ZFP90

Summary

ZFP90 (ZFP90 zinc finger protein, HGNC:23329) is a protein-coding gene on chromosome 16q22.1, encoding Zinc finger protein 90 homolog (Q8TF47). Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.

This gene encodes a member of the zinc finger protein family that modulates gene expression. The encoded protein derepresses the transcription of certain fetal cardiac genes and may contribute to the genetic reprogramming that occurs during the development of heart failure. Genome wide association studies have identified this gene among ulcerative colitis risk loci. Alternative splicing of this gene results in multiple transcript variants.

Source: NCBI Gene 146198 — RefSeq curated summary.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 87 total
• MANE Select transcript: NM_001305203

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23329
Approved symbol	ZFP90
Name	ZFP90 zinc finger protein
Location	16q22.1
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1954, NK10, ZNF756
Ensembl gene	ENSG00000184939
Ensembl biotype	protein_coding
OMIM	609451
Entrez	146198

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 12 protein_coding, 4 nonsense_mediated_decay, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000398253, ENST00000562156, ENST00000563169, ENST00000564323, ENST00000564558, ENST00000566573, ENST00000569109, ENST00000569323, ENST00000570495, ENST00000570884, ENST00000571382, ENST00000571720, ENST00000571809, ENST00000573113, ENST00000573161, ENST00000573685, ENST00000576305, ENST00000576805, ENST00000611381

RefSeq mRNA: 6 — MANE Select: NM_001305203 NM_001305203, NM_001305204, NM_001305206, NM_001305207, NM_001305208, NM_133458

CCDS: CCDS42183, CCDS76892, CCDS82003

Canonical transcript exons

ENST00000563169 — 5 exons

Exon	Start	End
ENSE00001532291	68558473	68558568
ENSE00002642258	68539291	68539479
ENSE00002648467	68563044	68567131
ENSE00003512841	68539758	68539825
ENSE00003648647	68557998	68558124

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 93.57.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.7842 / max 143.7486, expressed in 1755 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
154751	10.3177	1729
154749	2.8558	1160
154752	0.6108	385

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	93.57	gold quality
cortical plate	UBERON:0005343	93.42	gold quality
corpus callosum	UBERON:0002336	93.26	gold quality
pancreatic ductal cell	CL:0002079	93.08	gold quality
superior vestibular nucleus	UBERON:0007227	92.79	gold quality
inferior vagus X ganglion	UBERON:0005363	92.77	gold quality
medulla oblongata	UBERON:0001896	92.75	gold quality
ventral tegmental area	UBERON:0002691	92.40	gold quality
trigeminal ganglion	UBERON:0001675	92.33	gold quality
ventricular zone	UBERON:0003053	91.64	gold quality
dorsal root ganglion	UBERON:0000044	91.56	gold quality
subthalamic nucleus	UBERON:0001906	91.40	gold quality
pons	UBERON:0000988	91.24	gold quality
Brodmann (1909) area 46	UBERON:0006483	91.24	gold quality
dorsal plus ventral thalamus	UBERON:0001897	91.07	gold quality
thymus	UBERON:0002370	90.43	gold quality
bronchial epithelial cell	CL:0002328	90.40	gold quality
bronchus	UBERON:0002185	90.15	gold quality
nipple	UBERON:0002030	90.09	gold quality
secondary oocyte	CL:0000655	90.06	gold quality
substantia nigra pars compacta	UBERON:0001965	89.73	gold quality
tibia	UBERON:0000979	89.58	gold quality
lateral globus pallidus	UBERON:0002476	89.56	gold quality
substantia nigra pars reticulata	UBERON:0001966	89.37	gold quality
epithelial cell of pancreas	CL:0000083	89.21	gold quality
mucosa of paranasal sinus	UBERON:0005030	89.18	gold quality
midbrain	UBERON:0001891	89.06	gold quality
sperm	CL:0000019	88.96	gold quality
layer of synovial tissue	UBERON:0007616	88.96	gold quality
spinal cord	UBERON:0002240	88.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.15

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

2 targets.

