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ZGLP1

gene
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Also known as GLP1GLP-1GATAD3

Summary

ZGLP1 (zinc finger GATA like protein 1, HGNC:37245) is a protein-coding gene on chromosome 19p13.2, encoding GATA-type zinc finger protein 1 (P0C6A0). Transcriptional regulator that plays a key role in germ cell development.

ZGLP1 encodes an evolutionary conserved transcriptional regulator with GATA-like zinc fingers. In females, it is expressed in embryonic germ cells and is essential for oogenic fate determination. It acts downstream of bone morphogenetic protein (BMP) and is involved in the regulation of genes involved in RNA processing, transcription and chromatin modification, retrotransposon regulation, meiotic cell cycle, and oocyte development. In males it is not required for the germ cell sex determination but is required by the spermatogonia for efficiently completing the meiotic prophase.

Source: NCBI Gene 100125288 — RefSeq curated summary.

At a glance

  • GWAS associations: 3
  • Clinical variants (ClinVar): 1 total
  • Transcription factor: yes — 27 downstream targets (CollecTRI)
  • MANE Select transcript: NM_001409033

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:37245
Approved symbolZGLP1
Namezinc finger GATA like protein 1
Location19p13.2
Locus typegene with protein product
StatusApproved
AliasesGLP1, GLP-1, GATAD3
Ensembl geneENSG00000220201
Ensembl biotypeprotein_coding
OMIM611639
Entrez100125288

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 retained_intron

ENST00000403352, ENST00000403903, ENST00000480726, ENST00000707000

RefSeq mRNA: 2 — MANE Select: NM_001409033 NM_001103167, NM_001409033

Canonical transcript exons

ENST00000707000 — 5 exons

ExonStartEnd
ENSE000015545421030934910309815
ENSE000015577691030818510308550
ENSE000015634851030480310305208
ENSE000015642101030539010305483
ENSE000036181161030584610305952

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 90.44.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2403 / max 26.9472, expressed in 114 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter IDTPM avgSamples expressed
1791040.2403114

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099190.44gold quality
right hemisphere of cerebellumUBERON:001489085.21gold quality
cerebellar hemisphereUBERON:000224584.96gold quality
cerebellar cortexUBERON:000212984.86gold quality
nucleus accumbensUBERON:000188284.75gold quality
cerebellumUBERON:000203784.74gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047384.56gold quality
right frontal lobeUBERON:000281083.99gold quality
right lobe of thyroid glandUBERON:000111982.65gold quality
putamenUBERON:000187482.53gold quality
primary visual cortexUBERON:000243682.37gold quality
anterior cingulate cortexUBERON:000983582.30gold quality
caudate nucleusUBERON:000187382.27gold quality
monocyteCL:000057682.10gold quality
granulocyteCL:000009481.99gold quality
leukocyteCL:000073881.65gold quality
Brodmann (1909) area 9UBERON:001354081.62gold quality
pituitary glandUBERON:000000781.54gold quality
dorsolateral prefrontal cortexUBERON:000983481.22gold quality
adenohypophysisUBERON:000219680.95gold quality
Ammon’s hornUBERON:000195480.89gold quality
left lobe of thyroid glandUBERON:000112080.77gold quality
brainUBERON:000095580.76gold quality
thyroid glandUBERON:000204680.53gold quality
mucosa of transverse colonUBERON:000499180.43gold quality
cortical plateUBERON:000534380.37gold quality
amygdalaUBERON:000187680.04gold quality
hypothalamusUBERON:000189879.99gold quality
temporal lobeUBERON:000187179.92gold quality
cerebral cortexUBERON:000095679.81gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-ANND-3no0.84

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

27 targets.

TargetRegulation
ACTB
ADCY1
APOA1
AVP
CRH
EGFR
FFAR1
FOXA2
GAST
GCG
GIP
GLP1R
GNLY
IAPP
INS
KCNJ11
MAPK1
MAPK14
PAX6
PDX1
PIK3R1
PRKACA
RIPK1
SCT
SIRT1
TNF
TRIB3

JASPAR motifs

MotifNameFamily
MA2557.1ZGLP1C4-GATA-related

JASPAR matrix evidence (PMIDs): PMID:39605530

miRNA regulators (miRDB)

8 targeting ZGLP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-629-3P99.8567.991875
HSA-MIR-4713-5P99.7867.801794
HSA-MIR-182799.6368.573265
HSA-MIR-516B-5P99.5666.331495
HSA-MIR-532-3P99.3465.761195
HSA-MIR-3619-5P99.0068.872308
HSA-MIR-570198.9769.541502
HSA-MIR-429998.2866.96850

