ZFP62

Summary

ZFP62 (ZFP62 zinc finger protein, HGNC:23241) is a protein-coding gene on chromosome 5q35.3, encoding Zinc finger protein 62 homolog (Q8NB50). May play a role in differentiating skeletal muscle.

Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 643836 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 123 total
• MANE Select transcript: NM_001172638

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23241
Approved symbol	ZFP62
Name	ZFP62 zinc finger protein
Location	5q35.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ34231, ZET, ZNF755
Ensembl gene	ENSG00000196670
Ensembl biotype	protein_coding
OMIM	610281
Entrez	643836

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 5 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000502412, ENST00000504225, ENST00000506377, ENST00000506439, ENST00000507843, ENST00000509066, ENST00000512132

RefSeq mRNA: 9 — MANE Select: NM_001172638 NM_001172638, NM_001377939, NM_001377940, NM_001377941, NM_001377942, NM_001377943, NM_001377944, NM_001377945, NM_152283

CCDS: CCDS47357, CCDS54955

Canonical transcript exons

ENST00000502412 — 2 exons

Exon	Start	End
ENSE00002055349	180861219	180861276
ENSE00002074531	180847611	180851493

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 94.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.2718 / max 100.4753, expressed in 1743 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
65346	5.7722	1617
65344	1.2160	733
65345	1.1897	767
203823	0.9025	588
65347	0.1913	84

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	94.99	gold quality
sural nerve	UBERON:0015488	94.51	gold quality
calcaneal tendon	UBERON:0003701	94.04	gold quality
cortical plate	UBERON:0005343	93.81	gold quality
tendon	UBERON:0000043	93.47	gold quality
medial globus pallidus	UBERON:0002477	93.37	gold quality
ventricular zone	UBERON:0003053	93.20	gold quality
oocyte	CL:0000023	92.99	gold quality
tendon of biceps brachii	UBERON:0008188	92.40	gold quality
corpus epididymis	UBERON:0004359	92.01	gold quality
amniotic fluid	UBERON:0000173	91.79	gold quality
lower esophagus mucosa	UBERON:0035834	91.36	gold quality
globus pallidus	UBERON:0001875	91.22	gold quality
thymus	UBERON:0002370	91.17	gold quality
epithelium of nasopharynx	UBERON:0001951	90.63	gold quality
secondary oocyte	CL:0000655	90.48	gold quality
epithelial cell of pancreas	CL:0000083	90.40	gold quality
germinal epithelium of ovary	UBERON:0001304	89.79	gold quality
endometrium	UBERON:0001295	89.75	gold quality
oviduct epithelium	UBERON:0004804	89.25	gold quality
thyroid gland	UBERON:0002046	88.88	gold quality
ileal mucosa	UBERON:0000331	88.79	gold quality
caput epididymis	UBERON:0004358	88.78	gold quality
left lobe of thyroid gland	UBERON:0001120	88.66	gold quality
parietal pleura	UBERON:0002400	88.43	gold quality
esophagus squamous epithelium	UBERON:0006920	88.40	gold quality
ovary	UBERON:0000992	88.34	gold quality
rectum	UBERON:0001052	88.27	gold quality
right lobe of thyroid gland	UBERON:0001119	88.27	gold quality
lymph node	UBERON:0000029	88.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.28

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

57 targeting ZFP62, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-345-3P	99.89	70.23	1421
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-7154-5P	99.69	70.52	1900
HSA-MIR-670-5P	99.67	69.94	1565
HSA-MIR-3685	99.62	68.83	1621
HSA-MIR-6083	99.47	68.73	2393
HSA-MIR-2392	99.43	67.50	708
HSA-MIR-3140-5P	99.39	69.04	1136
HSA-MIR-125A-5P	99.36	70.59	1640
HSA-MIR-125B-5P	99.36	70.36	1662
HSA-MIR-18A-5P	99.29	71.05	806
HSA-MIR-18B-5P	99.29	71.05	806
HSA-MIR-4477B	99.23	70.49	1733

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp62	ENSMUSG00000046311
rattus_norvegicus	Zfp62	ENSRNOG00000051756
drosophila_melanogaster	CG18476	FBGN0037931
drosophila_melanogaster	CG10669	FBGN0039329

Paralogs (5): ZNF664 (ENSG00000179195), ZNF648 (ENSG00000179930), ZNF721 (ENSG00000182903), ZNF485 (ENSG00000198298), ZNF808 (ENSG00000198482)

Protein

Protein identifiers

Zinc finger protein 62 homolog — Q8NB50 (reviewed: Q8NB50)

All UniProt accessions (4): Q8NB50, D6R9C0, D6RBG3, D6RCF6

UniProt curated annotations — full annotation on UniProt →

Function. May play a role in differentiating skeletal muscle.

Subcellular location. Nucleus.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8NB50-1	1	yes
Q8NB50-2	2
Q8NB50-3	3

RefSeq proteins (9): NP_001166109, NP_001364868, NP_001364869, NP_001364870, NP_001364871, NP_001364872, NP_001364873, NP_001364874, NP_689496 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily
IPR050636	C2H2-ZF_domain-containing	Family

Pfam: PF00096, PF13912

UniProt features (44 total): zinc finger region 23, cross-link 9, compositionally biased region 3, sequence conflict 3, splice variant 2, sequence variant 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NB50-F1	68.31	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 5, 48, 62, 65, 82, 92, 587, 748, 882

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 91 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_UP, GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_UP, BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_DN, BURTON_ADIPOGENESIS_11, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, ONGUSAHA_BRCA1_TARGETS_DN, FEVR_CTNNB1_TARGETS_DN, ZWANG_DOWN_BY_2ND_EGF_PULSE, ESC_J1_UP_LATE.V1_DN, GSE14415_ACT_VS_CTRL_NATURAL_TREG_DN, ATF6_TARGET_GENES, CHAF1B_TARGET_GENES, HHEX_TARGET_GENES, KMT2D_TARGET_GENES, LHX3_TARGET_GENES

GO Biological Process (1): regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (2): zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
transition metal ion binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

820 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZFP62	MYF6	P23409	769
ZFP62	CWF19L2	Q2TBE0	543
ZFP62	ANKIB1	Q9P2G1	463
ZFP62	FAM218A	Q96MZ4	431
ZFP62	APBA1	Q02410	425
ZFP62	PGM2L1	Q6PCE3	419
ZFP62	DRICH1	Q6PGQ1	418
ZFP62	PRR20A	P86496	418
ZFP62	STK35	Q8TDR2	414
ZFP62	INPPL1	O15357	407
ZFP62	NEFM	P07197	402
ZFP62	KIF5B	P33176	398
ZFP62	CCDC28A-AS1	A0A096LPI5	393
ZFP62	SLC17A6	Q9P2U8	387
ZFP62	PHLDB3	Q6NSJ2	369

IntAct

93 interactions, top by confidence:

A	B	Type	Score
RPL14	RRP8	psi-mi:“MI:0914”(association)	0.640
RBM34	RRP8	psi-mi:“MI:0914”(association)	0.640
NPM1	NVL	psi-mi:“MI:0914”(association)	0.610
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
RRP8	NVL	psi-mi:“MI:0914”(association)	0.530
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ZNF2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
ZNF71	NVL	psi-mi:“MI:0914”(association)	0.530
KNOP1	DHX15	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
PUM3	RRP8	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
PPAN	PPM1G	psi-mi:“MI:0914”(association)	0.530
RBM4	NVL	psi-mi:“MI:0914”(association)	0.530
SRPK2	RRP9	psi-mi:“MI:0914”(association)	0.530
RPL7A	NVL	psi-mi:“MI:0914”(association)	0.530
LIN28B	ELAVL2	psi-mi:“MI:0914”(association)	0.530
ZFP62	DKC1	psi-mi:“MI:0915”(physical association)	0.400
PPAN	IGF2BP3	psi-mi:“MI:0914”(association)	0.350

BioGRID (88): ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS), ZFP62 (Affinity Capture-MS)

ESM2 similar proteins: A2VDQ7, A6NNF4, A8MQ14, A8MTY0, E9QAG8, O75290, O75373, P08043, P0CJ79, P10751, P17017, P17027, P17039, P35789, P51522, P51523, Q08AN1, Q14585, Q14587, Q3SYV7, Q3ZCX4, Q4R4C7, Q52M93, Q5MCW4, Q5R5U3, Q5R8X1, Q5R9F0, Q5SXM1, Q6ECI4, Q6JLC9, Q6P3V2, Q6P5C7, Q6ZN57, Q86UE3, Q86XN6, Q86YE8, Q8C827, Q8IYB9, Q8N4W9, Q8N7M2

Diamond homologs: Q5R8X1, Q8C827, Q8NB50, Q9H7R5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 88 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	14	30.6×	4e-16
Viral mRNA Translation	14	30.6×	4e-16
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	14	30.3×	4e-16
Selenocysteine synthesis	14	29.0×	6e-16
Eukaryotic Translation Termination	14	29.0×	6e-16
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	14	28.4×	6e-16
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	14	28.4×	6e-16
Formation of a pool of free 40S subunits	14	27.0×	1e-15

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	15	34.3×	6e-17
ribosomal large subunit biogenesis	5	27.4×	5e-05
rRNA processing	13	22.7×	2e-12
regulation of alternative mRNA splicing, via spliceosome	6	18.1×	5e-05
translation	14	17.8×	4e-12
ribosomal small subunit biogenesis	6	16.9×	6e-05
RNA processing	6	16.2×	7e-05
nucleosome assembly	5	8.7×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