Target	Regulation
IFNG
NPPB

miRNA regulators (miRDB)

75 targeting ZFP90, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-221-3P	99.86	71.56	1329
HSA-MIR-222-3P	99.86	71.35	1337
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-139-5P	99.80	69.50	1399
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-3913-5P	99.78	67.26	968
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-3934-3P	99.76	65.51	1351
HSA-MIR-4446-5P	99.72	69.19	2544
HSA-MIR-4527	99.66	67.43	714
HSA-MIR-875-3P	99.63	69.47	2548
HSA-MIR-6503-5P	99.62	66.96	597
HSA-MIR-5689	99.50	71.26	1154
HSA-MIR-5571-5P	99.49	66.99	1764
HSA-MIR-4251	99.40	69.19	3363

Literature-anchored findings (GeneRIF, showing 2)

• A 16q22.1 variant confers susceptibility to colorectal cancer as a distal regulator of ZFP90. (PMID:31641208)
• Assessing the Function of the ZFP90 Variant rs1170426 in SLE and the Association Between SLE Drug Target and Susceptibility Genes. (PMID:33796098)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Zfp90	ENSMUSG00000031907
rattus_norvegicus	Zfp90	ENSRNOG00000020087
drosophila_melanogaster	CG2712	FBGN0024975
drosophila_melanogaster	Phs	FBGN0036522
drosophila_melanogaster	CG3281	FBGN0260741

Paralogs (62): ZNF582 (ENSG00000018869), ZNF264 (ENSG00000083844), ZNF343 (ENSG00000088876), ZNF684 (ENSG00000117010), ZNF133 (ENSG00000125846), ZNF557 (ENSG00000130544), ZNF337 (ENSG00000130684), ZNF20 (ENSG00000132010), ZFP37 (ENSG00000136866), ZNF614 (ENSG00000142556), KRBOX4 (ENSG00000147121), ZNF599 (ENSG00000153896), ZNF19 (ENSG00000157429), ZNF589 (ENSG00000164048), PRDM9 (ENSG00000164256), ZNF180 (ENSG00000167384), ZNF558 (ENSG00000167785), ZNF35 (ENSG00000169981), ZNF778 (ENSG00000170100), ZNF439 (ENSG00000171291), ZNF440 (ENSG00000171295), ZNF556 (ENSG00000172000), ZNF554 (ENSG00000172006), ZNF596 (ENSG00000172748), ZNF80 (ENSG00000174255), ZNF266 (ENSG00000174652), ZNF25 (ENSG00000175395), ZNF77 (ENSG00000175691), ZNF169 (ENSG00000175787), ZNF404 (ENSG00000176222), ZNF491 (ENSG00000177599), ZNF620 (ENSG00000177842), ZNF619 (ENSG00000177873), ZNF875 (ENSG00000181666), ZNF329 (ENSG00000181894), ZNF566 (ENSG00000186017), ZNF529 (ENSG00000186020), ZNF749 (ENSG00000186230), ZNF555 (ENSG00000186300), ZNF70 (ENSG00000187792)

Protein

Protein identifiers

Zinc finger protein 90 homolog — Q8TF47 (reviewed: Q8TF47)

Alternative names: Zinc finger protein 756

All UniProt accessions (9): Q8TF47, H3BMI1, H3BVC6, I3L0T2, I3L0X7, I3L1L4, I3L2Q3, I3L3M0, J3QKQ8

UniProt curated annotations — full annotation on UniProt →

Function. Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes. Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg).

Subunit / interactions. Interacts (via N- and C-termini) with REST (via zinc-finger DNA-binding domain); the interaction inhibits REST repressor activity. Interacts with FOXP3 and TRIM28.

Subcellular location. Nucleus.

Tissue specificity. Expressed in heart. Isoform 2: Highly expressed in regulatory T-cells (Treg).