Literature-anchored findings (GeneRIF, showing 2)

  • Characterization and functional analysis of the mouse GLP-1 ortholog, and comparison to the human protein. (PMID:16982049)
  • There is minor contribution of endogenous GLP-1 and GLP-2 to postprandial lipemia in obese men. (PMID:26752550)

Cross-species orthologs

7 orthologs

OrganismSymbolGene ID
danio_reriozglp1ENSDARG00000067669
mus_musculusZglp1ENSMUSG00000079681
rattus_norvegicusZglp1ENSRNOG00000042601
drosophila_melanogastersrpFBGN0003507
drosophila_melanogasterGATAdFBGN0032223
caenorhabditis_elegansWBGENE00001250
caenorhabditis_elegansWBGENE00001252

Paralogs (7): GATA1 (ENSG00000102145), TRPS1 (ENSG00000104447), GATA3 (ENSG00000107485), GATA5 (ENSG00000130700), GATA4 (ENSG00000136574), GATA6 (ENSG00000141448), GATA2 (ENSG00000179348)

Protein

Protein identifiers

GATA-type zinc finger protein 1 — P0C6A0 (reviewed: P0C6A0)

Alternative names: GATA-like protein 1

All UniProt accessions (2): B5MCP8, P0C6A0

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional regulator that plays a key role in germ cell development. Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry. Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells. Regulates expression of STRA8, a central downstream effector for the meiotic program. Acts independently of retinoic acid (RA). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase.

Subcellular location. Nucleus.

Miscellaneous. Gene prediction based on EST data and conservation.

Isoforms (2)

UniProt IDNamesCanonical?
P0C6A0-22yes
P0C6A0-11

RefSeq proteins (2): NP_001096637, NP_001395962* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR000679Znf_GATADomain
IPR013088Znf_NHR/GATAHomologous_superfamily
IPR053116GATA-type_Znf_RegulatorFamily

Pfam: PF00320

UniProt features (5 total): region of interest 2, chain 1, zinc finger region 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-P0C6A0-F162.890.24

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 46 (showing top): GOBP_OOGENESIS, GOBP_MALE_GAMETE_GENERATION, HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_1_UP, GOBP_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM, GOBP_OOCYTE_DIFFERENTIATION, GOBP_FEMALE_GAMETE_GENERATION, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, chr19p13, GOMF_SEQUENCE_SPECIFIC_DNA_BINDING, GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY, ZNF592_TARGET_GENES, ZNF92_TARGET_GENES

GO Biological Process (8): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), spermatogenesis (GO:0007283), positive regulation of transcription by RNA polymerase II (GO:0045944), oocyte development (GO:0048599), regulation of DNA-templated transcription (GO:0006355), cell differentiation (GO:0030154), oogenesis (GO:0048477)

GO Molecular Function (5): DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), zinc ion binding (GO:0008270), sequence-specific DNA binding (GO:0043565), DNA binding (GO:0003677), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nucleoplasm (GO:0005654)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
regulation of transcription by RNA polymerase II3
transcription by RNA polymerase II3
germ cell development2
negative regulation of DNA-templated transcription1
regulation of DNA-templated transcription1
developmental process involved in reproduction1
male gamete generation1
positive regulation of DNA-templated transcription1
oocyte differentiation1
DNA-templated transcription1
regulation of gene expression1
regulation of RNA biosynthetic process1
cellular developmental process1
female gamete generation1
chromatin1
RNA polymerase II transcription regulatory region sequence-specific DNA binding1
DNA-binding transcription factor activity1
transition metal ion binding1
DNA binding1
nucleic acid binding1
cation binding1
intracellular membrane-bounded organelle1
nuclear lumen1
cellular anatomical structure1

Protein interactions and networks

STRING

1072 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
ZGLP1GATA6P78327826
ZGLP1MEIOSINC9JSJ3593
ZGLP1HENMT1Q5T8I9448
ZGLP1FOXL2P58012437
ZGLP1FDX2Q6P4F2435
ZGLP1DMRT1Q9Y5R6433
ZGLP1RAVER1Q8IY67419
ZGLP1MRPL4Q9BYD3397
ZGLP1TBPL2Q6SJ96396
ZGLP1FIGLAQ6QHK4378
ZGLP1ZBTB11O95625377
ZGLP1ICAM4Q14773376
ZGLP1TDRD9Q8NDG6363
ZGLP1NTAQ1Q96HA8360
ZGLP1REC8O95072359

