ENSG00000130803), ZNF331 (ENSG00000130844), ZNF227 (ENSG00000131115), ZNF141 (ENSG00000131127), ZNF132 (ENSG00000131849), ZNF189 (ENSG00000136870), ZIM3 (ENSG00000141946), ZFP14 (ENSG00000142065), ZNF514 (ENSG00000144026), ZNF300 (ENSG00000145908), RBAK (ENSG00000146587), ZNF157 (ENSG00000147117), ZNF182 (ENSG00000147118), ZNF41 (ENSG00000147124), ZNF7 (ENSG00000147789), ZNF117 (ENSG00000152926), ZNF221 (ENSG00000159905), ZNF235 (ENSG00000159917), ZNF714 (ENSG00000160352), ZNF577 (ENSG00000161551), ZNF12 (ENSG00000164631)

Protein

Protein identifiers

Zinc finger protein ZFP2 — Q6ZN57 (reviewed: Q6ZN57)

Alternative names: Zinc finger protein 751

All UniProt accessions (3): Q6ZN57, A0A1D5RMT2, E5RJD3

UniProt curated annotations — full annotation on UniProt →

Function. Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

RefSeq proteins (1): NP_085116* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096

UniProt features (16 total): zinc finger region 13, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ZN57-F1	79.80	0.73

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 76 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, AACTGGA_MIR145, TGGAAA_NFAT_Q4_01, XU_GH1_EXOGENOUS_TARGETS_DN, SANSOM_APC_MYC_TARGETS, SANSOM_APC_TARGETS_REQUIRE_MYC, STAT1_02, YKACATTT_UNKNOWN, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP, STAT1_03, TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GSE13522_WT_VS_IFNAR_KO_SKING_T_CRUZI_Y_STRAIN_INF_DN, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY

GO Biological Process (2): regulation of transcription by RNA polymerase II (GO:0006357), negative regulation of DNA-templated transcription (GO:0045892)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
transcription by RNA polymerase II	1
DNA-templated transcription	1
negative regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

414 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZFP2	RBM27	Q9P2N5	380
ZFP2	ZC3H11D	Q8NA57	370
ZFP2	BIVM	Q86UB2	336
ZFP2	POLR2L	P52436	335
ZFP2	TP53	P04637	332
ZFP2	TIGD7	Q6NT04	327
ZFP2	NBPF14	Q5TI25	290
ZFP2	TTPAL	Q9BTX7	289
ZFP2	TSPYL5	Q86VY4	288
ZFP2	ZMAT5	Q9UDW3	287
ZFP2	KLHDC1	Q8N7A1	287
ZFP2	TMEM144	Q7Z5S9	285
ZFP2	TCEAL2	Q9H3H9	275
ZFP2	LIX1L	Q8IVB5	272
ZFP2	A0A0A6YYG8	A0A0A6YYG8	269

IntAct

71 interactions, top by confidence:

A	B	Type	Score
MAP3K20	ZFP2	psi-mi:“MI:0915”(physical association)	0.780
ZFP2	MAP3K20	psi-mi:“MI:0915”(physical association)	0.780
KRT40	ZFP2	psi-mi:“MI:0915”(physical association)	0.720
ZFP2	TRIM41	psi-mi:“MI:0915”(physical association)	0.720
ZFP2	KRT40	psi-mi:“MI:0915”(physical association)	0.720
TRIM41	ZFP2	psi-mi:“MI:0915”(physical association)	0.720
ZFP2	GOLGA2	psi-mi:“MI:0915”(physical association)	0.560
ZFP2	MTUS2	psi-mi:“MI:0915”(physical association)	0.560
BCDIN3D	ZFP2	psi-mi:“MI:0915”(physical association)	0.560
GOLGA2	ZFP2	psi-mi:“MI:0915”(physical association)	0.560
MTUS2	ZFP2	psi-mi:“MI:0915”(physical association)	0.560
ZFP2	BCDIN3D	psi-mi:“MI:0915”(physical association)	0.560
IPO8	ZFP2	psi-mi:“MI:0915”(physical association)	0.560
ZFP2	PICK1	psi-mi:“MI:0915”(physical association)	0.560
	ZFP2	psi-mi:“MI:0915”(physical association)	0.560
ZFP2	DMWD	psi-mi:“MI:0915”(physical association)	0.560
ZFP2		psi-mi:“MI:0915”(physical association)	0.560
LMNA	ZFP2	psi-mi:“MI:0915”(physical association)	0.560
TSC1	ZFP2	psi-mi:“MI:0915”(physical association)	0.560
ZFP2	SPRED1	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (19): ZFP2 (Two-hybrid), ZFP2 (Two-hybrid), ZFP2 (Two-hybrid), TRIM41 (Two-hybrid), KRT40 (Two-hybrid), BCDIN3D (Two-hybrid), ZFP2 (Two-hybrid), ZFP2 (Affinity Capture-MS), ZFP2 (Affinity Capture-MS), ZFP2 (Two-hybrid), ZFP2 (Two-hybrid), ZFP2 (Two-hybrid), ZFP2 (Two-hybrid), ZFP2 (Two-hybrid), KRT40 (Two-hybrid)

ESM2 similar proteins: A2VDQ7, A6NNF4, A8MQ14, A8MTY0, E9QAG8, O75290, O75373, P08043, P0CJ79, P10751, P17017, P17027, P17039, P35789, P51522, P51523, Q08AN1, Q14585, Q14587, Q3SYV7, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5SXM1, Q6ECI4, Q6JLC9, Q6P3V2, Q6P5C7, Q6ZN57, Q86UE3, Q86XN6, Q86YE8, Q8C827, Q8IYB9, Q8N4W9, Q8N7M2

Diamond homologs: P08043, Q6ZN57, Q8N859, Q96ND8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

82 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	77
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1313 predictions. Top by Δscore:

Variant	Effect	Δscore
5:178895971:GAGG:G	donor_gain	1.0000
5:178895973:GG:G	donor_gain	1.0000
5:178895974:GG:G	donor_gain	1.0000
5:178913070:AGG:A	donor_loss	1.0000
5:178913072:GT:G	donor_loss	1.0000
5:178913073:T:A	donor_loss	1.0000
5:178895975:G:GG	donor_gain	0.9900
5:178895976:TGAG:T	donor_loss	0.9900
5:178895977:GAGT:G	donor_loss	0.9900
5:178898577:A:AG	acceptor_gain	0.9900
5:178898578:G:GG	acceptor_gain	0.9900
5:178898578:GCTCT:G	acceptor_gain	0.9900
5:178899858:G:GG	donor_gain	0.9900
5:178912977:A:G	acceptor_gain	0.9900
5:178913069:GAG:G	donor_gain	0.9800
5:178913072:G:GG	donor_gain	0.9800
5:178931236:GACT:G	acceptor_gain	0.9800
5:178898575:TCAG:T	acceptor_loss	0.9700
5:178898576:CA:C	acceptor_loss	0.9700
5:178898577:A:AT	acceptor_loss	0.9700
5:178898578:GCTC:G	acceptor_gain	0.9700
5:178912718:GG:G	donor_gain	0.9700
5:178912719:GG:G	donor_gain	0.9700
5:178931235:A:AG	acceptor_gain	0.9700
5:178931235:AGACT:A	acceptor_gain	0.9700
5:178931236:G:GG	acceptor_gain	0.9700
5:178931236:GACTG:G	acceptor_gain	0.9700
5:178898578:GCT:G	acceptor_gain	0.9600
5:178912978:G:GG	acceptor_gain	0.9600
5:178912979:CAG:C	acceptor_loss	0.9600

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000199107 (5:178896028 C>A), RS1000229326 (5:178932212 G>A,T), RS1000232035 (5:178899642 C>T), RS1000334680 (5:178933035 G>A), RS1000382886 (5:178920310 A>G), RS1000390432 (5:178926678 G>A), RS1000551197 (5:178919053 C>T), RS1000619468 (5:178902022 C>G), RS1000715517 (5:178921633 A>G), RS1000800793 (5:178928201 C>T), RS1000851676 (5:178921882 G>A), RS1000878393 (5:178919951 G>A), RS1000894109 (5:178927892 C>G,T), RS1000912958 (5:178908055 C>T), RS1001138406 (5:178906187 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010002_45	Refractive error	9.000000e-17

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression	5
trichostatin A	affects cotreatment, decreases expression	3
entinostat	decreases expression, affects cotreatment	2
Nickel	decreases expression	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
bisphenol A	increases expression	1
tri-o-cresyl phosphate	increases expression	1
hydroquinone	decreases expression	1
15-acetyldeoxynivalenol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Panobinostat	decreases expression, affects cotreatment	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Methotrexate	increases expression	1
Phenylmercuric Acetate	affects cotreatment, decreases expression	1
Silicon Dioxide	increases expression	1
Smoke	decreases expression	1
Okadaic Acid	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XV95	HEK293 eGFP-ZFP2	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.