Miscellaneous. Interacts (via 75-113 AA) with FOXP3. Interacts (via KRAB domain) with TRIM28.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8TF47-1	1	yes
Q8TF47-3	2, FOXP3-interacting KRAB-domain containing protein, FIK

RefSeq proteins (6): NP_001292132, NP_001292133, NP_001292135, NP_001292136, NP_001292137, NP_597715 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001909	KRAB	Domain
IPR013087	Znf_C2H2_type	Domain
IPR036051	KRAB_dom_sf	Homologous_superfamily
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF01352

UniProt features (19 total): zinc finger region 13, splice variant 2, chain 1, domain 1, cross-link 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TF47-F1	64.79	0.06

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 448

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-212436	Generic Transcription Pathway

MSigDB gene sets: 151 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_DN, chr16q22, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_UP, MODULE_205, LEE_AGING_MUSCLE_UP, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, CHEN_METABOLIC_SYNDROM_NETWORK, WONG_ADULT_TISSUE_STEM_MODULE, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GSE13522_WT_VS_IFNAR_KO_SKING_T_CRUZI_Y_STRAIN_INF_DN, GOMF_DNA_BINDING_TRANSCRIPTION_REPRESSOR_ACTIVITY, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, GSE14415_NATURAL_TREG_VS_FOXP3_KO_NATURAL_TREG_DN

GO Biological Process (5): regulation of transcription by RNA polymerase II (GO:0006357), positive regulation of DNA-templated transcription (GO:0045893), negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of DNA-templated transcription (GO:0006355), negative regulation of DNA-templated transcription (GO:0045892)

GO Molecular Function (7): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), zinc ion binding (GO:0008270), DNA binding (GO:0003677), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	3
DNA-templated transcription	3
transcription by RNA polymerase II	2
regulation of transcription by RNA polymerase II	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
positive regulation of RNA biosynthetic process	1
negative regulation of DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
negative regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
DNA-binding transcription factor activity	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
transition metal ion binding	1
nucleic acid binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

612 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ZFP90	CDH15	P55291	537
ZFP90	RHOBTB3	O94955	471
ZFP90	SVOPL	Q8N434	458
ZFP90	ST8SIA1	Q92185	456
ZFP90	LRGUK	Q96M69	454
ZFP90	MCCC1	Q96RQ3	429
ZFP90	COL26A1	Q96A83	427
ZFP90	ZC3H12C	Q9C0D7	426
ZFP90	SCML2	Q9UQR0	424
ZFP90	SCIN	Q9Y6U3	418
ZFP90	CLDN23	Q96B33	418
ZFP90	M0R233	M0R233	401
ZFP90	MTPN	P58546	386
ZFP90	AGBL3	Q8NEM8	378
ZFP90	LACTB	P83096	376

IntAct

82 interactions, top by confidence:

A	B	Type	Score
SUOX	ZFP90	psi-mi:“MI:0915”(physical association)	0.560
FRS3	ZFP90	psi-mi:“MI:0915”(physical association)	0.560
PKN1	ZFP90	psi-mi:“MI:0915”(physical association)	0.560
BOLA2-SMG1P6	ZFP90	psi-mi:“MI:0915”(physical association)	0.560
ZFP90	TDRKH	psi-mi:“MI:0915”(physical association)	0.560
ZFP90	ENKD1	psi-mi:“MI:0915”(physical association)	0.560
LMO1	ZFP90	psi-mi:“MI:0915”(physical association)	0.560
HOXC8	ZFP90	psi-mi:“MI:0915”(physical association)	0.560
ZFP90	CPNE7	psi-mi:“MI:0915”(physical association)	0.560
MLH1	ZFP90	psi-mi:“MI:0915”(physical association)	0.560
RUNX1T1	ZFP90	psi-mi:“MI:0915”(physical association)	0.560
ZFP90	EXOSC5	psi-mi:“MI:0915”(physical association)	0.560
ZFP90	GTPBP3	psi-mi:“MI:0915”(physical association)	0.560
PRKAB2	ZFP90	psi-mi:“MI:0915”(physical association)	0.560
ZFP90	TEKT4	psi-mi:“MI:0915”(physical association)	0.560
ZFP90	ABI2	psi-mi:“MI:0915”(physical association)	0.560
TRAPPC6A	ZFP90	psi-mi:“MI:0915”(physical association)	0.560
ZFP90	GCC1	psi-mi:“MI:0915”(physical association)	0.560
CCNC	ZFP90	psi-mi:“MI:0915”(physical association)	0.560
LONRF1	ZFP90	psi-mi:“MI:0915”(physical association)	0.560
ZFP90	MALSU1	psi-mi:“MI:0915”(physical association)	0.560
GLYCTK	ZFP90	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (36): ZFP90 (Affinity Capture-MS), ZFP90 (Two-hybrid), ZFP90 (Two-hybrid), ZFP90 (Two-hybrid), ZFP90 (Two-hybrid), ZFP90 (Two-hybrid), ZFP90 (Two-hybrid), ZFP90 (Two-hybrid), ZFP90 (Two-hybrid), ZFP90 (Two-hybrid), ZFP90 (Two-hybrid), ZFP90 (Two-hybrid), ZFP90 (Two-hybrid), ZFP90 (Two-hybrid), ZFP90 (Two-hybrid)