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A1B0GVZ6, A5D7I0, A6H7B4, A6NDZ8, A6NE82, A6NJ08, A6NJB7, A6NJI1, A6NL46, A6QP24, A8MUA0, A8MUI8, A8MV72, A8MX80, B2RW88, O94850, P0C6A0, P24097, P50617, Q0P5M0, Q0VD86, Q2KIL8, Q3B8N5, Q3SY00, Q3SYA9, Q3UN58, Q5BMD4, Q5JTZ5, Q5RBE4, Q5VZ46, Q66MI6, Q68US1, Q6GQV0, Q6PAC4, Q80TS7, Q80VY2, Q8BFY7, Q8BII1, Q8IXW0, Q8K2F3

Diamond homologs: B4XXY3, B7WN96, B8AX51, D4B3J8, G5EB20, G5EGF4, G5EGN3, N4XMB0, O13412, O13415, O13508, O61924, O94720, P0C6A0, P17429, P18494, P19212, P26343, P40349, P42944, P43574, P52172, P78688, Q01168, Q01582, Q10134, Q10280, Q10655, Q1K8E7, Q1WG82, Q4WV91, Q55C49, Q5A201, Q5A432, Q5AP95, Q6L5E5, Q8LC59, Q8LG10, Q8MQA7, Q90ZS6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance1
Likely benign0
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

882 predictions. Top by Δscore:

VariantEffectΔscore
19:10305370:C:CAdonor_gain1.0000
19:10305841:CTCA:Cdonor_loss1.0000
19:10305842:TCA:Tdonor_loss1.0000
19:10305843:CACCC:Cdonor_loss1.0000
19:10305844:AC:Adonor_gain1.0000
19:10305844:ACCCA:Adonor_loss1.0000
19:10305845:C:CAdonor_loss1.0000
19:10305845:CC:Cdonor_gain1.0000
19:10305948:GCAGG:Gacceptor_gain1.0000
19:10305949:CAGG:Cacceptor_gain1.0000
19:10305949:CAGGC:Cacceptor_gain1.0000
19:10305950:AGG:Aacceptor_gain1.0000
19:10305951:GG:Gacceptor_gain1.0000
19:10305951:GGC:Gacceptor_loss1.0000
19:10305953:C:CCacceptor_gain1.0000
19:10308179:CCCTA:Cdonor_loss1.0000
19:10308180:CCTA:Cdonor_loss1.0000
19:10308181:CTA:Cdonor_loss1.0000
19:10308182:TA:Tdonor_loss1.0000
19:10308183:ACC:Adonor_loss1.0000
19:10308183:ACCT:Adonor_loss1.0000
19:10308184:CCTGT:Cdonor_loss1.0000
19:10305207:ACCTA:Aacceptor_loss0.9900
19:10305209:CT:Cacceptor_loss0.9900
19:10305215:T:Cacceptor_gain0.9900
19:10305215:T:TCacceptor_gain0.9900
19:10305373:T:TAdonor_gain0.9900
19:10305480:GGCT:Gacceptor_gain0.9900
19:10305481:GCTC:Gacceptor_loss0.9900
19:10305482:CT:Cacceptor_gain0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1001288621 (19:10306407 C>A), RS1001347366 (19:10307027 C>G), RS1001522435 (19:10304315 T>A,C), RS1001559486 (19:10309315 C>T), RS1001995263 (19:10305789 G>A,C), RS1003863027 (19:10308535 T>A), RS1005946978 (19:10309855 G>C), RS1005969003 (19:10309700 G>T), RS1006043415 (19:10307982 A>C), RS1006491857 (19:10309877 GTTTTTGTTTTTT>G), RS1007467401 (19:10309395 A>C,G), RS1007666401 (19:10306403 G>A), RS1007802326 (19:10306771 C>A,T), RS1007995589 (19:10309640 G>T), RS1008003385 (19:10308044 T>C)

Disease associations

OMIM: gene MIM:611639 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

StudyTraitp-value
GCST002740_28Inflammatory skin disease8.000000e-08
GCST004131_88Inflammatory bowel disease2.000000e-11
GCST004132_111Crohn’s disease3.000000e-13

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

ChemicalActions (top 5)PubMed papers
aristolochic acid Iincreases expression1
bisphenol Adecreases expression1
beta-lapachonedecreases expression1
di-n-butylphosphoric acidaffects expression1
abrineincreases expression1
Sunitinibincreases expression1
Benzo(a)pyreneaffects methylation1
Smokedecreases expression1
Tobacco Smoke Pollutiondecreases expression1
Valproic Acidincreases methylation1
Okadaic Aciddecreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

  • Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): atopic eczema

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 74

This page pulls from 74 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot