ZFPM2-AS1

Summary

ZFPM2-AS1 (ZFPM2 antisense RNA 1, HGNC:50698) is a long non-coding RNA gene on chromosome 8q23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50698
Approved symbol	ZFPM2-AS1
Name	ZFPM2 antisense RNA 1
Location	8q23.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	SCAT3
Ensembl gene	ENSG00000251003
Ensembl biotype	lncRNA
Entrez	102723356
RNAcentral	URS00007E33EE — lncRNA, 1011 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 12 lncRNA, 1 retained_intron

ENST00000509144, ENST00000518932, ENST00000520078, ENST00000520433, ENST00000520594, ENST00000521622, ENST00000524045, ENST00000647695, ENST00000659633, ENST00000821409, ENST00000821410, ENST00000821411, ENST00000821412

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000509144 — 4 exons

Exon	Start	End
ENSE00002022160	105796940	105797224
ENSE00002070318	105798325	105798442
ENSE00002090253	106060381	106060443
ENSE00002131625	105927642	105927717

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 84.23.

FANTOM5 (CAGE): breadth broad, TPM avg 7.5465 / max 560.3771, expressed in 688 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
94356	6.9994	663
94355	0.2432	144
94357	0.1531	84
94358	0.1508	74

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	84.23	gold quality
endometrium	UBERON:0001295	84.21	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.11	gold quality
stromal cell of endometrium	CL:0002255	81.35	gold quality
tibial nerve	UBERON:0001323	81.19	gold quality
calcaneal tendon	UBERON:0003701	76.11	gold quality
sural nerve	UBERON:0015488	75.90	gold quality
metanephros cortex	UBERON:0010533	73.31	gold quality
fallopian tube	UBERON:0003889	71.95	gold quality
left ovary	UBERON:0002119	71.46	gold quality
cortex of kidney	UBERON:0001225	71.42	gold quality
ovary	UBERON:0000992	71.34	gold quality
adrenal tissue	UBERON:0018303	70.51	gold quality
right ovary	UBERON:0002118	70.41	gold quality
colonic epithelium	UBERON:0000397	70.37	gold quality
omental fat pad	UBERON:0010414	69.82	gold quality
urinary bladder	UBERON:0001255	69.63	gold quality
skeletal muscle tissue	UBERON:0001134	69.59	gold quality
kidney	UBERON:0002113	69.14	gold quality
adipose tissue	UBERON:0001013	68.66	gold quality
descending thoracic aorta	UBERON:0002345	68.37	gold quality
endocervix	UBERON:0000458	68.35	gold quality
placenta	UBERON:0001987	68.28	gold quality
body of uterus	UBERON:0009853	67.98	gold quality
left uterine tube	UBERON:0001303	67.78	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.75	gold quality
ventricular zone	UBERON:0003053	67.29	gold quality
myometrium	UBERON:0001296	67.26	gold quality
corpus callosum	UBERON:0002336	66.92	gold quality
adult mammalian kidney	UBERON:0000082	66.54	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	11.84
E-ANND-3	yes	4.83

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 17)

• Our findings demonstrated that ZFPM2-AS1 regulates gastric cancer progression and revealed a novel ZFPM2-AS1/MIF/p53 signaling axis (PMID:29985481)
• lncRNA ZFPM2-AS1 promotes proliferation via miR-18b-5p/VMA21 axis in lung adenocarcinoma. (PMID:31297866)
• LncRNA ZFPM2-AS1 promotes lung adenocarcinoma progression by interacting with UPF1 to destabilize ZFPM2. (PMID:31919993)
• ZFPM2-AS1 facilitates cell growth in esophageal squamous cell carcinoma via up-regulating TRAF4. (PMID:32065218)
• Long noncoding RNA ZFPM2-AS1 regulates ITGB1 by miR-1226-3p to promote cell proliferation and invasion in hepatocellular carcinoma. (PMID:32744687)
• Long noncoding RNA ZFPM2-AS1 acts as a miRNA sponge and promotes cell invasion through regulation of miR-139/GDF10 in hepatocellular carcinoma. (PMID:32795316)
• LncRNA ZFPM2-AS1 aggravates the malignant development of breast cancer via upregulating JMJD6. (PMID:33215431)
• Long noncoding RNA ZFPM2AS1 promotes colorectal cancer progression by sponging miR137 to regulate TRIM24. (PMID:33300060)
• ZFPM2-AS1 facilitates cell proliferation and migration in cutaneous malignant melanoma through modulating miR-650/NOTCH1 signaling. (PMID:33406278)
• STAT1-induced regulation of lncRNA ZFPM2-AS1 predicts poor prognosis and contributes to hepatocellular carcinoma progression via the miR-653/GOLM1 axis. (PMID:33414427)
• SP1-induced lncRNA ZFPM2 antisense RNA 1 (ZFPM2-AS1) aggravates glioma progression via the miR-515-5p/Superoxide dismutase 2 (SOD2) axis. (PMID:34077295)
• lncRNA ZFPM2-AS1 promotes retinoblastoma progression by targeting microRNA miR-511-3p/paired box protein 6 (PAX6) axis. (PMID:34989314)
• Long Non-coding RNA ZFPM2-AS1: A Novel Biomarker in the Pathogenesis of Human Cancers. (PMID:35098483)
• Long noncoding RNA ZFPM2-AS1 regulates renal cell carcinoma progression via miR-130a-3p/ESCO2. (PMID:35258173)
• ZFPM2-AS1: An Oncogenic Long Non-coding RNA in Multiple Cancer Types. (PMID:35578882)
• LncRNA ZFPM2-AS1 Enhances Retinoblastoma Development by Targeting the miR-3612/NT5E Signaling Axis. (PMID:35997119)
• Genome stabilityrelated lncRNA ZFPM2AS1 promotes tumor progression via miR30655p/XRCC4 in hepatocellular carcinoma. (PMID:36524359)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.