ESM2 similar proteins: A0A087WUV0, A0JNB1, A2VDP4, B2RUI1, P0CG31, P10072, P17025, P17036, P17097, P18733, P51814, Q08ER8, Q09FC8, Q0VGE8, Q14590, Q15937, Q16600, Q2M3X9, Q4V8A8, Q5CZA5, Q5R8G9, Q5RBX0, Q5VIY5, Q68DI1, Q6J6I6, Q6NX49, Q6P1L6, Q6PG37, Q6ZMS4, Q6ZMW2, Q80YP6, Q86UD4, Q86Y25, Q8IZ26, Q8N184, Q8NB42, Q8NEK5, Q8TAF7, Q8TF47, Q8WXB4

Diamond homologs: A0A1W2PQL4, A0JNB1, A0JPL0, A6NK53, A6QLU5, A6QPT6, A7MBI1, A8MT65, A8MUV8, A8MWA4, B2RXC5, B4DU55, B4DX44, E9PYI1, O14628, O75346, P0CH99, P0CI00, P17014, P17030, P17032, P17098, P51786, P85977, Q02386, Q06730, Q06732, Q0VAW7, Q12901, Q13360, Q14586, Q14588, Q14590, Q16587, Q2M3X9, Q2VY69, Q32M78, Q3ZCX4, Q49AA0, Q4R6J4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

87 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	80
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

995 predictions. Top by Δscore:

Variant	Effect	Δscore
16:68539823:CAGG:C	donor_loss	0.9900
16:68539826:G:GA	donor_loss	0.9900
16:68539827:T:G	donor_loss	0.9900
16:68558466:T:G	acceptor_gain	0.9900
16:68558466:T:TA	acceptor_gain	0.9900
16:68539370:A:G	donor_gain	0.9800
16:68539476:C:G	donor_gain	0.9800
16:68539480:G:GG	donor_gain	0.9800
16:68558125:G:GA	donor_loss	0.9800
16:68558126:TAAG:T	donor_loss	0.9800
16:68558374:GA:G	acceptor_gain	0.9800
16:68541766:GGCTT:G	donor_gain	0.9700
16:68541767:GCTTG:G	donor_gain	0.9700
16:68557994:ACAG:A	acceptor_loss	0.9700
16:68557997:G:GC	acceptor_loss	0.9700
16:68558085:G:T	donor_gain	0.9700
16:68558127:AAG:A	donor_loss	0.9700
16:68558465:AT:A	acceptor_gain	0.9700
16:68558471:AG:A	acceptor_gain	0.9700
16:68558472:GG:G	acceptor_gain	0.9700
16:68558541:G:GT	donor_gain	0.9700
16:68539379:G:GT	donor_gain	0.9600
16:68539380:GAGA:G	donor_gain	0.9600
16:68539383:A:G	donor_gain	0.9600
16:68539423:GCTC:G	donor_gain	0.9600
16:68539476:C:CG	donor_gain	0.9600
16:68539478:GA:G	donor_gain	0.9600
16:68539756:A:AG	acceptor_gain	0.9600
16:68539757:G:GG	acceptor_gain	0.9600
16:68558564:TCCAG:T	donor_loss	0.9600