123 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	114
Likely benign	7
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

865 predictions. Top by Δscore:

Variant	Effect	Δscore
5:180851494:C:CC	acceptor_gain	1.0000
5:180860101:A:T	acceptor_gain	1.0000
5:180861213:A:AC	donor_gain	1.0000
5:180861214:C:CC	donor_gain	1.0000
5:180861214:CGTA:C	donor_gain	1.0000
5:180861217:A:AC	donor_gain	1.0000
5:180861218:C:CC	donor_gain	1.0000
5:180861218:CTGG:C	donor_gain	1.0000
5:180851492:CA:C	acceptor_gain	0.9900
5:180851500:C:CT	acceptor_gain	0.9900
5:180851501:A:T	acceptor_gain	0.9900
5:180858947:TACG:T	donor_gain	0.9900
5:180858948:ACGA:A	donor_gain	0.9900
5:180858949:CGAC:C	donor_gain	0.9900
5:180858950:G:GT	donor_gain	0.9900
5:180860689:C:CT	acceptor_gain	0.9900
5:180851500:C:T	acceptor_gain	0.9800
5:180858949:CGA:C	donor_gain	0.9800
5:180860100:C:CT	acceptor_gain	0.9800
5:180860690:A:T	acceptor_gain	0.9800
5:180861110:C:CA	donor_gain	0.9800
5:180851489:TGACA:T	acceptor_gain	0.9700
5:180851490:GACA:G	acceptor_gain	0.9700
5:180858930:ACT:A	donor_gain	0.9700
5:180858931:CTC:C	donor_gain	0.9700
5:180858948:A:AC	donor_gain	0.9700
5:180858949:C:CC	donor_gain	0.9700
5:180851494:CTA:C	acceptor_loss	0.9600
5:180851495:T:C	acceptor_loss	0.9600
5:180861107:A:AC	donor_gain	0.9600

AlphaMissense

6065 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:180850373:G:C	F374L	1.000
5:180850373:G:T	F374L	1.000
5:180850375:A:G	F374L	1.000
5:180850457:A:C	F346L	1.000
5:180850457:A:T	F346L	1.000
5:180850459:A:G	F346L	1.000
5:180850541:G:C	F318L	1.000
5:180850541:G:T	F318L	1.000
5:180850543:A:G	F318L	1.000
5:180850709:G:C	F262L	1.000
5:180850709:G:T	F262L	1.000
5:180850711:A:G	F262L	1.000
5:180850793:G:C	F234L	1.000
5:180850793:G:T	F234L	1.000
5:180850795:A:G	F234L	1.000
5:180849197:G:C	F766L	0.999
5:180849197:G:T	F766L	0.999
5:180849199:A:G	F766L	0.999
5:180849701:G:C	F598L	0.999
5:180849701:G:T	F598L	0.999
5:180849703:A:G	F598L	0.999
5:180849768:A:G	L576P	0.999
5:180849837:C:G	R553P	0.999
5:180849852:A:G	L548P	0.999
5:180849869:G:C	F542L	0.999
5:180849869:G:T	F542L	0.999
5:180849871:A:G	F542L	0.999
5:180850096:G:C	H467D	0.999
5:180850104:A:G	L464P	0.999
5:180850121:G:C	F458L	0.999

dbSNP variants (sampled 300 via entrez): RS1000006226 (5:180831164 G>A), RS1000013042 (5:180849058 A>G), RS1000015 (5:180849788 T>C,G), RS1000025661 (5:180859094 C>T), RS1000036831 (5:180859316 A>G), RS1000065098 (5:180857786 C>T), RS1000217838 (5:180854671 T>A,C), RS1000258346 (5:180853678 T>C), RS1000288878 (5:180841320 C>T), RS1000305175 (5:180860730 G>C,T), RS1000422349 (5:180847293 A>G), RS1000490947 (5:180848709 T>C), RS1000532215 (5:180853784 G>A), RS1000563287 (5:180853624 T>A), RS1000719392 (5:180830261 T>C)

Disease associations

OMIM: gene MIM:610281 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, decreases expression	3
sodium arsenite	decreases expression, affects cotreatment, increases abundance	2
aristolochic acid I	decreases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
GSK-J4	decreases expression	1
TAK-243	increases sumoylation	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, increases expression	1
2-methyl-4-isothiazolin-3-one	decreases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
1-nitropyrene	increases expression	1
pentanal	decreases expression	1
perfluorooctane sulfonic acid	increases expression	1
abrine	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Leflunomide	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Carbamazepine	affects expression	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Gallic Acid	decreases expression	1
Hydralazine	affects cotreatment, increases expression	1
Hydrogen Peroxide	affects expression	1
Indomethacin	affects cotreatment, increases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Methyl Methanesulfonate	increases expression	1
Ozone	affects expression, increases abundance	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_HD07	HEK293 eGFP-ZFP62	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.