AlphaMissense

4258 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:68563658:T:C	F291L	0.999
16:68563660:C:A	F291L	0.999
16:68563660:C:G	F291L	0.999
16:68563742:T:C	F319L	0.999
16:68563744:C:A	F319L	0.999
16:68563744:C:G	F319L	0.999
16:68563783:C:A	H332Q	0.998
16:68563783:C:G	H332Q	0.998
16:68563826:T:C	F347L	0.998
16:68563828:T:A	F347L	0.998
16:68563828:T:G	F347L	0.998
16:68563910:T:C	F375L	0.998
16:68563912:T:A	F375L	0.998
16:68563912:T:G	F375L	0.998
16:68563994:T:C	F403L	0.998
16:68563996:T:A	F403L	0.998
16:68563996:T:G	F403L	0.998
16:68564387:T:C	F534L	0.998
16:68564389:T:A	F534L	0.998
16:68564389:T:G	F534L	0.998
16:68564555:T:C	F590L	0.998
16:68564557:C:A	F590L	0.998
16:68564557:C:G	F590L	0.998
16:68558032:T:C	F23S	0.997
16:68563771:C:A	H328Q	0.997
16:68563771:C:G	H328Q	0.997
16:68563776:G:C	R330P	0.997
16:68563973:T:C	C396R	0.997
16:68564023:T:A	H412Q	0.997
16:68564023:T:G	H412Q	0.997

dbSNP variants (sampled 300 via entrez): RS1000011007 (16:68554074 A>G), RS1000072919 (16:68540665 A>G,T), RS1000109310 (16:68531554 T>A,G), RS1000244230 (16:68543837 G>A), RS1000329971 (16:68557161 G>T), RS1000384703 (16:68551362 A>C,G), RS1000437001 (16:68551657 C>A,T), RS1000565296 (16:68542616 AGG>A), RS1000615206 (16:68555407 T>G), RS1000853886 (16:68536534 G>A), RS1000873269 (16:68558955 T>C), RS1000908835 (16:68531576 C>T), RS1000915104 (16:68552728 G>A), RS1000924684 (16:68574118 G>A,C), RS1000962430 (16:68531768 A>G)

Disease associations

OMIM: gene MIM:609451 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST000885_4	Response to antipsychotic treatment in schizophrenia (reasoning)	1.000000e-06
GCST000964_26	Ulcerative colitis	4.000000e-08
GCST001352_4	HIV-1 viral setpoint	6.000000e-06
GCST001728_15	Ulcerative colitis	4.000000e-08
GCST003622_10	Systemic lupus erythematosus	4.000000e-08
GCST003622_21	Systemic lupus erythematosus	2.000000e-08
GCST004133_66	Ulcerative colitis	4.000000e-08
GCST005752_112	Systemic lupus erythematosus	4.000000e-11
GCST005752_33	Systemic lupus erythematosus	8.000000e-07
GCST011956_103	Systemic lupus erythematosus	3.000000e-08
GCST90002381_93	Eosinophil count	6.000000e-18
GCST90002382_444	Eosinophil percentage of white cells	3.000000e-18

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004350	reasoning
EFO:0006319	HIV viral set point measurement
EFO:0004842	eosinophil count
EFO:0007991	eosinophil percentage of leukocytes

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, increases expression	4
sodium arsenite	decreases expression, increases expression	3
Cisplatin	affects cotreatment, increases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
GSK-J4	decreases expression	1
TAK-243	increases sumoylation	1
bufotalin	decreases expression	1
triphenyl phosphate	affects expression	1
2-methyl-4-isothiazolin-3-one	decreases expression	1
trichostatin A	increases expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
nutlin 3	affects cotreatment, increases expression	1
ICG 001	increases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	affects cotreatment, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	increases expression	1
Sunitinib	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Atrazine	decreases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Dactinomycin	increases expression, affects cotreatment	1
Doxorubicin	decreases expression	1
Estradiol	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.